Impact of Drug Transporter Studies on Drug Discovery and Development

Oral bioavailability of digoxin is enhanced by talinolol: Evidence for involvement of intestinal P-glycoprotein

Westphal, K. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.107579 · Cited by 177

Significance of P-glycoprotein for the pharmacology and clinical use of HIV protease inhibitors

Huisman, M. T., Smit, J. W., & Schinkel, A. H. (2000) · AIDS · doi:10.1097/00002030-200002180-00005 · Cited by 177

Itraconazole Decreases Renal Clearance of Digoxin

Jalava, K.-M., Partanen, J., & Neuvonen, P. J. (1997) · Therapeutic Drug Monitoring · doi:10.1097/00007691-199712000-00001 · Cited by 176

BindingDB Entry 50042069: Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats.

BindingDB (2013) · PubMed · doi:10.7270/q2571d9z · Cited by 172

Technological advances in high-throughput screening

Fernandes, P. B. (1998) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(98)80089-6 · Cited by 170

Characterization of the Human OATP-C (SLC21A6) Gene Promoter and Regulation of Liver-specific OATP Genes by Hepatocyte Nuclear Factor 1α

Jung, D., Hagenbuch, B., Gresh, L., Pontoglio, M., Meier, P. J., & Kullak-Ublick, G. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103988200 · Cited by 170

Molecular pharmacology of renal organic anion transporters

Van Aubel, R. A. M. H., Masereeuw, R., & Russel, F. G. M. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.279.2.f216 · Cited by 170

Gender differences in expression of organic cation transporter OCT2 in rat kidney

Urakami, Y., Nakamura, N., Takahashi, K., Okuda, M., Saito, H., Hashimoto, Y., & Inui, K.-I. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01491-x · Cited by 169

P-Glycoprotein Limits Oral Availability, Brain, and Fetal Penetration of Saquinavir Even with High Doses of Ritonavir

Huisman, M. T., Smit, J. W., Wiltshire, H. R., Hoetelmans, R. M. W., Beijnen, J. H., & Schinkel, A. H. (2001) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)09249-6 · Cited by 167

Three-Dimensional Quantitative Structure-Activity Relationships of Inhibitors of P-Glycoprotein

Ekins, S., Kim, R. B., Leake, B. F., Dantzig, A. H., Schuetz, E. G., Lan, L.-B., Yasuda, K., Shepard, R. L., Winter, M. A., Schuetz, J. D., et al. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.5.964 · Cited by 166

Characterization of an Organic Anion-Transporting Polypeptide (OATP-B) in Human Placenta

St-Pierre, M. V., Hagenbuch, B., Ugele, B., Meier, P. J., & Stallmach, T. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8431 · Cited by 165

Multispecific Organic Anion Transporter Is Responsible for the Biliary Excretion of the Camptothecin Derivative Irinotecan and its Metabolites in Rats

Chu, X.-Y., Kato, Y., Niinuma, K., Sudo, K.-I., Hakusui, H., & Sugiyama, Y. (1997) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36601-7 · Cited by 161

Transport Properties of Nonsteroidal Anti-Inflammatory Drugs by Organic Anion Transporter 1 Expressed in Xenopus laevisOocytes

Apiwattanakul, N., Sekine, T., Chairoungdua, A., Kanai, Y., Nakajima, N., Sophasan, S., & Endou, H. (1999) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)23181-3 · Cited by 158

Increase in cerivastatin systemic exposure after single and multiple dosing in cyclosporine-treated kidney transplant recipients

MUCK, W., MAI, I., FRITSCHE, L., OCHMANN, K., ROHDE, G., UNGER, S., JOHNE, A., BAUER, S., BUDDE, K., & ROOTS, I. (1999) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(99)70104-9 · Cited by 158

Pharmacokinetic interactions between two human immunodeficiency virus protease inhibitors, ritonavir and saquinavir*

Hsu, A., Granneman, G. R., Cao, G., Carothers, L., El-Shourbagy, T., Baroldi, P., Erdman, K., Brown, F., Sun, E., & Leonard, J. M. (1998) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(98)90041-8 · Cited by 158

Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver

Ismair, M. G., Stieger, B., Cattori, V., Hagenbuch, B., Fried, M., Meier, P. J., & Kullak-Ublick, G. A. (2001) · Gastroenterology · doi:10.1053/gast.2001.28704 · Cited by 156

Reversal of Multidrug Resistance by the P-Glycoprotein Modulator, LY335979, from the Bench to the Clinic

Dantzig, A., Law, K., Cao, J., et al. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013373903 · Cited by 156

A Pharmacophore for Human Pregnane X Receptor Ligands

Ekins, S., & Erickson, J. A. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.1.96 · Cited by 155

Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients

Malingré, M. M., Beijnen, J. H., Rosing, H., Koopman, F. J., Jewell, R. C., Paul, E. M., Huinink, W. W. T. B., & Schellens, J. H. M. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2000.1543 · Cited by 154

Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin–Johnson syndrome

Tsujii, H., König, J., Rost, D., Stöckel, B., Leuschner, U., & KEPPLER, D. O. R. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70459-2 · Cited by 152

P-glycoprotein inhibitor erythromycin increases oral bioavailability of talinolol in humans

Schwarz, U. I., Gramatté, T., Krappweis, J., et al. (2000) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp38161 · Cited by 146

Effects of Rifampin on Tacrolimus Pharmacokinetics in Healthy Volunteers

Hébert, M. F., Fisher, R. M., Marsh, C. L., et al. (1999) · The Journal of Clinical Pharmacology · doi:10.1177/00912709922007499 · Cited by 144

Expression and Functional Characterization of Rat Organic Anion Transporter 3 (rOat3) in the Choroid Plexus

Nagata, Y., Kusuhara, H., Endou, H., & Sugiyama, Y. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.5.982 · Cited by 144

Impaired Protein Maturation of the Conjugate Export Pump Multidrug Resistance Protein 2 As A Consequence of A Deletion Mutation in Dubin–Johnson Syndrome

Keitel, V., Kartenbeck, J., Nies, A. T., Spring, H., Brom, M., & KEPPLER, D. O. R. (2000) · Hepatology · doi:10.1053/jhep.2000.19791 · Cited by 144

Blood—Brain Barrier Is Involved in the Efflux Transport of a Neuroactive Steroid, Dehydroepiandrosterone Sulfate, via Organic Anion Transporting Polypeptide 2

Asaba, H., Hosoya, K., Takanaga, H., Ohtsuki, S., Tamura, E., Takizawa, T., & Terasaki, T. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751907.x · Cited by 144

Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver

Paulusma, C. C., Kothe, M., Bakker, C., Bosma, P. J., van Bokhoven, I., van Marle, J., Bolder, U., Tytgat, G. N. J., & Elferink, R. P. J. O. (2000) · Hepatology · doi:10.1002/hep.510310319 · Cited by 144

Nonsteroidal Anti-Inflammatory Drugs Efficiently Reduce the Transport and Cytotoxicity of Adefovir Mediated by the Human Renal Organic Anion Transporter 1

Mulato, A. S., Ho, E. S., & Cihlář, T. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38862-7 · Cited by 144

Involvement of an Organic Anion Transporter (Canalicular Multispecific Organic Anion Transporter/Multidrug Resistance-Associated Protein 2) in Gastrointestinal Secretion of Glutathione Conjugates in Rats

Gotoh, Y., Suzuki, H., Kinoshita, S., Hirohashi, T., Kato, Y., & Sugiyama, Y. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35309-1 · Cited by 144

Relationship between Development of Diarrhea and the Concentration of SN‐38, an Active Metabolite of CPT‐11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT‐11

Araki, E., Ishikawa, M., Iigo, M., Koide, T., Itabashi, M., & Hoshi, A. (1993) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1993.tb02031.x · Cited by 142

Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney

Uwai, Y., Okuda, M., Takami, K., Hashimoto, Y., & Inui, K. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01328-3 · Cited by 142

P-Glycoprotein Mediates the Efflux of Quinidine across the Blood-Brain Barrier

Kusuhara, H., Suzuki, H., Terasaki, T., et al. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37075-2 · Cited by 142

Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells

Takano, M., Hasegawa, R., Fukuda, T., Yumoto, R., Nagai, J., & Murakami, T. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00607-4 · Cited by 141

Functional Involvement of Rat Organic Anion Transporter 3 (rOat3;Slc22a8) in the Renal Uptake of Organic Anions

Hasegawa, M., Kusuhara, H., Sugiyama, D., Ito, K., Ueda, S., Endou, H., & Sugiyama, Y. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.3.746 · Cited by 141

A Naturally Occurring Mutation in the SLC21A6Gene Causing Impaired Membrane Localization of the Hepatocyte Uptake Transporter

Michalski, C. W., Cui, Y., Nies, A. T., Nussler, A. K., Neuhaus, P., Zanger, U. M., Klein, K., Eichelbaum, M. F., KEPPLER, D. O. R., & König, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207735200 · Cited by 140

The Effects of Human Immunodeficiency Virus in the Central Nervous System

Kolson, D. L., Lavi, E., & González‐Scarano, F. (1998) · Advances in virus research · doi:10.1016/s0065-3527(08)60804-0 · Cited by 137

PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein.

Kocher, O. N., Comella, N., Gilchrist, A., Pal, R., Tognazzi, K., Brown, L. F., & Knoll, J. H. M. (1999) · PubMed · Cited by 137

Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets

Roelofsen, H., Soroka, C. J., KEPPLER, D. O. R., & Boyer, J. L. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.8.1137 · Cited by 137

The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis

Tracy, T. S., Krohn, K., Jones, D. R., Bradley, J. D., Hall, S. D., & Brater, D. C. (1992) · European Journal of Clinical Pharmacology · doi:10.1007/bf00278469 · Cited by 134

Mechanisms and clinical implications of renal drug excretion *

Masereeuw, R., & Rüssel, F. G. M. (2001) · Drug Metabolism Reviews · doi:10.1081/dmr-120000654 · Cited by 133

Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor

Schellens, J. H. M., Creemers, G. J. M., Beijnen, J. H., Rosing, H., de Boer-Dennert, M. M., McDonald, M., Davies, B., & Verweij, J. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.243 · Cited by 131

Active Apical Secretory Efflux of the HIV Protease Inhibitors Saquinavir and Ritonavir in Caco-2 Cell Monolayers

Alsenz, J., Steffen, H., & Alex, R. (1998) · Pharmaceutical Research · doi:10.1023/a:1011924314899 · Cited by 130

Effects of rifampin on the pharmacokinetics and pharmacodynamics of glyburide and glipizide

Niemi, M., Backman, J. T., Neuvonen, M., Neuvonen, P. J., & Kivistö, K. T. (2001) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2001.115822 · Cited by 130

Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats.

Chu, X., Kato, Y., & Sugiyama, Y. (1997) · PubMed · Cited by 129

Rat Multispecific Organic Anion Transporter 1 (rOAT1) Transports Zidovudine, Acyclovir, and Other Antiviral Nucleoside Analogs

Wada, S., Tsuda, M., Sekine, T., Ho, S., Kimura, M., Kanai, Y., & Endou, H. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39144-x · Cited by 128

Induction of Rat Organic Anion Transporting Polypeptide 2 by Pregnenolone-16α-carbonitrile Is via Interaction with Pregnane X Receptor

Guo, G. L., Staudinger, J. L., Ogura, K., & Klaassen, C. D. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.4.832 · Cited by 127

Influence of Passive Permeability on Apparent P-glycoprotein Kinetics

Lentz, K. A., Polli, J. W., Wring, S. A., Humphreys, J. E., & Polli, J. E. (2000) · Pharmaceutical Research · doi:10.1023/a:1007692622216 · Cited by 126

BindingDB Entry 50040211: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1.

BindingDB (2013) · PubMed · doi:10.7270/q2h41sjq · Cited by 126

Grapefruit juice enhances intestinal absorption of the P-glycoprotein substrate talinolol

Spahn-Langguth, H., & Langguth, P. (2001) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00191-3 · Cited by 125

Carriers Involved in Targeting the Cytostatic Bile Acid-Cisplatin Derivatives cis-Diammine-chloro-cholylglycinate-platinum(II) and cis-Diammine-bisursodeoxycholate-platinum(II) toward Liver Cells

Briz, Ó., Serrano, M. A., Rebollo, N., Hagenbuch, B., Meier, P. J., Koepsell, H., & Marı́n, J. J. G. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.4.853 · Cited by 124

Regulation of Hepatic Transport Systems Involved in Bile Secretion During Liver Regeneration in Rats

Vos, T. A., Ros, J. E., Havinga, R., Moshage, H. J., Kuipers, F., Jansen, P. L. M., & Müller, M. M. (1999) · Hepatology · doi:10.1002/hep.510290638 · Cited by 123

The effects of relative timing of sirolimus and cyclosporine microemulsion formulation coadministration on the pharmacokinetics of each agent*

Kaplan, B. E., Meier‐Kriesche, H., Napoli, K. L., & Kahan, B. D. (1998) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(98)90120-5 · Cited by 123

The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers*

Chang, T. T., Benet, L. Z., & Hébert, M. F. (1996) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(96)80007-5 · Cited by 122

P-Glycoprotein-Dependent Disposition Kinetics of Tacrolimus: Studies in mdr la Knockout Mice

Yokogawa, K., Takahashi, M., Tamai, I., Konishi, H., Nomura, M., Moritani, S., Miyamoto, K., & Tsuji, A. (1999) · Pharmaceutical Research · doi:10.1023/a:1018993312773 · Cited by 121

Interaction of human organic anion transporters with various cephalosporin antibiotics

Takeda, M., Babu, E., Narikawa, S., & Endou, H. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01306-7 · Cited by 121

Changes in the Localization of the Rat Canalicular Conjugate Export Pump Mrp2 in Phalloidin–Induced Cholestasis

Rost, D., Kartenbeck, J., & KEPPLER, D. O. R. (1999) · Hepatology · doi:10.1002/hep.510290319 · Cited by 120

Saquinavir Soft-Gel Capsule Formulation

Perry, C. M., & Noble, S. (1998) · Drugs · doi:10.2165/00003495-199855030-00014 · Cited by 119

The Role of P-Glycoprotein and Canalicular Multispecific Organic Anion Transporter in the Hepatobiliary Excretion of Drugs

Kusuhara, H., Suzuki, H., & Sugiyama, Y. (1998) · Journal of Pharmaceutical Sciences · doi:10.1021/js970100b · Cited by 117

Characterization of ochratoxin A transport by human organic anion transporters

Jung, K. Y., Takeda, M., Kim, D. K., Tojo, A., Narikawa, S., Yoo, B. S., Hosoyamada, M., Ho, S., Sekine, T., & Endou, H. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01296-6 · Cited by 114

Interaction and Transport of Thiazide Diuretics, Loop Diuretics, and Acetazolamide via Rat Renal Organic Anion Transporter rOAT1

Uwai, Y., Saito, H., Hashimoto, Y., & Inui, K. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38896-2 · Cited by 114

Evaluation of a vincristine resistant Caco-2 cell line for use in a calcein AM extrusion screening assay for P-glycoprotein interaction

Eneroth, A., Åström, E., Hoogstraate, J. A., Schrenk, D., Conrad, S., Kauffmann, H.-M., & Gjellan, K. (2001) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00117-2 · Cited by 113

Pharmacogenomics of organic anion-transporting polypeptides (OATP)

Tirona, R. G., & Kim, R. B. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00077-7 · Cited by 112

Membrane Localization of the Electrogenic Cation Transporter rOCT1 in Rat Liver

Meyer‐Wentrup, F. A. G., Karbach, U., Gorboulev, V., Arndt, P., & Koepsell, H. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9034 · Cited by 112

The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function

Shoda, J., Kano, M., Oda, K., Kamiya, J., Nimura, Y., Suzuki, H., Sugiyama, Y., Miyazaki, H., Todoroki, T., Stengelin, S., et al. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.05339.x · Cited by 112

Functional Analysis of a Canalicular Multispecific Organic Anion Transporter Cloned from Rat Liver

Ito, K., Suzuki, H., Hirohashi, T., Kume, K., Shimizu, T., & Sugiyama, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1684 · Cited by 111

Nonlinear pharmacokinetics of CPT-11 in rats.

KANEDA, N., & YOKOKURA, T. (1990) · PubMed · Cited by 110

Erythromycin Coadministration Increases Plasma Atorvastatin Concentrations

Siedlik, P. H., Olson, S. C., Yang, B., & Stern, R. H. (1999) · The Journal of Clinical Pharmacology · doi:10.1177/009127009903900510 · Cited by 110

Protein Kinase C-Dependent Distribution of the Multidrug Resistance Protein 2 From the Canalicular to the Basolateral Membrane in Human Hepg2 Cells

Kubitz, R., Huth, C., Schmitt, M., Horbach, A., Kullak-Ublick, G. A., & Häussinger, D. (2001) · Hepatology · doi:10.1053/jhep.2001.25959 · Cited by 110

Transport of Ochratoxin A by Renal Multispecific Organic Anion Transporter 1

Tsuda, M., Sekine, T., Takeda, M., Ho, S., Kanai, Y., Kimura, M., & Endou, H. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38273-4 · Cited by 109

Blood-brain barrier function of P-glycoprotein

Tsuji, A., & Tamai, I. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00504-8 · Cited by 108

High-throughput screening approaches for investigating drug metabolism and pharmacokinetics

Roberts, S. (2001) · Xenobiotica · doi:10.1080/00498250110060978 · Cited by 104

Contribution of Organic Anion Transporters to the Renal Uptake of Anionic Compounds and Nucleoside Derivatives in Rat

Hasegawa, M., Kusuhara, H., Endou, H., & Sugiyama, Y. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.046847 · Cited by 102

The Potential for an Interaction between MRP2 (ABCC2) and Various Therapeutic Agents: Probenecid as a Candidate Inhibitor of the Biliary Excretion of Irinotecan Metabolites

Horikawa, M., Kato, Y., Tyson, C. A., & Sugiyama, Y. (2002) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.17.23 · Cited by 101

Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1

Kakyo, M., Unno, M., Tokui, T., Nakagomi, R., Nishio, T., Iwasashi, H., Nakai, D., Seki, M., Suzuki, M., Naitoh, T., et al. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70333-1 · Cited by 101

The human multidrug resistance protein 2 gene: Functional characterization of the 5′-flanking region and expression in hepatic cells

Tanaka, T., Uchiumi, T., Hinoshita, E., Inokuchi, A., Toh, S., Wada, M., Takano, H., Kohno, K., & Kuwano, M. (1999) · Hepatology · doi:10.1002/hep.510300617 · Cited by 101

The entry of antiviral and antiretroviral drugs into the central nervous system

Groothuis, D. R., & Levy, R. M. (1997) · Journal of NeuroVirology · doi:10.3109/13550289709031185 · Cited by 101

Selective Protein Adduct Formation of Diclofenac Glucuronide Is Critically Dependent on the Rat Canalicular Conjugate Export Pump (Mrp2)

Seitz, S., Kretz-Rommel, A., Elferink, R. P. J. O., & Boelsterli, U. A. (1998) · Chemical Research in Toxicology · doi:10.1021/tx970203+ · Cited by 101

Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity

Takeda, M., Tojo, A., Sekine, T., Hosoyamada, M., Kanai, Y., & Endou, H. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00789.x · Cited by 97

Recognition of β-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1cells

Terada, T., Saito, H., Mukai, M., & Inui, K. (1997) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1997.273.5.f706 · Cited by 96

Characterization of the 5′‐flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene

Stöckel, B., König, J., Nies, A. T., Cui, Y., Brom, M., & KEPPLER, D. O. R. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01106.x · Cited by 95

Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression

Kauffmann, H.-M., Pfannschmidt, S., Zöller, H., Benz, A., Vorderstemann, B., Webster, J. I., & Schrenk, D. (2002) · Toxicology · doi:10.1016/s0300-483x(01)00570-4 · Cited by 95

Multiplicity of biliary excretion mechanisms for the camptothecin derivative irinotecan (CPT-11), its metabolite SN-38, and its glucuronide: role of canalicular multispecific organic anion transporter and P-glycoprotein

Sugiyama, Y., Kato, Y., & Chu, X. (1998) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800051078 · Cited by 95

Diltiazem Increases Tacrolimus Concentrations

Hébert, M. F., & Lam, A. Y. (1999) · Annals of Pharmacotherapy · doi:10.1345/aph.18356 · Cited by 95

Clinical pharmacokinetics of doxorubicin in combination with GF120918, a potent inhibitor of MDR1 P-glycoprotein

Sparreboom, A., Planting, A. S. T., Jewell, R. C., van der Burg, M. E., van der Gaast, A., de Bruijn, P., Loos, W. J., Nooter, K., Chandler, L. H., Paul, E. M., et al. (1999) · Anti-Cancer Drugs · doi:10.1097/00001813-199909000-00005 · Cited by 94

Functional Characterization of Rat Organic Anion Transporter 2 in LLC-PK1 Cells

Morita, N., Kusuhara, H., Sekine, T., Endou, H., & Sugiyama, Y. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29490-8 · Cited by 93

Role of efflux transport across the blood-brain barrier and blood-cerebrospinal fluid barrier on the disposition of xenobiotics in the central nervous system

Suzuki, H., Terasaki, T., & Sugiyama, Y. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00503-6 · Cited by 93

A Ligand-Based Approach to Understanding Selectivity of Nuclear Hormone Receptors PXR, CAR, FXR, LXRα, and LXRβ

Ekins, S., Mirny, L. A., & Schuetz, E. G. (2002) · Pharmaceutical Research · doi:10.1023/a:1021429105173 · Cited by 92

Effect of probenecid on the distribution and elimination of ciprofloxacin in humans

Jaehde, U., Sörgel, F., Reiter, A., et al. (1995) · Clinical Pharmacology & Therapeutics · doi:10.1016/0009-9236(95)90173-6 · Cited by 92

The effects of nonsteroidal antiinflammatory drugs on methotrexate (MTX) pharmacokinetics: impairment of renal clearance of MTX at weekly maintenance doses but not at 7.5 mg.

Jm, K., & Ra, H. (1995) · PubMed · Cited by 92

Biliary excretion mechanism of CPT-11 and its metabolites in humans: involvement of primary active transporters.

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