The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Single-Molecule Analysis of Chemotactic Signaling in Dictyostelium Cells
Abstract
Single-molecule imaging techniques were used to reveal the binding of individual cyclic adenosine 3′,5′-monophosphate molecules to heterotrimeric guanine nucleotide–binding protein coupled receptors on the surface of living Dictyostelium discoideum cells. The binding sites were uniformly distributed and diffused rapidly in the plane of the membrane. The probabilities of individual association and dissociation events were greater for receptors at the anterior end of the cell. Agonist-induced receptor phosphorylation had little effect on any of the monitored properties, whereas G protein coupling influenced the binding kinetics. These observations illustrate the dynamic properties of receptors involved in gradient sensing and suggest that these may be polarized in chemotactic cells.
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Cites
Parent, C. A., & Devreotes, P. N. (1999) · Science · doi:10.1126/science.284.5415.765 · Cited by 890
Self-citationSingle-molecule imaging of EGFR signalling on the surface of living cells
Sako, Y., Minoghchi, S., & Yanagida, T. (2000) · Nature Cell Biology · doi:10.1038/35004044 · Cited by 890
Self-citationG Protein Signaling Events Are Activated at the Leading Edge of Chemotactic Cells
Parent, C. A., Blacklock, B. J., Froehlich, W. M., Murphy, D. B., & Devreotes, P. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81784-5 · Cited by 617
Self-citationDesensitization of G-protein-coupled Receptors
Xiao, Z., Yao, Y., Long, Y., & Devreotes, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.3.1440 · Cited by 521
Self-citationMeili, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.8.2092 · Cited by 441
Tokunaga, M., Kitamura, K., Saito, K., Iwane, A. H., & Yanagida, T. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6732 · Cited by 310
Self-citationYumura, S., Mori, H., & Fukui, Y. (1984) · The Journal of cell biology · doi:10.1083/jcb.99.3.894 · Cited by 309
Localization of the G Protein βγ Complex in Living Cells During Chemotaxis
Jin, T., Zhang, N., Long, Y., Parent, C. A., & Devreotes, P. N. (2000) · Science · doi:10.1126/science.287.5455.1034 · Cited by 277
Self-citationMOLECULAR GENETICS OF SIGNAL TRANSDUCTION IN DICTYOSTELIUM
Parent, C. A., & Devreotes, P. N. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.002211 · Cited by 269
Self-citationXiao, Z., Zhang, N., Murphy, D. B., & Devreotes, P. N. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.2.365 · Cited by 236
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Tumor Suppressor PTEN Mediates Sensing of Chemoattractant Gradients
Iijima, M., & Devreotes, P. (2002) · Cell · doi:10.1016/s0092-8674(02)00745-6 · Cited by 677
Self-citationSwaney, K. F., Huang, C.-H., & Devreotes, P. N. (2010) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.093008.131228 · Cited by 494
Self-citationEukaryotic Chemotaxis: Distinctions between Directional Sensing and Polarization
Devreotes, P., & Janetopoulos, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300010200 · Cited by 447
Self-citationDirect imaging of lateral movements of AMPA receptors inside synapses
Tardin, C., Cognet, L., Bats, C., Lounis, B., & Choquet, D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg463 · Cited by 384
Xie, X. S., Yu, J., & Yang, W. Y. (2006) · Science · doi:10.1126/science.1127566 · Cited by 257
Metadata
- Authors
- Ueda, M., Sako, Y., Tanaka, T., Devreotes, P., & Yanagida, T.
- Venue
- Science
- Published
- 2001-10-26
- Volume
- 294
- Issue
- 5543
- Pages
- 864-867
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2038364742
- Cited by
- 324
- References
- 16
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
