The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Lactate supports a metabolic-epigenetic link in macrophage polarization
Open accessAbstract
Macrophages use mitochondrial lactate metabolism for ACLY-dependent histone acetylation, immune suppression, and tumor progression.
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Cites
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337
Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
Metabolic regulation of gene expression by histone lactylation
Zhang, D., Tang, Z., Huang, H., Zhou, G., Cui, C., Weng, Y., Liu, W., Kim, S., Lee, S., Perez-Neut, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1678-1 · Cited by 4,371
Tumour-associated macrophages as treatment targets in oncology
Mantovani, A., Marchesi, F., Malesci, A., Laghi, L., & Allavena, P. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.217 · Cited by 4,033
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840
On Respiratory Impairment in Cancer Cells
Warburg, O. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,468
Functional Polarization of Tumour-Associated Macrophages by Tumour-Derived Lactic Acid
Colegio, O. R., Chu, N.-Q., Szabo, A. L., Chu, T., Rhebergen, A. M., Jairam, V., Cyrus, N., Brokowski, C. E., Eisenbarth, S. C., Phillips, G. M., et al. (2014) · Nature · doi:10.1038/nature13490 · Cited by 3,046
ATP-citrate lyase links cellular metabolism to histone acetylation
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298
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Cited by
Lactylation of METTL16 promotes cuproptosis via m6A-modification on FDX1 mRNA in gastric cancer
Sun, L., Zhang, Y., Yang, B., Sun, S., Zhang, P., Luo, Z., Feng, T., Cui, Z., Zhu, T., Li, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42025-8 · Cited by 490
Lactate and lactylation in cancer
Chen, J., Huang, Z., Chen, Y., Tian, H., Chai, P., Shen, Y., Yao, Y., Xu, S., Ge, S., & Jia, R. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02082-x · Cited by 477
Lactic acid and lactate: revisiting the physiological roles in the tumor microenvironment
Apostolova, P., & Pearce, E. L. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.10.005 · Cited by 346
De Leo, A., Ugolini, A., Yu, X., Scirocchi, F., Scocozza, D., Peixoto, B., Pace, A., D’Angelo, L., Liu, J. K. C., Etame, A. B., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.04.006 · Cited by 319
Acetyl-CoA metabolism in cancer
Guertin, D. A., & Wellen, K. E. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-022-00543-5 · Cited by 303
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Metadata
- Authors
- Noe, J. T., Rendon, B. E., Geller, A. E., Conroy, L. R., Morrissey, S. M., Young, L. E. A., Bruntz, R. C., Kim, E. J., Wise-Mitchell, A., Barbosa de Souza Rizzo, M., Relich, E. R., Baby, B. V., Johnson, L. A., Affronti, H. C., McMasters, K. M., Clem, B. F., Gentry, M. S., Yan, J., Wellen, K. E., Sun, R. C., & Mitchell, R. A.
- Venue
- Science Advances
- Published
- 2021-11-12
- Volume
- 7
- Issue
- 46
- Pages
- eabi8602-eabi8602
- ISSN
- 2375-2548 (ISSN-L)
- OpenAlex
- W3214672543
- Cited by
- 283
- References
- 47
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Noe, J. T., Rendon, B. E., Geller, A. E., Conroy, L. R., Morrissey, S. M., Young, L. E. A., Bruntz, R. C., Kim, E. J., Wise-Mitchell, A., Barbosa de Souza Rizzo, M., Relich, E. R., Baby, B. V., Johnson, L. A., Affronti, H. C., McMasters, K. M., Clem, B. F., Gentry, M. S., Yan, J., Wellen, K. E., . . . Mitchell, R. A. (2021). Lactate supports a metabolic-epigenetic link in macrophage polarization. Science Advances. https://doi.org/10.1126/sciadv.abi8602
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
