The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Hepatitis C Virus IRES RNA-Induced Changes in the Conformation of the 40 S Ribosomal Subunit
Abstract
Initiation of protein synthesis in eukaryotes requires recruitment of the 40 S ribosomal subunit to the messenger RNA (mRNA). In most cases, this depends on recognition of a modified nucleotide cap on the 5′ end of the mRNA. However, an alternate pathway uses a structured RNA element in the 5′ untranslated region of the messenger or viral RNA called an internal ribosomal entry site (IRES). Here, we present a cryo-electron microscopy map of the hepatitis C virus (HCV) IRES bound to the 40 S ribosomal subunit at about 20 Å resolution. IRES binding induces a pronounced conformational change in the 40 S subunit and closes the mRNA binding cleft, suggesting a mechanism for IRES-mediated positioning of mRNA in the ribosomal decoding center.
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Cites
Structure of the 30S ribosomal subunit
Wimberly, B. T., Brodersen, D. E., Clemons, W. M., Morgan-Warren, R. J., Carter, A. P., Vonrhein, C., Hartsch, T., & Ramakrishnan, V. (2000) · Nature · doi:10.1038/35030006 · Cited by 2,035
Structure of Functionally Activated Small Ribosomal Subunit at 3.3 Å Resolution
Schluenzen, F., Tocilj, A., Zarivach, R., Harms, J., Gluehmann, M., Janell, D., Bashan, A., Bartels, H., Agmon, I., Franceschi, F., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00084-2 · Cited by 979
Cited by
The Pathway of HCV IRES-Mediated Translation Initiation
Otto, G. A., & Puglisi, J. D. (2004) · Cell · doi:10.1016/j.cell.2004.09.038 · Cited by 296
IRES-mediated cap-independent translation, a path leading to hidden proteome
Yang, Y., & Wang, Z. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz091 · Cited by 260
Zhou, M., Sandercock, A. M., Fraser, C. S., Ridlova, G., Stephens, E., Schenauer, M. R., Yokoi-Fong, T., Barsky, D., Leary, J. A., Hershey, J. W., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801313105 · Cited by 256
Self-citationIRES Trans-Acting Factors, Key Actors of the Stress Response
Godet, A.-C., David, F., Hantelys, F., Tatin, F., Lacazette, E., Garmy-Susini, B., & Prats, A.-C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040924 · Cited by 202
New modes of translational control in development, behavior, and disease.
Sonenberg, N., & Hinnebusch, A. G. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.11.018 · Cited by 187
Metadata
- Authors
- Spahn, C. M. T., Kieft, J. S., Grassucci, R. A., Penczek, P. A., Zhou, K., Doudna, J. A., & Frank, J.
- Venue
- Science
- Published
- 2001-03-09
- Volume
- 291
- Issue
- 5510
- Pages
- 1959-1962
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966303376
- Cited by
- 476
- References
- 2
- FWCI
- 8.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Spahn, C. M. T., Kieft, J. S., Grassucci, R. A., Penczek, P. A., Zhou, K., Doudna, J. A., & Frank, J. (2001). Hepatitis C Virus IRES RNA-Induced Changes in the Conformation of the 40 S Ribosomal Subunit. Science. https://doi.org/10.1126/science.1058409
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