MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program
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Liposomes carrying MBD2 siRNA protect mice against BLM-induced lung injury and fibrosis by targeting macrophage M2 program.
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IPF patients are predominantly infiltrated by M2 macrophages during disease progression.
“IPF patients are predominantly infiltrated by M2 macrophages during disease progression 12, 13.”
From Nicotinamide phosphoribosyltransferase prompts bleomycin-induced pulmonary fibrosis by driving macrophage M2 polarization in mice (2024) · cites this paper as [13]
The Results section reports M2 macrophages in fibrotic lung tissue from patients with IPF, and the Discussion describes infiltrated M2 macrophages in fibrotic lungs. It does not establish that M2 macrophages predominate among infiltrating cells in IPF patients or track their infiltration during human disease progression; the reported link with progression comes from mice. (LLM, conf=0.85)
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“IPF patients are predominantly infiltrated by M2 macrophages during disease progression [12, 13].”
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- Authors
- Wang, Y., Zhang, L., Wu, G.-R., Zhou, Q., Yue, H., Rao, L.-Z., Yuan, T., Mo, B., Wang, F.-X., Chen, L.-M., Sun, F., Song, J., Xiong, F., Zhang, S., Yu, Q., Yang, P., Xu, Y., Zhao, J., Zhang, H., Xiong, W., & Wang, C.-Y.
- Affiliations
- Tongji Hospital (CN)
- The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China.
- Guilin Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Zhang, Huilan
- Xiong, Weining
- Wang, Cong-Yi
- ORCID
- Venue
- Science Advances
- Published
- 2021-01
- Volume
- 7
- Issue
- 1
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC7775789
- OpenAlex
- W3107456091
- Cited by
- 227
- References
- 55
- Citations by year
- 2026: 32 · 2025: 49 · 2024: 49 · 2023: 37 · 2022: 39 · 2021: 19 · 2020: 1
- FWCI
- 23.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology (2016YFC1305002 and 2017YFC1309603)
- National Natural Science Foundation of China (81530024, 9174920038, 81800068, 81920108009, 81770823 and 81670729)
- NHC Drug Discovery Program (2017ZX09304022-07)
- the Department of Science and Technology of Hubei Province (2017ACA096)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Keywords
- MBD2, pulmonary fibrosis, M2 macrophages, macrophage polarization, siRNA, therapeutic target
- MeSH terms
- COVID-19, Animals, Bleomycin, Carcinoma, Non-Small-Cell Lung, DNA-Binding Proteins, Fibrosis, Gene Expression Regulation, Humans, Liposomes, Lung Neoplasms, Macrophages, Male, Mice, Inbred C57BL, Pulmonary Fibrosis, Scleroderma, Systemic, Signal Transduction, Lung Diseases, Interstitial, Mice, Knockout, Gene Expression Profiling, RNA, Small Interfering, Mice, Transforming Growth Factor beta1
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