The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
Abstract
Single-cell mouse embryos were infected in vitro with recombinant lentiviral vectors to generate transgenic mice carrying the green fluorescent protein (GFP) gene driven by a ubiquitously expressing promoter . Eighty percent of founder mice carried at least one copy of the transgene, and 90% of these expressed GFP at high levels. Progeny inherited the transgene(s) and displayed green fluorescence. Mice generated using lentiviral vectors with muscle-specific and T lymphocyte–specific promoters expressed high levels of GFP only in the appropriate cell types. We have also generated transgenic rats that express GFP at high levels, suggesting that this technique can be used to produce other transgenic animal species.
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Cites
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Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis
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GluN2B-Containing NMDA Receptors Promote Wiring of Adult-Born Neurons into Olfactory Bulb Circuits
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“Lentiviral particles were produced by the Charité Viral Core Facility as previously described (46).”
Effect of Bmi1 over-expression on gene expression in adult and embryonic murine neural stem cells
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A dynamic in vitro model of Down syndrome neurogenesis with trisomy 21 gene dosage correction
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Metadata
- Authors
- Lois, C., Hong, E. J., Pease, S., Brown, E. J., & Baltimore, D.
- Venue
- Science
- Published
- 2002-02
- Volume
- 295
- Issue
- 5556
- Pages
- 868-872
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2037174767
- Cited by
- 1,999
- References
- 2
- FWCI
- 37.52
- Type
- journal article
- Language
- en
- Open access
- closed
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