The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Operant Reward Learning in Aplysia : Neuronal Correlates and Mechanisms
Open accessAbstract
Operant conditioning is a form of associative learning through which an animal learns about the consequences of its behavior. Here, we report an appetitive operant conditioning procedure in Aplysia that induces long-term memory. Biophysical changes that accompanied the memory were found in an identified neuron (cell B51) that is considered critical for the expression of behavior that was rewarded. Similar cellular changes in B51 were produced by contingent reinforcement of B51 with dopamine in a single-cell analog of the operant procedure. These findings allow for the detailed analysis of the cellular and molecular processes underlying operant conditioning.
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“For example, Aplysia californica is only capable of modifying the strength of preexisting associations between reflex-eliciting stimuli, and thus its mode of AL does not meet condition ii (see Carew et al., 1981; Hawkins et al., 1983; Brembs et al., 2002; Hawkins and Byrne, 2015 provide a review).”
From The Transition to Minimal Consciousness through the Evolution of Associative Learning (2016) · cites this paper as Brembs et al., 2002
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Citations
Cites
Multiple reward signals in the brain
Schultz, W. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044563 · Cited by 1,303
Dopamine responses comply with basic assumptions of formal learning theory
Waelti, P., Dickinson, A., & Schultz, W. (2001) · Nature · doi:10.1038/35083500 · Cited by 1,018
A cellular mechanism of reward-related learning
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Localization of a Short-Term Memory in Drosophila
Zars, T. D., Fischer, M., Schulz, R. A., & Heisenberg, M. (2000) · Science · doi:10.1126/science.288.5466.672 · Cited by 605
Associative Conditioning of Single Sensory Neurons Suggests a Cellular Mechanism for Learning
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Inhibitory Cerebello-Olivary Projections and Blocking Effect in Classical Conditioning
Kim, J. J., Krupa, D. J., & Thompson, R. F. (1998) · Science · doi:10.1126/science.279.5350.570 · Cited by 212
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A Systems Approach to the Cellular Analysis of Associative Learning in the Pond Snail LymnaeaPreprint
Benjamin, P. R., Staras, K., & Kemenes, G. (2000) · Learning & Memory · doi:10.1101/lm.7.3.124 · Cited by 167
Research works printed but not linked: 2
- I. P. Pavlov Conditioned Reflexes (Oxford University Press Oxford 1927).
- We thank E. Antzoulatos for helpful discussions and E. Wilkinson for invaluable technical assistance. B.B. is a scholar of the Emmy-Noether Programm of the Deutsche Forschungsgemeinschaft. Supported by NIH grant MH 58321. Supporting Online Material www.sciencemag.org/cgi/content/full/296/5573/1706/DC1 Materials and Methods SOM Text Fig. S1 and S2 References and Notes Movies S1 and S2
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Getting formal with dopamine and reward
Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574
The Molecular and Systems Biology of Memory
Kandel, E. R., Dudai, Y., & Mayford, M. R. (2014) · Cell · doi:10.1016/j.cell.2014.03.001 · Cited by 1,134
Kelley, A. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.016 · Cited by 788
Updating dopamine reward signals
Schultz, W. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.11.012 · Cited by 651
The Restless Engram: Consolidations Never End
Dudai, Y. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150500 · Cited by 644
Metadata
- Authors
- Brembs, B., Lorenzetti, F. D., Reyes, F. D., Baxter, D. A., & Byrne, J. H.
- Affiliations
- Department of Neurobiology and Anatomy, W. M. Keck Center for the Neurobiology of Learning and Memory, The University of Texas–Houston Medical School, Houston, TX 77030, USA.
- Corresponding author
- Lorenzetti, Fred D.
- Byrne, John H.
- ORCID
- Byrne, John H.
- Venue
- Science
- Published
- 2002-05-31
- Volume
- 296
- Issue
- 5573
- Pages
- 1706-1709
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2055848231
- Cited by
- 338
- References
- 22
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 32 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 10 · 2019: 9 · 2018: 6 · 2017: 24 · 2016: 13 · 2015: 14 · 2014: 18 · 2013: 12 · 2012: 13
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- University of Regensburg Publication Server (University of Regensburg)
- Funders
- National Institute of Mental Health (R01MH058321, MH58321)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- operant conditioning, Aplysia, appetitive learning, long-term memory, dopamine, contingent reinforcement, associative learning
- MeSH terms
- Animals, Aplysia, Cells, Cultured, Conditioning, Operant, Dopamine, Eating, Electric Stimulation, Electrophysiology, Esophagus, Feeding Behavior, Food, Iontophoresis, Membrane Potentials, Memory, Nerve Net, Neuronal Plasticity, Neurons, Reinforcement, Psychology, Reward, Ganglia, Invertebrate, Patch-Clamp Techniques
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