The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites
Open accessAbstract
Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy.
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Factors affecting wound healing
Guo, S., & DiPietro, L. A. (2010) · Journal of Dental Research · doi:10.1177/0022034509359125 · Cited by 5,792
Lab-on-Skin: A Review of Flexible and Stretchable Electronics for Wearable Health Monitoring
Liu, Y., Pharr, M., & Salvatore, G. A. (2017) · ACS Nano · doi:10.1021/acsnano.7b04898 · Cited by 1,725
Self-citationLim, C., Hong, Y. J., Jung, J., Shin, Y., Sunwoo, S.-H., Baik, S., Park, O. K., Choi, S. H., Hyeon, T., Kim, J. H., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd3716 · Cited by 365
Self-citationRegenerated sciatic nerve axons stimulated through a chronically implanted macro-sieve electrode
MacEwan, M. R., Zellmer, E. R., Wheeler, J. J., Burton, H., & Moran, D. W. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00557 · Cited by 48 · cited 1×
“A dominating additional concern for any type of therapeutic or diagnostic device that requires direct physical interfaces with the wound site is in the potential for damage to fragile soft tissues during removal after a period of use (14, 15).”
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Cited by
Breakthrough treatments for accelerated wound healing
Freedman, B. R., Hwang, C., Talbot, S., Hibler, B., Matoori, S., & Mooney, D. J. (2023) · Science Advances · doi:10.1126/sciadv.ade7007 · Cited by 447
Wound management materials and technologies from bench to bedside and beyond
Wang, C., Shirzaei Sani, E., Shih, C.-D., Lim, C. T., Wang, J., Armstrong, D. G., & Gao, W. (2024) · Nature Reviews Materials · doi:10.1038/s41578-024-00693-y · Cited by 396
Metadata
- Authors
- Song, J. W., Ryu, H., Bai, W., Xie, Z., Vázquez-Guardado, A., Nandoliya, K., Avila, R., Lee, G., Song, Z., Kim, J., Lee, M.-K., Liu, Y., Kim, M., Wang, H., Wu, Y., Yoon, H.-J., Kwak, S. S., Shin, J., Kwon, K., Lu, W., Chen, X., Huang, Y., Ameer, G. A., & Rogers, J. A.
- Venue
- Science Advances
- Published
- 2023-02-24
- Volume
- 9
- Issue
- 8
- Pages
- eade4687-eade4687
- ISSN
- 2375-2548 (ISSN-L)
- OpenAlex
- W4321481099
- Cited by
- 199
- References
- 4
- FWCI
- 18.78
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
