Alterations in brain neural network and stress system in atopic dermatitis: Novel therapeutic interventions
Open accessAbstract
Atopic dermatitis is a common chronic inflammatory skin disease, with most cases experiencing skin barrier dysfunction and enhanced allergen entry, accompanied by cytokine production which evokes predominantly type-2-skewed immune responses, itch, and scratching behavior. Although intense itch and excessive scratching behavior affect progression of skin lesions, it is unclear what causes them. Data suggest that scratching behavior stimulates brain dopaminergic reward and habit learning systems, strengthening habitual scratching behavior, while nocturnal scratching behavior presumably increases locus coeruleus-noradrenergic system activity, prompting sleep disturbances. At the early stage of atopic dermatitis, increased cortisol levels, due to hypothalamic-pituitary-adrenal axis overactivation caused by such system stimulation, can induce dorsolateral prefrontal cortex disturbance with reinforcement of habitual scratching behavior and may aggravate type-2-skewed immune responses in the skin. During the later phases, whereas blunted hypothalamic-pituitary-adrenal axis function and the shift of type-2-dominated to type-1-co-dominated inflammation are induced, noradrenergic system overactivation-associated dorsolateral prefrontal cortex disruption is ongoing and responsible for itch cognitive distortion to catastrophize about itch, which leads to a vicious spiral along with habitual scratching behavior and skin lesions. Data are presented in this review indicating that while skin immune system dysfunction initiates pathologic changes in atopic dermatitis, brain neural network and stress system alterations can promote the progression of this condition. It is also suggested that cognitive distortion contributes to pathology in atopic dermatitis as with some psychiatric disorders and chronic pain. The proposed mechanistic model could lead to development of novel medications for slowing or terminating the relentless progression of this disorder. SIGNIFICANCE STATEMENT: Although conventional pharmacological interventions focusing on skin homeostasis and itch occurrence significantly attenuate clinical signs in atopic dermatitis patients, achievement of 100% improvement is less than 40% in several double-blind, randomized, placebo-controlled trials. Our model predicts that itch cognitive distortion, due to dorsolateral prefrontal cortex disturbance, can significantly contribute to the progression of atopic dermatitis and that agents capable of improving brain neural network, stress system, and skin homeostasis may be effective as interventions in the treatment of this condition.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Skin problems such as dermatitis, eczema, and rash are related to stress levels, which worsen them.
“Skin problems, such as dermatitis, eczema, and rash, are related to stress levels, which worsen them [91].”
From The Risk Factors of Chronic Pain in Victims of Violence: A Scoping Review (2023) · cites this paper as [91]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340 · see citing works
Auphan, N., DiDonato, J. A., Rosette, C., Helmberg, A., & Karin, M. (1995) · Science · doi:10.1126/science.270.5234.286 · Cited by 2,390 · see citing works
The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress
Smith, S. M., & Vale, W. W. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/ssmith · Cited by 1,948 · see citing works
Langan, S., Irvine, A. D., & Weidinger, S. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31286-1 · Cited by 1,943 · see citing works
Nucleus locus ceruleus: new evidence of anatomical and physiological specificity
Foote, S. L., Bloom, F. E., & Aston-Jones, G. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.3.844 · Cited by 1,901 · see citing works
Tan, D., Manchester, L. C., Terron, M. P., Flores, L. J., & Reiter, R. J. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00407.x · Cited by 1,601 · see citing works
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477 · see citing works
Chronic back pain is associated with decreased prefrontal and thalamic gray matter density
Apkarian, A. V., Sosa, Y., Sonty, S., Levy, R. M., Harden, R. N., Parrish, T. B., & Gitelman, D. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2541-04.2004 · Cited by 1,434 · see citing works
Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk
Cohen, S., Janicki-Deverts, D., Doyle, W. J., Miller, G. E., Frank, E., Rabin, B. S., & Turner, R. B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118355109 · Cited by 1,419 · see citing works
Guidelines of care for the management of atopic dermatitis
Eichenfield, L. F., Tom, W. L., Chamlin, S. L., Feldman, S. R., Hanifin, J. M., Simpson, E. L., Berger, T. G., Bergman, J. N., Cohen, D. E., Cooper, K. D., et al. (2013) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.10.010 · Cited by 1,305 · see citing works
Cognitive neuroscience of self-regulation failure
Heatherton, T. F., & Wagner, D. D. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.12.005 · Cited by 1,033 · see citing works
Ikoma, A., Steinhoff, M. S., Ständer, S., Yosipovitch, G., & Schmelz, M. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1950 · Cited by 962 · see citing works
Cevikbas, F., Wang, X., Akiyama, T., Kempkes, C., Savinko, T., Antal, A. S., Kukova, G., Buhl, T., Ikoma, A., Buddenkotte, J., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.10.048 · Cited by 806 · see citing works
Neurocognitive aspects of pain perception
Wiech, K., Ploner, M., & Tracey, I. (2008) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2008.05.005 · Cited by 737 · see citing works
Wellman, C. L. (2001) · Journal of Neurobiology · doi:10.1002/neu.1079 · Cited by 594 · see citing works
Cellular and molecular immunologic mechanisms in patients with atopic dermatitis
Werfel, T., Allam, J., Biedermann, T., Eyerich, K., Gilles, S., Guttman‐Yassky, E., Hoetzenecker, W., Knol, E. F., Simon, H., Wollenberg, A., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.06.010 · Cited by 593 · see citing works
Anti–Interleukin-31 Receptor A Antibody for Atopic Dermatitis
Ruzicka, T., Hanifin, J. M., Furue, M., Pulka, G., Mlynarczyk, I., Wollenberg, A., Galus, R., Etoh, T., Mihara, R., Yoshida, H., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1606490 · Cited by 592 · see citing works
Getting the pain you expect: mechanisms of placebo, nocebo and reappraisal effects in humans
Tracey, I. (2010) · Nature Medicine · doi:10.1038/nm.2229 · Cited by 553 · see citing works
Miller, G. E., Chen, E., Sze, J., Marin, T., Arevalo, J. M. G., Doll, R., Ma, R., & Cole, S. W. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.017 · Cited by 552 · see citing works
Blauvelt, A., Teixeira, H. D., Simpson, E. L., Costanzo, A., De Bruin-Weller, M., Barbarot, S., Prajapati, V. H., Lio, P., Hu, X., Wu, T., et al. (2021) · JAMA Dermatology · doi:10.1001/jamadermatol.2021.3023 · Cited by 516 · see citing works
Fuxench, Z. C. C., Block, J. K., Boguniewicz, M., Boyle, J. M., Fonacier, L. S., Gelfand, J. M., Grayson, M. H., Margolis, D. J., Mitchell, L., Silverberg, J. I., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.08.028 · Cited by 420 · see citing works
Yerra, V. G., Negi, G., Sharma, S. S., & Kumar, A. (2013) · Redox Biology · doi:10.1016/j.redox.2013.07.005 · Cited by 414 · see citing works
Widespread reductions in gray matter volume in depression
Grieve, S. M., Korgaonkar, M. S., Koslow, S. H., Gordon, E., & Williams, L. M. (2013) · NeuroImage: Clinical · doi:10.1016/j.nicl.2013.08.016 · Cited by 388 · see citing works
A brief review about melatonin, a pineal hormone
do Amaral, F. G., & Cipolla‐Neto, J. (2018) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000066 · Cited by 387 · see citing works
Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis
Spergel, J. M., Mizoguchi, E., Oettgen, H. C., Bhan, A. K., & Geha, R. S. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5669 · Cited by 383 · see citing works
Arnsten, A. F. T., Raskind, M. A., Taylor, F. B., & Connor, D. F. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.10.002 · Cited by 381 · see citing works
Extrinsic and intrinsic types of atopic dermatitis
TOKURA, Y. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.02.008 · Cited by 351 · see citing works
Liu, R.-J., & Aghajanian, G. K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706679105 · Cited by 346 · see citing works
Hill, M. N., & Tasker, J. G. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.030 · Cited by 341 · see citing works
Sleep Disturbances in Depression
Murphy, M. J., & Peterson, M. J. (2014) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2014.11.009 · Cited by 321 · see citing works
García-Lorenzo, D., Santos, C. L.-D., Ewenczyk, C., Leu‐Semenescu, S., Galléa, C., Quattrocchi, G., Lobo, P. P., Poupon, C., Benali, H., Arnulf, I., et al. (2013) · Brain · doi:10.1093/brain/awt152 · Cited by 314 · see citing works
Glucocorticoids—All-Rounders Tackling the Versatile Players of the Immune System
Strehl, C., Ehlers, L., Gaber, T., & Buttgereit, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01744 · Cited by 308 · see citing works
Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions
Slominski, A. T., Hardeland, R., Zmijewski, M. A., Slominski, R. M., Reiter, R. J., & Paus, R. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.10.025 · Cited by 293 · see citing works
Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive
Eban-Rothschild, A., Appelbaum, L., & de Lecea, L. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.294 · Cited by 282 · see citing works
Franchimont, D. P., Galon, J., Gadina, M., Visconti, R., Zhou, Y.-J., Aringer, M., Frucht, D. M., Chrousos, G. P., & O’Shea, J. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.1768 · Cited by 261 · see citing works
Sleep deprivation potentiates HPA axis stress reactivity in healthy adults.
Minkel, J., Moreta, M., Muto, J., Htaik, O., Jones, C., Basner, M., & Dinges, D. (2014) · Health Psychology · doi:10.1037/a0034219 · Cited by 261 · see citing works
Buske-Kirschbaum, A., Geiben, A. C., Höllig, H., Morschhäuser, E., & Hellhammer, D. H. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2001-010872 · Cited by 241 · see citing works
Tian, R., Hou, G., Li, D., & Yuan, T. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/780616 · Cited by 237 · see citing works
The role of executive functioning in CBT: a pilot study with anxious older adults
Mohlman, J., & Gorman, J. M. (2005) · Behaviour Research and Therapy · doi:10.1016/j.brat.2004.03.007 · Cited by 229 · see citing works
Role of microglial m1/m2 polarization in relapse and remission of psychiatric disorders and diseases
Nakagawa, Y., & Chiba, K. (2014) · Pharmaceuticals · doi:10.3390/ph7121028 · Cited by 215 · see citing works
Self-citationEfficacy and Safety of Upadacitinib in Patients With Moderate to Severe Atopic Dermatitis
Simpson, E. L., Papp, K. A., Blauvelt, A., Chu, C., Hong, H., Katoh, N., Calimlim, B., Thyssen, J. P., Chiou, A. S., Bissonnette, R., et al. (2022) · JAMA Dermatology · doi:10.1001/jamadermatol.2022.0029 · Cited by 215 · see citing works
Diversity and plasticity of microglial cells in psychiatric and neurological disorders
Nakagawa, Y., & Chiba, K. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.010 · Cited by 208 · see citing works
Self-citationMorinobu, A., Gadina, M., Strober, W., Visconti, R., Fornace, A. J., Montagna, C., Feldman, G. M., Nishikomori, R., & O’Shea, J. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182618999 · Cited by 207 · see citing works
Morris, L. S., Kundu, P., Dowell, N., Mechelmans, D. J., Favre, P., Irvine, M. A., Robbins, T. W., Daw, N., Bullmore, E. T., Harrison, N. A., et al. (2016) · Cortex · doi:10.1016/j.cortex.2015.11.004 · Cited by 198 · see citing works
Barrier dysfunction in the skin allergy
Egawa, G., & Kabashima, K. (2017) · Allergology International · doi:10.1016/j.alit.2017.10.002 · Cited by 196 · see citing works
Chamlin, S. L., Mattson, C. L., Frieden, I. J., Williams, M. L. K., Mancini, A. J., Cella, D. F., & Chren, M. (2005) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.159.8.745 · Cited by 186 · see citing works
The interplay between genetic and environmental factors in the pathogenesis of atopic dermatitis
Otsuka, A., Nomura, T., Rerknimitr, P., Seidel, J. A., Honda, T., & Kabashima, K. (2017) · Immunological Reviews · doi:10.1111/imr.12545 · Cited by 185 · see citing works
Biedermann, T., Skabytska, Y., Kaesler, S., & Volz, T. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00353 · Cited by 180 · see citing works
Ishiuji, Y., Coghill, R. C., Patel, T. S., Oshiro, Y., Kraft, R., & Yosipovitch, G. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09308.x · Cited by 176 · see citing works
Zhong, M., Wang, X., Xiao, J., Yi, J., Zhu, X., Liao, J., Wang, W., & Yao, S. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.08.007 · Cited by 170 · see citing works
Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance
Chang, Y.-S., Lin, M.-H., Lee, J., Lee, P., Dai, Y., Chu, K., Sun, C. H., Lin, Y., Wang, L., Yu, H., et al. (2015) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2015.3092 · Cited by 167 · see citing works
Atopic Dermatitis, Melatonin, and Sleep Disturbance
Chang, Y.-S., Chou, Y.-T., Lee, J., Lee, P., Dai, Y.-S., Sun, C. H., Lin, Y., Wang, L., Yu, H., Yang, Y., et al. (2014) · PEDIATRICS · doi:10.1542/peds.2014-0376 · Cited by 166 · see citing works
Ziegler, Cass, & Herman, J. P. (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00337.x · Cited by 162 · see citing works
Smith, K. S., & Graybiel, A. M. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.1/ksmith · Cited by 156 · see citing works
Petrosino, S., Verde, R., Vaia, M., Allarà, M., Iuvone, T., & Marzo, V. D. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.244368 · Cited by 155 · see citing works
Electrically evoked itch in humans
Ikoma, A., Handwerker, H. O., Miyachi, Y., & Schmelz, M. (2004) · Pain · doi:10.1016/j.pain.2004.10.003 · Cited by 150 · see citing works
Sleep disorders and atopic dermatitis: A 2-way street?
Chang, Y.-S., & Chiang, B. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.08.005 · Cited by 147 · see citing works
Neural basis of contagious itch and why some people are more prone to it
Holle, H., Warne, K., Seth, A. K., Critchley, H. D., & Ward, J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216160109 · Cited by 145 · see citing works
Conrad, C. D., McLaughlin, K. J., Harman, J. S., Foltz, C. H., Wieczorek, L., Lightner, E. N., & Wright, R. L. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2121-07.2007 · Cited by 143 · see citing works
Lomazzo, E., Bîndilă, L., Remmers, F., Lerner, R., Schwitter, C., Hoheisel, U., & Lutz, B. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.198 · Cited by 141 · see citing works
Rohleder, N. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.015 · Cited by 136 · see citing works
Brain’s Reward Circuits Mediate Itch Relief. A Functional MRI Study of Active Scratching
Papoiu, A. D. P., Nattkemper, L. A., Sanders, K. M., Kraft, R., Chan, Y.-H., Coghill, R. C., & Yosipovitch, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082389 · Cited by 131 · see citing works
Papoiu, A. D. P., Wang, H., Coghill, R. C., Chan, Y., & Yosipovitch, G. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10318.x · Cited by 123 · see citing works
A therapeutic effect of cbd-enriched ointment in inflammatory skin diseases and cutaneous scars.
Palmieri, B., Laurino, C., & Vadalà, M. (2019) · PubMed · doi:10.7417/ct.2019.2116 · Cited by 118 · see citing works
Attenuated cortisol response to alcohol in heavy social drinkers
King, A., Munisamy, G., de Wit, H., & Lin, S. (2006) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2005.10.008 · Cited by 114 · see citing works
Cannabinoids, Endocannabinoids and Sleep
Kesner, A. J., & Lovinger, D. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00125 · Cited by 112 · see citing works
Huang, H.-W., Zheng, B.-L., Jiang, L., Lin, Z., Zhang, G., Shen, L., & Xi, X. (2015) · Critical Care · doi:10.1186/s13054-015-0842-8 · Cited by 98 · see citing works
Contagious itch: what we know and what we would like to know
Schut, C., Grossman, S., Gieler, U., Kupfer, J., & Yosipovitch, G. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00057 · Cited by 96 · see citing works
Chiurchiù, V., Cencioni, M. T., Bisicchia, E., Bardi, M. D., Gasperini, C., Borsellino, G., Centonze, D., Battistini, L., & Maccarrone, M. (2013) · Annals of Neurology · doi:10.1002/ana.23875 · Cited by 90 · see citing works
Olmarker, K. (1991) · Acta Orthopaedica Scandinavica · doi:10.3109/17453679109153920 · Cited by 88 · see citing works
Presynaptic Noradrenergic Regulation of Glutamate Inputs to Hypothalamic Magnocellular Neurones
Boudaba, C., Di, S., & Tasker, J. G. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01063.x · Cited by 87 · see citing works
An fMRI study of emotional face processing in adolescent major depression
Hall, L. M. J., Klimes‐Dougan, B., Hunt, R. H., Thomas, K. M., Houri, A. K., Noack, E., Mueller, B. A., Lim, K. O., & Cullen, K. R. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.06.037 · Cited by 87 · see citing works
Konakchieva, R., Mitev, Y., Almeida, O., & Patchev, V. (1998) · Neuroendocrinology · doi:10.1159/000054312 · Cited by 82 · see citing works
The cerebral representation of scratching-induced pleasantness
Mochizuki, H., Tanaka, S., Morita, T., Wasaka, T., Sadato, N., & Kakigi, R. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00374.2013 · Cited by 81 · see citing works
The locus coeruleus, catecholamines, and REM sleep: a critical review.
Ramm, P. (1979) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(79)90212-7 · Cited by 79 · see citing works
The Itch-Scratch Cycle: A Review of the Mechanisms
Rinaldi, G. (2019) · Dermatology Practical & Conceptual · doi:10.5826/dpc.0902a03 · Cited by 76 · see citing works
Correlation between Severity of Atopic Dermatitis and Sleep Quality in Children and Adults
Kong, T. S., Han, T. Y., Lee, J. H., & Son, S. J. (2016) · Annals of Dermatology · doi:10.5021/ad.2016.28.3.321 · Cited by 75 · see citing works
Gambling pathology is associated with dampened cortisol response among men and women
Paris, J. J., Franco, C. A., Sodano, R., Frye, C. A., & Wulfert, E. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.04.002 · Cited by 72 · see citing works
Belda, X., & Armario, A. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1613-5 · Cited by 72 · see citing works
Nakagawa, Y., & Chiba, K. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.234476 · Cited by 72 · see citing works
Self-citationSevilla, L. M., Jiménez‐Panizo, A., Alegre‐Martí, A., Estébanez‐Perpiñá, E., Caelles, C., & Pérez, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810049 · Cited by 72 · see citing works
A gradient of glucocorticoid sensitivity among helper T cell cytokines
Banuelos, J., & Lu, N. (2016) · Cytokine & growth factor reviews · doi:10.1016/j.cytogfr.2016.05.002 · Cited by 70 · see citing works
Endocannabinoid Signaling Regulates Sleep Stability
Pava, M. J., Makriyannis, A., & Lovinger, D. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152473 · Cited by 69 · see citing works
Internet-Delivered Cognitive Behavior Therapy for Atopic Dermatitis
Hedman‐Lagerlöf, E., Fust, J., Axelsson, E., Bonnert, M., Lalouni, M., Molander, O., Agrell, P., Bergman, A., Lindefors, N., & Bradley, M. (2021) · JAMA Dermatology · doi:10.1001/jamadermatol.2021.1450 · Cited by 69 · see citing works
Effect of melatonin on T/B cell activation and immune regulation in pinealectomy mice
Luo, J., Zhang, Z., Sun, H., Song, J. H., Chen, X., Huang, J., Lin, X., & Zhou, R. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117191 · Cited by 68 · see citing works
Kanda, N., & Watanabe, S. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.10.010 · Cited by 66 · see citing works
Health Utility Scores of Atopic Dermatitis in US Adults
Silverberg, J. I., Gelfand, J. M., Margolis, D. J., Boguniewicz, M., Fonacier, L. S., Grayson, M. H., Ong, P. Y., Fuxench, Z. C. C., & Simpson, E. L. (2018) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2018.11.043 · Cited by 62 · see citing works
Evidence for alterations in central noradrenergic signaling in irritable bowel syndrome
Berman, S. M., Suyenobu, B. Y., Naliboff, B. D., Bueller, J. A., Stains, J., Wong, H. Y., Mandelkern, M. A., FitzGerald, L., Ohning, G., Gupta, A., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.08.028 · Cited by 60 · see citing works
Cortico-subcortical activation patterns for itch and pain imagery
Mochizuki, H., Baumgärtner, U., Kamping, S., Ruttorf, M., Schad, L. R., Flor, H., Kakigi, R., & Treede, R. (2013) · Pain · doi:10.1016/j.pain.2013.06.007 · Cited by 60 · see citing works
Mochizuki, H., Schut, C., Nattkemper, L. A., & Yosipovitch, G. (2016) · Allergology International · doi:10.1016/j.alit.2016.08.013 · Cited by 59 · see citing works
Nam, G., Jeong, S. K., Park, B. M., Lee, S. H., Kim, H. J., Hong, S.-P., Kim, B. J., & Kim, B.-W. (2016) · Annals of Dermatology · doi:10.5021/ad.2016.28.1.22 · Cited by 57 · see citing works
Cytokine modulation of atopic itch
Trier, A. M., & Kim, B. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.05.005 · Cited by 55 · see citing works
Sasso, O., Summa, M., Armirotti, A., Pontis, S., Mei, C. D., & Piomelli, D. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.07.853 · Cited by 53 · see citing works
Berenson, L. S., Yang, J., Sleckman, B. P., Murphy, T. L., & MURPHY, K. M. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.8.4616 · Cited by 52 · see citing works
Kim, H. J., Kim, B., Park, B. M., Jeon, J. E., Lee, S. H., Mann, S., Ahn, S. K., Hong, S., & Jeong, S. K. (2015) · International Journal of Dermatology · doi:10.1111/ijd.12841 · Cited by 52 · see citing works
Evoked itch perception is associated with changes in functional brain connectivity
Desbordes, G., Li, A., Loggia, M. L., Kim, J., Schalock, P. C., Lerner, E. A., Tran, T. N., Ring, J., Rosen, B. R., Kaptchuk, T. J., et al. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.12.002 · Cited by 50 · see citing works
The locus coeruleus and regulation of behavioral flexibility and attention: clinical implications
Aston‐Jones, G., Iba, M., Clayton, E. C., Rajkowski, J., & Cohen, J. D. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9780511544156.008 · Cited by 49 · see citing works
Ardakani, A. T., Farrehi, M., Sharif, M. R., Ostadmohammadi, V., Mirhosseini, N. Z., Kheirkhah, D., Moosavi, G. A., Behnejad, M., Reiter, R. J., & Asemi, Z. (2018) · Pediatric Allergy and Immunology · doi:10.1111/pai.12978 · Cited by 49 · see citing works
Alhouayek, M., Bottemanne, P., Makriyannis, A., & Muccioli, G. G. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.01.001 · Cited by 47 · see citing works
Association of atopic dermatitis severity with cognitive function in adults
Silverberg, J. I., Lei, D. K., Yousaf, M., Janmohamed, S. R., Vakharia, P. P., Chopra, R., Chavda, R., Gabriel, S., Patel, K. R., Singam, V., et al. (2020) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2020.05.041 · Cited by 46 · see citing works
Kobayashi, H., Kikuchi, K., Tsubono, Y., & Tagami, H. (2003) · Dermatology · doi:10.1159/000068892 · Cited by 42 · see citing works
Katas, H., Hussain, Z., Amin, M. C. I. M., Kumolosasi, E., & Sahudin, S. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s71543 · Cited by 40 · see citing works
Oláh, A., Ambrus, L., Nicolussi, S., et al. (2016) · Experimental Dermatology · doi:10.1111/exd.12930 · Cited by 39 · see citing works
Mochizuki, H., & Kakigi, R. (2015) · The Journal of Dermatology · doi:10.1111/1346-8138.12956 · Cited by 36 · see citing works
Brain Processing of Contagious Itch in Patients with Atopic Dermatitis
Schut, C., Mochizuki, H., Grossman, S. K., Lin, A. C., Conklin, C. J., Mohamed, F. B., Gieler, U., Kupfer, J., & Yosipovitch, G. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01267 · Cited by 36 · see citing works
Current pharmaceutical developments in atopic dermatitis
Misery, L., Huet, F., Gouin, O., Ständer, S., & Deleuran, M. S. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.12.003 · Cited by 35 · see citing works
Effects of glucocorticoids on STAT4 activation in human T cells are stimulus-dependent
Fahey, A. J., Robins, R. A., Kindle, K. B., Heery, D. M., & Constantinescu, C. S. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0605296 · Cited by 34 · see citing works
Altered catecholamine synthesis and degradation in the epidermis of patients with atopic eczema
Schallreuter, K. U., Pittelkow, M. R., Swanson, N. N., et al. (1997) · Archives of Dermatological Research · doi:10.1007/s004030050258 · Cited by 33 · see citing works
Macedonio, G., Stefanucci, A., Maccallini, C., et al. (2016) · Protein and Peptide Letters · doi:10.2174/0929866523666161007152435 · Cited by 29 · see citing works
Effects of Melatonin on Anterior Pituitary Plasticity: A Comparison Between Mammals and Teleosts
Ciani, E., Haug, T. M., Maugars, G., Weltzien, F., Falcón, J., & Fontaine, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.605111 · Cited by 28 · see citing works
Generating physical symptoms from visual cues: An experimental study
Ogden, J., & Zoukas, S. (2009) · Psychology Health & Medicine · doi:10.1080/13548500903311547 · Cited by 27 · see citing works
Henriquez, J. E., Crawford, R. B., & Kaminski, N. E. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.02.013 · Cited by 25 · see citing works
Salivary Cortisol Response to Stress in Young Children with Atopic Dermatitis
Kojima, R., Matsuda, A., Nomura, I., Matsubara, O., Nonoyama, S., Ohya, Y., Saito, H., & Matsumoto, K. (2012) · Pediatric Dermatology · doi:10.1111/j.1525-1470.2012.01770.x · Cited by 24 · see citing works
Baskey, G., Singh, A., Sharma, R., et al. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.10.006 · Cited by 24 · see citing works
Ran, X.-R., Yang, Y., Meng, Y., Li, Y., Zhou, L., Wang, Z., & Zhu, J. (2019) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2019.04.002 · Cited by 24 · see citing works
Nakagawa, Y., & Yamada, S. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173737 · Cited by 23 · see citing works
Self-citationThe Relationship between Depression Severity and Cognitive Errors
Blake, E., Dobson, K. S., Sheptycki, A. R., & Drapeau, M. (2016) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.2016.70.2.203 · Cited by 22 · see citing works
Anandamide modulation of circadian- and stress-dependent effects on rat short-term memory
Santori, A., Colucci, P., Mancini, G. F., Morena, M., Palmery, M., Trezza, V., Puglisi‐Allegra, S., Hill, M. N., & Campolongo, P. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.06.018 · Cited by 22 · see citing works
Milanick, W. J., Polo‐Parada, L., Dantzler, H. A., & Kline, D. D. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12791 · Cited by 21 · see citing works
Nakagawa, Y., & Yamada, S. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01234-3 · Cited by 19 · see citing works
Self-citationYoon, N. Y., Jung, M. Y., Kim, D. H., Lee, H. J., & Choi, E. H. (2015) · Archives of Dermatological Research · doi:10.1007/s00403-015-1558-y · Cited by 17 · see citing works
Nakagawa, Y., & Yamada, S. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107455 · Cited by 17 · see citing works
Self-citationNFκB and glucocorticoid receptor activity in steroid resistance
Dawson, C., Dhanda, A., Conway-Campbell, B. L., di Mambro, A. J., Lightman, S. L., & Dayan, C. M. (2011) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2011.641977 · Cited by 13 · see citing works
Yudina, M. M., Геннадиевна, Т. Г., Lvov, A. N., et al. (2011) · Acta Dermato Venereologica · doi:10.2340/00015555-1173 · Cited by 11 · see citing works
Scratching the Surface: A Review of Dermatitis
Woo, T. E., Somayaji, R., Haber, R., & Parsons, L. M. (2019) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000604184.92824.43 · Cited by 11 · see citing works
Nakagawa, Y. (2017) · Journal of Drug and Alcohol Research · doi:10.4303/jdar/236017 · Cited by 10 · see citing works
Self-citationAssessment of the sensory threshold in patients with atopic dermatitis and psoriasis
Krzyżanowska, M., Muszer, K., Chabowski, K., et al. (2015) · Advances in Dermatology and Allergology · doi:10.5114/pdia.2014.44013 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Risk Factors of Chronic Pain in Victims of Violence: A Scoping Review
Uvelli, A., Duranti, C., Salvo, G., Coluccia, A., Gualtieri, G., & Ferretti, F. (2023) · Healthcare · doi:10.3390/healthcare11172421 · Cited by 10 · see citing works
- Authors
- Nakagawa, Y., & Yamada, S.
- Affiliations
- Shizuoka University (JP)
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2023-05
- Volume
- 385
- Issue
- 2
- Pages
- 78-87
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W4321764918
- Cited by
- 20
- References
- 128
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 6 · 2023: 3
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mitsubishi Tanabe Pharma Corporation
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- atopic dermatitis, pruritus, scratching behavior, brain neural networks, stress system, hypothalamic-pituitary-adrenal axis, dorsolateral prefrontal cortex, cognitive distortions, Th2 immune response, type 1 immune response, sleep disorders, neuroimmune interactions, therapeutic interventions
- MeSH terms
- Brain, Dermatitis, Atopic, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Pruritus, Randomized Controlled Trials as Topic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
