Cited by 90Bone Metabolism and DiseasesBone health and osteoporosis researchMedicinal Plant Pharmacodynamics Research

Targeting actin-bundling protein L-plastin as an anabolic therapy for bone loss

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Li, Xiaoqun, Wang, Lipeng, Huang, Biaotong, Gu, Yanqiu, Luo, Ying, Zhi, Xin, Hu, Yan, Zhang, Hao +12 more·2020·Science Advances

Abstract

Targeting L-plastin suppresses bone resorption and promotes bone formation by disrupting preosteoclast fusion.

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Crossref · 10.1126/sciadv.abb7135

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Authors
Li, X., Wang, L., Huang, B., Gu, Y., Luo, Y., Zhi, X., Hu, Y., Zhang, H., Gu, Z., Cui, J., Cao, L., Guo, J., Wang, Y., Zhou, Q., Jiang, H., Fang, C., Weng, W., Chen, X., Chen, X., & Su, J.
Affiliations
  • Second Military Medical University (CN)
  • Shanghai University (CN)
  • Department of Orthopedics, Shanghai Baoshan Luodian Hospital, Shanghai 201900, China.
Corresponding author
  • Li, Xiaoqun
  • Wang, Lipeng
  • Huang, Biaotong
  • Gu, Yanqiu
  • Chen, Xiaofei
  • Chen, Xiao
  • Su, Jiacan
Venue
Science Advances
Published
2020-11-20
Volume
6
Issue
47
ISSN
2375-2548 (ISSN-L)
OpenAlex
W3098001023
Cited by
90
References
45
Citations by year
2026: 2 · 2025: 17 · 2024: 17 · 2023: 22 · 2022: 28 · 2021: 4
FWCI
4.38
Type
journal article
Language
en
Open access
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • Natural Science Foundation of Shanghai (19ZR1419600)
  • National Natural Science Foundation of China (81771491, 81871099, 81501052, 81701364, 81901426, 81703526, 81973291)
  • Shanghai Sailing Program (19YF1447300)
  • National Key Research and Development Plan (2018YFC2001500)
  • Municipal Human Resources Development Program for Outstanding Leaders in Medical Disciplines in Shanghai (2017BR011)
  • National Natural Science Foundation (NNSF) Key Research Program in Aging (91749204)
  • Science and Technology Support Project in Biomedical Field of Shanghai Science and Technology Innovation Plan (18431902300)
  • Shanghai Baoshan District Science and Technology Commission Special Funds for Scientific and Technological Innovation (17-E-33)
  • Scientific Research Project of Shanghai Municipal Health and Family Planning Commission (201640156, 201740237)
  • Shanghai Phospherus project (19QA1411500)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Medicinal Plant Pharmacodynamics Research
Keywords
L-plastin, actin bundling, osteoporosis, bone loss, osteoclast fusion, anabolic therapy, oroxylin A, RANKL, ovariectomy, fracture healing, bone formation
MeSH terms
Actins, Animals, Female, Membrane Glycoproteins, Microfilament Proteins, Osteoclasts, Osteogenesis, Platelet Endothelial Cell Adhesion Molecule-1, Mice

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