Cited by 282Sleep and Wakefulness ResearchCircadian rhythm and melatoninNeuroscience of respiration and sleep

Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive

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Eban-Rothschild, Ada, Appelbaum, Lior, de Lecea, Luis·2018·Neuropsychopharmacology

Abstract

Humans have been fascinated by sleep for millennia. After almost a century of scientific interrogation, significant progress has been made in understanding the neuronal regulation and functions of sleep. The application of new methods in neuroscience that enable the analysis of genetically defined neuronal circuits with unprecedented specificity and precision has been paramount in this endeavor. In this review, we first discuss electrophysiological and behavioral features of sleep/wake states and the principal neuronal populations involved in their regulation. Next, we describe the main modulatory drives of sleep and wakefulness, including homeostatic, circadian, and motivational processes. Finally, we describe a revised integrative model for sleep/wake regulation.

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Crossref · 10.1038/npp.2017.294

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  • The specific form of memory replay and synaptic plasticity arising in adversarial learning may be induced through differential activation of neuromodulators, as observed during transition across sleep stages and in shaping memory replay in general.

    “The specific form of memory replay and synaptic plasticity arising in adversarial learning may be induced through differential activation of neuromodulators, as it is also observed during the transition across sleep stages [47], and in shaping memory replay in general [48].”

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Authors
Eban-Rothschild, A., Appelbaum, L., & de Lecea, L.
Affiliations
  • University of Michigan (US)
  • Bar-Ilan University (IL)
Corresponding author
Eban-Rothschild, Ada
Venue
Neuropsychopharmacology
Published
2017-12-05
Volume
43
Issue
5
Pages
937-952
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
OpenAlex
W2773928801
Cited by
282
References
277
Citations by year
2026: 36 · 2025: 39 · 2024: 43 · 2023: 36 · 2022: 36 · 2021: 33 · 2020: 31 · 2019: 17 · 2018: 10
FWCI
1.76
Type
journal article
Language
en
Open access
Locations
  • Neuropsychopharmacology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Alliance for Research on Schizophrenia and Depression
  • Israel Science Foundation (690/15)
  • National Institutes of Health (R01-AG04767)
  • National Institute of Mental Health (R01MH102638, R01MH087592)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
sleep-wake regulation, neural circuits, homeostatic sleep drive, circadian rhythm, motivation, sleep homeostasis, sleep-wake states
MeSH terms
Animals, Circadian Rhythm, Drive, Homeostasis, Humans, Models, Biological, Motivation, Neurons, Sleep, Wakefulness, Electrophysiological Phenomena

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