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Synthetic Metallochaperone ZMC1 Rescues Mutant p53 Conformation by Transporting Zinc into Cells as an Ionophore
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“ZMC1 acts as an ionophore,443 transferring zinc ions from the extracellular space to the cytoplasm, maintaining the cytoplasmic zinc ion concentration within an appropriate range and thus reactivating the p53 mutant.444–446”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [444]
In the citing paper
“In addition, ZMC1 can chelate redox-active copper,447 increase intracellular reactive oxygen levels and decrease glutathione concentrations to exert antitumor effects.441,444”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [444]
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Citations
Cites
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,551 · cited 2×
“Each p53 monomer coordinates a single Zn 2+ via C176, C238, C242, and H179 (Cho et al. , 1994).”
BackgroundSenescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473
TP53 mutations in human cancers: origins, consequences, and clinical use.
Olivier, M., Hollstein, M., & Hainaut, P. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001008 · Cited by 2,199 · cited 14×
“cancers (Olivier et al., 2010).”
BackgroundInfluentialThe first 30 years of p53: growing ever more complex.
Levine, A. J., & Oren, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2723 · Cited by 1,967
Restoration of p53 function leads to tumour regression in vivo
Ventura, A., Kirsch, D. G., McLaughlin, M. E., Tuveson, D. A., Grimm, J., Lintault, L., Newman, J., Reczek, E. E., Weissleder, R., & Jacks, T. (2007) · Nature · doi:10.1038/nature05541 · Cited by 1,820 · cited 2×
“Despite the prevalence of p53mutations in cancer and clear indications that the restoration of p53 function can be therapeutic, developing drugs with this activity has proven a challenge, as evidenced by the lack of clinically available therapies that target mutant p53 (Ventura et al., 2007; Xue et al., 2007).”
Background
Research works printed but not linked: 23
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Cited by
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
Targeting mutant p53 for efficient cancer therapy
Bykov, V. J. N., Eriksson, S. E., Bianchi, J., & Wiman, K. G. (2018) · Nature Reviews Cancer · doi:10.1038/nrc.2017.109 · Cited by 889
The biological inorganic chemistry of zinc ions
Krężel, A., & Maret, W. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.04.010 · Cited by 768
Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others
Sabapathy, K., & Lane, D. P. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.151 · Cited by 517
Targeting Therapies for the p53 Protein in Cancer Treatments
Levine, A. J. (2019) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055455 · Cited by 84
Metadata
- Authors
- Blanden, A. R., Yu, X., Wolfe, A. J., Gilleran, J. A., Augeri, D. J., O’Dell, R. S., Olson, E. C., Kimball, S. D., Emge, T. J., Movileanu, L., Carpizo, D. R., & Loh, S. N.
- Venue
- Molecular Pharmacology
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 87
- Issue
- 5
- Pages
- 825-831
- ISSN
- 0026-895X
- Cited by
- 79
- References
- 5
- Language
- en
- Update notices
- erratum (2015-12-01)
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
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- CoChat. (2026). Citation check: Synthetic Metallochaperone ZMC1 Rescues Mutant p53 Conformation by Transporting Zinc into Cells as an Ionophore. https://app.cochat.ai/papers/10.1124/mol.114.097550
- The paper
- Blanden, A. R., Yu, X., Wolfe, A. J., Gilleran, J. A., Augeri, D. J., O’Dell, R. S., Olson, E. C., Kimball, S. D., Emge, T. J., Movileanu, L., Carpizo, D. R., & Loh, S. N. (2015). Synthetic Metallochaperone ZMC1 Rescues Mutant p53 Conformation by Transporting Zinc into Cells as an Ionophore. Molecular Pharmacology. https://doi.org/10.1124/mol.114.097550
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
