Targeting actin-bundling protein L-plastin as an anabolic therapy for bone loss
Open accessAbstract
Targeting L-plastin suppresses bone resorption and promotes bone formation by disrupting preosteoclast fusion.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Molecules affecting osteoclast fusion and angiogenesis, such as SIGLEC15, L-plastin, and TLR2, have been successively discovered.
“Since then, molecules affecting osteoclast fusion and angiogenesis, such as SIGLEC15, L-plastin, and TLR2, have been successively discovered52–54.”
From Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis (2025) · cites this paper as [53]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Dou, C., Ding, N., Luo, F., Hou, T., Cao, Z., Bai, Y., Liu, C., Xu, J., & Dong, S. (2017) · Advanced Science · doi:10.1002/advs.201700578 · Cited by 105 · see citing works
RetractedCompston, J. E., McClung, M. R., & Leslie, W. D. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32112-3 · Cited by 2,449 · see citing works
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
Kusumbe, A. P., Ramasamy, S. K., & Adams, R. H. (2014) · Nature · doi:10.1038/nature13145 · Cited by 2,155 · see citing works
Wright, N. C., Looker, A. C., Saag, K. G., Curtis, J. R., Delzell, E. S., Randall, S., & Dawson-Hughes, B. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2269 · Cited by 1,801 · see citing works
Actin Dynamics, Architecture, and Mechanics in Cell Motility
Blanchoin, L., Boujemaa‐Paterski, R., Sykes, C., & Plastino, J. (2014) · Physiological Reviews · doi:10.1152/physrev.00018.2013 · Cited by 1,468 · see citing works
PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis
Xie, H., Cui, Z., Wang, L., Xia, Z., Hu, Y., Xian, L., Li, C., Xie, L., Crane, J., Wan, M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3668 · Cited by 951 · see citing works
Self-citationDC-STAMP is essential for cell–cell fusion in osteoclasts and foreign body giant cells
Yagi, M., Miyamoto, T., Sawatani, Y., Iwamoto, K., Hosogane, N., Fujita, N., Morita, K., Ninomiya, K., Suzuki, T., Miyamoto, K., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050645 · Cited by 890 · see citing works
Developmental origin, functional maintenance and genetic rescue of osteoclasts
Jacome-Galarza, C. E., Percin, G. I., Muller, J. T., Mass, E., Lazarov, T., Eitler, J., Rauner, M., Yadav, V. K., Crozet, L., Bohm, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1105-7 · Cited by 475 · see citing works
Targeting skeletal endothelium to ameliorate bone loss
Xu, R., Yallowitz, A. R., Qin, A., Wu, Z., Shin, D. Y., Kim, J., Debnath, S., Ji, G., Bostrom, M. P., Yang, X., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0020-z · Cited by 376 · see citing works
Unveiling the Mechanisms of Cell-Cell Fusion
Chen, E. H., & Olson, E. N. (2005) · Science · doi:10.1126/science.1104799 · Cited by 355 · see citing works
Overview of the fracture healing cascade
Phillips, A. M. (2005) · Injury · doi:10.1016/j.injury.2005.07.027 · Cited by 311 · see citing works
Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned
Drake, M. T., Clarke, B. L., Oursler, M. J., & Khosla, S. (2017) · Endocrine Reviews · doi:10.1210/er.2015-1114 · Cited by 282 · see citing works
Compston Juliet, E., McClung Michael, R., & Leslie William, D. (2019) · The Lancet · Cited by 261 · see citing works
Seeman, E. (2009) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v19.i3.40 · Cited by 242 · see citing works
Common signalling pathways in macrophage and osteoclast multinucleation
Pereira, M., Petretto, E. G., Gordon, S., Bassett, J. H. D., Williams, G. R., & Behmoaras, J. V. (2018) · Journal of Cell Science · doi:10.1242/jcs.216267 · Cited by 189 · see citing works
den Bossche, J. V., MALISSEN, B., Mantovani, A., BAETSELIER, P. D., & Ginderachter, J. A. V. (2011) · Blood · doi:10.1182/blood-2011-10-384289 · Cited by 185 · see citing works
Adam, S., Simon, N., Steffen, U., Andes, F. T., Scholtysek, C., Müller, D. I. H., Weidner, D., Andreev, D., Kleyer, A., Culemann, S., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay4447 · Cited by 132 · see citing works
Shinomiya, H. (2012) · International Journal of Cell Biology · doi:10.1155/2012/213492 · Cited by 122 · see citing works
Chan, J. K.-K., Glass, G. E., Ersek, A., Freidin, A. J., Williams, G. A., Gowers, K. H. C., Santo, A. I. E., Jeffery, R. E., Otto, W. R., Poulsom, R., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404487 · Cited by 122 · see citing works
Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss
Weske, S., Vaidya, M., Reese, A., Lipinski, K. V. W., Keul, P., Bayer, J. K., Fischer, J. W., Flögel, U., Nelsen, J., Epple, M., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0005-y · Cited by 121 · see citing works
Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell–cell fusion
Oikawa, T., Oyama, M., Kozuka‐Hata, H., Uehara, S., Udagawa, N., Saya, H., & Matsuo, K. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201111116 · Cited by 109 · see citing works
Chen, X., Cao, Y. W., Lv, D., Zhu, Z., Zhang, J., & Chai, Y. (2012) · Journal of Chromatography A · doi:10.1016/j.chroma.2012.04.034 · Cited by 101 · see citing works
Self-citationFascin Rigidity and L-plastin Flexibility Cooperate in Cancer Cell Invadopodia and Filopodia
Audenhove, I. V., Denert, M., Boucherie, C., Pieters, L., Cornelissen, M., & Gettemans, J. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.706937 · Cited by 77 · see citing works
Ding, X., Cao, Y. W., Yuan, Y., Gong, Z., Liu, Y., Zhao, L., Lv, L., Zhang, G., Wang, D., Jia, D. T., et al. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b02709 · Cited by 75 · see citing works
Self-citationThe actin‐bundling protein L‐plastin supports T‐cell motility and activation
Morley, S. C. (2013) · Immunological Reviews · doi:10.1111/imr.12102 · Cited by 68 · see citing works
Effects of ketoralac tromethamine and indomethacin on primary and secondary bone healing
Reikeraas, O., & Engebretsen, L. F. (1998) · Archives of Orthopaedic and Trauma Surgery · doi:10.1007/s004020050310 · Cited by 56 · see citing works
Delanote, V., Vanloo, B., Catillon, M., Friederich, E., Vandekerckhove, J. S., & Gettemans, J. (2009) · The FASEB Journal · doi:10.1096/fj.09-134304 · Cited by 55 · see citing works
Harvestine, J. N., Gonzalez‐Fernandez, T., Sebastian, A., Hum, N. R., Genetos, D. C., Loots, G. G., & Leach, J. K. (2020) · Science Advances · doi:10.1126/sciadv.aay2387 · Cited by 51 · see citing works
Chen, C., Cai, Q., He, W., Lam, T. B. L., Lin, J., Zhao, Y., Chen, X., Gu, P., Huang, H., Xue, M., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.437 · Cited by 48 · see citing works
Self-citationZalli, D., Neff, L., Nagano, K., Shin, N. Y., Witke, W., Gori, F., & Baron, R. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2851 · Cited by 46 · see citing works
Liu, W., Guo, T.-F., Jing, Z.-T., Yang, Z. P., Liu, L., Yang, Y., Lin, X., & Tong, Q.-Y. (2018) · The FASEB Journal · doi:10.1096/fj.201701144r · Cited by 44 · see citing works
Adhesion and Fusion of Muscle Cells Are Promoted by Filopodia
Segal, D., Dhanyasi, N., Schejter, E. D., & Shilo, B. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.07.010 · Cited by 40 · see citing works
The Calcium-Dependent Switch Helix of L-Plastin Regulates Actin Bundling
Ishida, H., Jensen, K. V., Woodman, A. G., Hyndman, M. E., & Vogel, H. J. (2017) · Scientific Reports · doi:10.1038/srep40662 · Cited by 40 · see citing works
Wabnitz, G. H., Michalke, F., Stober, C., Kirchgessner, H., Jahraus, B., van den Boomen, D. J. H., & Samstag, Y. (2011) · European Journal of Immunology · doi:10.1002/eji.201041366 · Cited by 39 · see citing works
Role of actin filaments in fusopod formation and osteoclastogenesis
Wang, Y., Brooks, P. J., Jang, J. J., Silver, A. S., Arora, P. D., McCulloch, C. A., & Glogauer, M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.04.001 · Cited by 36 · see citing works
Self-citationSpatial oxidation of L-plastin downmodulates actin-based functions of tumor cells
Balta, E., Hardt, R., Liang, J., Kirchgessner, H., Orlik, C., Jahraus, B., Hillmer, S., Meuer, S. C., Hübner, K., Wabnitz, G. H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11909-z · Cited by 35 · see citing works
Lommel, M. J., Trairatphisan, P., Gäbler, K., Laurini, C., Muller, A., Kaoma, T., Vallar, L., Sauter, T., & Schaffner‐Reckinger, E. (2015) · The FASEB Journal · doi:10.1096/fj.15-276311 · Cited by 34 · see citing works
New roles of filopodia and podosomes in the differentiation and fusion process of osteoclasts
Song, R., Liu, X. Z., Zhu, J., Zhang, J. M., Gao, Q., Zhao, H., Sheng, A., Yuan, Y., Gu, J., Zou, H., et al. (2014) · Genetics and Molecular Research · doi:10.4238/2014.july.2.7 · Cited by 33 · see citing works
L-Plastin promotes podosome longevity and supports macrophage motility
Zhou, J. Y., Szasz, T. P., Stewart-Hutchinson, P. J., Sivapalan, J., Todd, E. M., Deady, L. E., Cooper, J. A., Onken, M. D., & Morley, S. C. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.08.012 · Cited by 29 · see citing works
Angiotensin II regulates phosphorylation of actin‐associated proteins in human podocytes
Sievers, L. K., Möller‐Kerutt, A., Klosowski, R., Wolters, D. A., Schaffner‐Reckinger, E., Weide, T., Pavenstädt, H., & Vollenbröker, B. (2017) · The FASEB Journal · doi:10.1096/fj.201700142r · Cited by 24 · see citing works
Chellaiah, M., Moorer, M. C., Majumdar, S., Aljohani, H., Morley, S., Yingling, V., & Stains, J. (2020) · Bone Research · doi:10.1038/s41413-019-0079-2 · Cited by 19 · see citing works
Chen, C., Cai, Q., He, W., Li, Z., Zhou, F., Liu, Z., Zhong, G., Chen, X., Zhao, Y., Dong, W., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29677 · Cited by 17 · see citing works
Self-citationChellaiah, M. A., Ma, T., & Majumdar, S. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.09.014 · Cited by 17 · see citing works
Visual Osteoclast Fusion via A Fluorescence Method
Li, B., Yu, F., Wu, F., Wang, K., Lou, F., Zhang, D., Liao, X., Yin, B., Wang, C., & Ye, L. (2018) · Scientific Reports · doi:10.1038/s41598-018-28205-3 · Cited by 11 · see citing works
Neto, E. C. D. M., Kumar, A., Shadick, N. A., Michon, A., Matsudaira, P. T., Eaton, R. B., Kumar, P., & Schur, P. H. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115917 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Silk fibroin-based biomaterials for cartilage/osteochondral repair
Zhou, Z., Cui, J., Wu, S., Geng, Z., & Su, J. (2022) · Theranostics · doi:10.7150/thno.74548 · Cited by 223 · see citing works
Self-citationMaintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression
Zhang, H., Wang, L., Cui, J., Wang, S., Han, Y., Shao, H., Wang, C., Hu, Y., Li, X., Zhou, Q., et al. (2023) · Science Advances · doi:10.1126/sciadv.abo7868 · Cited by 212 · see citing works
Self-citationExosome-guided bone targeted delivery of Antagomir-188 as an anabolic therapy for bone loss
Hu, Y., Li, X., Zhang, Q., Gu, Z., Luo, Y., Guo, J., Wang, X., Jing, Y., Chen, X., & Su, J. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.02.014 · Cited by 210 · see citing works
Self-citationGuo, J., Wang, F., Hu, Y., Luo, Y., Wei, Y., Xu, K., Zhang, H., Liu, H., Bo, L., Lv, S., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100881 · Cited by 182 · see citing works
Self-citationDiets intervene osteoporosis via gut-bone axis
Zhang, Y., Song, P., Wang, S., Liu, H., Shi, Z., & Su, J. (2024) · Gut Microbes · doi:10.1080/19490976.2023.2295432 · Cited by 180 · see citing works
Self-citationLiu, H., Zhang, H., Han, Y., Hu, Y., Geng, Z., & Su, J. (2022) · Theranostics · doi:10.7150/thno.78034 · Cited by 101 · see citing works
Self-citationLiu, H., Geng, Z., & Su, J. (2022) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2022.04 · Cited by 94 · see citing works
Self-citationLiu, X., Li, F., Dong, Z., Gu, C., Mao, D., Chen, J., Luo, L., Huang, Y., Xiao, J., Li, Z., et al. (2023) · Science Advances · doi:10.1126/sciadv.adf3329 · Cited by 92 · see citing works
Bone-targeted biomaterials: Strategies and applications
Ren, X., Chen, X., Geng, Z., & Su, J. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.137133 · Cited by 92 · see citing works
Self-citationFang, C., Guo, J., Wang, Y., Li, X., Zhang, H., Cui, J., Hu, Y., Jing, Y., Chen, X., & Su, J. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00747-9 · Cited by 81 · see citing works
Self-citationEngineered bacterial extracellular vesicles for osteoporosis therapy
Liu, H., Li, M., Zhang, T., Liu, X., Zhang, H., Geng, Z., & Su, J. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.138309 · Cited by 78 · see citing works
Self-citationTao, S., Li, X., Wei, W.-J., Wei, Z., Zhang, C., Wang, F., Dawes, H., & Guo, S. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121465 · Cited by 74 · see citing works
Self-citationHydrogels for bone organoid construction: From a materiobiological perspective
Wu, S., Wu, X., Wang, X., & Su, J. (2022) · Journal of Material Science and Technology · doi:10.1016/j.jmst.2022.07.008 · Cited by 72 · see citing works
Self-citationWang, Y.-J., Cui, J., Gu, Z.-R., Fang, C., Hu, Y., Weng, W., Li, X.-Q., Zhou, Q.-R., Chen, H., Zhang, H., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.723988 · Cited by 64 · see citing works
Self-citationLi, X., Fang, S., Wang, S., Xie, Y., Xia, Y., Wang, P., Hao, Z., Xu, S., & Zhang, Y. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02342-6 · Cited by 65 · see citing works
Self-citationThe “Three in One” Bone Repair Strategy for Osteoporotic Fractures
Chen, X., Hu, Y., Geng, Z., & Su, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.910602 · Cited by 63 · see citing works
Self-citationMatrix stiffness regulates osteoclast fate through integrin-dependent mechanotransduction
Wang, X., Ji, L., Wang, J., & Liu, C. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.03.014 · Cited by 61 · see citing works
Single‐cell <scp>RNA</scp> sequencing in osteoarthritis
Gu, Y., Hu, Y., Zhang, H., Wang, S., Xu, K., & Su, J. (2023) · Cell Proliferation · doi:10.1111/cpr.13517 · Cited by 59 · see citing works
Self-citationSelection and identification of a novel ssDNA aptamer targeting human skeletal muscle
Sun, S., Liu, H., Hu, Y., Wang, Y., Zhao, M., Yuan, Y., Han, Y., Jing, Y., Cui, J., Ren, X., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.05.016 · Cited by 57 · see citing works
Self-citationConstruction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration
Meng, F., Yin, Z., Ren, X., Geng, Z., & Su, J. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14051069 · Cited by 52 · see citing works
Self-citationFilopodia In Vitro and In Vivo
Blake, T. C. A., & Gallop, J. L. (2023) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-020223-025210 · Cited by 50 · see citing works
Research Progress of Ferroptosis Regulatory Network and Bone Remodeling in Osteoporosis
Yan, C., Zhang, J., An, F., Wang, J., Shi, Y., Yuan, L., Lv, D., Zhao, Y., & Wang, Y. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.910675 · Cited by 44 · see citing works
Self-citationResearch Progress of Exosomes in Bone Diseases: Mechanism, Diagnosis and Therapy
Meng, F., Xu, X. J., Yin, Z., Gao, F., Wang, X., & Geng, Z. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.866627 · Cited by 44 · see citing works
Smart osteoclasts targeted nanomedicine based on amorphous CaCO3 for effective osteoporosis reversal
Yu, B., Gao, Q., Sheng, S., Zhou, F., Geng, Z., Wei, Y., Zhang, H., Hu, Y., Wang, S., Huang, J., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02412-9 · Cited by 43 · see citing works
Self-citationZhang, Z., Ding, P., Meng, Y., Lin, T., Zhang, Z., Shu, H., Ma, J., Stuart, M. A. C., Gao, Y., Wang, J., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade7379 · Cited by 38 · see citing works
Jia, D. T., Liu, C., Zhu, Z., Cao, Y. W., Wen, W., Hong, Z., Liu, Y., Liu, E., Chen, L., Chen, C., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1095 · Cited by 36 · see citing works
Self-citationRepair and regeneration: ferroptosis in the process of remodeling and fibrosis in impaired organs
Yin, J., Xu, X., Guo, Y., Sun, C., Yang, Y., Liu, H., Yu, P., Wu, T. S., & Song, X. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02181-2 · Cited by 38 · see citing works
Intestinal organoids and organoids extracellular vesicles for inflammatory bowel disease treatment
Liu, H., Sun, J., Wang, M., Wang, S., Su, J., & Xu, C. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.142842 · Cited by 37 · see citing works
Self-citationDong, Y., Chen, S., He, H., Sun, Z.-R., Jiang, L.-X., Gu, Y., Zhang, Y., Feng, F., Chen, C., Fan, Z., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01052-3 · Cited by 33 · see citing works
Self-citationExpert consensus on the bone repair strategy for osteoporotic fractures in China
Zhang, H., Hu, Y., Chen, X., Wang, S., Cao, L., Dong, S., Shi, Z., Chen, Y., Xiong, L., Zhang, Y., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.989648 · Cited by 31 · see citing works
Self-citationXie, C., Wu, T., Wang, Y., Capon, R. J., Xu, R., & Yang, X. (2024) · Organic Letters · doi:10.1021/acs.orglett.4c01065 · Cited by 29 · see citing works
Self-citationCheung, K. C.-P., Ma, J., Xingxuan, C., & Jia, W. P. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1051134 · Cited by 33 · see citing works
Engineering Neutrophil Immunomodulatory Hydrogels Promoted Angiogenesis
Gao, Z., Yu, Y., Dai, K., Zhang, T., Ji, L., Wang, X., Wang, J., & Liu, C. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c08600 · Cited by 28 · see citing works
Tao, Y., Chen, Y., Wang, S., Chen, W., Zhou, D., Chen, D., Zhang, C., Wu, Z., Yan, J., Zhang, H., et al. (2022) · Composites Part B Engineering · doi:10.1016/j.compositesb.2022.110288 · Cited by 28 · see citing works
Self-citationDong, Q. Z., Fu, H., Li, W., Ji, X., Yin, Y., Zhang, Y., Zhu, Y., Li, G., Jia, H., Zhang, H., et al. (2025) · Bone Research · doi:10.1038/s41413-024-00394-w · Cited by 29 · see citing works
Self-citationChen, Y., Xiao, H., Liu, Z., Teng, F., Yang, A., Geng, B., Sheng, X., & Xia, Y. (2024) · Biomolecules · doi:10.3390/biom14080970 · Cited by 25 · see citing works
Lin, X., Xu, F., Zhang, K., Qiu, W., Zhang, H., Hao, Q., Li, M., Deng, X., Tian, Y. E., Chen, Z., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.796227 · Cited by 24 · see citing works
Self-citationAtsttrin regulates osteoblastogenesis and osteoclastogenesis through the TNFR pathway
Liu, K., Wang, Z., Liu, J., Zhao, W. H., Qiao, F., He, Q., Shi, J., Meng, Q., Wei, J., & Cheng, L. (2023) · Communications Biology · doi:10.1038/s42003-023-05635-y · Cited by 24 · see citing works
Yu, B., Xu, X. J., Yin, Z., Cao, L., Li, M., & Huang, J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.844050 · Cited by 23 · see citing works
Self-citationFeng, R., Hu, W., Li, Y., Yao, X., Li, J., Li, X., Zhang, J., Wu, Y. H., Kang, F., & Dong, S. (2024) · Mechanobiology in Medicine · doi:10.1016/j.mbm.2024.100043 · Cited by 18 · see citing works
Self-citationMa, Q., Xiong, Y., Jie, Z., Li, C., Wang, C., Cai, J., Zhang, Y., Li, J., You, Y., Chang, M., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156205 · Cited by 17 · see citing works
Self-citationSong, W., Sheng, Q., Bai, Y., Li, L., Ning, X., Liu, Y., Song, C., Wang, T., Dong, X., Luo, Y., et al. (2023) · npj Science of Food · doi:10.1038/s41538-023-00190-6 · Cited by 17 · see citing works
Self-citationInguito, K. L., Schofield, M. M., Faghri, A. D., Bloom, E. T., Heino, M., West, V. C., Ebron, K. M. M., Elliott, D. M., & Parreno, J. (2022) · Molecular Biology of the Cell · doi:10.1091/mbc.e22-02-0067 · Cited by 17 · see citing works
Jin, F., Zhu, Y., Liu, M., Wang, R., Cui, Y., Wu, Y., Liu, G., Wang, Y., Wang, X., & Ren, Z. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.72487 · Cited by 16 · see citing works
Self-citationLiang, M., Wang, K., Wei, X., Gong, X., Tang, H., Xue, H., Wang, J., Yin, P., Zhang, L., Ma, Z., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101228 · Cited by 16 · see citing works
Ma, Q., Wang, S., Xue, H., Ni, L., Yuan, P., Shen, Y., Zheng, B., Wang, Q., Zhang, J., Wang, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61938-0 · Cited by 15 · see citing works
“Flow cytometry was performed as previously reported 53 .”
Chen, Y., Zheng, J., Mo, L., Chen, F., Li, R., Wang, Y., Liang, Q., Chen, Z., Dai, W., Chen, L., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155688 · Cited by 15 · see citing works
Self-citationLu, S., & Fang, C. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113321 · Cited by 14 · see citing works
Self-citationThe intricate mechanism of PLS3 in bone homeostasis and disease
Zhong, W., Pathak, J. L., Liang, Y., Zhytnik, L., Pals, G., Eekhoff, E. M. W., Bravenboer, N., & Micha, D. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1168306 · Cited by 13 · see citing works
Meng, L., Ma, W., Jiang, Y., Li, X., Zhang, M., Yuan, R., Fu, Y., Ma, H., Lu, X., Han, L., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202404549 · Cited by 13 · see citing works
Self-citationSchwebach, C. L., Kudryashova, E., & Kudryashov, D. S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.635783 · Cited by 12 · see citing works
Yang, Q., Wu, T., Wu, X., Ren, M., Liu, F., & Yang, S. L. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c00172 · Cited by 11 · see citing works
Lai, Y., Li, H., Zhou, T., Chen, H., Yang, J., Mo, G., Li, Y., Li, Q., Deng, X., Fan, S., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.08.033 · Cited by 11 · see citing works
Zhang, J., Hu, W., Li, Y., Kang, F., Yao, X., Li, J., & Dong, S. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.04.007 · Cited by 10 · see citing works
Wang, F., Guo, J., Wang, Y., Hu, Y., Zhang, H., Chen, J., Jing, Y., Cao, L., Chen, X., & Su, J. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.07.009 · Cited by 10 · see citing works
Self-citationLi, J.-Y., Wang, T., Ma, L., & Zheng, L. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119544 · Cited by 8 · see citing works
Engineering approaches to manipulate osteoclast behavior for bone regeneration
Cheng, X., Tian, W., Yang, J., Wang, J., & Zhang, Y. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101043 · Cited by 8 · see citing works
Li, Z., Liu, C., Liu, X., Wang, N., Gao, L., Bao, X., Liu, S., & Xue, P. (2022) · Stem Cells International · doi:10.1155/2022/5226771 · Cited by 8 · see citing works
CUL4A‐mediated ZEB1/microRNA‐340‐5p/HMGB1 axis promotes the development of osteoporosis
Chen, H., Zheng, Q., Lv, Y., Yang, Z., & Fu, Q. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23373 · Cited by 8 · see citing works
Chen, Z., Rajamanickam, K. R., Ding, M., Kim, S. K., Park, S.-W., Kim, E., Lee, S., & Lee, T. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00114 · Cited by 7 · see citing works
Wang, H., & Shi, Y. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.12031 · Cited by 7 · see citing works
Hong, H.-F., Lin, C., Fang, M., Liu, J., Hsu, H., Chang, C., & Wang, H. (2024) · Biomedical Chromatography · doi:10.1002/bmc.5846 · Cited by 6 · see citing works
Liu, H., Gu, R., Huang, Q., Liu, Y., Liu, C., Liao, S., Feng, W., Xie, T., Zhao, J., Xu, J., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.870553 · Cited by 6 · see citing works
Efficacy and Safety of Generic Alendronate for Osteoporosis Treatment
Jarusriwanna, A., Malisorn, S., Tananoo, S., Areewong, K., Rasamimongkol, S., & Laoruengthana, A. (2024) · Orthopedic Research and Reviews · doi:10.2147/orr.s445202 · Cited by 7 · see citing works
Karanjin counteracts OVX-induced bone loss by dual regulating bone remodeling
Ma, Q., Li, C., Lin, G., Shi, J., Wang, C., Wang, H., Cai, J., Zhang, Y., Li, J., Chang, M., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157099 · Cited by 5 · see citing works
Self-citationZhang, Z., Tao, Z., Zhang, W., Zhang, Z., Zhang, X., Xu, X., Yang, B., Meng, Y., Tao, X., & Zhou, X. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01591-1 · Cited by 5 · see citing works
Xue, Y., Xia, J., Ma, C., Dai, W., & Zhang, Z. (2024) · Journal of Back and Musculoskeletal Rehabilitation · doi:10.3233/bmr-230324 · Cited by 5 · see citing works
Huang, Y., Wang, S., Hu, D., Zhang, L., & Shi, S. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114694 · Cited by 5 · see citing works
AS-605240 Blunts Osteoporosis by Inhibition of Bone Resorption
Sun, J., Cai, G., Shen, J., Cheng, P., Zhang, J., Jiang, D., Xu, X., Lu, F., Chen, L., & Chen, H. (2023) · Drug Design Development and Therapy · doi:10.2147/dddt.s403231 · Cited by 5 · see citing works
Li, Y., Gu, Y., Zhang, W., Li, T., Chen, C., Wang, C., Chai, Y., Ma, X., & Chen, X. (2025) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2025.101259 · Cited by 4 · see citing works
Self-citationNew insights into the role of long non-coding RNAs in osteoporosis
Zhang, W., Liu, Y., Luo, Y., Shu, X., Pu, C., Zhang, B., Feng, P., Xiong, A., & Kong, Q. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175753 · Cited by 4 · see citing works
Self-citationHIF-1α: linking subchondral bone and cartilage as a therapeutic target in osteoarthritis.
Zhang, K., & Fu, W. (2024) · PubMed Central · doi:10.12336/biomatertransl.2024.01.010 · Cited by 5 · see citing works
Cai, P., Yan, S., Lu, Y., Zhou, X., Wang, X., Wang, M., & Yin, Z. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12741 · Cited by 3 · see citing works
RetractedPerini, M. M. D. L., Valuch, C. R., Dadwal, U. C., Awosanya, O. D., Mostardo, S. L., Blosser, R. J., Knox, A. M., McGuire, A. C., Battina, H. L., Nazzal, M. K., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.935391 · Cited by 3 · see citing works
Jiang, Y., Tao, Y., Chen, Y., Xu, X. J., Ding, G., Wang, S., Liu, G., Li, M., & Su, J. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.875531 · Cited by 4 · see citing works
Self-citationZhang, Y., Fang, S., Wang, Z., Zhou, Q., Gao, R., Zhao, T., Weng, W., Xie, Y., & Li, X. (2025) · Nano Research · doi:10.26599/nr.2025.94907354 · Cited by 2 · see citing works
Self-citationLi, X., Wu, J., Kong, Q., Hu, M., Li, Y., Wei, Z., Jiang, H., Zhou, X., & Ma, J. (2025) · JCI Insight · doi:10.1172/jci.insight.190598 · Cited by 2 · see citing works
Self-citationLi, M., Zhang, Y., Fang, Y., & Chen, S. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.116115 · Cited by 2 · see citing works
Chen, W.-J., Livneh, H., Li, H.-H., Wang, Y., Lu, M., Tsai, T., & Chien, K. (2023) · International Journal of General Medicine · doi:10.2147/ijgm.s416705 · Cited by 2 · see citing works
Self-citationGnoumou, E., Tran, T.-T. A., Yang, T.-T., Quach, T.-T. T., & Wang, C. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145769 · Cited by 2 · see citing works
Yin, Y., Yao, K., Zhang, Q., Huang, X., Li, S., Chen, X., & Li, Z. (2025) · ACS Omega · doi:10.1021/acsomega.5c03693 · Cited by 1 · see citing works
Self-citationLiang, W., Tang, C., & Wu, Y. (2025) · Connective Tissue Research · doi:10.1080/03008207.2025.2582833 · Cited by 1 · see citing works
Characteristics of osteoclasts at different developmental stages and therapeutic strategies
Fan, Z., Shuai, F., Xie, Y., Lin, Y., Yao, Y., Han, X., & Yin, Y. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118703 · Cited by 1 · see citing works
Inguito, K. L., Schofield, M. M., Faghri, A. D., Bloom, E. T., Heino, M., Elliott, D. M., & Parreno, J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.15.480605 · Cited by 1 · see citing works
Liu, H., Chen, X., & Su, J. (2022) · doi:10.32388/p6ayks · Cited by 1 · see citing works
Self-citationTargeting GDF15 as a potential therapy for low back pain originating from endplatePreprint
Li, X., Wu, J., Kong, Q., Hu, M., Wei, Z., Jiang, H., Zhang, Z., Gao, R., Zhou, X., & Ma, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.11.528124
Self-citationSu, J., Yang, H., Yu, B., Li, R., Hong, Y., Shen, M., Shen, T., Wang, X., Liu, H., Xu, K., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5367877
Self-citationEvaluation of binding, affinity and metabolic regulatory activity of a transketolase inhibitor
Jia, D. T., Liu, C., Liu, W., Fu, J. W., Chen, X., & Wang, H. (2025) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2025.07.012
Self-citationLi, X., Fang, S., Wang, S., Xie, Y., Xia, Y., Wang, P., Hao, Z., Xu, S., & Zhang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.25422357
Self-citationYu, L., Zhou, B., Liu, W., Li, W., Wei, Q., Zhang, Y., Li, C., Li, W., Li, Y., Li, G., et al. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102232
Self-citation
- Authors
- Li, X., Wang, L., Huang, B., Gu, Y., Luo, Y., Zhi, X., Hu, Y., Zhang, H., Gu, Z., Cui, J., Cao, L., Guo, J., Wang, Y., Zhou, Q., Jiang, H., Fang, C., Weng, W., Chen, X., Chen, X., & Su, J.
- Affiliations
- Second Military Medical University (CN)
- Shanghai University (CN)
- Department of Orthopedics, Shanghai Baoshan Luodian Hospital, Shanghai 201900, China.
- Corresponding author
- Li, Xiaoqun
- Wang, Lipeng
- Huang, Biaotong
- Gu, Yanqiu
- Chen, Xiaofei
- Chen, Xiao
- Su, Jiacan
- ORCID
- Venue
- Science Advances
- Published
- 2020-11-20
- Volume
- 6
- Issue
- 47
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC7673802
- OpenAlex
- W3098001023
- Cited by
- 90
- References
- 45
- Citations by year
- 2026: 2 · 2025: 17 · 2024: 17 · 2023: 22 · 2022: 28 · 2021: 4
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Shanghai (19ZR1419600)
- National Natural Science Foundation of China (81771491, 81871099, 81501052, 81701364, 81901426, 81703526, 81973291)
- Shanghai Sailing Program (19YF1447300)
- National Key Research and Development Plan (2018YFC2001500)
- Municipal Human Resources Development Program for Outstanding Leaders in Medical Disciplines in Shanghai (2017BR011)
- National Natural Science Foundation (NNSF) Key Research Program in Aging (91749204)
- Science and Technology Support Project in Biomedical Field of Shanghai Science and Technology Innovation Plan (18431902300)
- Shanghai Baoshan District Science and Technology Commission Special Funds for Scientific and Technological Innovation (17-E-33)
- Scientific Research Project of Shanghai Municipal Health and Family Planning Commission (201640156, 201740237)
- Shanghai Phospherus project (19QA1411500)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Medicinal Plant Pharmacodynamics Research
- Keywords
- L-plastin, actin bundling, osteoporosis, bone loss, osteoclast fusion, anabolic therapy, oroxylin A, RANKL, ovariectomy, fracture healing, bone formation
- MeSH terms
- Actins, Animals, Female, Membrane Glycoproteins, Microfilament Proteins, Osteoclasts, Osteogenesis, Platelet Endothelial Cell Adhesion Molecule-1, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review