Senescence Induced by Altered Telomere State, Not Telomere Loss

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Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

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Untitled work

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TRF2 Protects Human Telomeres from End-to-End Fusions

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Long G Tails at Both Ends of Human Chromosomes Suggest a C Strand Degradation Mechanism for Telomere Shortening

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p16INK4a as a Second Effector of the Telomere Damage Pathway

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Werner Protein Protects Nonproliferating Cells from Oxidative DNA Damage

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Telomeres: Implications for Cancer Development

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Regulation of the Extrinsic Apoptotic Pathway by the Extracellular Matrix Glycoprotein EMILIN2

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A novel pseudoknot element is essential for the action of a yeast telomerasePreprint

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Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases

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Trypanosome Telomeres Are Protected by a Homologue of Mammalian TRF2

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TRF2 binds branched DNA to safeguard telomere integrity

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Contribution of p16INK4a to replicative senescence of human fibroblasts

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Immortalization and Transformation of Human Cells

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A New Steroid Derivative Stabilizes G-Quadruplexes and Induces Telomere Uncapping in Human Tumor Cells

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Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T‐cell leukemia

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The Ras/Raf-1/MEK1/ERK Signaling Pathway Coupled to Integrin Expression Mediates Cholinergic Regulation of Keratinocyte Directional Migration

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Targeting G-quadruplex nucleic acids with heterocyclic alkaloids and their derivatives

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Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles

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Saturated fatty acid metabolism is key link between cell division, cancer, and senescence in cellular and whole organism aging

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Arginine Methylation Regulates Telomere Length and Stability

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Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions

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Telomere‐based DNA damage responses: a new approach to melanoma

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Telomerase inhibition, telomere shortening, cell growth suppression and induction of apoptosis by telomestatin in childhood neuroblastoma cells

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Mechanisms Underlying Recurrent Genomic Amplification in Human Cancers

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High resolution long-read telomere sequencing reveals dynamic mechanisms in aging and cancer

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Bone Marrow-Derived Cells: The Influence of Aging and Cellular Senescence

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Aging of stromal-derived human breast fibroblasts might contribute to breast cancer progression

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Telomeres, Nutrition, and Longevity: Can We Really Navigate Our Aging?

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Knockdown of HNRNPA1 inhibits lung adenocarcinoma cell proliferation through cell cycle arrest at G0/G1 phase

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The BUB3-BUB1 Complex Promotes Telomere DNA Replication

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RecQ helicases in DNA double strand break repair and telomere maintenance

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Post-translational modifications of TRF1 and TRF2 and their roles in telomere maintenance

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Telomere Protection Mechanisms Change during Neurogenesis and Neuronal Maturation: Newly Generated Neurons Are Hypersensitive to Telomere and DNA Damage

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Recent Advances in Stem Cell Neurobiology

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Aging of progenitor cells: limitation for regenerative capacity?**Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.

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Antitumor Polycyclic Acridines. 20. Search for DNA Quadruplex Binding Selectivity in a Series of 8,13-Dimethylquino[4,3,2-kl]acridinium Salts: Telomere- Targeted Agents

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Telomere ResQue and preservation—Roles for the Werner syndrome protein and other RecQ helicases

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The Role of the Poly(ADP-ribose) Polymerase Tankyrase1 in Telomere Length Control by the TRF1 Component of the Shelterin Complex

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Telomerase and tumorigenesis

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Up-regulation of leucocytes genes implicated in telomere dysfunction and cellular senescence correlates with depression and anxiety severity scores

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WRN Controls Formation of Extrachromosomal Telomeric Circles and Is Required for TRF2ΔB-Mediated Telomere Shortening

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Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres

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Regulators and Effectors of Siah Ubiquitin Ligases

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Tankyrase, a positive regulator of telomere elongation, is over expressed in human breast cancer

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Short Telomeres in Hatchling Snakes: Erythrocyte Telomere Dynamics and Longevity in Tropical Pythons

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Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA

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Telomerase expression in lung preneoplasia and neoplasia

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Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy

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Telomerase Maintains Telomere Structure in Normal Human Cells

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Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex

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Telomeres and the DNA damage response: why the fox is guarding the henhouse

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Telomere content correlates with stage and prognosis in breast cancer

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Molecular Aspects of Senescence and Organismal Ageing—DNA Damage Response, Telomeres, Inflammation and Chromatin

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Uncoupling of Longevity and Telomere Length in C. elegans

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Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.

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Replicative senescence and the art of counting

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Telomere Gap Between Granulocytes and Lymphocytes Is a Determinant for Hematopoetic Progenitor Cell Impairment in Patients With Previous Myocardial Infarction

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Growth, telomere dynamics and successful and unsuccessful human aging

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TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells

Biroccio, A., Rizzo, A., Elli, R., Koering, C.-E., Belleville, A., Benassi, B., Leonetti, C., Stevens, M. F. G., D’Incalci, M., Zupi, G., et al. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.03.010 · Cited by 76

Telomeres and chromosomal instability

Mathieu, N., Pirzio, L. M., Freulet-Marrière, M.-A., Desmaze, C., & Sabatier, L. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3296-0 · Cited by 69

Telomeres and Cancer: Resolving the Paradox

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Cellular Senescence in Idiopathic Pulmonary Fibrosis

Kellogg, D. L., Kellogg, D. L., Musi, N., & Nambiar, A. M. (2021) · Current Molecular Biology Reports · doi:10.1007/s40610-021-00145-4 · Cited by 67

Curcumol Suppresses CCF-Mediated Hepatocyte Senescence Through Blocking LC3B–Lamin B1 Interaction in Alcoholic Fatty Liver Disease

Qi, X., Zheng, S., Ma, M., Lian, N., Wang, H., Chen, L., Song, A., Lu, C., Zheng, S., & Jin, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.912825 · Cited by 65

A role for WRN in telomere-based DNA damage responses

Eller, M. S., Liao, X., Liu, S., Hanna, K., Bäckvall, H., Opresko, P. L., Bohr, V. A., & Gilchrest, B. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607332103 · Cited by 65

Induction of premature senescence in human lung cancer by fungal immunomodulatory protein from Ganoderma tsugae

Liao, C.-H., Hsiao, Y., Lin, C., Yeh, C.-S., Wang, J. C., Ni, C.-H., Hsu, C., & Ko, J. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.01.044 · Cited by 64

Oxidation in the nucleotide pool, the DNA damage response and cellular senescence: Defective bricks build a defective house

Rai, P. (2010) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2010.07.010 · Cited by 66

The Mre11 Complex and the Response to Dysfunctional Telomeres

Attwooll, C. L., Akpınar, M., & Petrini, J. H. J. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00479-09 · Cited by 66

Endothelial Progenitor Cells Dysfunction and Senescence: Contribution to Oxidative Stress

Imanishi, T., Tsujioka, H., & Akasaka, T. (2008) · Current Cardiology Reviews · doi:10.2174/157340308786349435 · Cited by 65

Catalytic Metallodrugs: Substrate‐Selective Metal Catalysts as Therapeutics

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LINE-1 induces hTERT and ensures telomere maintenance in tumour cell lines

Aschacher, T., Wolf, B., Enzmann, F., Kienzl, P., Meßner, B., Sampl, S., Svoboda, M., Mechtcheriakova, D., Holzmann, K., & Bergmann, M. M. (2015) · Oncogene · doi:10.1038/onc.2015.65 · Cited by 66

Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis

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The role of telomeres and telomerase in the pathology of human cancer and aging

Shin, J., Hong, A., Solomon, M. J., & Lee, C. S. (2006) · Pathology · doi:10.1080/00313020600580468 · Cited by 66

Quantitative theory of telomere length regulation and cellular senescence

Rodriguez-Brenes, I. A., & Peskin, C. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914502107 · Cited by 62

Telomeres and telomerase as targets for cancer therapy

Zimmermann, S., & Martens, U. M. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6481-8 · Cited by 63

Neomycin-capped aromatic platforms: quadruplex DNA recognition and telomerase inhibition

Kaiser, M., Cian, A. D., Sainlos, M., Renner, C., Mergny, J., & Teulade‐Fichou, M. (2006) · Organic & Biomolecular Chemistry · doi:10.1039/b516378a · Cited by 63

Cellular Memory and Hematopoietic Stem Cell Aging

Kamminga, L. M., & de Haan, G. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0345 · Cited by 63

Telomere Repeat Binding Factor 2 Interacts with Base Excision Repair Proteins and Stimulates DNA Synthesis by DNA Polymerase β

Müftüoğlu, M., Wong, H. K., Imam, S. Z., Wilson, D. M., Bohr, V. A., & Opresko, P. L. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2742 · Cited by 66

The Protein Network Surrounding the Human Telomere Repeat Binding Factors TRF1, TRF2, and POT1

Giannone, R. J., McDonald, W. H., Hurst, G. B., Shen, R., Wang, Y., & Liu, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012407 · Cited by 64

Distinct Roles of TRF1 in the Regulation of Telomere Structure and Lengthening

Okamoto, K., Iwano, T., Tachibana, M., & Shinkai, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802395200 · Cited by 63

Oligonucleotide Models of Telomeric DNA and RNA Form a Hybrid G-quadruplex Structure as a Potential Component of Telomeres

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Evidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence

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Telomere dysfunction and activation of alternative lengthening of telomeres in B-lymphocytes infected by Epstein–Barr virus

Kamranvar, S. A., Chen, X., & Masucci, M. G. (2013) · Oncogene · doi:10.1038/onc.2013.189 · Cited by 61

Telomere dysfunction and genome instability

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