Cited by 89Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice

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Nakai, Nobuhiro, Nagano, Masatoshi, Saitow, Fumihito, Watanabe, Yasuhito, Kawamura, Yoshinobu, Kawamoto, Akiko, Tamada, Kota, Mizuma, Hiroshi +16 more·2017·Science Advances

Abstract

Serotonin enhancement during developmental stages restores autism symptoms in a mouse model of human 15q11-13 duplication.

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Crossref · 10.1126/sciadv.1603001

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  • The 15q11.3 duplication mouse model exhibits reduced excitatory transmission in DR 5-HT neurons and low glucose metabolism in the DR, suggesting reduced DR 5-HT activity.

    “chromosomal 15q11.3duplication, exhibits reduced excitatory transmission in DR 5-HT neurons and low glucose metabolism in the DR, suggesting reduced DR 5-HT activity [122].”

    From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [122]

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Authors
Nakai, N., Nagano, M., Saitow, F., Watanabe, Y., Kawamura, Y., Kawamoto, A., Tamada, K., Mizuma, H., Onoe, H., Watanabe, Y., Monai, H., Hirase, H., Nakatani, J., Inagaki, H., Kawada, T., Miyazaki, T., Watanabe, M., Sato, Y., Okabe, S., Kitamura, K., Kano, M., Hashimoto, K., Suzuki, H., & Takumi, T.
Affiliations
  • Hiroshima University (JP)
  • Nippon Medical School (JP)
  • RIKEN (JP)
  • RIKEN Center for Brain Science (JP)
  • Shiga University of Medical Science (JP)
  • Hokkaido University (JP)
  • The University of Tokyo (JP)
  • Japan Science and Technology Agency (JP)
Corresponding author
  • Nakai, Nobuhiro
  • Nagano, Masatoshi
  • Saitow, Fumihito
  • Watanabe, Yasuhito
  • Suzuki, Hidenori
  • Takumi, Toru
Venue
Science Advances
Published
2017-06-02
Volume
3
Issue
6
Pages
e1603001-e1603001
ISSN
2375-2548 (ISSN-L)
OpenAlex
W2675424776
Cited by
89
References
47
Citations by year
2026: 9 · 2025: 8 · 2024: 8 · 2023: 10 · 2022: 6 · 2021: 10 · 2020: 10 · 2019: 11 · 2018: 14 · 2017: 2 · 2013: 1
FWCI
5.81
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
Funders
  • Takeda Science Foundation
  • Takeda Pharmaceutical Company
  • National Center of Neurology and Psychiatry
  • Japan Society for the Promotion of Science (25460345, 26461554, 25000015, 16K19066, 16H06463, 26250014, 16H06316, 17K10085, 25117006, 17H01387, 16K13110)
  • Japan Science and Technology Agency (26250014)
  • Core Research for Evolutional Science and Technology
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
serotonin, autism spectrum disorder, therapeutic potential, mouse model
MeSH terms
Autism Spectrum Disorder, Animals, Brain, Chromosomes, Disease Models, Animal, Glucose, Models, Biological, Synaptic Transmission, Serotonin, Social Behavior, Somatosensory Cortex, Pyramidal Cells, Mice, DNA Copy Number Variations

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