Technological advances in high-throughput screening

Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin

Miyawaki, A., Llopis, J. L., Heim, R., McCaffery, J. M., Adams, J. A., Ikura, M., & Tsien, R. Y. (1997) · Nature · doi:10.1038/42264 · Cited by 3,250 · see citing works

On/off blinking and switching behaviour of single molecules of green fluorescent protein

Dickson, R. M., Cubitt, A. B., Tsien, R. Y., & Moerner, W. E. (1997) · Nature · doi:10.1038/41048 · Cited by 1,343 · see citing works

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.

Fei, H., Okano, H. J., Li, C., Lee, G.-H., Zhao, C., Darnell, R., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.7001 · Cited by 766 · see citing works

Quantitation of Transcription and Clonal Selection of Single Living Cells with β-Lactamase as Reporter

Zlokarnik, G., Negulescu, P. A., Knapp, T. E., Mere, L., Burres, N. S., Feng, L., Whitney, M. A., Roemer, K., & Tsien, R. Y. (1998) · Science · doi:10.1126/science.279.5347.84 · Cited by 691 · see citing works

Optical Amplification of Ligand-Receptor Binding Using Liquid Crystals

Gupta, V. K., Skaife, J. J., Dubrovsky, T. B., & Abbott, N. L. (1998) · Science · doi:10.1126/science.279.5359.2077 · Cited by 476 · see citing works

Detection in Living Cells of Ca2+-dependent Changes in the Fluorescence Emission of an Indicator Composed of Two Green Fluorescent Protein Variants Linked by a Calmodulin-binding Sequence

Romoser, V. A., Hinkle, P. M., & Persechini, A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.13270 · Cited by 398 · see citing works

Applications of the green fluorescent protein in cell biology and biotechnology

Misteli, T., & Spector, D. L. (1997) · Nature Biotechnology · doi:10.1038/nbt1097-961 · Cited by 357 · see citing works

Monitoring conformational dynamics of a single molecule by selective fluorescence spectroscopy

Eggeling, C., Fries, J. R., Brand, L., Guenther, R., & Seidel, C. A. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1556 · Cited by 341 · see citing works

Molecular Photoionic AND Logic Gates with Bright Fluorescence and “Off−On” Digital Action

de Silva, A. P., Gunaratne, H. Q. N., & McCoy, C. P. (1997) · Journal of the American Chemical Society · doi:10.1021/ja9712229 · Cited by 328 · see citing works

Fluorescence correlation spectroscopy: Diagnostics for sparse molecules

Maiti, S., Haupts, U. M., & Webb, W. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.11753 · Cited by 318 · see citing works

Real-time enzyme kinetics monitored by dual-color fluorescence cross-correlation spectroscopy

Kettling, U., Koltermann, A., Schwille, P., & Eigen, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1416 · Cited by 308 · see citing works

Activation of prokaryotic transcription through arbitrary protein–protein contacts

Dove, S. L., Joung, J. K., & Hochschild, A. (1997) · Nature · doi:10.1038/386627a0 · Cited by 283 · see citing works

Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen

Liberles, S. D., Diver, S. T., Austin, D. J., & Schreiber, S. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.7825 · Cited by 199 · see citing works

Rapid assay processing by integration of dual-color fluorescence cross-correlation spectroscopy: High throughput screening for enzyme activity

Koltermann, A., Kettling, U., Bieschke, J., Winkler, T., & Eigen, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1421 · Cited by 155 · see citing works

Combinatorial Approach to the Hydrothermal Synthesis of Zeolites

Akporiaye, D. E., Dahl, I. M., Karlsson, A., & Wendelbo, R. (1998) · Angewandte Chemie International Edition · doi:10.1002/(sici)1521-3773(19980316)37:5 · Cited by 150 · see citing works

Lanthanides as probes for time-resolved fluorometric immunoassays

Hemmilä, I. A. (1988) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365518809085747 · Cited by 143 · see citing works

Improved Fluorescence and Dual Color Detection with Enhanced Blue and Green Variants of the Green Fluorescent Protein

Yang, T.-T., Sinai, P., Green, G., Kitts, P., Chen, Y., Lybarger, L. P., Chervenak, R. P., Patterson, G. H., Piston, D. W., & Kain, S. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.8212 · Cited by 140 · see citing works

Protein–Protein Contacts that Activate and Repress Prokaryotic Transcription

Hochschild, A., & Dove, S. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81126-5 · Cited by 135 · see citing works

A yeast genetic system for selecting small molecule inhibitors of protein–protein interactions in nanodroplets

Huang, J., & Schreiber, S. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13396 · Cited by 129 · see citing works

G-protein-coupled receptors in Saccharomyces cerevisiae: high-throughput screening assays for drug discovery

Pausch, M. H. (1997) · Trends in biotechnology · doi:10.1016/s0167-7799(97)01119-0 · Cited by 121 · see citing works

Multiple-Drug-Resistance Phenomenon in the Yeast Saccharomyces cerevisiae: Involvement of Two Hexose Transporters

Nourani, A., Wésolowski‐Louvel, M., Delaveau, T., Jacq, C., & Delahodde, A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5453 · Cited by 119 · see citing works

A Conditionally Expressed Third Partner Stabilizes or Prevents the Formation of a Transcriptional Activator in a Three-hybrid System

Tirode, F., Malaguti, C., Romero, F., Attar, R. M., Camonis, J., & Egly, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.37.22995 · Cited by 117 · see citing works

A Fluorescence Polarization Competition Immunoassay for Tyrosine Kinases

Seethala, R., & Menzel, R. (1998) · Analytical Biochemistry · doi:10.1006/abio.1997.2455 · Cited by 87 · see citing works

A Homogeneous, Fluorescence Polarization Assay for Src-Family Tyrosine Kinases

Seethala, R., & Menzel, R. (1997) · Analytical Biochemistry · doi:10.1006/abio.1997.2365 · Cited by 75 · see citing works

High-throughput screening

Persidis, A. (1998) · Nature Biotechnology · doi:10.1038/nbt0598-488 · Cited by 70 · see citing works

The future is function

Fields, S. (1997) · Nature Genetics · doi:10.1038/ng0497-325 · Cited by 65 · see citing works

Proteomics

Persidis, A. (1998) · Nature Biotechnology · doi:10.1038/nbt0498-393 · Cited by 65 · see citing works

Lanthanides as probes for time-resolved fluorometric immunoassays

Hemmilä, I. A. (1988) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365518809085747 · Cited by 63 · see citing works

Mutation of a Protease-sensitive Region in Firefly Luciferase Alters Light Emission Properties

Thompson, J. F., Geoghegan, K. F., Lloyd, D. B., Lanzetti, A. J., Magyar, R. A., Anderson, S. M., & Branchini, B. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18766 · Cited by 59 · see citing works

Use of a Novel Homogeneous Fluorescent Technology in High Throughput Screening

Kolb, J. M., Yamanaka, G. A., & Manly, S. P. (1996) · SLAS DISCOVERY · doi:10.1177/108705719600100407 · Cited by 57 · see citing works

Investigation of Growth Hormone Releasing Hormone Receptor Structure and Activity Using Yeast Expression Technologies

Kajkowski, E. M., Price, L. A., Pausch, M. H., Young, K. H., & Ozenberger, B. A. (1997) · Journal of Receptors and Signal Transduction · doi:10.3109/10799899709036610 · Cited by 54 · see citing works

Light on high-throughput screening: fluorescence-based assay technologies

Rogers, M. V. (1997) · Drug Discovery Today · doi:10.1016/s1359-6446(97)01016-7 · Cited by 42 · see citing works

A translational repression assay procedure (TRAP) for RNA–protein interactions in vivo

Paraskeva, E., Atzberger, A., & Hentze, M. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.951 · Cited by 39 · see citing works

High throughput on-bead monitoring of solid phase reactions by Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS)

Chan, T. Y., Chen, R., Sofia, M. J., Smith, B. C., & Glennon, D. (1997) · Tetrahedron Letters · doi:10.1016/s0040-4039(97)00496-6 · Cited by 33 · see citing works

Analysis of a peptide hormone–receptor interaction in the yeast two-hybrid system

Zhu, J.-W., & Kahn, C. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13063 · Cited by 27 · see citing works

Useful Vectors for the Two-Hybrid System in Mammalian Cells

Büchert, M., Schneider, S., Adams, M. T., Hefti, H. P., Moelling, K., & Hovens, C. M. (1997) · BioTechniques · doi:10.2144/97233bm10 · Cited by 21 · see citing works

A Scintillating Microplate Assay for the Assessment of Protein Kinase Activity

Nakayama, G. R., Nova, M. P., & Parandoosh, Z. (1998) · SLAS DISCOVERY · doi:10.1177/108705719800300106 · Cited by 17 · see citing works

Core system model: understanding the impact of reliability on high-throughput screening systems

Brandt, D. (1998) · Drug Discovery Today · doi:10.1016/s1359-6446(97)01136-7 · Cited by 13 · see citing works

The creation of a camptothecin-sensitive Escherichia coli based on the expression of the human topoisomerase I

Taylor, S. T., & Menzel, R. (1995) · Gene · doi:10.1016/0378-1119(95)00608-7 · Cited by 10 · see citing works

Ultra-High Throughput Screening

Shumate, C., Beckey, S., Coassin, P. J., & Stylli, H. (1997) · Laboratory Automation News · doi:10.1177/221106829700200406 · Cited by 6 · see citing works

High-throughput screening

Wallace, R. W. (1998) · Drug Discovery Today · doi:10.1016/s1359-6446(98)01171-4 · Cited by 5 · see citing works

Lead validation platforms

Persidis, A. (1998) · Nature Biotechnology · doi:10.1038/nbt0198-100 · Cited by 4 · see citing works

FLUORESCENT SENSORS

FREEMANTLE, M. (1998) · Chemical & Engineering News · doi:10.1021/cen-v076n009.p035 · Cited by 2 · see citing works

Liquid crystals detect proteins with a glow

BRENNAN, M. B. (1998) · Chemical & Engineering News · doi:10.1021/cen-v076n013.p007 · Cited by 1 · see citing works

Chemosensor exploits anion competition

FREEMANTLE, M. (1998) · Chemical & Engineering News · doi:10.1021/cen-v076n010.p005a · Cited by 1 · see citing works

Combining docking and molecular dynamic simulations in drug design

Alonso, H., Bliznyuk, A. A., & Gready, J. E. (2006) · Medicinal Research Reviews · doi:10.1002/med.20067 · Cited by 767 · see citing works

Mechanism-Based Profiling of Enzyme Families

Evans, M. J., & Cravatt, B. F. (2006) · Chemical Reviews · doi:10.1021/cr050288g · Cited by 568 · see citing works

Methods for reducing biosensor membrane biofouling

Wisniewski, N., & Reichert, M. (2000) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/s0927-7765(99)00148-4 · Cited by 543 · see citing works

Survey of the year 2003 commercial optical biosensor literature

Rich, R. L., & Myszka, D. G. (2004) · Journal of Molecular Recognition · doi:10.1002/jmr.726 · Cited by 505 · see citing works

Modulators of Protein–Protein Interactions

Milroy, L.-G., Grossmann, T. N., Hennig, S., Brunsveld, L., & Ottmann, C. (2014) · Chemical Reviews · doi:10.1021/cr400698c · Cited by 497 · see citing works

Impact of Drug Transporter Studies on Drug Discovery and Development

Mizuno, N., Niwa, T., Yotsumoto, Y., & Sugiyama, Y. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.3.1 · Cited by 490 · see citing works

Development and Application of Cell-Based Biosensors

Pancrazio, J. J., Whelan, J., Borkholder, D. A., Ma, W., & Stenger, D. A. (1999) · Annals of Biomedical Engineering · doi:10.1114/1.225 · Cited by 391 · see citing works

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

Leung, D., Hardouin, C., Boger, D. L., & Cravatt, B. F. (2003) · Nature Biotechnology · doi:10.1038/nbt826 · Cited by 387 · see citing works

A bacterial two-hybrid selection system for studying protein–DNA and protein–protein interactions

Joung, J. K., Ramm, E. I., & Pabo, C. O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.110149297 · Cited by 357 · see citing works

Raman Spectroscopy Cell-based Biosensors

Notingher, I. (2007) · Sensors · doi:10.3390/s7081343 · Cited by 345 · see citing works

High-Throughput Screening in Drug Metabolism and Pharmacokinetic Support of Drug Discovery

White, R. E. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.133 · Cited by 305 · see citing works

Discrimination between ricin and sulphur mustard toxicity in vitro using Raman spectroscopy

Notingher, I., Green, C. A., Dyer, C. D., Perkins, E. A., Hopkins, N., Lindsay, C., & Hench, L. L. (2004) · Journal of The Royal Society Interface · doi:10.1098/rsif.2004.0008 · Cited by 291 · see citing works

NMR-based screening in drug discovery

Hajduk, P. J., Meadows, R. P., & Fesik, S. W. (1999) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500003528 · Cited by 229 · see citing works

Cell-Based Assays for High-Throughput Screening

An, W. F., & Tolliday, N. J. (2010) · Molecular Biotechnology · doi:10.1007/s12033-010-9251-z · Cited by 222 · see citing works

R ATIOMETRIC S INGLE -M OLECULE S TUDIES OF F REELY D IFFUSING B IOMOLECULES

Deniz, A. A., Laurence, T. A., Dahan, M., Chemla, D. S., Schultz, P. G., & Weiss, S. (2001) · Annual Review of Physical Chemistry · doi:10.1146/annurev.physchem.52.1.233 · Cited by 204 · see citing works

Biochemometrics for Natural Products Research: Comparison of Data Analysis Approaches and Application to Identification of Bioactive Compounds

Kellogg, J. J., Todd, D. A., Egan, J. M., Raja, H. A., Oberlies, N. H., Kvalheim, O. M., & Cech, N. B. (2016) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b01014 · Cited by 189 · see citing works

The Role of Cyclooxygenase and Lipoxygenase in Cancer Chemoprevention

Cuendet, M., & Pezzuto, M. (2000) · Drug metabolism and drug interactions · doi:10.1515/dmdi.2000.17.1-4.109 · Cited by 182 · see citing works

Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities

Caesar, L. K., Montaser, R., Keller, N. P., & Kelleher, N. L. (2021) · Natural Product Reports · doi:10.1039/d1np00036e · Cited by 189 · see citing works

Molecular docking for virtual screening of natural product databases

Ma, D., Chan, D. S., & Leung, C. (2011) · Chemical Science · doi:10.1039/c1sc00152c · Cited by 176 · see citing works

Time resolved amplification of cryptate emission: a versatile technology to trace biomolecular interactions

Bazin, H., Trinquet, E., & Mathis, G. (2002) · Reviews in Molecular Biotechnology · doi:10.1016/s1389-0352(01)00040-x · Cited by 158 · see citing works

Real-Time Quantitative Polymerase Chain Reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA Levels in Caco-2 Cell Lines, Human Duodenal Enterocytes, Normal Colorectal Tissues, and Colorectal Adenocarcinomas

Nakamura, T., Sakaeda, T., Ohmoto, N., Tamura, T., Aoyama, N., Shirakawa, T., Kamigaki, T., Nakamura, T., Kim, K. I., Kim, S. R., et al. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.1.4 · Cited by 136 · see citing works

Optical Imaging Fiber-Based Single Live Cell Arrays: A High-Density Cell Assay Platform

Biran, I., & Walt, D. R. (2002) · Analytical Chemistry · doi:10.1021/ac020009e · Cited by 132 · see citing works

Automation for Genomics, Part Two: Sequencers, Microarrays, and Future TrendsPreprint

Meldrum, D. (2000) · Genome Research · doi:10.1101/gr.157400 · Cited by 132 · see citing works

Potential Cancer-Chemopreventive Activities of Wine Stilbenoids and Flavans Extracted From Grape (Vitis vinifera) Cell Cultures

Waffo‐Téguo, P., Hawthorne, M., Cuendet, M., Mérillon, J., Kinghorn, A. D., Pezzuto, J. M., & Mehta, R. G. (2001) · Nutrition and Cancer · doi:10.1207/s15327914nc402_14 · Cited by 131 · see citing works

Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism

Miret‐Casals, L., Sebastián, D., Brea, J. M., Rico-Leo, E. M., Palacı́n, M., Fernández‐Salguero, P. M., Loza, M. I., Alberício, F., & Antonio Zorzano, A. (2017) · Cell chemical biology · doi:10.1016/j.chembiol.2017.12.001 · Cited by 129 · see citing works

Cellular platforms for HTS: three case studies

Johnston, P. A., & Johnston, P. A. (2002) · Drug Discovery Today · doi:10.1016/s1359-6446(01)02140-7 · Cited by 129 · see citing works

Homogeneous time resolved fluorescence resonance energy transfer using rare earth cryptates as a tool for probing molecular interactions in biology

Bazin, H., Préaudat, M., Trinquet, E., & Mathis, G. (2001) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/s1386-1425(01)00493-0 · Cited by 125 · see citing works

High‐throughput screening for stability and inhibitory activity of compounds toward cytochrome P450‐mediated metabolism

Ansede, J. H., & Thakker, D. R. (2003) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10545 · Cited by 109 · see citing works

Quantitating fluorescence intensity from fluorophore: The definition of MESF assignment

Schwartz, A., Wang, L., Early, E. A., Gaigalas, A. K., Zhang, Y. Z., Marti, G. E., & Vogt, R. F. (2002) · Journal of Research of the National Institute of Standards and Technology · doi:10.6028/jres.107.009 · Cited by 108 · see citing works

Pharmacokinetic theory of cassette dosing in drug discovery screening.

White, R. E., & Manitpisitkul, P. (2001) · PubMed · Cited by 107 · see citing works

NMR metabolomics and drug discovery

Powers, R. (2009) · Magnetic Resonance in Chemistry · doi:10.1002/mrc.2461 · Cited by 106 · see citing works

High Throughput Fluorescence Polarization: A Homogeneous Alternative to Radioligand Binding for Cell Surface Receptors

Allen, M. J., Reeves, J. J., & Mellor, G. W. (2000) · SLAS DISCOVERY · doi:10.1177/108705710000500202 · Cited by 103 · see citing works

Isolation and characterization of bioactive principles of the leaves and stems of Physalis philadelphica

Su, B.-N., Misico, R. I., Park, E. J., Santarsiero, B. D., Mesecar, A. D., Fong, H. H. S., Pezzuto, J. M., & Kinghorn, A. D. (2002) · Tetrahedron · doi:10.1016/s0040-4020(02)00277-6 · Cited by 102 · see citing works

Complex phenotypic assays in high-throughput screening

Clemons, P. A. (2004) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2004.04.002 · Cited by 101 · see citing works

Detection of the toxin domoic acid from clam extracts using a portable surface plasmon resonance biosensor

Stevens, R. C., Soelberg, S. D., Eberhart, B.-T. L., Spencer, S., Wekell, J. C., Chinowsky, T. M., Trainer, V. L., & Furlong, C. E. (2006) · Harmful Algae · doi:10.1016/j.hal.2006.08.001 · Cited by 98 · see citing works

Virtual screening to enrich hit lists from high‐throughput screening: A case study on small‐molecule inhibitors of angiogenin

Jenkins, J. L., Kao, R. Y. T., & Shapiro, R. (2002) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.10270 · Cited by 98 · see citing works

Induction of Quinone Reductase as a Primary Screen for Natural Product Anticarcinogens

Kang, Y., & Pezzuto, J. M. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)82021-4 · Cited by 93 · see citing works

Application of High-Throughput, Molecular-Targeted Screening to Anticancer Drug Discovery

Shoemaker, R., Scudiero, D. A., Melillo, G., Currens, M. J., Monks, A. P., Rabow, A. A., Covell, D. G., & Sausville, E. A. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394317 · Cited by 91 · see citing works

Screening of Small Molecule Interactor Library by Using In-Cell NMR Spectroscopy (SMILI-NMR)

Xie, J., Thapa, R., Reverdatto, S., Burz, D. S., & Shekhtman, A. G. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm9000743 · Cited by 79 · see citing works

Drug Transporters: Their Role and Importance in the Selection and Development of New Drugs

Mizuno, N., & Sugiyama, Y. (2002) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.17.93 · Cited by 75 · see citing works

Discovery of cancer preventive agents from natural products: From plants to prevention

Mehta, R. G., & Pezzuto, J. M. (2002) · Current Oncology Reports · doi:10.1007/s11912-002-0059-2 · Cited by 72 · see citing works

Molecular and Pharmacokinetic Properties of 222 Commercially Available Oral Drugs in Humans.

Sakaeda, T., Okamura, N., Nagata, S., Yagami, T., Horinouchi, M., Okumura, K., Yamashita, F., & Hashida, M. (2001) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.24.935 · Cited by 66 · see citing works

Homogeneous Cell- and Bead-Based Assays for High Throughput Screening Using Fluorometric Microvolume Assay Technology

Miraglia, S. J., Swartzman, E. E., Mellentin, J. D., Evangelista, L., Smith, C. J. S., Gunawan, I., Lohman, K. L., Goldberg, E. M., Manian, B. S., & Yuan, P.-M. (1999) · SLAS DISCOVERY · doi:10.1177/108705719900400407 · Cited by 66 · see citing works

A Mass Spectrometry Plate Reader: Monitoring Enzyme Activity and Inhibition with a Desorption/Ionization on Silicon (DIOS) Platform

Shen, Z., Go, E. P., Gámez, A., Apon, J. V., Fokin, V. V., Greig, M., Ventura, M. C., Crowell, J. E., Blixt, O., Paulson, J. C., et al. (2004) · ChemBioChem · doi:10.1002/cbic.200400008 · Cited by 66 · see citing works

MS/NMR: A Structure-Based Approach for Discovering Protein Ligands and for Drug Design by Coupling Size Exclusion Chromatography, Mass Spectrometry, and Nuclear Magnetic Resonance Spectroscopy

Moy, F. J., Haraki, K., Mobilio, D., Walker, G., Powers, R., Tabei, K., Tong, H., & Siegel, M. M. (2001) · Analytical Chemistry · doi:10.1021/ac0006270 · Cited by 66 · see citing works

Reliable high-throughput functional screening with 3-FABS

Dalvit, C., Ardini, E., Fogliatto, G., Mongelli, N., & Veronesi, M. (2004) · Drug Discovery Today · doi:10.1016/s1359-6446(04)03161-7 · Cited by 64 · see citing works

Design of Adenosine Kinase Inhibitors from the NMR-Based Screening of Fragments

Hajduk, P. J., Gomtsyan, A. R., DiDomenico, S., Cowart, M., Bayburt, E. K., Solomon, L. R., Severin, J. M., Smith, R. A., Walter, K. A., Holzman, T. F., et al. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm000373a · Cited by 64 · see citing works

Biomineralization. From Biology to Biotechnology and Medical Application. Herausgegeben von Edmund Baeuerlein

Epple, M. (2001) · Angewandte Chemie · doi:10.1002/1521-3757(20010917)113:18

Analysis of large libraries of protein mutants using flow cytometry

Georgiou, G. (2001) · Advances in protein chemistry · doi:10.1016/s0065-3233(01)55007-x · Cited by 63 · see citing works

A System for Dual Protein Expression in Pichia pastoris and Escherichia coli

Lueking, A., Holz, C., Gotthold, C., Lehrach, H. R., & Cahill, D. J. (2000) · Protein Expression and Purification · doi:10.1006/prep.2000.1317 · Cited by 59 · see citing works

Lateral displacement as a function of particle size using a piecewise curved planar interdigitated electrode array

Han, K.-H., Han, S., & Frazier, A. B. (2009) · Lab on a Chip · doi:10.1039/b909753h · Cited by 54 · see citing works

A live-cell high-throughput screening assay for identification of fatty acid uptake inhibitors

Li, H., Black, P. N., & Dirusso, C. (2004) · Analytical Biochemistry · doi:10.1016/j.ab.2004.09.025 · Cited by 54 · see citing works

Potentially Cancer Chemopreventive And Anti-Inflammatory Terpenoids From Natural Sources

Akihisa, T., Yasukawa, K., & Tokuda, H. (2003) · Studies in natural products chemistry · doi:10.1016/s1572-5995(03)80005-4 · Cited by 53 · see citing works

G Protein-Coupled Receptor Signaling Analysis Using Homogenous Time-Resolved Förster Resonance Energy Transfer (HTRF®) Technology

Nørskov-Lauritsen, L., Thomsen, A. R. B., & Bräuner‐Osborne, H. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15022554 · Cited by 52 · see citing works

Antifouling strategies for protecting bioelectronic devices

Chen, X., & Noy, A. (2021) · APL Materials · doi:10.1063/5.0029994 · Cited by 44 · see citing works

Fluoresceinated FKBP12 ligands for a high-throughput fluorescence polarization assay

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Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells

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