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Cited by 72

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Structural insights into the mechanism of human NPC1L1-mediated cholesterol uptake

Hu, Miaoqing, Yang, Fan, Huang, Yawen, You, Xin, Liu, Desheng, Sun, Shan, Sui, Sen-Fang·2021·Science Advances
DOI 10.1126/sciadv.abg3188PMC PMC8284890
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Abstract

Structures of NPC1L1 reveal how NPC1L1 senses the cholesterol level by conformational changes of the sterol-sensing domain.

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Crossref · 10.1126/sciadv.abg3188

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  • Structural analyses have revealed that the N-terminal domain of NPC1L1 possesses a cavity that accommodates cholesterol.

    “Structural analyses have revealed that the N-terminal domain of NPC1L1 possesses a cavity that accommodates cholesterol (14–16).”

    From Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake (2023) · cites this paper as [14]

    The Introduction reports that the N-terminal domain binds cholesterol directly in vitro. It does not describe a cholesterol-accommodating cavity in that domain: the Results locate the observed cholesterol-filled cavity in the transmembrane sterol-sensing domain, and report that the N-terminal domain was not resolved in the authors’ structure. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

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Metadata

Authors
Hu, M., Yang, F., Huang, Y., You, X., Liu, D., Sun, S., & Sui, S.-F.
Affiliations
State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing 100084, China.
ORCID
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2021-07-16
Volume
7
Issue
29
ISSN
2375-2548
DOI
10.1126/sciadv.abg3188
PMC
PMC8284890
Cited by
72
References
4
Language
en
Licence
creativecommons.org/licenses/by-nc/4.0/ (vor)
Funders
  • National Natural Science Foundation of China (91954118, 31861143048, 31670745, 31670746)
  • National Basic Research Program of China (2017YFA0504600, 2016YFA0501101)

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