Impact of Drug Transporter Studies on Drug Discovery and Development

Initial sequencing and analysis of the human genome

International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216

The sequence of the human genome

Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

Hoffmeyer, S., Burk, O., von Richter, O., Arnold, H. P., Brockmöller, J., Johne, A., Cascorbi, I., Gerloff, T., Roots, I., Eichelbaum, M., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3473 · Cited by 2,365

A multidrug resistance transporter from human MCF-7 breast cancer cells

Doyle, L. A., Yang, W., Abruzzo, L. V., Krogmann, T., Gao, Y., Rishi, A. K., & Ross, D. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15665 · Cited by 2,322

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Schinkel, A. H., Smit, J. J. M., van Tellingen, O., Beijnen, J. H., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., van der Valk, M. A., Robanus-Maandag, E. C., te Riele, H. P. J., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90212-7 · Cited by 2,281

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

Schinkel, A. H., & Jonker, J. W. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00169-2 · Cited by 1,386

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

Staudinger, J. L., Goodwin, B., Jones, S. A., Hawkins-Brown, D., MacKenzie, K. I., LaTour, A., Liu, Y., Klaassen, C. D., Brown, K. K., Reinhard, J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051551698 · Cited by 1,379

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Schinkel, A. H., Wagenaar, E., Mol, C. A., & van Deemter, L. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118699 · Cited by 1,264

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

Schinkel, A. H., & Jonker, J. W. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.027 · Cited by 1,231

PDZ Domains and the Organization of Supramolecular Complexes

Sheng, M., & Sala, C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1 · Cited by 1,200

Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.

Maliepaard, M., Scheffer, G. L., Faneyte, I. F., van Gastelen, M. A., Pijnenborg, A. C. L. M., Schinkel, A. H., van de Vijver, M. J., Scheper, R. J., & Schellens, J. H. M. (2001) · PubMed · Cited by 1,130

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Schinkel, A. H., Wagenaar, E., van Deemter, L., Mol, C. A., & Borst, P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118214 · Cited by 1,107

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

Kim, R. B., Fromm, M. F., Wandel, C., Leake, B., Wood, A. J., Roden, D. M., & Wilkinson, G. R. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1269 · Cited by 1,054

Identification of functionally variant MDR1 alleles among European Americans and African Americans

Kim, R. (2001) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2001.117412 · Cited by 1,009

The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver

Gerloff, T., Stieger, B., Hagenbuch, B., Madon, J., Landmann, L., Roth, J., Hofmann, A. F., & Meier, P. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.10046 · Cited by 939

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

Schinkel, A. H., Mayer, U., Wagenaar, E., Mol, C. A. A. M., van Deemter, L., Smit, J. J. M., van der Valk, M. A., Voordouw, A. C., Spits, H., van Tellingen, O., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4028 · Cited by 937

SXR, a novel steroid and xenobioticsensing nuclear receptor

Blumberg, B., Sabbagh, W., Juguilon, H., Bolado, J., van Meter, C. M., Ong, E. S., & Evans, R. M. (1998) · Genes & Development · doi:10.1101/gad.12.20.3195 · Cited by 919

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

Greiner, B., Eichelbaum, M., Fritz, P., Kreichgauer, H.-P., von Richter, O., Zundler, J., & Kroemer, H. K. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6663 · Cited by 917

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

Kast, H. R., Goodwin, B., Tarr, P. T., Jones, S. A., Anisfeld, A. M., Stoltz, C. M., Tontonoz, P., Kliewer, S., Willson, T. M., & Edwards, P. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109326200 · Cited by 916

Indinavir concentrations and St John's wort

Piscitelli, S. C., Burstein, A. H., Chaitt, D., Alfaro, R. M., & Falloon, J. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05712-8 · Cited by 874

Identification of a human nuclear receptor defines a new signaling pathway for CYP 3 A induction

Bertilsson, G., Heidrich, J., Svensson, K., Åsman, M., Jendeberg, L., Sydow-Bäckman, M., Ohlsson, R., Postlind, H., Blomquist, P., & Berkenstam, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12208 · Cited by 872

The superfamily of organic anion transporting polypeptides

Hagenbuch, B., & Meier, P. J. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00633-8 · Cited by 861

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy

Wacher, V. J., Wu, C., & Benet, L. Z. (1995) · Molecular Carcinogenesis · doi:10.1002/mc.2940130302 · Cited by 857

Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

Geick, A., Eichelbaum, M., & Burk, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010173200 · Cited by 848

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

Synold, T. W., Dussault, I., & Forman, B. M. (2001) · Nature Medicine · doi:10.1038/87912 · Cited by 840

Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene

Paulusma, C. C., Bosma, P. J., Zaman, G. J. R., Bakker, C. T. M., Otter, M., Scheffer, G. L., Scheper, R. J., Borst, P., & Elferink, R. P. J. O. (1996) · Science · doi:10.1126/science.271.5252.1126 · Cited by 822

Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor

Ananthanarayanan, M., Balasubramanian, N., Makishima, M., Mangelsdorf, D. J., & Suchy, F. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011610200 · Cited by 801

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

König, J., Nies, A. T., Cui, Y., Leier, I., & Keppler, D. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(99)00169-8 · Cited by 791

Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects

Cascorbi, I. (2001) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2001.114164 · Cited by 747

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

Kullak-Ublick, G. A., Ismair, M. G., Stieger, B., Landmann, L., Huber, R., Pizzagalli, F., Fattinger, K., Meier, P. J., & Hagenbuch, B. (2001) · Gastroenterology · doi:10.1053/gast.2001.21176 · Cited by 723

Rational Use of in Vitro P-glycoprotein Assays in Drug Discovery

Polli, J. W., Wring, S. A., Humphreys, J. E., Huang, L., Morgan, J. B., Webster, L. O., & Serabjit-Singh, C. S. (2001) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29270-3 · Cited by 662

The ATP-dependent glutathione S-conjugate export pump

Ishikawa, T. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90489-v · Cited by 654

The multidrug resistance protein family

Borst, P., Evers, R., Kool, M., & Wijnholds, J. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(99)00167-4 · Cited by 648

MRP3, an organic anion transporter able to transport anti-cancer drugs

Kool, M., van der Linden, M., de Haas, M., Scheffer, G. L., de Vree, J. M. L., Smith, A. J., Jansen, G., Peters, G. J., Ponne, N., Scheper, R. J., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6914 · Cited by 645

Drug excretion mediated by a new prototype of polyspecific transporter

Gründemann, D., Gorboulev, V., Gambaryan, S., Veyhl, M., & Koepsell, H. (1994) · Nature · doi:10.1038/372549a0 · Cited by 643

Molecular Identification and Characterization of Novel Members of the Human Organic Anion Transporter (OATP) Family

Tamai, I., Nezu, J.-I., Uchino, H., Sai, Y., Oku, A., Shimane, M., & Tsuji, A. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2922 · Cited by 642

A Novel Human Hepatic Organic Anion Transporting Polypeptide (OATP2)

Hsiang, B., Zhu, Y., Wang, Z., Wu, Y., Sasseville, V., Yang, W.-P., & Kirchgessner, T. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37161 · Cited by 641

Cloning and Characterization of Two Human Polyspecific Organic Cation Transporters

GORBOULEV, V., ULZHEIMER, J. C., AKHOUNDOVA, A., ULZHEIMER-TEUBER, I., KARBACH, U., QUESTER, S., BAUMANN, C., LANG, F., BUSCH, A. E., & KOEPSELL, H. (1997) · DNA and Cell Biology · doi:10.1089/dna.1997.16.871 · Cited by 638

Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan

Jonker, J. W. (2000) · Journal of the National Cancer Institute · doi:10.1093/jnci/92.20.1651 · Cited by 638

Polymorphisms in OATP-C

Tirona, R. G., Leake, B. F., Merino, G., & Kim, R. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103792200 · Cited by 626

Expression Cloning and Characterization of a Novel Multispecific Organic Anion Transporter

Sekine, T., Watanabe, N., Hosoyamada, M., Kanai, Y., & Endou, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18526 · Cited by 625

A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane

König, J., Cui, Y., Nies, A. T., & Keppler, D. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.278.1.g156 · Cited by 620

Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs

Doan, K. M. M., Humphreys, J. E., Webster, L. O., Wring, S. A., Shampine, L. J., Serabjit-Singh, C. J., Adkison, K. K., & Polli, J. W. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.039255 · Cited by 614

Fruit juices inhibit organic anion transporting polypeptide–mediated drug uptake to decrease the oral availability of fexofenadine

Dresser, G. K., Bailey, D. G., Leake, B. F., Schwarz, U. I., Dawson, P. A., Freeman, D. J., & Kim, R. B. (2002) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2002.121152 · Cited by 606

OATP and P-Glycoprotein Transporters Mediate the Cellular Uptake and Excretion of Fexofenadine

Cvetkovic, M., Leake, B., Fromm, M. F., Wilkinson, G. R., & Kim, R. B. (1999) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)15235-x · Cited by 597

Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)*1

JOHNE, A. (1999) · Clinical Pharmacology & Therapeutics · doi:10.1053/cp.1999.v66.a101944 · Cited by 586

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

Dürr, D. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.112240 · Cited by 584

Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver

Stieger, B., Fattinger, K., Madon, J., Kullak-Ublick, G. A., & Meier, P. J. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70224-1 · Cited by 582

Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter

Nezu, J.-I., Tamai, I., Oku, A., Ohashi, R., Yabuuchi, H., Hashimoto, N., Nikaido, H., Sai, Y., Koizumi, A., Shoji, Y., et al. (1999) · Nature Genetics · doi:10.1038/5030 · Cited by 554

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

Paulusma, C. C., Kool, M., Bosma, P. J., Scheffer, G. L., ter Borg, F., Scheper, R. J., Tytgat, G. N., Borst, P., Baas, F., & Elferink, R. O. (1997) · Hepatology · doi:10.1002/hep.510250635 · Cited by 552

Identification of a Novel Gene Family Encoding Human Liver-specific Organic Anion Transporter LST-1

Abe, T., Kakyo, M., Tokui, T., Nakagomi, R., Nishio, T., Nakai, D., Nomura, H., Unno, M., Suzuki, M., Naitoh, T., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17159 · Cited by 543

Drug Transporters in the Central Nervous System: Brain Barriers and Brain Parenchyma Considerations

Lee, G., Dallas, S., Hong, M., & Bendayan, R. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01513-8 · Cited by 539

Localization and Genomic Organization of a New Hepatocellular Organic Anion Transporting Polypeptide

König, J., Cui, Y., Nies, A. T., & Keppler, D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001448200 · Cited by 522

The Gut as a Barrier to Drug Absorption: Combined Role of Cytochrome P450 3A and P-Glycoprotein

Zhang, Y., & Benet, L. Z. (2001) · Clinical Pharmacokinetics · doi:10.2165/00003088-200140030-00002 · Cited by 518

Hepatic Uptake of Bilirubin and Its Conjugates by the Human Organic Anion Transporter SLC21A6

Cui, Y., König, J., Leier, I., Buchholz, U., & Keppler, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m004968200 · Cited by 515

Prediction of Pharmacokinetic Alterations Caused by Drug-Drug Interactions: Metabolic Interaction in the Liver

Ito, K., Iwatsubo, T., Kanamitsu, S., Ueda, K., Suzuki, H., & Sugiyama, Y. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01372-3 · Cited by 512

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics

Nishizato, Y. (2003) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(03)00060-2 · Cited by 511

Identification and Characterization of Human Organic Anion Transporter 3 Expressing Predominantly in the Kidney

Cha, S. H., Sekine, T., Fukushima, J.-I., Kanai, Y., Kobayashi, Y., Goya, T., & Endou, H. (2001) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12589-8 · Cited by 508

Characterization of the Human Multidrug Resistance Protein Isoform Mrp3 Localized to the Basolateral Hepatocyte Membrane

König, J., Rost, D., Cui, Y., & Keppler, D. (1999) · Hepatology · doi:10.1002/hep.510290404 · Cited by 504

Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain

Kusuhara, H., Sekine, T., Utsunomiya-Tate, N., Tsuda, M., Kojima, R., Cha, S. H., Sugiyama, Y., Kanai, Y., & Endou, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13675 · Cited by 489

HIV-1 Protease Inhibitors Are Substrates for the MDR 1 Multidrug Transporter

Lee, C. G. L., Gottesman, M. M., Cardarelli, C. O., Ramachandra, M., Jeang, K.-T., Ambudkar, S. V., Pastan, I., & Dey, S. (1998) · Biochemistry · doi:10.1021/bi972709x · Cited by 477

Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system.

Hagenbuch, B., Stieger, B., Foguet, M., Lübbert, H., & Meier, P. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10629 · Cited by 476

Interrelationship Between Substrates and Inhibitors of Human CYP3A and P-Glycoprotein

Kirn, R. B., Wandel, C., Leake, B., Cvetkovic, M., Fromm, M. F., Dempsey, P. J., Roden, M. M., Belas, F., Chaudhary, A. K., Roden, D. M., et al. (1999) · Pharmaceutical Research · doi:10.1023/a:1018877803319 · Cited by 454

Cellular and molecular aspects of drug transport in the kidney

Inui, K.-I., Masuda, S., & Saito, H. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00251.x · Cited by 450

Correlation of Gene Expression of Ten Drug Efflux Proteins of the ATP-Binding Cassette Transporter Family in Normal Human Jejunum and in Human Intestinal Epithelial Caco-2 Cell Monolayers

Taipalensuu, J., Törnblom, H., Lindberg, G., Einarsson, C., Sjöqvist, F., Melhus, H., Garberg, P., Sjöström, B., Lundgren, B., & Artursson, P. (2001) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29314-9 · Cited by 444

Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin

Wang, D.-S., Jonker, J. W., Kato, Y., Kusuhara, H., Schinkel, A. H., & Sugiyama, Y. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.034140 · Cited by 441

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

Wijnholds, J., Evers, R., van Leusden, M. R., Mol, C. A. A. M., Zaman, G. J. R., Mayer, U., Beijnen, J. H., Valk, M. V. D., Krimpenfort, P., & Borst, P. (1997) · Nature Medicine · doi:10.1038/nm1197-1275 · Cited by 432

Increased drug delivery to the brain by P-glycoprotein inhibition

Sadeque, A. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.109156 · Cited by 426

Role of transport proteins in drug absorption, distribution and excretion

Ayrton, A., & Morgan, P. (2001) · Xenobiotica · doi:10.1080/00498250110060969 · Cited by 421

Cloning and Functional Expression of a Human Liver Organic Cation Transporter

Zhang, L., Dresser, M. J., Gray, A. T., Yost, S. C., Terashita, S., & Giacomini, K. M. (1997) · Molecular Pharmacology · doi:10.1124/mol.51.6.913 · Cited by 417

Organic Anion-Transporting Polypeptides Mediate Transport of Opioid Peptides across Blood-Brain Barrier

Gao, B., Hagenbuch, B., Kullak-Ublick, G. A., Benke, D., Aguzzi, A., & Meier, P. J. (2000) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39041-x · Cited by 412

MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity

Ameyaw, M.-M., Regateiro, F., Li, T., Liu, X., Tariq, M., Mobarek, A., Thornton, N., Folayan, G. O., Githang'a, J., Indalo, A., et al. (2001) · Pharmacogenetics · doi:10.1097/00008571-200104000-00005 · Cited by 409

Cloning and Functional Characterization of a Potential-sensitive, Polyspecific Organic Cation Transporter (OCT3) Most Abundantly Expressed in Placenta

Kekuda, R., Prasad, P. D., Wu, X., Wang, H., Fei, Y.-J., Leibach, F. H., & Ganapathy, V. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.26.15971 · Cited by 409

P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs

Fromm, M. F. (2000) · Int. Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp38069 · Cited by 399

Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome

Kartenbeck, J., Leuschner, U., Mayer, R., & Keppler, D. (1996) · Hepatology · doi:10.1002/hep.510230519 · Cited by 398

Pharmacological Inhibition of P-glycoprotein Transport Enhances the Distribution of HIV-1 Protease Inhibitors into Brain and Testes

Choo, E. F., Leake, B., Wandel, C., Imamura, H., Wood, A. J. J., Wilkinson, G. R., & Kim, R. B. (2000) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)15144-6 · Cited by 395

Nonsteroidal anti-inflammatory drugs

Moses, V. S., & Bertone, A. L. (2002) · Veterinary Clinics of North America: Equine Practice · doi:10.1016/s0749-0739(01)00002-5 · Cited by 394

Carrier-Mediated Intestinal Transport of Drugs

Tsuji, A., & Tamai, I. (1996) · Pharmaceutical Research · doi:10.1023/a:1016086003070 · Cited by 392

Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport

Oude Elferink, R. P. J., Meijer, D. K. F., Kuipers, F., Jansen, P. L. M., Groen, A. K., & Groothuis, G. M. M. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(95)00006-d · Cited by 386

Identity of the Organic Cation Transporter OCT3 as the Extraneuronal Monoamine Transporter (uptake2) and Evidence for the Expression of the Transporter in the Brain

Wu, X., Kekuda, R., Huang, W., Fei, Y.-J., Leibach, F. H., Chen, J., Conway, S. J., & Ganapathy, V. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32776 · Cited by 370

Transporter-Mediated Permeation of Drugs Across the Blood–Brain Barrier

Tamai, I., & Tsuji, A. (2000) · Journal of Pharmaceutical Sciences · doi:10.1002/1520-6017(200011)89:11<1371::aid-jps1>3.0.co;2-d · Cited by 363

Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver

Meier, P. J., Eckhardt, U., Schroeder, A., Hagenbuch, B., & Stieger, B. (1997) · Hepatology · doi:10.1002/hep.510260641 · Cited by 362

Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases

Zollner, G. (2001) · Hepatology · doi:10.1053/jhep.2001.22646 · Cited by 362

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

Wijnholds, J., de Lange, E. C. M., Scheffer, G. L., van den Berg, D.-J., Mol, C. A. A. M., van der Valk, M., Schinkel, A. H., Scheper, R. J., Breimer, D. D., & Borst, P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8267 · Cited by 360

Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney

Hosoyamada, M., Sekine, T., Kanai, Y., & Endou, H. (1999) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1999.276.1.f122 · Cited by 358

Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure

Smit, J. W., Huisman, M. T., van Tellingen, O., Wiltshire, H. R., & Schinkel, A. H. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7963 · Cited by 352

Untitled work

(2001) · PubMed · Cited by 350

Characterization of the Transport Properties of Cloned Rat Multidrug Resistance-associated Protein 3 (MRP3)

Hirohashi, T., Suzuki, H., & Sugiyama, Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.15181 · Cited by 347

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