Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive
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Humans have been fascinated by sleep for millennia. After almost a century of scientific interrogation, significant progress has been made in understanding the neuronal regulation and functions of sleep. The application of new methods in neuroscience that enable the analysis of genetically defined neuronal circuits with unprecedented specificity and precision has been paramount in this endeavor. In this review, we first discuss electrophysiological and behavioral features of sleep/wake states and the principal neuronal populations involved in their regulation. Next, we describe the main modulatory drives of sleep and wakefulness, including homeostatic, circadian, and motivational processes. Finally, we describe a revised integrative model for sleep/wake regulation.
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Sleep deprivation, vigilant attention, and brain function: a review
Hudson, A. N., Dongen, H. P. A. V., & Honn, K. A. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0432-6 · Cited by 397 · see citing works
Jones, B. E. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0444-2 · Cited by 265 · see citing works
Rising temperatures erode human sleep globally
Minor, K., Bjerre-Nielsen, A., Jonasdottir, S. S., Lehmann, S., & Obradovich, N. (2022) · One Earth · doi:10.1016/j.oneear.2022.04.008 · Cited by 261 · see citing works
Sleep Deprivation and Neurological Disorders
Bishir, M., Bhat, A., Essa, M. M., Ekpo, O. E., Ihunwo, A. O., Veeraraghavan, V. P., Surapaneni, K. M., Mahalakshmi, A. M., Ray, B., Tuladhar, S., et al. (2020) · BioMed Research International · doi:10.1155/2020/5764017 · Cited by 253 · see citing works
Andersen, M. L., Araujo, P., Frange, C., & Tufik, S. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.07.019 · Cited by 218 · see citing works
A wireless and battery-less implant for multimodal closed-loop neuromodulation in small animals
Ouyang, W., Lu, W., Zhang, Y., Liu, Y., Kim, J. U., Shen, H., Wu, Y., Luan, H., Kilner, K. J., Lee, S. P., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01029-x · Cited by 186 · see citing works
Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons
Zada, D., Bronshtein, I., Lerer‐Goldshtein, T., Garini, Y., & Appelbaum, L. (2019) · Nature Communications · doi:10.1038/s41467-019-08806-w · Cited by 154 · see citing works
Self-citationMolecular Mechanisms of Cancer-Induced Sleep Disruption
Walker, W. H., II, & Borniger, J. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112780 · Cited by 146 · see citing works
Cutler, A. J., Mattingly, G. W., & Maletic, V. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02514-2 · Cited by 147 · see citing works
Mattingly, S. M., Grover, T., Martinez, G. J., Aledavood, T., Robles-Granda, P., Nies, K., Striegel, A., & Mark, G. J. (2021) · npj Digital Medicine · doi:10.1038/s41746-021-00435-2 · Cited by 118 · see citing works
Parp1 promotes sleep, which enhances DNA repair in neurons
Zada, D., Sela, Y., Matosevich, N., Monsonego, A., Lerer‐Goldshtein, T., Nir, Y., & Appelbaum, L. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.10.026 · Cited by 115 · see citing works
Self-citationDisrupted sleep and circadian rhythms in schizophrenia and their interaction with dopamine signaling
Ashton, A., & Jagannath, A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00636 · Cited by 106 · see citing works
Dopamine pathways mediating affective state transitions after sleep loss
Wu, M., Zhang, X., Feng, S., Freda, S. N., Kumari, P., Dumrongprechachan, V., & Kozorovitskiy, Y. (2023) · Neuron · doi:10.1016/j.neuron.2023.10.002 · Cited by 90 · see citing works
Activation of orexin system facilitates anesthesia emergence and pain control
Zhou, W., Cheung, K., Kyu, S., Wang, L., Guan, Z., Kurien, P. A., Bickler, P. E., & Jan, L. Y. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808622115 · Cited by 81 · see citing works
A gut-secreted peptide suppresses arousability from sleep
Titos, I., Juginović, A., Vaccaro, A., Nambara, K., Gorelik, P., Mazor, O., & Rogulja, D. (2023) · Cell · doi:10.1016/j.cell.2023.02.022 · Cited by 80 · see citing works
The Microbiota–Gut–Brain Axis in Metabolic Syndrome and Sleep Disorders: A Systematic Review
dos Santos, A., & Galié, S. (2024) · Nutrients · doi:10.3390/nu16030390 · Cited by 81 · see citing works
Mehr, J. B., Mitchison, D., Bowrey, H. E., & James, M. H. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01052-z · Cited by 68 · see citing works
Recent advances in understanding the roles of hypocretin/orexin in arousal, affect, and motivation
Nevárez, N., & de Lecea, L. (2018) · F1000Research · doi:10.12688/f1000research.15097.1 · Cited by 67 · see citing works
The Interaction Between Sleep and Epilepsy
Roliz, A. H., & Kothare, S. V. (2022) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-022-01219-1 · Cited by 63 · see citing works
Morrone, C. D., Raghuraman, R., Hussaini, S. A., & Yu, W. H. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00617-4 · Cited by 64 · see citing works
EEG-based neural networks approaches for fatigue and drowsiness detection: A survey
Othmani, A., Sabri, A. Q. M., Aslan, S., Chaieb, F., Rameh, H., Alfred, R., & Cohen, D. (2023) · Neurocomputing · doi:10.1016/j.neucom.2023.126709 · Cited by 63 · see citing works
Methamphetamine and sleep impairments: neurobehavioral correlates and molecular mechanisms
Vrajová, M., Šlamberová, R., Höschl, C., & Ovsepian, S. V. (2021) · SLEEP · doi:10.1093/sleep/zsab001 · Cited by 66 · see citing works
Sleep Disorders Associated with Neurodegenerative Diseases
Anghel, L., Ciubară, A., Nechita, A., Nechita, L., Manole, C., Baroiu, L., Ciubară, A. B., & Mușat, C. L. (2023) · Diagnostics · doi:10.3390/diagnostics13182898 · Cited by 62 · see citing works
Role of Glia in the Regulation of Sleep in Health and Disease
Garofalo, S., Picard, K., Limatola, C., Nadjar, A., Pascual, O., & Tremblay, M. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190022 · Cited by 63 · see citing works
Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice
Song, J., Chu, S., Cui, Y., Qian, Y., Li, X., Xu, F., Shao, X., Ma, Z., Xia, T., & Gu, X. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.04.009 · Cited by 55 · see citing works
Astrocytes—The Ultimate Effectors of Long-Range Neuromodulatory Networks?
Pacholko, A. G., Wotton, C. A., & Bekar, L. K. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.581075 · Cited by 54 · see citing works
Sleepiness as a Local Phenomenon
D’Ambrosio, S., Castelnovo, A., Guglielmi, O., Nobili, L., Sarasso, S., & Garbarino, S. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01086 · Cited by 54 · see citing works
Herring, W. J., Roth, T., Krystal, A. D., & Michelson, D. (2019) · Journal of Sleep Research · doi:10.1111/jsr.12782 · Cited by 53 · see citing works
A Review of Equine Sleep: Implications for Equine Welfare
Greening, L., & McBride, S. D. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.916737 · Cited by 54 · see citing works
Beuckmann, C. T., Ueno, T., Nakagawa, M., Suzuki, M., & Akasofu, S. (2019) · SLEEP · doi:10.1093/sleep/zsz076 · Cited by 53 · see citing works
Lam, L. T.-M., & Lam, M. K. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182211782 · Cited by 50 · see citing works
Sleep deficiency promotes Alzheimer's disease development and progression
Lv, Y.-N., Cui, Y., Zhang, B., & Huang, S.-M. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.1053942 · Cited by 50 · see citing works
Boss, C., Gatfield, J., Brotschi, C., Heidmann, B., Sifferlen, T., von Raumer, M., Schmidt, G., Williams, J. T., Treiber, A., & Roch, C. (2020) · ChemMedChem · doi:10.1002/cmdc.202000453 · Cited by 49 · see citing works
Sleep as a translationally-relevant endpoint in studies of autism spectrum disorder (ASD)
Missig, G., McDougle, C. J., & Carlezon, W. A. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0409-5 · Cited by 45 · see citing works
Giardino, W. J., & Pomrenze, M. B. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.613025 · Cited by 46 · see citing works
The hypothalamic link between arousal and sleep homeostasis in mice
Yamagata, T., Kahn, M. C., Prius-Mengual, J., Meijer, E. J., Šabanović, M., Guillaumin, M. C. C., van der Vinne, V., Huang, Y., McKillop, L. E., Jagannath, A., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2101580118 · Cited by 45 · see citing works
Sleep deprivation: a risk for epileptic seizures
Dell’Aquila, J. T., & Soti, V. (2022) · Sleep Science · doi:10.5935/1984-0063.20220046 · Cited by 44 · see citing works
Neuromodulator and neuropeptide sensors and probes for precise circuit interrogation in vivo
Muir, J., Anguiano, M., & Kim, C. K. (2024) · Science · doi:10.1126/science.adn6671 · Cited by 45 · see citing works
Compartment specific regulation of sleep by mushroom body requires GABA and dopaminergic signaling
Driscoll, M., Buchert, S. N., Coleman, V., McLaughlin, M., Nguyen, A., & Sitaraman, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-99531-2 · Cited by 40 · see citing works
The neuroanatomy and neurochemistry of sleep-wake control
Gompf, H. S., & Anaclet, C. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.12.012 · Cited by 39 · see citing works
Circadian rhythm and sleep-wake systems share the dynamic extracellular synaptic milieu
Cooper, J. M., Halter, K. A., & Prosser, R. A. (2018) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2018.04.001 · Cited by 37 · see citing works
Zimmerman, K. A., Cournoyer, J., Lai, H., Snider, S. B., Fischer, D. B., Kemp, S. P. T., Karton, C., Hoshizaki, T. B., Ghajari, M., & Sharp, D. J. (2022) · Brain · doi:10.1093/brain/awac485 · Cited by 39 · see citing works
Newly identified sleep–wake and circadian circuits as potential therapeutic targets
Venner, A., Todd, W. D., Fraigne, J. J., Bowrey, H. E., Eban-Rothschild, A., Kaur, S., & Anaclet, C. (2019) · SLEEP · doi:10.1093/sleep/zsz023 · Cited by 36 · see citing works
Self-citationArousal State-Dependent Alterations in VTA-GABAergic Neuronal Activity
Eban-Rothschild, A., Borniger, J. C., Rothschild, G., Giardino, W. J., Morrow, J. G., & de Lecea, L. (2020) · eNeuro · doi:10.1523/eneuro.0356-19.2020 · Cited by 36 · see citing works
Self-citationNeural cell state shifts and fate loss in ageing and age-related diseases
Traxler, L., Lucciola, R., Herdy, J. R., Jones, J. R., Mertens, J., & Gage, F. H. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00815-0 · Cited by 34 · see citing works
Sleep homeostasis during daytime food entrainment in mice
Northeast, R. C., Huang, Y., McKillop, L. E., Bechtold, D. A., Peirson, S. N., Piggins, H. D., & Vyazovskiy, V. V. (2019) · SLEEP · doi:10.1093/sleep/zsz157 · Cited by 32 · see citing works
Perspective on the Multiple Pathways to Changing Brain States
Tantirigama, M. L. S., Zolnik, T. A., Judkewitz, B., Larkum, M. E., & Sachdev, R. N. S. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.00023 · Cited by 32 · see citing works
Linking the need to sleep with synaptic function
Cirelli, C., & Tononi, G. (2019) · Science · doi:10.1126/science.aay5304 · Cited by 32 · see citing works
Involvement of the adenosine A1 receptor in the hypnotic effect of rosmarinic acid
Kim, T., Bormate, K. J., Custodio, R. J. P., Cheong, J. H., Lee, B. K., Kim, H. J., & Jung, Y. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112483 · Cited by 31 · see citing works
Mechanisms of the Rapid Effects of Ketamine on Depression and Sleep Disturbances: A Narrative Review
Song, B., & Zhu, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.782457 · Cited by 31 · see citing works
Sleep and ageing: from human studies to rodent models
McKillop, L. E., & Vyazovskiy, V. V. (2020) · Current Opinion in Physiology · doi:10.1016/j.cophys.2020.03.004 · Cited by 29 · see citing works
Sleep deprivation-induced pre- and postsynaptic modulation of orexin neurons
Briggs, C., Bowes, S. C., Semba, K., & Hirasawa, M. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.12.025 · Cited by 27 · see citing works
Monfared, R. V., Alhassen, W., Truong, T. M., Gonzales, M. A. M., Vachirakorntong, V., Chen, S., Baldi, P., Civelli, O., & Alachkar, A. (2021) · Cells · doi:10.3390/cells10112967 · Cited by 28 · see citing works
Picard, K., Corsi, G., Decoeur, F., Castro, M. A. D., Bordeleau, M., Persillet, M., Layé, S., Limatola, C., Tremblay, M., & Nadjar, A. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.09.016 · Cited by 26 · see citing works
Kang, J., Park, M. K., Oh, C., & Kim, T. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115412 · Cited by 27 · see citing works
Carra, M. C., Balagny, P., & Bouchard, P. (2024) · Periodontology 2000 · doi:10.1111/prd.12611 · Cited by 28 · see citing works
Sleep and psychiatric disorders: Bidirectional interactions and shared neurobiological mechanisms
Hyndych, A., Koval, K., Dzeruzhynska, N., & Mader, E. C. (2025) · PLOS mental health. · doi:10.1371/journal.pmen.0000531 · Cited by 32 · see citing works
Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits
Banks, G. T., Guillaumin, M. C. C., Heise, I., Lau, P., Yin, M., Bourbia, N., Aguilar, C., Bowl, M. R., Esapa, C. T., Brown, L. A., et al. (2020) · Science Advances · doi:10.1126/sciadv.abb3567 · Cited by 25 · see citing works
Preliminary Results Regarding Sleep in a Zebrafish Model of Autism Spectrum Disorder
Robea, M. A., Ciobica, A. S., Curpăn, A.-Ș., Plavan, G. I., Strungaru, Ș.-A., Lefter, R. M., & Nicoară, M. (2021) · Brain Sciences · doi:10.3390/brainsci11050556 · Cited by 25 · see citing works
Murthy, S. V., Fathima, S. N., & Mote, R. (2022) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2022.27.1.108 · Cited by 24 · see citing works
Active Time-Restricted Feeding Improved Sleep-Wake Cycle in db/db Mice
Hou, T., Wang, C., Joshi, S., O’Hara, B. F., Gong, M. C., & Guo, Z. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00969 · Cited by 24 · see citing works
Largest scale dissociation of brain activity at propofol-induced loss of consciousness
Pujol, J., Blanco‐Hinojo, L., Gallart, L., Moltó, L., Martínez‐Vilavella, G., Vilà, E., Pacreu, S., Hernández, I. A., Deus, J., Pérez, V., et al. (2020) · SLEEP · doi:10.1093/sleep/zsaa152 · Cited by 23 · see citing works
Many faces of sleep regulation: beyond the time of day and prior wake time
Duhart, J. M., Inami, S., & Koh, K. (2021) · FEBS Journal · doi:10.1111/febs.16320 · Cited by 21 · see citing works
Sleep dysregulation in sympathetic-mediated diseases: implications for disease progression
Olivares, M. J., Toledo, C., Ortolani, D., Ortíz, F. C., Díaz, H. S., Iturriaga, R., & Río, R. D. (2022) · SLEEP · doi:10.1093/sleep/zsac166 · Cited by 21 · see citing works
Dual orexin receptor antagonists as promising therapeutics for Alzheimer’s disease
Ragsdale, S. M., Radovich, J. M., Coiduras, I. I., McCall, W. V., Grant, S. C., Lee, C. S., & Wilber, A. A. (2025) · npj Biological Timing and Sleep · doi:10.1038/s44323-025-00025-5 · Cited by 20 · see citing works
How Sleep Shapes Thalamocortical Circuit Function in the Visual System
Durkin, J., & Aton, S. J. (2019) · Annual Review of Vision Science · doi:10.1146/annurev-vision-091718-014715 · Cited by 20 · see citing works
Galli, O., Jones, C. W., Larson, O., Basner, M., & Dinges, D. (2021) · Sleep · doi:10.1093/sleep/zsab278 · Cited by 16 · see citing works
Nakagawa, Y., & Yamada, S. (2023) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.122.001482 · Cited by 20 · see citing works
McGregor, J. N., Farris, C. A., Ensley, S., Schneider, A. M., Fosque, L. J., Wang, C., Tilden, E. I., Liu, Y., Tu, J., Elmore, H., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.08.006 · Cited by 23 · see citing works
Keene, A. C., & Appelbaum, L. (2019) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-813743-7.00024-4 · Cited by 22 · see citing works
Self-citationLin, L., Gupta, S. N., Zheng, W., Si, K., & Zhu, J. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00960-8 · Cited by 20 · see citing works
FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function
Gerstner, J. R., Flores, C. C., Lefton, M., Rogers, B., & Davis, C. J. (2023) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2023.1212213 · Cited by 22 · see citing works
Banks, S., Jones, C. W., McCauley, M. E., Dorrian, J., Basner, M., Maislin, G., Dongen, H. P. A. V., & Dinges, D. F. (2023) · Journal of Sleep Research · doi:10.1111/jsr.14117 · Cited by 20 · see citing works
Objective evaluation of excessive daytime sleepiness
Taillard, J., Micoulaud‐Franchi, J., Martin, V., Peter‐Derex, L., & Vecchierini, M. (2024) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2023.102938 · Cited by 20 · see citing works
Nakagawa, Y., & Yamada, S. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01234-3 · Cited by 19 · see citing works
Presynaptic and postsynaptic long-term plasticity in sleep homeostasis
Huang, S., & Sigrist, S. J. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.11.010 · Cited by 15 · see citing works
Ricci, A., He, F., Fang, J., Calhoun, S. L., Vgontzas, A. N., Liao, D., Younes, M. K., Bixler, E. O., & Fernández‐Mendoza, J. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.05.002 · Cited by 18 · see citing works
Murillo‐Rodríguez, E., Millán‐Aldaco, D., Cicconcelli, D., Giorgetti, V., Arankowsky‐Sandoval, G., Alcaraz-Silva, J., Imperatori, C., Machado, S. E. D. C., Budde, H., & Torterolo, P. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05769-z · Cited by 18 · see citing works
Intrinsic maturation of sleep output neurons regulates sleep ontogeny in Drosophila
Gong, N. N., Luong, N. B. H., Dang, A. H., Mainwaring, B., Shields, E., Schmeckpeper, K., Bonasio, R., & Kayser, M. S. (2022) · Current Biology · doi:10.1016/j.cub.2022.07.054 · Cited by 17 · see citing works
Faltraco, F., Palm, D., Uzoni, A., Borchert, L., Simon, F. A. J., Tucha, O. M., & Thome, J. (2021) · Journal of Neural Transmission · doi:10.1007/s00702-021-02374-4 · Cited by 18 · see citing works
Sleep and motivated behaviors, from physiology to pathology
Sotelo, M. I., Tyan, J., Dzera, J., & Eban-Rothschild, A. (2020) · Current Opinion in Physiology · doi:10.1016/j.cophys.2020.01.006 · Cited by 18 · see citing works
Self-citationSleep as the Foundation of Brain Health
Ibrahim, A., Högl, B., & Stefani, A. (2025) · Seminars in Neurology · doi:10.1055/a-2566-4073 · Cited by 20 · see citing works
Dopamine, Psychosis, and Symptom Fluctuation: A Narrative Review
Novak, G., & Seeman, M. (2022) · Healthcare · doi:10.3390/healthcare10091713 · Cited by 17 · see citing works
Sleep Disturbances Predict Cognitive Decline in Cognitively Healthy Adults
Zawar, I., Mattos, M. K., Manning, C. A., Patrie, J. T., & Quigg, M. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221244 · Cited by 16 · see citing works
A clock-dependent brake for rhythmic arousal in the dorsomedial hypothalamus
Liu, Q., Bell, B. J., Kim, D. W., Lee, S., Keleş, M. F., Liu, Q., Blum, I. D., Wang, A. A., Blank, E. J., Xiong, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41877-4 · Cited by 15 · see citing works
Hericium erinaceus mycelium ameliorate anxiety induced by continuous sleep disturbance in vivo
Li, T., Lee, T.-Y., Lo, Y., Lee, L., Li, I.-C., Chen, C., & Chang, F. (2021) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-021-03463-3 · Cited by 16 · see citing works
Clinical and Experimental Human Sleep-Wake Pharmacogenetics
Landolt, H., Holst, S. C., & Valomon, A. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_175 · Cited by 15 · see citing works
Stress-induced sleep-like inactivity modulates stress susceptibility in mice
Nagai, M., Nagai, H., Numa, C., & Furuyashiki, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-76717-8 · Cited by 15 · see citing works
Light/Clock Influences Membrane Potential Dynamics to Regulate Sleep States
Tabuchi, M., Coates, K. E., Bautista, O., & Zukowski, L. H. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.625369 · Cited by 15 · see citing works
Hernandez, L. M., Kim, M., Hernandez, C., Thompson, W. K., Fan, C. C., Galván, A., Dapretto, M., Bookheimer, S. Y., Fuligni, A. J., & Gandal, M. J. (2022) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2021.12.011 · Cited by 14 · see citing works
Ye, M., Lee, S., Yu, H. J., Kim, K.-R., Park, H.-J., Kang, I., Kang, S. A., Chung, Y.-S., & Shim, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087043 · Cited by 14 · see citing works
Bandarabadi, M., Li, S., Aeschlimann, L., Colombo, G., Tzanoulinou, S., Tafti, M., Becchetti, A., Boutrel, B., & Vassalli, A. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02329-z · Cited by 16 · see citing works
Mild Traumatic Brain Injury Affects Orexin/Hypocretin Physiology Differently in Male and Female Mice
Somach, R. T., Jean, I. D., Farrugia, A. M., & Cohen, A. S. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2023.0125 · Cited by 13 · see citing works
Effects of non-invasive ventilation on sleep in chronic hypercapnic respiratory failure
Shah, N. M., Steier, J. S., Hart, N., & Kaltsakas, G. (2023) · Thorax · doi:10.1136/thorax-2023-220035 · Cited by 13 · see citing works
Crosstalk between the subiculum and sleep–wake regulation: A review
Rahimi, S., Joyce, L., Fenzl, T., & Drexel, M. (2024) · Journal of Sleep Research · doi:10.1111/jsr.14134 · Cited by 12 · see citing works
Vasilev, G., Miteva, D., Gulinac, M., Chervenkov, L., Kitanova, M., & Velikova, T. V. (2024) · Gastroenterology Insights · doi:10.3390/gastroent15030041 · Cited by 14 · see citing works
Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome
Jo, K., Kim, H., Choi, H., Lee, S.-S., Bang, M., & Suh, H. J. (2018) · Food Science and Biotechnology · doi:10.1007/s10068-018-0431-0 · Cited by 13 · see citing works
Chen, J., Cho, K. E., Skwarzyńska, D., Clancy, S., Conley, N. J., Clinton, S. M., Li, X., Lin, L., & Zhu, J. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1062-19.2020 · Cited by 13 · see citing works
Li, I.-C., Chang, F., Kuo, C., Chu, H., Li, T., & Chen, C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.788965 · Cited by 13 · see citing works
Wondie, A., Taderegew, M. M., Girma, B., Getawey, A., Tsega, D., Terefe, T. F., Mitiku, S., & Berhanu, H. (2022) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-022-00931-9 · Cited by 13 · see citing works
- Authors
- Eban-Rothschild, A., Appelbaum, L., & de Lecea, L.
- Affiliations
- University of Michigan (US)
- Bar-Ilan University (IL)
- Corresponding author
- Eban-Rothschild, Ada
- Venue
- Neuropsychopharmacology
- Published
- 2017-12-05
- Volume
- 43
- Issue
- 5
- Pages
- 937-952
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC5854814
- OpenAlex
- W2773928801
- Cited by
- 282
- References
- 277
- Citations by year
- 2026: 36 · 2025: 39 · 2024: 43 · 2023: 36 · 2022: 36 · 2021: 33 · 2020: 31 · 2019: 17 · 2018: 10
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Israel Science Foundation (690/15)
- National Institutes of Health (R01-AG04767)
- National Institute of Mental Health (R01MH102638, R01MH087592)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- sleep-wake regulation, neural circuits, homeostatic sleep drive, circadian rhythm, motivation, sleep homeostasis, sleep-wake states
- MeSH terms
- Animals, Circadian Rhythm, Drive, Homeostasis, Humans, Models, Biological, Motivation, Neurons, Sleep, Wakefulness, Electrophysiological Phenomena
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