Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier

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The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

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The blood–brain barrier: an overview

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Liposomal Formulations in Clinical Use: An Updated Review

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Revisiting the role of ABC transporters in multidrug-resistant cancer

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A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

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Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

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New developments in liposomal drug delivery

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Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics

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International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update

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From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

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Strategies for delivering therapeutics across the blood–brain barrier

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Overcoming the blood–brain tumor barrier for effective glioblastoma treatment

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Current Strategies for Brain Drug Delivery

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Exosomes and Ectosomes in Intercellular Communication

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The blood–brain barrier in health and disease: Important unanswered questions

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Engineering hybrid exosomes by membrane fusion with liposomes

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BLOOD-BRAIN BARRIER DRUG TARGETING: THE FUTURE OF BRAIN DRUG DEVELOPMENT

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Characteristics of Compounds that Cross the Blood-Brain Barrier

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Limitations of Animal Studies for Predicting Toxicity in Clinical Trials

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Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

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Enzyme-Replacement Therapy in Mucopolysaccharidosis I

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PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

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Re-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics

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Structural and Mechanistic Principles of ABC Transporters

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Glucose transporters in brain in health and disease

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Surface Functionalization of Exosomes Using Click Chemistry

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Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability

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Effect of Focused Ultrasound Applied With an Ultrasound Contrast Agent on the Tight Junctional Integrity of the Brain Microvascular Endothelium

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Impact of Drug Transporter Studies on Drug Discovery and Development

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Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges

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Strategies to advance translational research into brain barriers

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Crossing the Blood–Brain Barrier: Recent Advances in Drug Delivery to the Brain

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Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

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A comprehensive review on recent preparation techniques of liposomes

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Influence of the Surface Properties on Nanoparticle-Mediated Transport of Drugs to the Brain

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Application of Solid Lipid Nanoparticles to Improve the Efficiency of Anticancer Drugs

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Solid lipid nanoparticles: a review on recent perspectives and patents

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Pharmacology of adenosine A2A receptors

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Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease

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Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice

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Transferrin-targeted, resveratrol-loaded liposomes for the treatment of glioblastoma

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Exosomes derived from mesenchymal stem cells attenuate inflammation and demyelination of the central nervous system in EAE rats by regulating the polarization of microglia

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Transport of small molecules through the blood-brain barrier: biology and methodology

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Transcranial Pulse Stimulation with Ultrasound in Alzheimer's Disease—A New Navigated Focal Brain Therapy

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The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier

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Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery

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Overcoming the Blood–Brain Barrier. Challenges and Tricks for CNS Drug Delivery

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Manganese Oxide Nanoparticles As MRI Contrast Agents In Tumor Multimodal Imaging And Therapy

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Intranasal administration of interferon beta bypasses the blood–brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis

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Exploring different approaches to improve the success of drug discovery and development projects: a review

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Blood-Brain Barrier Dysfunction in CNS Disorders and Putative Therapeutic Targets: An Overview

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Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid-β (Aβ) Aggregation: Potential Therapeutics of Alzheimer’s Disease

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Uptake of ANG1005, A Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer

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Brain microvascular pericytes in health and disease

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Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice

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Investigating the optimum size of nanoparticles for their delivery into the brain assisted by focused ultrasound-induced blood–brain barrier opening

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Delivery of 125 I-NGF to the Brain via the Olfactory Route

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Methotrexate-Loaded Extracellular Vesicles Functionalized with Therapeutic and Targeted Peptides for the Treatment of Glioblastoma Multiforme

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Targeting Adenosine Receptor Signaling in Cancer Immunotherapy

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Delivery of Small Interfering RNA to Inhibit Vascular Endothelial Growth Factor in Zebrafish Using Natural Brain Endothelia Cell-Secreted Exosome Nanovesicles for the Treatment of Brain Cancer

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Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human

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Chemotherapy targeted to cancers through tumoral hormone receptors

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Cryptococcal meningitis: improving access to essential antifungal medicines in resource-poor countries

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A phase I/II study of intrathecal idursulfase-IT in children with severe mucopolysaccharidosis II

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Evaluation of permeability, doxorubicin delivery, and drug retention in a rat brain tumor model after ultrasound-induced blood-tumor barrier disruption

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Theranostic applications of nanoparticles in neurodegenerative disorders

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Dual functionalized liposomes for efficient co-delivery of anti-cancer chemotherapeutics for the treatment of glioblastoma

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Effects on P-Glycoprotein Expression after Blood-Brain Barrier Disruption Using Focused Ultrasound and Microbubbles

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Intrathecal delivery of protein therapeutics to the brain: a critical reassessment.

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Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases

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Ultrasound-mediated drug delivery to the brain: principles, progress and prospects

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Gold Nanoparticles as X-Ray, CT, and Multimodal Imaging Contrast Agents: Formulation, Targeting, and Methodology

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Development of neuropeptide drugs that cross the blood-brain barrier

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Gene therapy put on hold as third child develops cancer

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Clinical Perspective of FDA Approved Drugs With P-Glycoprotein Inhibition Activities for Potential Cancer Therapeutics

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Drug delivery across the blood–brain barrier using focused ultrasound

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Adenosine receptor signaling: a key to opening the blood–brain door

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Recent advances in nano delivery systems for blood-brain barrier (BBB) penetration and targeting of brain tumors

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Nanoparticles for Brain-Specific Drug and Genetic Material delivery, Imaging and Diagnosis

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ABC Transporters at the Blood–Brain Interfaces, Their Study Models, and Drug Delivery Implications in Gliomas

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A review on Parkinson’s disease treatment

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DCE-MRI blood–brain barrier assessment in acute ischemic stroke

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Impact of P-Glycoprotein–Mediated Active Efflux on Drug Distribution into Lumbar Cerebrospinal Fluid in Nonhuman Primates

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Evaluation of Disease Lesions in the Developing Canine MPS IIIA Brain

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Development of neuropeptide drugs that cross the blood-brain barrier

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Low-dose, continual enzyme delivery ameliorates some aspects of established brain disease in a mouse model of a childhood-onset neurodegenerative disorder

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Analysis of Pathways in Triple-Negative Breast Cancer Cells Treated with the Combination of Electrochemotherapy and Cisplatin

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Dexamethasone ameliorates Alzheimer’s pathological condition via inhibiting Nf-κB and mTOR signaling pathways

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Regulatory Gene Network Pathway among Brain Cancer and Associated Disease: a Computational Analysis

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99mTc-Anionic Linear Globular Dendrimer-G2-Phenylalanine Conjugate: Novel Brain Tumor SPECT Imaging

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JIMD Reports, Volume 43

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Alzheimer's Disease: Treatment Strategies and Their Limitations.

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Nanotechnology-based drug delivery for the treatment of CNS disorders

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Unraveling the complexity of human brain: Structure, function in healthy and disease states

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Blood-brain barrier permeability in the ischemic stroke: An update

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An Updated Overview of Cyclodextrin-Based Drug Delivery Systems for Cancer Therapy

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Alzheimer’s disease and drug delivery across the blood–brain barrier: approaches and challenges

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An update on pathogenesis and clinical scenario for Parkinson’s disease: diagnosis and treatment

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A blood–brain barrier- and blood–brain tumor barrier-penetrating siRNA delivery system targeting gliomas for brain tumor immunotherapy

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How Precise are Nanomedicines in Overcoming the Blood–Brain Barrier? A Comprehensive Review of the Literature

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Recent Advancements and Strategies for Overcoming the Blood–Brain Barrier Using Albumin-Based Drug Delivery Systems to Treat Brain Cancer, with a Focus on Glioblastoma

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Global Trends of Exosomes Application in Clinical Trials: A Scoping Review

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Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology

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Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive review

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Brain Endothelial Cells in Blood–Brain Barrier Regulation and Neurological Therapy

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Insights into Targeted and Stimulus‐Responsive Nanocarriers for Brain Cancer Treatment

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Advancing Brain Targeting: Cost-Effective Surface-Modified Nanoparticles for Faster Market Entry

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Biosensor integrated brain-on-a-chip platforms: Progress and prospects in clinical translation

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Clinical translation of nanomedicines for brain diseases: Current challenges and future directions

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Niosomal Bupropion: Exploring Therapeutic Frontiers through Behavioral Profiling

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Recent Developments in Glioblastoma‐On‐A‐Chip for Advanced Drug Screening Applications

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Riluzole-loaded lipid nanoparticles for brain delivery: Preparation, optimization and characterization

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Nanoscale drug formulations for the treatment of Alzheimer's disease progression

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Oxime Therapy for Brain AChE Reactivation and Neuroprotection after Organophosphate Poisoning

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Membrane Vesicles Derived from Gut Microbiota and Probiotics: Cutting-Edge Therapeutic Approaches for Multidrug-Resistant Superbugs Linked to Neurological Anomalies

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Neurotrophic factor-based pharmacological approaches in neurological disorders

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Thermosensitive Mucoadhesive Intranasal In Situ Gel of Risperidone for Nose-to-Brain Targeting: Physiochemical and Pharmacokinetics Study

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Non-Invasive Techniques of Nose to Brain Delivery Using Nanoparticulate Carriers: Hopes and Hurdles

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Strategic nanocarriers to control neurodegenerative disorders: Concept, challenges, and future perspective

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Navigating the brain: the role of exosomal shuttles in precision therapeutics

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Engineering with Biomedical Sciences Changing the Horizon of Healthcare-A Review

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Dysfunction of ABC Transporters at the Surface of BBB: Potential Implications in Intractable Epilepsy and Applications of Nanotechnology Enabled Drug Delivery

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Current Landscape and Emerging Opportunities of Gene Therapy with Non-viral Episomal Vectors

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Anti-miRNA103/107 encapsulated in transferrin-conjugated lipid nanoparticles crosses blood-brain barrier and reduces brain ischemic damage

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Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads

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Exosome Content–Mediated Signaling Pathways in Multiple Sclerosis

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Effects of Ultrasound for Bio‐Applications

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Nanotechnology in glioblastoma therapy: Advances in drug delivery systems and diagnostic approaches

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Current non-invasive strategies for brain drug delivery: overcoming blood–brain barrier transport

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Advancements in neurotherapeutics: nanoparticles overcoming the blood–brain barrier for precise CNS targeting

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Exploring the Potential of Aptamers in Targeting Neuroinflammation and Neurodegenerative Disorders: Opportunities and Challenges

Kong, A. H.-Y., Wu, A. J., Ho, O. K.-Y., Leung, M. M.-K., Huang, S., Yu, Y., Zhang, G., Lü, A., Li, M., & Cheung, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411780 · Cited by 22 · see citing works

Trojan Horse Delivery Strategies of Natural Medicine Monomers: Challenges and Limitations in Improving Brain Targeting

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Chitosan nanovectors for siRNA delivery: New horizons for nonviral gene therapy

Rahimi, M., Kariminezhad, Z., Rondon, E.-P., Fahmi, H., Fernandes, J., & Benderdour, M. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.123581 · Cited by 19 · see citing works

Potential Roles of Natural Antioxidants in Modulating Neurodegenerative Disease Pathways

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Update on Therapeutic potential of emerging nanoformulations of phytocompounds in Alzheimer's and Parkinson's disease

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Application and progress of inorganic composites in haemostasis: a review

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ROS Regulation in CNS Disorder Therapy: Unveiling the Dual Roles of Nanomedicine

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Role of Blood-Brain barrier in bacterial translocation

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New Strategies for Stroke Therapy: Nanoencapsulated Neuroglobin

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Exosomes encapsulated in hydrogels for effective central nervous system drug delivery

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Global Advancements in Bioactive Material Manufacturing for Drug Delivery: A Comprehensive Study

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Challenges and Opportunities for Incorporating Physiological Information into Pharmacokinetic Models of Intranasal Drug Delivery to the Brain: A Review of the Current Status and Future Trajectories

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Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer’s disease patients

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Crossing the blood–brain barrier: nanoparticle-based strategies for neurodegenerative disease therapy

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Advancing through the blood-brain barrier: mechanisms, challenges and drug delivery strategies

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Advances in mRNA nanomedicines for malignant brain tumor therapy

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Recent advances towards overcoming the blood–brain barrier

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CNN ‐based deep learning approach for classification of invasive ductal and metastasis types of breast carcinoma

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Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies

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Emerging role of mesenchymal stem cells-derived extracellular vesicles in vascular dementia

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Aducanumab delivery via focused ultrasound-induced transient blood–brain barrier opening in vivo

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From Polyphenols to Prodrugs: Bridging the Blood–Brain Barrier with Nanomedicine and Neurotherapeutics

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Microfluidic-Based Technologies for Crossing the Blood–Brain Barrier Against Alzheimer’s Disease: Novel Strategies and Challenges

Ferrari, I., Limiti, E., Giannitelli, S. M., Trombetta, M., Rainer, A., D’Amelio, M., Barbera, L. L., & Gori, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199478 · Cited by 13 · see citing works

Advanced Drug Delivery Strategies for Overcoming Biological Barriers: Tumor Microenvironment and Blood–Brain Barrier

Lei, Y., Xiao, T., Hu, X., & Lin, H. (2026) · Drugs in R&D · doi:10.1007/s40268-026-00538-9 · Cited by 14 · see citing works

Immunotherapy in Alzheimer’s Disease: Current Status and Future Directions

Vashisth, K., Sharma, S., Ghosh, S., Babu, M. A., Ghosh, S., Iqbal, D., Kamal, M., Almutary, A. G., Jha, S. K., Ojha, S. K., et al. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230603 · Cited by 13 · see citing works

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

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Potential of exosomes for targeted therapy in neuroinfectious disease management: crossing the blood–brain barrier

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Patient-Derived Blood-Brain Barrier Model for Screening Copper Bis(thiosemicarbazone) Complexes as Potential Therapeutics in Alzheimer’s Disease

Wasielewska, J. M., Szostak, K., McInnes, L. E., Quek, H., Chaves, J. C. S., Liddell, J. R., Koıstınaho, J., Oikari, L. E., Donnelly, P. S., & White, A. R. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00743 · Cited by 12 · see citing works

Evolution of Alzheimer’s Disease Therapeutics: From Conventional Drugs to Medicinal Plants, Immunotherapy, Microbiotherapy and Nanotherapy

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Diagnostics of brain tumor in the early stage: current status and future perspectives

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Advanced nanotheranostic approaches for targeted glioblastoma treatment: a synergistic fusion of CRISPR-Cas gene editing, AI-driven tumor profiling, and BBB-modulation

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