The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update
Open accessAbstract
In the 10 years since our previous International Union of Basic and Clinical Pharmacology report on the nomenclature and classification of adenosine receptors, no developments have led to major changes in the recommendations. However, there have been so many other developments that an update is needed. The fact that the structure of one of the adenosine receptors has recently been solved has already led to new ways of in silico screening of ligands. The evidence that adenosine receptors can form homo- and heteromultimers has accumulated, but the functional significance of such complexes remains unclear. The availability of mice with genetic modification of all the adenosine receptors has led to a clarification of the functional roles of adenosine, and to excellent means to study the specificity of drugs. There are also interesting associations between disease and structural variants in one or more of the adenosine receptors. Several new selective agonists and antagonists have become available. They provide improved possibilities for receptor classification. There are also developments hinting at the usefulness of allosteric modulators. Many drugs targeting adenosine receptors are in clinical trials, but the established therapeutic use is still very limited.
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Citations
Cites
The structure and function of G-protein-coupled receptors
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Adenosine Receptors as Therapeutic Targets
Jacobson, K. A., & Gao, Z.-G. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1983 · Cited by 1,431 · cited 1×
“Selective agonists and antagonists for all four adenosine receptor subtypes are available (Müller, 2000a,b; Yan et al., 2003; Jacobson and Gao, 2006; Müller and Ferré, 2007; Elzein and Zablocki, 2008; Müller and Jacobson, 2011).”
BackgroundSelf-citationAllosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
Jeffrey Conn, P., Christopoulos, A., & Lindsley, C. W. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2760 · Cited by 1,063
Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
Huang, Z.-L., Qu, W.-M., Eguchi, N., Chen, J.-F., Schwarzschild, M. A., Fredholm, B. B., Urade, Y., & Hayaishi, O. (2005) · Nature Neuroscience · doi:10.1038/nn1491 · Cited by 640
Self-citationAssociation between A2a receptor gene polymorphisms and caffeine-induced anxiety
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“Alsene et al. (2003) and Childs et al. (2008) found a significant association between self-reported anxiety after caffeine administration and a number of polymorphisms on the A2A receptor gene, among others the known 1976C T and the new 2592C Tins polymorphisms.”
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Pharmacology of Adenosine Receptors: The State of the Art
Borea, P. A., Gessi, S., Merighi, S., Vincenzi, F., & Varani, K. (2018) · Physiological Reviews · doi:10.1152/physrev.00049.2017 · Cited by 783
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Metadata
- Authors
- Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Linden, J., & Müller, C. E.
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 63
- Issue
- 1
- Pages
- 1-34
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W2168634451
- Cited by
- 1,301
- References
- 7
- FWCI
- 60.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
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