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New modes of translational control in development, behavior, and disease.
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The strategic position of mTORC1 at the nexus of nutrient/stress sensing pathways may contribute to the importance of TOR function in regulating lifespan in invertebrates and mammals.
“At the cellular level, mTORC1 helps to coordinate growth and survival responses induced by alterations in nutrient availability, energy status, growth factor stimuli and exposure to potentially lethal cell stresses27–29; this strategic position at the nexus of nutrient/stress sensing pathways may contribute to the importance of TOR function in regulating lifespan in invertebrates and in mammals as”
From Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) · cites this paper as [29]
Rapamycin may extend lifespan in old genetically heterogeneous mice through a combination of anti-neoplastic effects and effects on cellular stress resistance and response to nutrient dynamics.
“Rapamycin may extend lifespan in old genetically heterogeneous mice through a combination of anti-neoplastic effects25,26 and effects on cellular stress resistance and response to nutrient dynamics27–29.”
From Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) · cites this paper as [29]
mTORC1 helps coordinate growth and survival responses induced by alterations in nutrient availability, energy status, growth factor stimuli, and exposure to cell stresses.
“At the cellular level, mTORC1 helps to coordinate growth and survival responses induced by alterations in nutrient availability, energy status, growth factor stimuli and exposure to potentially lethal cell stresses27–29; this strategic position at the nexus of nutrient/stress sensing pathways may contribute to the importance of TOR function in regulating lifespan in invertebrates and in mammals as”
From Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) · cites this paper as [29]
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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677
RNA regulons: coordination of post-transcriptional events
Keene, J. D. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2111 · Cited by 1,321
Yang, H.-S., Jansen, A. P., Komar, A. A., Zheng, X., Merrick, W. C., Costes, S., Lockett, S. J., Sonenberg, N., & Colburn, N. H. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.26-37.2003 · Cited by 494
Self-citationCurrent advances in local protein synthesis and synaptic plasticity
Pfeiffer, B. E., & Huber, K. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1797-06.2006 · Cited by 168
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Metadata
- Authors
- Sonenberg, N., & Hinnebusch, A. G.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 28
- Issue
- 5
- Pages
- 721-729
- ISSN
- 1097-2765
- Cited by
- 187
- References
- 4
- Language
- en
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