Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice
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Serotonin enhancement during developmental stages restores autism symptoms in a mouse model of human 15q11-13 duplication.
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The 15q11.3 duplication mouse model exhibits reduced excitatory transmission in DR 5-HT neurons and low glucose metabolism in the DR, suggesting reduced DR 5-HT activity.
“chromosomal 15q11.3duplication, exhibits reduced excitatory transmission in DR 5-HT neurons and low glucose metabolism in the DR, suggesting reduced DR 5-HT activity [122].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [122]
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- Authors
- Nakai, N., Nagano, M., Saitow, F., Watanabe, Y., Kawamura, Y., Kawamoto, A., Tamada, K., Mizuma, H., Onoe, H., Watanabe, Y., Monai, H., Hirase, H., Nakatani, J., Inagaki, H., Kawada, T., Miyazaki, T., Watanabe, M., Sato, Y., Okabe, S., Kitamura, K., Kano, M., Hashimoto, K., Suzuki, H., & Takumi, T.
- Affiliations
- Hiroshima University (JP)
- Nippon Medical School (JP)
- RIKEN (JP)
- RIKEN Center for Brain Science (JP)
- Shiga University of Medical Science (JP)
- Hokkaido University (JP)
- The University of Tokyo (JP)
- Japan Science and Technology Agency (JP)
- Corresponding author
- Nakai, Nobuhiro
- Nagano, Masatoshi
- Saitow, Fumihito
- Watanabe, Yasuhito
- Suzuki, Hidenori
- Takumi, Toru
- ORCID
- Venue
- Science Advances
- Published
- 2017-06-02
- Volume
- 3
- Issue
- 6
- Pages
- e1603001-e1603001
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC5479676
- OpenAlex
- W2675424776
- Cited by
- 89
- References
- 47
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 8 · 2023: 10 · 2022: 6 · 2021: 10 · 2020: 10 · 2019: 11 · 2018: 14 · 2017: 2 · 2013: 1
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Funders
- Takeda Science Foundation
- Takeda Pharmaceutical Company
- National Center of Neurology and Psychiatry
- Japan Society for the Promotion of Science (25460345, 26461554, 25000015, 16K19066, 16H06463, 26250014, 16H06316, 17K10085, 25117006, 17H01387, 16K13110)
- Japan Science and Technology Agency (26250014)
- Core Research for Evolutional Science and Technology
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- serotonin, autism spectrum disorder, therapeutic potential, mouse model
- MeSH terms
- Autism Spectrum Disorder, Animals, Brain, Chromosomes, Disease Models, Animal, Glucose, Models, Biological, Synaptic Transmission, Serotonin, Social Behavior, Somatosensory Cortex, Pyramidal Cells, Mice, DNA Copy Number Variations
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