Cited by 187

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New modes of translational control in development, behavior, and disease.

Sonenberg, Nahum, Hinnebusch, Alan G.·2007·Molecular Cell

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Crossref · 10.1016/j.molcel.2007.11.018

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  • The strategic position of mTORC1 at the nexus of nutrient/stress sensing pathways may contribute to the importance of TOR function in regulating lifespan in invertebrates and mammals.

    “At the cellular level, mTORC1 helps to coordinate growth and survival responses induced by alterations in nutrient availability, energy status, growth factor stimuli and exposure to potentially lethal cell stresses27–29; this strategic position at the nexus of nutrient/stress sensing pathways may contribute to the importance of TOR function in regulating lifespan in invertebrates and in mammals as”
  • Rapamycin may extend lifespan in old genetically heterogeneous mice through a combination of anti-neoplastic effects and effects on cellular stress resistance and response to nutrient dynamics.

    “Rapamycin may extend lifespan in old genetically heterogeneous mice through a combination of anti-neoplastic effects25,26 and effects on cellular stress resistance and response to nutrient dynamics27–29.”
  • mTORC1 helps coordinate growth and survival responses induced by alterations in nutrient availability, energy status, growth factor stimuli, and exposure to cell stresses.

    “At the cellular level, mTORC1 helps to coordinate growth and survival responses induced by alterations in nutrient availability, energy status, growth factor stimuli and exposure to potentially lethal cell stresses27–29; this strategic position at the nexus of nutrient/stress sensing pathways may contribute to the importance of TOR function in regulating lifespan in invertebrates and in mammals as”

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Metadata

Authors
Sonenberg, N., & Hinnebusch, A. G.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2007-12
Volume
28
Issue
5
Pages
721-729
ISSN
1097-2765
Cited by
187
References
4
Language
en

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