Senescence Induced by Altered Telomere State, Not Telomere Loss

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Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

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Untitled work

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TRF2 Protects Human Telomeres from End-to-End Fusions

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Long G Tails at Both Ends of Human Chromosomes Suggest a C Strand Degradation Mechanism for Telomere Shortening

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Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2

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Evidence that exposure of the telomere 3′ overhang sequence induces senescence

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How Telomerase Reaches Its End: Mechanism of Telomerase Regulation by the Telomeric Complex

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Telomere length reflects phenotypic quality and costs of reproduction in a long-lived seabird

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Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2

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Chromosome rearrangements resulting from telomere dysfunction and their role in cancer

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Regulation of telomerase activity and anti‐apoptotic function by protein–protein interaction and phosphorylation

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Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532

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Small interfering RNA-mediated reduction in heterogeneous nuclear ribonucleoparticule A1/A2 proteins induces apoptosis in human cancer cells but not in normal mortal cell lines.

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Up-Regulation of Telomere-Binding Proteins, TRF1, TRF2, and TIN2 Is Related to Telomere Shortening during Human Multistep Hepatocarcinogenesis

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Vascular cell senescence and vascular aging

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Telomeres, interstitial telomeric repeat sequences, and chromosomal aberrations

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Comparison between TRF2 and TRF1 of their telomeric DNA‐bound structures and DNA‐binding activities

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Dissecting Aging and Senescence—Current Concepts and Open Lessons

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Activation of PPARγ/P53 signaling is required for curcumin to induce hepatic stellate cell senescence

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Indecent Exposure

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Role of Telomeres and Telomerase in the Pathogenesis of Human Cancer

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MYC Is a Major Determinant of Mitotic Cell Fate

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TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends

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ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

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C. elegans Telomeres Contain G-Strand and C-Strand Overhangs that Are Bound by Distinct Proteins

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Telomere dysfunction, genome instability and cancer

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Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-1991.

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Telomerase Is Required for Zebrafish Lifespan

Henriques, C. M., Carneiro, M. C., Tenente, I. M., Jacinto, A., & Ferreira, M. G. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003214 · Cited by 133

Cancer and aging: the importance of telomeres in genome maintenance

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MLL Associates with Telomeres and Regulates Telomeric Repeat-Containing RNA Transcription

Caslini, C., Connelly, J. A., Serna, A. N., Broccoli, D., & Hess, J. L. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00195-09 · Cited by 140

TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA

Machwe, A., Xiao, L., & Orren, D. K. (2004) · Oncogene · doi:10.1038/sj.onc.1206906 · Cited by 130

Telomere Loop Dynamics in Chromosome End Protection

Ly, D. V., Low, R. R. J., Frölich, S., Bartolec, T. K., Kafer, G. R., Pickett, H. A., Gaus, K., & Cesare, A. J. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.06.025 · Cited by 134

Functional interaction between DNA‐PKcs and telomerase in telomere length maintenance

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Impaired hematopoietic stem cell functioning after serial transplantation and during normal aging

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Comparisons of telomere lengths in peripheral blood and cerebellum in Alzheimer's disease

Lukens, J. N., Deerlin, V. M. V., Clark, C. M., Xie, S. X., & Johnson, F. B. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.05.666 · Cited by 130

Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and aging

Zhang, H. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20919 · Cited by 136

Molecular signature of oncogenic ras-induced senescence

Mason, D. X., Jackson, T. J., & Lin, A. W. (2004) · Oncogene · doi:10.1038/sj.onc.1208172 · Cited by 127

Mechanisms of chromosome instability in cancers

Jefford, C. E., & Irminger‐Finger, I. (2006) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2006.02.005 · Cited by 129

PARP1 Is a TRF2-associated Poly(ADP-Ribose)Polymerase and Protects Eroded Telomeres

Gomez, M., Wu, J., Schreiber, V., Dunlap, J. R., Dantzer, F., Wang, Y., & Liu, Y. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0672 · Cited by 125

Senolytics for Cancer Therapy: Is All that Glitters Really Gold?

Carpenter, V. J., Saleh, T., & Gewirtz, D. A. (2021) · Cancers · doi:10.3390/cancers13040723 · Cited by 124

TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres

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Telomere Position Effect and Silencing of Transgenes near Telomeres in the Mouse

Pedram, M., Sprung, C. N., Gao, Q., Lo, A. W. I., Reynolds, G. E., & Murnane, J. P. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.5.1865-1878.2006 · Cited by 134

Cell death during crisis is mediated by mitotic telomere deprotection

Hayashi, M. T., Cesare, A. J., Rivera, T., & Karlseder, J. (2015) · Nature · doi:10.1038/nature14513 · Cited by 125

Telomere Inhibition and Telomere Disruption as Processes for Drug Targeting

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Hormones and growth factors regulate telomerase activity in ageing and cancer

Bayne, S., & Liu, J. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.05.009 · Cited by 127

Human Telomere Structure and Biology

Riethman, H. C. (2008) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.8.021506.172017 · Cited by 128

The Transcriptome of Prematurely Aging Yeast Cells Is Similar to That of Telomerase-deficient Cells

Lesur, I., & Campbell, J. L. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-10-0742 · Cited by 131

Water-Soluble Ruthenium(II) Complexes with Chiral 4-(2,3-Dihydroxypropyl)-formamide Oxoaporphine (FOA): In Vitro and in Vivo Anticancer Activity by Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity, and Induction of Tumor Cell Apoptosis

Chen, Z., Qin, Q., Qin, J.-L., Zhou, J., Li, Y., Li, N., Liu, Y., & Liang, H. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00444 · Cited by 123

Telomere uncapping and alternative lengthening of telomeres

Cesare, A. J., & Reddel, R. R. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.11.006 · Cited by 125

Human Telomeres Have Different Overhang Sizes at Leading versus Lagging Strands

Chai, W., Du, Q., Shay, J. W., & Wright, W. E. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.12.004 · Cited by 119

Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: assessing the health of the endothelium

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Binding of berberine to human telomeric quadruplex – spectroscopic, calorimetric and molecular modeling studies

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Nitric oxide and endothelial cellular senescence

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Telomerase and telomere length in multiple myeloma: correlations with disease heterogeneity, cytogenetic status, and overall survival

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Telomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeats

Ohki, R. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh309 · Cited by 114

Telomeres, Telomerase and Ageing

Saretzki, G. C. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-2835-0_9 · Cited by 120

Telomerase activity in the subventricular zone of adult mice

Caporaso, G. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00103-9 · Cited by 113

TRF2 promotes, remodels and protects telomeric Holliday junctions

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Importance of TRF1 for Functional Telomere Structure

Iwano, T., Tachibana, M., Reth, M. G., & Shinkai, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309138200 · Cited by 115

A three-state model of telomere control over human proliferative boundaries

Cesare, A. J., & Karlseder, J. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.08.007 · Cited by 106

Telomere Dysfunction Drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome

Colla, S., Ong, D. S. T., Ogoti, Y., Marchesini, M., Mistry, N. A., Clise-Dwyer, K., Ang, S. A., Storti, P., Viale, A., Giuliani, N., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.007 · Cited by 105

FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping

Wang, L., Chen, R., Li, G., Wang, Z., Liu, J., Liang, Y., & Liu, J. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.004 · Cited by 112

Measuring vertebrate telomeres: applications and limitations

Nakagawa, S., Gemmell, N. J., & Burke, T. A. (2004) · Molecular Ecology · doi:10.1111/j.1365-294x.2004.02291.x · Cited by 116

Telomere attrition: metabolic regulation and signalling function?

Casagrande, S., & Hau, M. (2019) · Biology Letters · doi:10.1098/rsbl.2018.0885 · Cited by 115

Regulation of Telomere Length and Suppression of Genomic Instability in Human Somatic Cells by Ku86

Myung, K., Ghosh, G., Fattah, F. J., Li, G., Kim, H., Dutia, A., Pak, E. D., Smith, S. N., & Hendrickson, E. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.11.5050-5059.2004 · Cited by 113

Mice Deficient in Telomerase Activity Develop Hypertension Because of an Excess of Endothelin Production

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A balance between elongation and trimming regulates telomere stability in stem cells

Rivera, T., Haggblom, C., Cosconati, S., & Karlseder, J. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3335 · Cited by 108

Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress

Rubio, M. Á., Davalos, A. R., & Campisi, J. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.04.004 · Cited by 105

Telomere looping in P. sativum (common garden pea)

Cesare, A. J., Quinney, N. L., Willcox, S., Subramanian, D., & Griffith, J. D. (2003) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01882.x · Cited by 110

Telomeres in aging and disease: lessons from zebrafish

Carneiro, M. C., de Castro, I. P., & Ferreira, M. G. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.025130 · Cited by 109

Treating Cancer by Targeting Telomeres and Telomerase

Ivancich, M., Schrank, Z., Wojdyla, L. M., Leviskas, B., Kuckovic, A., Sanjali, A., & Puri, N. (2017) · Antioxidants · doi:10.3390/antiox6010015 · Cited by 109

Nicotinamide extends replicative lifespan of human cells

Kang, H. T., Lee, H. I., & Hwang, E. S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00234.x · Cited by 105

Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence

Fujita, K., Horikawa, I., Mondal, A. M., Jenkins, L. M. M., Appella, E., Vojtěšek, B., Bourdon, J., Lane, D. P., & Harris, C. C. (2010) · Nature Cell Biology · doi:10.1038/ncb2123 · Cited by 111

DNA damage responses in neural cells: Focus on the telomere

Zhang, P., Dilley, C. M., & Mattson, M. P. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.052 · Cited by 106

Smurf2 up-regulation activates telomere-dependent senescence

Zhang, H., & Cohen, S. N. (2004) · Genes & Development · doi:10.1101/gad.1253004 · Cited by 100

Telomere Shortening and Cellular Senescence in a Model of Chronic Renal Allograft Rejection

Joosten, S. A., van Ham, V., Nolan, C. E., Borrias, M. C., Jardine, A. G., Shiels, P. G., van Kooten, C., & Paul, L. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63926-0 · Cited by 101

Chromosome instability in cancer: how, when, and why?

Gisselsson, D. (2003) · Advances in cancer research · doi:10.1016/s0065-230x(03)87164-6 · Cited by 102

The 4q subtelomere harboring the FSHD locus is specifically anchored with peripheral heterochromatin unlike most human telomeres

Tam, R., Smith, K. P., & Lawrence, J. B. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403128 · Cited by 101

Apoptosis, necrosis and cellular senescence: chaperone occupancy as a potential switch

Sőti, C., Sreedhar, A. S., & Csermely, P. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00031.x · Cited by 101

Telomere recombination requires the MUS81 endonuclease

Zeng, S., Xiang, T., Pandita, T. K., González-Suárez, I., Gonzalo, S., Harris, C. C., & Yang, Q. (2009) · Nature Cell Biology · doi:10.1038/ncb1867 · Cited by 99

Telomere‐associated proteins: cross‐talk between telomere maintenance and telomere‐lengthening mechanisms

Boeck, G. D., Forsyth, R. G., Praet, M. M., & Hogendoorn, P. C. W. (2008) · The Journal of Pathology · doi:10.1002/path.2500 · Cited by 102

Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells

Zhou, G., Liu, X., Li, Y., Xu, S., Ma, C., Wu, X., Cheng, Y., Yu, Z., Zhao, G., & Chen, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.7483 · Cited by 107

Divergent patterns of telomere maintenance mechanisms among human sarcomas: Sharply contrasting prevalence of the alternative lengthening of telomeres mechanism in Ewing's sarcomas and osteosarcomas

Ulaner, G. A., Hoffman, A. R., Otero, J. E., Huang, H., Zhao, Z., Mazumdar, M., Gorlick, R. G., Meyers, P. A., Healey, J. H., & Ladanyi, M. (2004) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20074 · Cited by 99

Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length

Hapangama, D. K., Turner, M. A., Drury, J. A., Quenby, S. M., Saretzki, G. C., Martin-Ruiz, C. M., & von Zglinicki, T. (2008) · Human Reproduction · doi:10.1093/humrep/den172 · Cited by 98

New developments in telomere length analysis

Baird, D. M. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.02.008 · Cited by 99

The shortest telomeres drive karyotype evolution in transformed cells

Der‐Sarkissian, H., Bacchetti, S., Cazes, L., & Londoño‐Vallejo, A. (2004) · Oncogene · doi:10.1038/sj.onc.1207152 · Cited by 97

Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey

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Ets2 binding site single nucleotide polymorphism at the hTERT gene promoter – effect on telomerase expression and telomere length maintenance in non-small cell lung cancer

Hsu, C., Hsu, N.-Y., Lee, L., & Ko, J. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.02.014 · Cited by 93

Telomerase: regulation, function and transformation

Dong, C. K., Masutomi, K., & Hahn, W. C. (2005) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2004.12.005 · Cited by 96

Functional Subdomain in the Ankyrin Domain of Tankyrase 1 Required for Poly(ADP-Ribosyl)ation of TRF1 and Telomere Elongation

Seimiya, H., Muramatsu, Y., Smith, S. H., & Tsuruo, T. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.1944-1955.2004 · Cited by 95

Telomeres and telomerase as targets for anticancer drug development

Olaussen, K. A., Dubrana, K., Dômont, J., Spano, J., Sabatier, L., & Soria, J. (2006) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2005.08.007 · Cited by 96

Pathways and functions of the Werner syndrome protein

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Two retrotransposons maintain telomeres in Drosophila

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Fission yeast Ccq1 is telomerase recruiter and local checkpoint controllerPreprint

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