Cited by 1,218Gout, Hyperuricemia, Uric AcidBiochemical and Molecular ResearchAdenosine and Purinergic Signaling

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Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol

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Pacher, Pál, Nivorozhkin, Alex, Szabó, Csaba·2006·Pharmacological Reviews

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Abstract

The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the cornerstone of the clinical management of gout and conditions associated with hyperuricemia for several decades. More recent data indicate that XO also plays an important role in various forms of ischemic and other types of tissue and vascular injuries, inflammatory diseases, and chronic heart failure. Allopurinol and its active metabolite oxypurinol showed considerable promise in the treatment of these conditions both in experimental animals and in small-scale human clinical trials. Although some of the beneficial effects of these compounds may be unrelated to the inhibition of the XO, the encouraging findings rekindled significant interest in the development of additional, novel series of XO inhibitors for various therapeutic indications. Here we present a critical overview of the effects of XO inhibitors in various pathophysiological conditions and also review the various emerging therapeutic strategies offered by this approach.

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Superoxide Dismutase
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399
Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.
Ames, B. N., Cathcart, R., Schwiers, E., & Hochstein, P. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.6858 · Cited by 2,915
Hypercholesterolemia increases endothelial superoxide anion production.
Ohara, Y., Peterson, T. E., & Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116491 · Cited by 1,765
The mononuclear molybdenum enzymes
Hille, R., Hall, J., & Basu, P. (2014) · Chemical Reviews · doi:10.1021/cr400443z · Cited by 1,738
The Mononuclear Molybdenum Enzymes
Hille, R. (1996) · Chemical Reviews · doi:10.1021/cr950061t · Cited by 1,501
Febuxostat Compared with Allopurinol in Patients with Hyperuricemia and Gout
Becker, M. A., Schumacher, H. R., Wortmann, R. L., MacDonald, P. A., Eustace, D., Palo, W. A., Streit, J., & Joseph-Ridge, N. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050373 · Cited by 1,357
Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism
Mazzali, M., Hughes, J., Kim, Y.-G., Jefferson, J. A., Kang, D., GORDON, K. L., Lan, H. Y., Kivlighn, S. D., & Johnson, R. J. (2001) · Hypertension · doi:10.1161/hy1101.092839 · Cited by 1,298
Hyperuricemia induces endothelial dysfunction
Khosla, U. M., Zharikov, S. I., Finch, J., Nakagawa, T., Roncal, C., Mu, W., Krotova, K. Y., Block, E. R., Prabhakar, S. S., & Johnson, R. J. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00273.x · Cited by 1,197
The Reduction of Cytochrome c by Milk Xanthine Oxidase
McCord, J. M., & Fridovich, I. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)91929-0 · Cited by 1,196
Superoxide radicals in feline intestinal ischemia
Granger, D. N., Rutili, G., & McCord, J. M. (1981) · Gastroenterology · doi:10.1016/0016-5085(81)90648-x · Cited by 1,184
Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications
Berry, C. E., & Hare, J. M. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.055913 · Cited by 925
Structure and function of xanthine oxidoreductase: where are we now?
Harrison, R. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00956-5 · Cited by 807
Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology
Li, J.-M., & Shah, A. M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00124.2004 · Cited by 773
Does superoxide underlie the pathogenesis of hypertension?
Nakazono, K., Watanabe, N., Matsuno, K., Sasaki, J., Sato, T., & Inoue, M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10045 · Cited by 746
Ischemic injury in the cat small intestine: Role of superoxide radicals
Parks, D. A., Bulkley, G. B., Granger, D. N., Hamilton, S. R., & McCord, J. M. (1982) · Gastroenterology · doi:10.1016/0016-5085(82)90115-9 · Cited by 741
Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion
Enroth, C., Eger, B. T., Okamoto, K., Nishino, T., Nishino, T., & Pai, E. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.20.10723 · Cited by 733
Xanthine oxidase and neutrophil infiltration in intestinal ischemia
Grisham, M. B., Hernandez, L. A., & Granger, D. N. (1986) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1986.251.4.g567 · Cited by 722
Peroxynitrite-mediated oxidation of dihydrorhodamine 123
Kooy, N. W., Royall, J. A., Ischiropoulos, H., & Beckman, J. S. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90138-4 · Cited by 720
The purine path to chemotherapy
Elion, G. B. (1989) · Science · doi:10.1126/science.2649979 · Cited by 687
Enhanced Peroxynitrite Formation Is Associated with Vascular Aging
van der Loo, B., Labugger, R., Skepper, J. N., Bachschmid, M. M., Kilo, J., Powell, J. M., Palacios‐Callender, M., Erusalimsky, J. D., Quaschning, T., Maliñski, T., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.12.1731 · Cited by 684
Xanthine oxidase as a source of free radical damage in myocardial ischemia
CHAMBERS, D., PARKS, D., PATTERSON, G., ROY, R., MCCORD, J., YOSHIDA, S., PARMLEY, L., & DOWNEY, J. (1985) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(85)80017-1 · Cited by 672
Retrograde axonal transport of horseradish peroxidase from spinal cord to brain stem cell groups in the cat
Kuypers, H. G. J. M., & Maisky, V. A. (1975) · Neuroscience Letters · doi:10.1016/0304-3940(75)90004-x · Cited by 607
Uric Acid and Survival in Chronic Heart Failure: Validation and Application in Metabolic, Functional, and Hemodynamic Staging
Anker, S. D., Doehner, W., Rauchhaus, M., Sharma, R., Francis, D., Knosalla, C., Davos, C. H., Cicoira, M., Shamim, W., Kemp, M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000065637.10517.a0 · Cited by 593
Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis
Hooper, D. C., Spitsin, S. V., Kean, R. B., Champion, J. M., Dickson, G. M., Chaudhry, I., & Koprowski, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.675 · Cited by 571
Aging-Induced Phenotypic Changes and Oxidative Stress Impair Coronary Arteriolar Function
Csiszár, A., Ungvari, Z. I., Edwards, J. G., Kaminski, P. M., Wolin, M. S., Koller, Á., & Kaley, G. (2002) · Circulation Research · doi:10.1161/01.res.0000020401.61826.ea · Cited by 569
Effects of Xanthine Oxidase Inhibition With Allopurinol on Endothelial Function and Peripheral Blood Flow in Hyperuricemic Patients With Chronic Heart Failure
Doehner, W., Schoene, N., Rauchhaus, M., Leyva‐Leon, F., Pavitt, D. V., Reaveley, D. A., Schuler, G. C., Coats, A. J. S., Anker, S. D., & Hambrecht, R. (2002) · Circulation · doi:10.1161/01.cir.0000017502.58595.ed · Cited by 565
Allopurinol Improves Endothelial Dysfunction in Chronic Heart Failure
Farquharson, C. A. J., Butler, R., Hill, A., Belch, J. J. F., & Struthers, A. D. (2002) · Circulation · doi:10.1161/01.cir.0000022140.61460.1d · Cited by 504
Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions
Millar, T. M., Stevens, C. R., Benjamin, N., Eisenthal, R., Harrison, R., & Blake, D. R. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00430-x · Cited by 491
Crystal Structure of the Xanthine Oxidase-Related Aldehyde Oxido-Reductase from D. gigas
Romão, M. J., Archer, M., Moura, I., Moura, J. J. G., LeGall, J., Engh, R. A., Schneider, M., Hof, P., & Huber, R. (1995) · Science · doi:10.1126/science.270.5239.1170 · Cited by 481
Allopurinol Normalizes Endothelial Dysfunction in Type 2 Diabetics With Mild Hypertension
Butler, R., Morris, A. D., Belch, J. J. F., Hill, A., & Struthers, A. D. (2000) · Hypertension · doi:10.1161/01.hyp.35.3.746 · Cited by 463
Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress
McNally, J. S., Davis, M. E., Giddens, D. P., Saha, A., Hwang, J., Dikalov, S., Jo, H., & Harrison, D. G. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00515.2003 · Cited by 461
Peroxynitrite Is a Major Contributor to Cytokine-Induced Myocardial Contractile Failure
Ferdinandy, P., Danial, H., Ambrus, I., Rothery, R. A., & Schulz, R. (2000) · Circulation Research · doi:10.1161/01.res.87.3.241 · Cited by 457
Gout
Terkeltaub, R. A. (2003) · New England Journal of Medicine · doi:10.1056/nejmcp030733 · Cited by 456
Serum Uric Acid and Cardiovascular Events in Successfully Treated Hypertensive Patients
Alderman, M. H., Cohen, H. W., Madhavan, S., & Kivlighn, S. D. (1999) · Hypertension · doi:10.1161/01.hyp.34.1.144 · Cited by 438
Allopurinol Improves Myocardial Efficiency in Patients With Idiopathic Dilated Cardiomyopathy
Cappola, T. P., Kass, D. A., Nelson, G. S., Berger, R. D., Rosas, G. O., Kobeissi, Z. A., Marbán, E., & Hare, J. M. (2001) · Circulation · doi:10.1161/hc4501.098928 · Cited by 436
An Extremely Potent Inhibitor of Xanthine Oxidoreductase
Okamoto, K., Eger, B. T., Nishino, T., Kondo, S., Pai, E. F., & Nishino, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208307200 · Cited by 434
Increasing prevalence of gout and hyperuricemia over 10 years among older adults in a managed care population.
Wallace, K. L., Riedel, A. A., Joseph‐Ridge, N., & Wortmann, R. L. (2004) · PubMed · Cited by 426
Vascular NADPH oxidases: molecular mechanisms of activation
Brandes, R. P., & Kreuzer, J. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.08.007 · Cited by 411
Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase
Godber, B. L. J., Doel, J. J., Sapkota, G. P., Blake, D. R., Stevens, C. R., Eisenthal, R., & Harrison, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7757 · Cited by 411
Reactive Oxygen Species, Mitochondria, and NAD(P)H Oxidases in the Development and Progression of Heart Failure
Sorescu, D., & Griendling, K. K. (2002) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2002.00717.x · Cited by 403
Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease
Aslan, M., Ryan, T. M., Adler, B., Townes, T. M., Parks, D. A., Thompson, J. A., Tousson, A., Gladwin, M. T., Patel, R. P., Tarpey, M. M., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221292098 · Cited by 391
Xanthine Oxidase Is Involved in Free Radical Production in Type 1 Diabetes
Desco, C., Asensi, M. A., Márquez, R., Martínez-Valls, J. F., Vento, M., Pallardó, F. V., Sastre, J., & Viña, J. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1118 · Cited by 391
Progress Towards the Discovery of Xanthine Oxidase Inhibitors
Borges, F., Fernandes, E. G. R., & Roleira, F. M. F. (2002) · Current Medicinal Chemistry · doi:10.2174/0929867023371229 · Cited by 373
Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits.
White, C. R., Darley-Usmar, V, Berrington, W. R., McAdams, M., Gore, J. Z., Thompson, J. A., Parks, D. A., Tarpey, M. M., & Freeman, B. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8745 · Cited by 367
Oxidative Stress, Metabolism of Ethanol and Alcohol-Related Diseases
Zima, T., Fialová, L., Mestek, O., Kalousová, M., Crkovska, J., Malbohan, I. M., Štípek, S., Mikulikova, L., & Popov, P. (2001) · Journal of Biomedical Science · doi:10.1007/bf02255972 · Cited by 354
Aberrant inflammation and resistance to glucocorticoids in Annexin 1 −/− Mouse
Hannon, R., Croxtall, J. D., Getting, S. J., Roviezzo, F., Yona, S., Paul‐Clark, M. J., Gavins, F. N. E., Perretti, M., Morris, J. F., Buckingham, J. C., et al. (2002) · The FASEB Journal · doi:10.1096/fj.02-0239fje · Cited by 351
Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues.
Engerson, T. D., McKelvey, T. G., Rhyne, D. B., Boggio, E. B., Snyder, S. J., & Jones, H. P. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112990 · Cited by 350
Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase
Takano, Y., Hase-Aoki, K., Horiuchi, H., Zhao, L., Kasahara, Y., Kondo, S., & Becker, M. A. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.10.031 · Cited by 339
Role of Nitrosative Stress and Peroxynitrite in the Pathogenesis of Diabetic Complications. Emerging New Therapeutical Strategies
Pacher, P., Obrosova, I. G., Mabley, J. G., & Szabó, C. (2005) · Current Medicinal Chemistry · doi:10.2174/0929867053363207 · Cited by 335
Self-citation
Dependence on O2- generation by xanthine oxidase of pathogenesis of influenza virus infection in mice.
Akaike, T., Ando, M., Oda, T., Doi, T., Ijiri, S., Araki, S., & Maeda, H. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114499 · Cited by 333
Ischemia-induced vascular changes: role of xanthine oxidase and hydroxyl radicals
Parks, D. A., & Granger, D. N. (1983) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1983.245.2.g285 · Cited by 322
Allopurinol Hypersensitivity Syndrome: A Review
Arellano, F., & Sacristán, J. A. (1993) · Annals of Pharmacotherapy · doi:10.1177/106002809302700317 · Cited by 321
Vascular and Hepatocellular Peroxynitrite Formation during Acetaminophen Toxicity: Role of Mitochondrial Oxidant Stress
Knight, T. R. (2001) · Toxicological Sciences · doi:10.1093/toxsci/62.2.212 · Cited by 313
Uric acid in chronic heart failure: a marker of chronic inflammation.
Leyva, F., Anker, S., Godsland, I., Teixeira, M. M., Hellewell, P., Kox, W., Poole-wilson, P., & Coats, A. (1998) · European Heart Journal · doi:10.1053/euhj.1998.1188 · Cited by 303
Role of Oxidative Stress and Antioxidant Therapy in Alcoholic and Nonalcoholic Liver Diseases
Lieber, C. S. (1996) · Advances in pharmacology · doi:10.1016/s1054-3589(08)61001-7 · Cited by 301
Hyperuricemia and urate nephropathy in urate oxidase-deficient mice.
Wu, X., Wakamiya, M., Vaishnav, S., Geske, R. S., Montgomery, C. A., Jones, P., Bradley, A., & Caskey, C. T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.742 · Cited by 292
Reperfusion injury after intestinal ischemia
Schoenberg, M. H., & Beger, H. G. (1993) · Critical Care Medicine · doi:10.1097/00003246-199309000-00023 · Cited by 288
The crystal structure of xanthine oxidoreductase during catalysis: Implications for reaction mechanism and enzyme inhibition
Okamoto, K., Matsumoto, K., Hille, R., Eger, B. T., Pai, E. F., & Nishino, T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400973101 · Cited by 286
Conversion of xanthine dehydrogenase to oxidase in ischemic rat intestine: a reevaluation
Parks, D. A., Williams, T. K., & Beckman, J. S. (1988) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1988.254.5.g768 · Cited by 282
Potent Metalloporphyrin Peroxynitrite Decomposition Catalyst Protects Against the Development of Doxorubicin-Induced Cardiac Dysfunction
Pacher, P., Liaudet, L., Bai, P., Mabley, J. G., Kaminski, P. M., Virág, L., Deb, A., Szabó, É., Ungvari, Z. I., Wolin, M. S., et al. (2003) · Circulation · doi:10.1161/01.cir.0000048192.52098.dd · Cited by 279
Self-citation
Binding of Xanthine Oxidase to Vascular Endothelium
Houston, M., Estévez, Á. G., Chumley, P. H., Aslan, M., Marklund, S. L., Parks, D. A., & Freeman, B. Α. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.8.4985 · Cited by 271
Ischemia and reperfusion-induced arrhythmias in the rat. Effects of xanthine oxidase inhibition with allopurinol.
MANNING, A. S., COLTART, D. J., & Hearse, D. J. (1984) · Circulation Research · doi:10.1161/01.res.55.4.545 · Cited by 264
Xanthine oxidase activity associated with arterial blood pressure in spontaneously hypertensive rats
Suzuki, H., DeLano, F. A., Parks, D. A., Jamshidi, N., Granger, D. N., Ishii, H., Suematsu, M., Zweifach, B. W., & Schmid‐Schönbein, G. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4754 · Cited by 262
Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the cat intestine
Granger, D. N., McCord, J. M., Parks, D. A., & Höllwarth, M. E. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90078-8 · Cited by 257
The association between gout and nephrolithiasis: The National Health and Nutrition Examination Survey III, 1988-1994
Kramer, H., & Curhan, G. C. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.33911 · Cited by 254
Generation of Nitric Oxide by a Nitrite Reductase Activity of Xanthine Oxidase: A Potential Pathway for Nitric Oxide Formation in the Absence of Nitric Oxide Synthase Activity
Zhang, Z., Naughton, D., Winyard, P. G., Benjamin, N., Blake, D. R., & Symons, M. C. R. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9226 · Cited by 246
Xanthine Oxidase Inhibition With Oxypurinol Improves Endothelial Vasodilator Function in Hypercholesterolemic but Not in Hypertensive Patients
Cardillo, C., Kilcoyne, C. M., Cannon, R. O., Quyyumi, A. A., & Panza, J. A. (1997) · Hypertension · doi:10.1161/01.hyp.30.1.57 · Cited by 246
Intravenous Allopurinol Decreases Myocardial Oxygen Consumption and Increases Mechanical Efficiency in Dogs With Pacing-Induced Heart Failure
Ekelund, U. E. G., Harrison, R. W., Shokek, O., Thakkar, R. N., Tunin, R. S., Senzaki, H., Kass, D. A., Marbán, E., & Hare, J. M. (1999) · Circulation Research · doi:10.1161/01.res.85.5.437 · Cited by 239
Nitrosative stress and pharmacological modulation of heart failure
Pacher, P., Schulz, R., Liaudet, L., & Szabó, C. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.04.003 · Cited by 237
Self-citation
Reduction of Perinatal Hypoxic-Ischemic Brain Damage with Allopurinol
Palmer, C., Vannucci, R. C., & Towfighi, J. (1990) · Pediatric Research · doi:10.1203/00006450-199004000-00003 · Cited by 237
Reperfusion injury pathophysiology in sickle transgenic mice
Osarogiagbon, U. R., Choong, S., Belcher, J. D., Vercellotti, G. M., Paller, M. S., & Hebbel, R. P. (2000) · Blood · doi:10.1182/blood.v96.1.314 · Cited by 236
Role of oxygen free radicals in shock, ischemia, and organ preservation.
Parks, D. A., Bulkley, G. B., & Granger, D. N. (1983) · PubMed · Cited by 236
Uric acid: role in cardiovascular disease and effects of losartan
Alderman, M. H., & Viswanathan‐Aiyer, K. (2004) · Current Medical Research and Opinion · doi:10.1185/030079904125002982 · Cited by 231
Substrate Control of Free Radical Generation from Xanthine Oxidase in the Postischemic Heart
Xia, Y., & Zweier, J. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.32.18797 · Cited by 229
Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling
Khan, S. A., Lee, K., Minhas, K. M., González, D. R., Raju, S. V. Y., Tejani, A. D., Li, D., Berkowitz, D. E., & Hare, J. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404136101 · Cited by 227
The Physiology of Endothelial Xanthine Oxidase: From Urate Catabolism to Reperfusion Injury to Inflammatory Signal Transduction
Meneshian, A., & Bulkley, G. B. (2002) · Microcirculation · doi:10.1038/sj.mn.7800136 · Cited by 225
Xanthine Oxidase Inhibition Reverses Endothelial Dysfunction in Heavy Smokers
Guthikonda, S., Sinkey, C., Barenz, T., & Haynes, W. G. (2003) · Circulation · doi:10.1161/01.cir.0000046448.26751.58 · Cited by 225
Management of Acute and Chronic Gouty Arthritis
Schlesinger, N. (2004) · Drugs · doi:10.2165/00003495-200464210-00003 · Cited by 223
Effect of hyperuricemia upon endothelial function in patients at increased cardiovascular risk
Mercuro, G. G., Vitale, C., Cerquetani, E., Zoncu, S., Deidda, M., Fini, M., & Rosano, G. M. C. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.06.032 · Cited by 223
Physiological Roles of Xanthine Oxidoreductase
Harrison, R. (2004) · Drug Metabolism Reviews · doi:10.1081/dmr-120037569 · Cited by 218
Oxygen free radicals and contrast nephropathy
Katholi, R., Woods, W. T., Taylor, G., Deitrick, C. L., Womack, K. A., Katholi, C. R., & McCann, W. P. (1998) · American Journal of Kidney Diseases · doi:10.1053/ajkd.1998.v32.pm9669426 · Cited by 215
Novel NAD(P)H oxidases in the cardiovascular system: Table 1
Griendling, K. K. (2004) · Heart · doi:10.1136/hrt.2003.029397 · Cited by 215
The Conversion of Xanthine Dehydrogenase to Xanthine Oxidase and the Role of the Enzyme in Reperfusion Injury1
Nishino, T. (1994) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124480 · Cited by 212
Xanthine oxidoreductase is central to the evolution and function of the innate immune system
Vorbach, C., Harrison, R., & Capecchi, M. R. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00237-0 · Cited by 210
Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains.
Patt, A., Harken, A. H., Burton, L. K., Rodell, T. C., Piermattei, D., Schorr, W., Parker, N. B., Berger, E. M., Horesh, I. R., & Terada, L. S. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113488 · Cited by 209
Allopurinol Attenuates Left Ventricular Remodeling and Dysfunction After Experimental Myocardial Infarction
Engberding, N., Spiekermann, S., Schaefer, A., Heineke, A., Wiencke, A., Müller, M. F., Fuchs, M., Hilfiker‐Kleiner, D., Hornig, B., Drexler, H., et al. (2004) · Circulation · doi:10.1161/01.cir.0000144303.24894.1c · Cited by 209
Crystal Structures of the Active and Alloxanthine-Inhibited Forms of Xanthine Dehydrogenase from Rhodobacter capsulatus
Truglio, J. J., Theis, K. W., Leimkühler, S., Rappa, R., Rajagopalan, K. V., & Kisker, C. (2002) · Structure · doi:10.1016/s0969-2126(01)00697-9 · Cited by 207
Hemorrhagic shock-induced bacterial translocation is reduced by xanthine oxidase inhibition or inactivation.
Deitch, E. A., Bridges, W. C., Baker, J., W., J., Ma, L., Grisham, M. B., Dn, G., Rd, S., & Berg, R. D. (1988) · PubMed · Cited by 206
Role of Oxidative-Nitrosative Stress and Downstream Pathways in Various Forms of Cardiomyopathy and Heart Failure
Ungvari, Z. I., Gupte, S. A., Recchia, F. A., Bátkai, S., & Pacher, P. (2005) · Current Vascular Pharmacology · doi:10.2174/1570161054368607 · Cited by 205
Self-citation
Role of xanthine oxidase inhibitor as free radical scavenger: A novel mechanism of action of allopurinol and oxypurinol in myocardial salvage
Das, D. K., Engelman, R. M., Clement, R., Otani, H., Prasad, M. R., & Rao, P. S. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)91112-0 · Cited by 204
Role of reactive oxygen metabolites in experimental colitis.
Keshavarzian, A., Morgan, G., Sedghi, S., Gordon, J. H., & Doria, M. I. (1990) · Gut · doi:10.1136/gut.31.7.786 · Cited by 198
Imbalance Between Xanthine Oxidase and Nitric Oxide Synthase Signaling Pathways Underlies Mechanoenergetic Uncoupling in the Failing Heart
Saavedra, W. F., Paolocci, N., John, M. E. S., Skaf, M. W., Stewart, G. C., Xie, J.-S., Harrison, R. W., Zeichner, J., Mudrick, D. W., Marbán, E., et al. (2002) · Circulation Research · doi:10.1161/hh0302.104531 · Cited by 196
Xanthine Oxidase-mediated Decomposition of S-Nitrosothiols
Trujillo, M., Álvarez, M. N., Peluffo, G., Freeman, B. Α., & Radí, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.7828 · Cited by 195
Effect of Allopurinol on Postasphyxial Free Radical Formation, Cerebral Hemodynamics, and Electrical Brain Activity
van Bel, F., Shadid, M., Moison, R. M. W., Dorrepaal, C. A., Fontijn, J. R., Monteiro, L. M., van de Bor, M., & Berger, H. M. (1998) · PEDIATRICS · doi:10.1542/peds.101.2.185 · Cited by 195
Role of Xanthine Oxidoreductase as an Antimicrobial Agent
Martin, H. M., Hancock, J. T., Salisbury, V. C., & Harrison, R. (2004) · Infection and Immunity · doi:10.1128/iai.72.9.4933-4939.2004 · Cited by 192
Reduction of the size of infarction by allopurinol in the ischemic-reperfused canine heart.
Werns, S. W., Shea, M. J., Mitsos, S. E., Dysko, R. C., Fantone, J. C., Schork, M. A., Abrams, G. D., Pitt, B., & Lucchesi, B. R. (1986) · Circulation · doi:10.1161/01.cir.73.3.518 · Cited by 190
Circulating xanthine oxidase: potential mediator of ischemic injury
Yokoyama, Y., Beckman, J. S., Beckman, T. K., Wheat, J. K., Cash, T., Freeman, B. Α., & Parks, D. A. (1990) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1990.258.4.g564 · Cited by 188
Tyrosine Nitration by Peroxynitrite Formed from Nitric Oxide and Superoxide Generated by Xanthine Oxidase
Sawa, T., Akaike, T., & Maeda, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910169199 · Cited by 186
Hypocalcemia and osteopathy in mice with kidney‐specific megalin gene defect
Leheste, J.-R., Melsen, F., Wellner, M., Jansen, P., Schlichting, U., Renner‐Müller, I., Andreassen, T. T., Wolf, E., Bachmann, S., Nykjær, A., et al. (2002) · The FASEB Journal · doi:10.1096/fj.02-0578fje · Cited by 185
Failure of the xanthine oxidase inhibitor allopurinol to limit infarct size after ischemia and reperfusion in dogs.
Reimer, K. A., & Jennings, R. B. (1985) · Circulation · doi:10.1161/01.cir.71.5.1069 · Cited by 180
Gout: On the brink of novel therapeutic options for an ancient disease
Bieber, J. D., & Terkeltaub, R. A. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20438 · Cited by 179
Nitric oxide and excitation–contraction coupling
Hare, J. M. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00143-3 · Cited by 179
Nitric Oxide Regulation of Myocardial Contractility and Calcium Cycling
Khan, S. A., Skaf, M. W., Harrison, R. W., Lee, K. H., Minhas, K. M., Kumar, A., Fradley, M., Shoukas, A. A., Berkowitz, D. E., & Hare, J. M. (2003) · Circulation Research · doi:10.1161/01.res.0000078171.52542.9e · Cited by 178
Chemical Suppression of the Immune Response
Hitchings, G. H., & Elion, G. B. (1962) · Blood · doi:10.1182/blood.v20.1.111.111 · Cited by 177
Aldose Reductase Inhibition Counteracts Oxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase Activation in Tissue Sites for Diabetes Complications
Obrosova, I. G., Pacher, P., Szabó, C., Zsengellér, Z. K., Hirooka, H., Stevens, M. J., & Yorek, M. A. (2005) · Diabetes · doi:10.2337/diabetes.54.1.234 · Cited by 177
Self-citation
Part I: Pathogenetic Role of Peroxynitrite in the Development of Diabetes and Diabetic Vascular Complications: Studies With FP15, A Novel Potent Peroxynitrite Decomposition Catalyst
Szabó, C., Mabley, J. G., Moeller, S. M., Shimanovich, R., Pacher, P., Virág, L., Soriano, F. G., van Duzer, J. H., Williams, W., Salzman, A. L., et al. (2002) · Molecular Medicine · doi:10.1007/bf03402167 · Cited by 175
Self-citation
Allopurinol Administered after Inducing Hypoxia-Ischemia Reduces Brain Injury in 7-Day-Old Rats
Palmer, C., Towfighi, J., Roberts, R. L., & Heitjan, D. F. (1993) · Pediatric Research · doi:10.1203/00006450-199304000-00018 · Cited by 174
Poly(ADP-Ribose) Polymerase Is Activated in Subjects at Risk of Developing Type 2 Diabetes and Is Associated With Impaired Vascular Reactivity
Szabó, C., Zanchi, A., Komjáti, K., Pacher, P., Królewski, A. S., Quist, W. C., LoGerfo, F. W., Horton, E. S., & Veves, A. (2002) · Circulation · doi:10.1161/01.cir.0000038365.78031.9c · Cited by 171
Self-citation
Xanthine Oxidoreductase Inhibition Causes Reverse Remodeling in Rats With Dilated Cardiomyopathy
Minhas, K. M., Saraiva, R. M., Schuleri, K. H., Lehrke, S., Zheng, M., SALIARIS, A. P., Berry, C. E., Vandegaer, K., Li, D., & Hare, J. M. (2005) · Circulation Research · doi:10.1161/01.res.0000200181.59551.71 · Cited by 170
Mechanism of the Conversion of Xanthine Dehydrogenase to Xanthine Oxidase
Nishino, T., Okamoto, K., Kawaguchi, Y., Hori, H., Matsumura, T., Eger, B. T., PAI, E. F., & Nishino, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501830200 · Cited by 168
Cellular distribution, metabolism and regulation of the xanthine oxidoreductase enzyme system
Pritsos, C. A. (2000) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(00)00203-9 · Cited by 167
Allopurinol and dimethylthiourea reduce brain infarction following middle cerebral artery occlusion in rats.
Martz, D., Rayos, G. H., Schielke, G. P., & Betz, A. L. (1989) · Stroke · doi:10.1161/01.str.20.4.488 · Cited by 166
Reduction of acute cisplatin ototoxicity and nephrotoxicity in rats by oral administration of allopurinol and ebselen
Lynch, E. D., Gu, R., Pierce, C., & Kil, J. (2004) · Hearing Research · doi:10.1016/j.heares.2004.08.002 · Cited by 164
Xanthine oxidase: a critical mediator of myocardial injury during ischemia and reperfusion?
Hearse, D. J., MANNING, A. S., Downey, J. M., & Yellon, D. M. (1986) · PubMed · Cited by 162
Role of Xanthine Oxidase and Its Inhibitor in Hypoxia: Reoxygenation Injury
Saugstad, O. D. (1996) · PEDIATRICS · doi:10.1542/peds.98.1.103 · Cited by 155
Pharmacokinetics and Pharmacodynamics of Febuxostat, a New Non-purine Selective Inhibitor of Xanthine Oxidase in Subjects with Renal Impairment
Mayer, M. D., Khosravan, R., Vernillet, L., Wu, J., Joseph‐Ridge, N., & Mulford, D. J. (2005) · American Journal of Therapeutics · doi:10.1097/00045391-200501000-00005 · Cited by 154
Induction of nitric oxide synthesis and xanthine oxidase and their roles in the antimicrobial mechanism against Salmonella typhimurium infection in mice
Umezawa, K., Akaike, T., Fujii, S., Suga, M., Setoguchi, K., Ozawa, A., & Maeda, H. (1997) · Infection and Immunity · doi:10.1128/iai.65.7.2932-2940.1997 · Cited by 154
Mechanisms of conversion of xanthine dehydrogenase to xanthine oxidase in ischemic rat liver and kidney
McKelvey, T. G., Höllwarth, M. E., Granger, D. N., Engerson, T. D., Landler, U., & Jones, H. P. (1988) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1988.254.5.g753 · Cited by 151
Enhanced NO and superoxide generation in dysfunctional hearts from endotoxemic rats
Khadour, F., Panas, D. L., Ferdinandy, P., Schulze, C. J., Csont, T., Lalu, M. M., Wildhirt, S. M., & Schulz, R. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00549.2001 · Cited by 150
Effect of allopurinol on mortality and hospitalisations in chronic heart failure: a retrospective cohort study
Struthers, A. D., Donnan, P. T., Lindsay, P., McNaughton, D., Broomhall, J., & MacDonald, T. M. (2002) · Heart · doi:10.1136/heart.87.3.229 · Cited by 146
Identification of uric acid and xanthine oxidase in atherosclerotic plaque11This study was supported by a grant from the Committee on Research Allocation, Department of Surgery, State University of New York Health Science Center at Brooklyn, Brooklyn, New York.
Patetsios, P., Song, M., Shutze, W. P., Pappas, C., Rodino, W., Ramirez, J. A., & Panetta, T. F. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01621-6 · Cited by 143
Uric acid and cardiovascular risk
Alderman, M. H. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(02)00143-1 · Cited by 140
A randomized controlled trial of allopurinol in coronary bypass surgery
Johnson, W. D., Kayser, K. L., Brenowitz, J. B., & Saedi, S. F. (1991) · American Heart Journal · doi:10.1016/0002-8703(91)90950-m · Cited by 139
Effect of allopurinol on hemorrhagic shock
Crowell, J. W., Ce, J., & Ee, S. (1969) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1969.216.4.744 · Cited by 139
Effects of supplementing hypothermic crystalloid cardioplegic solution with catalase, superoxide dismutase, allopurinol, or deferoxamine on functional recovery of globally ischemic and reperfused isolated hearts
Myers, C. L., Weiss, S. J., Kirsh, M. M., Shepard, B. M., & Shlafer, M. (1986) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)36093-3 · Cited by 139
Xanthine oxidase produces hydrogen peroxide which contributes to reperfusion injury of ischemic, isolated, perfused rat hearts.
Brown, J. M., Terada, L. S., Grosso, M. A., Whitmann, G. J., Velasco, S. E., Patt, A., Harken, A. H., & Repine, J. E. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113448 · Cited by 137
Phosphorylation of Xanthine Dehydrogenase/Oxidase in Hypoxia
Kayyali, U. S., Donaldson, C., Huang, H., Abdelnour, R., & Hassoun, P. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010100200 · Cited by 136
Vascular Release of Superoxide Radicals Is Enhanced in Hypercholesterolemic Rabbits
Mügge, A., Brandes, R. P., Böger, R. H., Dwenger, A., Bode‐Böger, S. M., Kienke, S., Frölich, J. C., & Lichtlen, P. R. (1994) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199424060-00019 · Cited by 135
Xanthine oxidase activity in the circulation of rats following hemorrhagic shock
Tan, S., Yokoyama, Y., Dickens, E., Cash, T., Freeman, B. Α., & Parks, D. A. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90040-2 · Cited by 134
Gout
Rott, K. T., & Agudelo, C. A. (2003) · JAMA · doi:10.1001/jama.289.21.2857 · Cited by 131
Circulating xanthine oxidase mediates lung neutrophil sequestration after intestinal ischemia-reperfusion
Terada, L. S., Dormish, J. J., Shanley, P. F., Leff, J. A., Anderson, B. O., & Repine, J. E. (1992) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1992.263.3.l394 · Cited by 130
Synthesis and structure–activity relationships of 1-Phenylpyrazoles as xanthine oxidase inhibitors
Ishibuchi, S., Morimoto, H., Oe, T., Ikebe, T., Inoue, H., Fukunari, A., Kamezawa, M., YAMADA, I., & Naka, Y. (2001) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)00093-2 · Cited by 128
Gout: epidemiology and lifestyle choices.
Choi, H. K., & Curhan, G. C. (2005) · PubMed · Cited by 126
Xanthine oxidase is not a source of free radicals in the ischemic rabbit heart
Downey, J. M., Miura, T., Eddy, L. J., Chambers, D. E., Mellert, T. K., Hearse, D. J., & Yellon, D. M. (1987) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(87)80350-4 · Cited by 126
Cellular expression of xanthine oxidoreductase protein in normal human tissues.
Linder, N., Rapola, J., & Raivio, K. O. (1999) · PubMed · Cited by 125
Endothelial Dysfunction and Xanthine Oxidoreductase Activity in Rats With Human Renin and Angiotensinogen Genes
Mervaala, E. M. A., Cheng, Z. J., Tikkanen, I. T., Lapatto, R., Nurminen, K., Vapaatalo, H., Müller, D. N., Fiebeler, A., Ganten, U., Ganten, D., et al. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.414 · Cited by 123
THE ROLE OF O2‐ IN THE CHEMILUMINESCENCE OF LUMINOL*
Hodgson, E. K., & Fridovich, I. (1973) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1973.tb06449.x · Cited by 120
Enhanced Expression and Activity of Xanthine Oxidoreductase in the Failing Heart
de Jong, J. W., Schoemaker, R. G., de Jonge, R., Bernocchi, P., Keijzer, E., Harrison, R., Sharma, H. S., & Ceconi, C. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1240 · Cited by 120
Xanthine Oxidase Binding to Glycosaminoglycans: Kinetics and Superoxide Dismutase Interactions of Immobilized Xanthine Oxidase–Heparin Complexes
Radí, R., Rubbo, H., Bush, K., & Freeman, B. Α. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.9844 · Cited by 120
Prevention of free radical-induced myocardial reperfusion injury with allopurinol
Stewart, J. R., Crute, S. L., Loughlin, V., Hess, M. L., & Greenfield, L. J. (1985) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)38664-7 · Cited by 119
Y-700 [1-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl]-1 H-pyrazole-4-carboxylic Acid]: A Potent Xanthine Oxidoreductase Inhibitor with Hepatic Excretion
Fukunari, A., Okamoto, K., Nishino, T., Eger, B. T., PAI, E. F., Kamezawa, M., YAMADA, I., & Katô, N. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.070433 · Cited by 116
Allopurinol Enhances the Contractile Response to Dobutamine and Exercise in Dogs With Pacing-Induced Heart Failure
Ukai, T., Cheng, C., Tachibana, H., Igawa, A., Zhang, Z.-S., Cheng, H.-J., & Little, W. C. (2001) · Circulation · doi:10.1161/01.cir.103.5.750 · Cited by 115
Regulation of Xanthine Oxidoreductase Protein Expression by Hydrogen Peroxide and Calcium
McNally, J. S., Saxena, A., Cai, H. “., Dikalov, S., & Harrison, D. G. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000170827.16296.6e · Cited by 115
Organ distribution and molecular forms of human xanthine dehydrogenase/xanthine oxidase protein.
Sarnesto, A., Linder, N., & Raivio, K. O. (1996) · PubMed · Cited by 114
Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat
Nakashima, M., Niwa, M., Iwai, T., & Uematsu, T. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00257-3 · Cited by 114
Reactive Oxygen Species Play an Important Role in the Activation of Heat Shock Factor 1 in Ischemic-Reperfused Heart
Nishizawa, J., Nakai, A., Matsuda, K., Komeda, M., Ban, T., & Nagata, K. (1999) · Circulation · doi:10.1161/01.cir.99.7.934 · Cited by 112
Confirmation of Superoxide Generation via Xanthine Oxidase in Streptozotocin-induced Diabetic Mice
Matsumoto, S., Koshiishi, I., Inoguchi, T., Nawata, H., & Utsumi, H. (2003) · Free Radical Research · doi:10.1080/1071576031000107344 · Cited by 112
A Reappraisal of Xanthine Dehydrogenase and Oxidase in Hypoxic Reperfusion Injury: the Role of NADH as an Electron Donor
Zhang, Z., Blake, D. R., Stevens, C. R., Kanuler, J. M., Ward, P. G., Symons, M. C. R., Benboubetra, M., & Harrison, R. (1998) · Free Radical Research · doi:10.3109/10715769809065801 · Cited by 110
Chronic Treatment With Allopurinol Boosts Survival and Cardiac Contractility in Murine Postischemic Cardiomyopathy
Stull, L. B., Leppo, M. K., Szweda, L. I., Gao, W. D., & Marbán, E. (2004) · Circulation Research · doi:10.1161/01.res.0000148635.73331.c5 · Cited by 110
Role of xanthine oxidase in ischemia/reperfusion injury
Linas, S. L., Whittenburg, D., & Repine, J. E. (1990) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1990.258.3.f711 · Cited by 109
Role of oxygen free radicals in shock, ischemia, and organ preservation
Bingham, H. G. (1984) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-198408000-00086 · Cited by 109
Upregulation of Xanthine Oxidase by Lipopolysaccharide, Interleukin-1, and Hypoxia: Role in Acute Lung Injury
Hassoun, P. M., Yu, F., Côté, C., Zulueta, J. J., Sawhney, R., Skinner, K. A., Skinner, H. B., Parks, D. A., & Lanzillo, J. J. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.1.9709116 · Cited by 108
Free radicals and pathogenesis during ischemia and reperfusion of the cat small intestine
Nilsson, U. A., Schoenberg, M. H., Åneman, A., Poch, B., Magadum, S., Beger, H. G., & Lundgren, O. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90695-5 · Cited by 107
Allopurinol: Intravenous Use for Prevention and Treatment of Hyperuricemia
Smalley, R. V., Guaspari, A., Haase-Statz, S., Anderson, S. A., Cederberg, D., & Hohneker, J. A. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.8.1758 · Cited by 107
Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase
Kuwabara, Y., Nishino, T., Okamoto, K., Matsumura, T., Eger, B. T., PAI, E. F., & Nishino, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1431485100 · Cited by 107
Contribution of oxygen-derived free radicals to experimental necrotizing enterocolitis.
Clark, D. A., Fornabaio, D. M., McNeill, H., Mullane, K., Caravella, S. J., & Miller, M. J. (1988) · PubMed Central · Cited by 107
Increased production of luminol enhanced chemiluminescence by the inflamed colonic mucosa in patients with ulcerative colitis.
Sedghi, S., Fields, J. Z., Klamut, M., Urban, G., Durkin, M., Winship, D. H., Fretland, D. J., Olyaee, M. S., & Keshavarzian, A. (1993) · Gut · doi:10.1136/gut.34.9.1191 · Cited by 106
Allopurinol reduces B-type natriuretic peptide concentrations and haemoglobin but does not alter exercise capacity in chronic heart failure
Gavin, A. D., & Struthers, A. D. (2005) · Heart · doi:10.1136/hrt.2004.040477 · Cited by 106
Effect of allopurinol on ischemia and reperfusion-induced cerebral injury in spontaneously hypertensive rats.
Itoh, T., Kawakami, M., Yamauchi, Y., Shimizu, S., & Nakamura, M. (1986) · Stroke · doi:10.1161/01.str.17.6.1284 · Cited by 106
Drug-Induced Severe Skin Reactions
Wolkenstein, P., & Revuz, J. E. (1995) · Drug Safety · doi:10.2165/00002018-199513010-00007 · Cited by 104
Effects of allopurinol, propranolol and methylprednisolone on infarct size in experimental myocardial infarction
Shatney, C. H., MacCarter, D., & Lillehei, R. C. (1976) · The American Journal of Cardiology · doi:10.1016/0002-9149(76)90398-2 · Cited by 104
A Prospective, Randomized, Placebo-Controlled Trial of Prednisone and Allopurinol in the Prevention of ERCP-Induced Pancreatitis
Budzyńska, A., Marek, T., Nowak, A. J., Kaczor, R., & Nowakowska-Duława, E. (2001) · Endoscopy · doi:10.1055/s-2001-16520 · Cited by 102
A Mechanism of Oxygen Free Radical Production in the Dahl Hypertensive Rat
SWEI, A., Lacy, F., DeLano, F. A., Parks, D. A., & Schmid‐Schönbein, G. W. (1999) · Microcirculation · doi:10.1111/j.1549-8719.1999.tb00100.x · Cited by 100
The Reductive Half-reaction of Xanthine Oxidase
Xia, M., Dempski, R. E., & Hille, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.6.3323 · Cited by 99
Xanthine oxidoreductase in human mammary epithelial cells: activation in response to inflammatory cytokines
Page, S., POWELL, D., Benboubetra, M., Stevens, C. R., Blake, D. R., Selase, F., Wolstenholme, A. J., & Harrison, R. (1998) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(98)00028-2 · Cited by 98
Infarct size limitation by the xanthine oxidase inhibitor, allopurinol, in closed-chest dogs with small infarcts
Akizuki, S., Yoshida, S., Chambers, D. E., Eddy, L. J., Parmley, L. F., Yellon, D. M., & Downey, J. M. (1985) · Cardiovascular Research · doi:10.1093/cvr/19.11.686 · Cited by 98
Elevated serum uric acid levels are associated with diastolic dysfunction in patients with dilated cardiomyopathy
Cicoira, M., Zanolla, L., Rossi, A., Golia, G., Franceschini, L., Brighetti, G., Zeni, P., & Zardini, P. (2002) · American Heart Journal · doi:10.1067/mhj.2002.122122 · Cited by 97
MECHANISMS OF ENDOTOXIN-INDUCED INTESTINAL INJURY IN A HYPERDYNAMIC MODEL OF SEPSIS
Xu, D.-Z., Lu, Q., Guillory, D., Cruz, N., Berg, R. D., & Deitch, E. A. (1993) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199305000-00010 · Cited by 97
Oxidant stress during reperfusion of ischemic liver: No evidence for a role of xanthine oxidase
Metzger, J., Dore, S. P., & Lauterburg, B. H. (1988) · Hepatology · doi:10.1002/hep.1840080324 · Cited by 97
Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure
Pacher, P., Liaudet, L., Mabley, J. G., Komjáti, K., & Szabó, C. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02062-4 · Cited by 97
Self-citation
Evidence for a pathogenetic role of xanthine oxidase in the "stunned" myocardium
Charlat, M. I., O’Neill, P. G., Egan, J., Abernethy, D. R., Michael, L. H., Myers, M. L., Roberts, R., & Bolli, R. (1987) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1987.252.3.h566 · Cited by 96
Febuxostat (TMX‐67), a Novel, Non‐Purine, Selective Inhibitor of Xanthine Oxidase, Is Safe and Decreases Serum Urate in Healthy Volunteers
Becker, M. A., Kisicki, J. C., Khosravan, R., Wu, J., Mulford, D. J., Hunt, B., MacDonald, P., & Joseph‐Ridge, N. (2004) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1081/ncn-200027372 · Cited by 96
Recent advances in the management of gout and hyperuricemia
Wortmann, R. L. (2005) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000162060.25895.a5 · Cited by 95
Novel Myofilament Ca 2+ -Sensitizing Property of Xanthine Oxidase Inhibitors
Pérez, N. G., Gao, W. D., & Marbán, E. (1998) · Circulation Research · doi:10.1161/01.res.83.4.423 · Cited by 95
Allopurinol pretreatment improves postoperative recovery and reduces lipid peroxidation in patients undergoing coronary artery bypass grafting
Coghlan, G., Flitter, W. D., Clutton, S. M., Panda, R., Daly, R., Wright, G., Ilsley, C. D. J., & Slater, T. F. (1994) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(94)70478-3 · Cited by 94
Effects of Antioxidants and Free Radical Scavengers in Three Different Models of Acute Pancreatitis
Niederau, C., Niederau, M., Borchard, F., Ude, K., Luthen, R. E., Strohmeyer, G. W., Ferrell, L. D., & Grendell, J. H. (1992) · Pancreas · doi:10.1097/00006676-199207000-00011 · Cited by 92
Effect of Allopurinol Pretreatment on Free Radical Generation after Primary Coronary Angioplasty for Acute Myocardial Infarction
Guan, W., Osanai, T., Kamada, T., Hanada, H., Ishizaka, H., Onodera, H., Iwasa, A., Fujita, N., Kudo, S., Ohkubo, T., et al. (2003) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200305000-00005 · Cited by 91
A Defect of Neuronal Nitric Oxide Synthase Increases Xanthine Oxidase-Derived Superoxide Anion and Attenuates the Control of Myocardial Oxygen Consumption by Nitric Oxide Derived From Endothelial Nitric Oxide Synthase
Kinugawa, S., Huang, H., Wang, Z., Kaminski, P. M., Wolin, M. S., & Hintze, T. H. (2005) · Circulation Research · doi:10.1161/01.res.0000155331.09458.a7 · Cited by 90
Transient reduction in myocardial free oxygen radical levels is involved in the improved cardiac function and structure after long-term allopurinol treatment initiated in established chronic heart failure
Mellin, V., Isabelle, M., Oudot, A., Vergely, C., Monteil, C., Meglio, B. D., Henry, J., Dautréaux, B., Rochette, L., Thuillez, C., et al. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi305 · Cited by 90
Inhibition of Xanthine Oxidase and Xanthine Dehydrogenase by Nitric Oxide
Ichimori, K., Fukahori, M., Nakazawa, H. K., Okamoto, K., & Nishino, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7763 · Cited by 89
Modification by oxygen free radical scavengers of the metabolic and cardiovascular effects of endotoxin infusion in conscious rats.
McKechnie, K. C. W., Bl, F., & Parratt, J. R. (1986) · PubMed · Cited by 88
Elevated levels of xanthine oxidase in serum of patients with inflammatory and autoimmune rheumatic diseases
Miesel, R., & Zuber, M. A. (1993) · Inflammation · doi:10.1007/bf00914193 · Cited by 87
Xanthine oxidase-derived superoxide causes reoxygenation injury of ischemic cerebral endothelial cells
Beetsch, J. W., Park, T. S., Dugan, L. L., Shah, A. R., & Gidday, J. M. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01407-8 · Cited by 86
Endothelial dysfunction in aging animals: the role of poly(ADP‐ribose) polymerase activation
Pacher, P., Mabley, J. G., Soriano, F. G., Liaudet, L., Komjáti, K., & Szabó, C. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704627 · Cited by 86
Self-citation
Influence of antihyperuricemic therapy on the clinical and radiographic progression of gout
McCarthy, G., Barthelemy, C. R., Veum, J. A., & Wortmann, R. L. (1991) · Arthritis & Rheumatism · doi:10.1002/art.1780341203 · Cited by 84
Improvement of Cardiac Function by Allopurinol in Patients Undergoing Cardiac Surgery
Castelli, P., Condemi, A. M., Brambillasca, C., Fundaro, P. M., Botta, M., Lemma, M. G., Vanelli, P., Santoli, C., Gatti, S., & Riva, E. (1995) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199501000-00019 · Cited by 84
Allopurinol Prevents Early Alcohol-Induced Liver Injury in Rats
Kono, H., Rusyn, I., Bradford, B. U., Connor, H. D., Mason, R. P., & Thurman, R. G. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39232-8 · Cited by 84
Physiologic Levels of Uric Acid Inhibit Xanthine Oxidase in Human Plasma
Tan, S., Radí, R., Gaudier, F. L., Evans, R. A., Rivera, A., Kirk, K. A., & Parks, D. A. (1993) · Pediatric Research · doi:10.1203/00006450-199309000-00013 · Cited by 83
Role of oxygen-derived free radical scavengers in the management of recurrent attacks of ulcerative colitis: a new approach.
Salim, A. S. (1992) · PubMed · Cited by 82
Protection from reperfusion injury in the isolated rat heart by postischaemic deferoxamine and oxypurinol administration
Badylak, S. F., Simmons, A. W., Turek, J. J., & Babbs, C. F. (1987) · Cardiovascular Research · doi:10.1093/cvr/21.7.500 · Cited by 78
Xanthine oxidoreductase is asymmetrically localised on the outer surface of human endothelial and epithelial cells in culture
Rouquette, M., Page, S., Bryant, R., Benboubetra, M., Stevens, C. R., Blake, D. R., Whish, W. D., Harrison, R., & Tosh, D. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00385-8 · Cited by 78
Angiotensin II-Mediated Endothelial Dysfunction: Role of Poly(ADP-ribose) Polymerase Activation
Szabó, C., Pacher, P., Zsengellér, Z. K., Vaslin, A., Komjáti, K., Benkő, R., Chen, M., Mabley, J. G., & Kollai, M. (2004) · Molecular Medicine · doi:10.2119/2004-00001.szabo · Cited by 77
Self-citation
Simultaneous Liver and Lung Injury Following Gut Ischemia is Mediated by Xanthine Oxidase
Poggetti, R. S., Moore, F. A., Moore, E. E., KOEIKE, K., & Banerjee, A. M. (1992) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199206000-00008 · Cited by 77
Superoxide radical involvement in the pathogenesis of burn shock.
Sáez, J. C., Ward, P. H., Günther, B., & Vivaldi, E. (1984) · PubMed · Cited by 77
Potentiation of Nitric Oxide--Mediated Vasorelaxation by Xanthine Oxidase Inhibitors
Miyamoto, Y., Akaike, T., Yoshida, M., Goto, S., Horie, H., & Maeda, H. (1996) · Experimental Biology and Medicine · doi:10.3181/00379727-211-43982 · Cited by 76
Circulating Xanthine Oxidase in Human Ischemia Reperfusion
Tan, S., Gelman, S., Wheat, J. K., & Parks, D. A. (1995) · Southern Medical Journal · doi:10.1097/00007611-199504000-00021 · Cited by 76
Nitric Oxide Reversibly Suppresses Xanthine Oxidase Activity
Fukahori, M., Ichimori, K., Ishida, H., Nakagawa, H., & Okino, H. (1994) · Free Radical Research · doi:10.3109/10715769409056572 · Cited by 75
Vasculitis with allopurinol therapy
Jarzobski, J. A., Ferry, J., Wombolt, D. G., Fitch, D. M., & Egan, J. D. (1970) · American Heart Journal · doi:10.1016/0002-8703(70)90401-1 · Cited by 75
The effect of initial management of hyperleukocytosis on early complications and outcome of children with acute lymphoblastic leukemia.
Maurer, H., Steinherz, P. G., Gaynon, P. S., Finklestein, J. Z., Sather, H. N., Reaman, G. H., Bleyer, W. A., & Hammond, G. D. (1988) · Journal of Clinical Oncology · doi:10.1200/jco.1988.6.9.1425 · Cited by 74

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4 of the 451 references couldn’t be matched to a known paper.

Research works printed but not linked: 4

Giler, 1977, Elevation of serum xanthine oxidase activity following halothane anesthesia in man, Experientia, 33, 1356, 10.1007/BF01920178 · DOI
Mabley, 2003, Pathogenetic role of xanthine oxidase in a murine model of acute lung injury, FASEB J, 17, A247
Nivorozhkin, 2003, A novel xanthine oxidase inhibitor, AN-01-24, protects against development of colitis in mice, FASEB J, 17, A265
Nivorozhkin, 2003, A novel class of potent non-purine based xanthine oxidase inhibitors: antihyperuricemic and hepatoprotective effects, FASEB J, 17, A253

Sorted by citations

Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Self-citation
Reactive Oxygen Species in Inflammation and Tissue Injury
Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P., & Malik, A. B. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5149 · Cited by 4,897
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
Chouchani, E. T., Pell, V. R., Gaude, E., Aksentijević, D., Sundier, S. Y., Robb, E. L., Logan, A., Nadtochiy, S. M., Ord, E. N. J., Smith, A. C., et al. (2014) · Nature · doi:10.1038/nature13909 · Cited by 2,907
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077
Self-citation
Prescribed drugs containing nitrogen heterocycles: an overview
Heravi, M. M., & Zadsirjan, V. (2020) · RSC Advances · doi:10.1039/d0ra09198g · Cited by 1,254

See all 1,218

Authors: Pacher, P., Nivorozhkin, A., & Szabó, C.
Affiliations: National Institutes of Health (US)
Semmelweis University (HU)
ORCID: Pacher, Pál
Nivorozhkin, Alex
Szabó, Csaba
Venue: Pharmacological Reviews
Publisher: Elsevier BV
Published: 2006-03
Volume: 58
Issue: 1
Pages: 87-114
ISSN: 0031-6997 (ISSN-L)
DOI: 10.1124/pr.58.1.6
PMC: PMC2233605
OpenAlex: W2119515450
Cited by: 1,218
References: 451
Citations by year: 2026: 34 · 2025: 51 · 2024: 60 · 2023: 56 · 2022: 83 · 2021: 75 · 2020: 85 · 2019: 84 · 2018: 72 · 2017: 71 · 2016: 67 · 2015: 76 · 2014: 75 · 2013: 67 · 2012: 72
FWCI: 5.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacological Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (Z01AA000375)
Topics: Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
Keywords: xanthine oxidase inhibitors, allopurinol, oxypurinol, gout, hyperuricemia, ischemic injury, vascular injury, inflammation, chronic heart failure, drug repurposing
MeSH terms: Allopurinol, Animals, Cardiovascular Diseases, Enzyme Inhibitors, Humans, Superoxides, Xanthine Oxidase, Inflammatory Bowel Diseases, Reperfusion Injury

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Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol

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