Cited by 543Electrochemical sensors and biosensorsPolymer Surface Interaction StudiesAnalytical Chemistry and Sensors

Methods for reducing biosensor membrane biofouling

Wisniewski, Natalie, Reichert, Monty·2000·Colloids and Surfaces B: Biointerfaces

Abstract

The deleterious effect that biofouling has on sensor stability is a serious impediment to the development of long term implanted biosensors. This paper reviews the surface modification strategies currently employed to minimize membrane biofouling of in vivo sensors. Nine sensor modifications are discussed herein: hydrogels, phospholipid-based biomimicry, flow-based systems, Nafion, surfactants, naturally derived materials, covalent attachments, diamond-like carbons, and topology.

Integrity signals

Registry

Crossref · 10.1016/s0927-7765(99)00148-4

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138 of 138 references verified0 citation errors · 0 not checkable

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  • Electrode fouling, or passivation, occurs when diffusible small molecules contact the electrode surface after penetrating the sensor membrane.

    “Electrode fouling (often called electrode passivation) is another cause of sensor instability, and occurs when diffusible small molecules come into contact with the surface of the electrode after penetration of the sensor membrane.74”

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Authors
Wisniewski, N., & Reichert, M.
Affiliations
Duke University (US)
Corresponding author
Reichert, Monty
Venue
Colloids and Surfaces B: Biointerfaces
Publisher
Elsevier BV
Published
2000-10
Volume
18
Issue
3-4
Pages
197-219
ISSN
0927-7765 (ISSN-L)
OpenAlex
W2055926917
Cited by
543
References
138
Citations by year
2026: 21 · 2025: 12 · 2024: 13 · 2023: 9 · 2022: 11 · 2021: 36 · 2020: 26 · 2019: 28 · 2018: 21 · 2017: 16 · 2016: 25 · 2015: 33 · 2014: 28 · 2013: 26 · 2012: 39
FWCI
10.36
Type
journal article
Language
en
Open access
closed
Locations
  • Colloids and Surfaces B Biointerfaces (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • Fonds National de la Recherche Luxembourg
Topics
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
Keywords
membrane biofouling, surface modification, hydrogels, Nafion, surfactants, diamond-like carbon, surface topology, sensor stability

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