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Operant Reward Learning in Aplysia : Neuronal Correlates and Mechanisms

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Brembs, Björn, Lorenzetti, Fred D., Reyes, Fredy D., Baxter, Douglas A., Byrne, John H.·2002·Science

DOI 10.1126/science.1069434

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Abstract

Operant conditioning is a form of associative learning through which an animal learns about the consequences of its behavior. Here, we report an appetitive operant conditioning procedure in Aplysia that induces long-term memory. Biophysical changes that accompanied the memory were found in an identified neuron (cell B51) that is considered critical for the expression of behavior that was rewarded. Similar cellular changes in B51 were produced by contingent reinforcement of B51 with dopamine in a single-cell analog of the operant procedure. These findings allow for the detailed analysis of the cellular and molecular processes underlying operant conditioning.

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I. P. Pavlov Conditioned Reflexes (Oxford University Press Oxford 1927).
We thank E. Antzoulatos for helpful discussions and E. Wilkinson for invaluable technical assistance. B.B. is a scholar of the Emmy-Noether Programm of the Deutsche Forschungsgemeinschaft. Supported by NIH grant MH 58321. Supporting Online Material www.sciencemag.org/cgi/content/full/296/5573/1706/DC1 Materials and Methods SOM Text Fig. S1 and S2 References and Notes Movies S1 and S2

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Authors: Brembs, B., Lorenzetti, F. D., Reyes, F. D., Baxter, D. A., & Byrne, J. H.
Affiliations: Department of Neurobiology and Anatomy, W. M. Keck Center for the Neurobiology of Learning and Memory, The University of Texas–Houston Medical School, Houston, TX 77030, USA.
Corresponding author: Lorenzetti, Fred D.
Byrne, John H.
ORCID: Byrne, John H.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2002-05-31
Volume: 296
Issue: 5573
Pages: 1706-1709
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1069434
OpenAlex: W2055848231
Cited by: 338
References: 22
Citations by year: 2026: 5 · 2025: 5 · 2024: 32 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 10 · 2019: 9 · 2018: 6 · 2017: 24 · 2016: 13 · 2015: 14 · 2014: 18 · 2013: 12 · 2012: 13
FWCI: 7.34
Type: journal article
Language: en
Open access: green
doi.org
Locations: Science (publishedVersion)
PubMed (publishedVersion)
University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
University of Regensburg Publication Server (University of Regensburg)
Funders: National Institute of Mental Health (R01MH058321, MH58321)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: operant conditioning, Aplysia, appetitive learning, long-term memory, dopamine, contingent reinforcement, associative learning
MeSH terms: Animals, Aplysia, Cells, Cultured, Conditioning, Operant, Dopamine, Eating, Electric Stimulation, Electrophysiology, Esophagus, Feeding Behavior, Food, Iontophoresis, Membrane Potentials, Memory, Nerve Net, Neuronal Plasticity, Neurons, Reinforcement, Psychology, Reward, Ganglia, Invertebrate, Patch-Clamp Techniques

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Operant Reward Learning in Aplysia : Neuronal Correlates and Mechanisms

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