Cited by 73Telomeres, Telomerase, and SenescenceStress Responses and CortisolGenetics, Aging, and Longevity in Model Organisms

Up-regulation of leucocytes genes implicated in telomere dysfunction and cellular senescence correlates with depression and anxiety severity scores

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Teyssier, Jean-Raymond, Chauvet-Gelinier, Jean-Christophe, Ragot, Sylviane, Bonin, Bernard·2012·PLoS ONE

Abstract

BACKGROUND: Major depressive disorder (MDD) is frequently associated with chronic medical illness responsible of increased disability and mortality. Inflammation and oxidative stress are considered to be the major mediators of the allostatic load, and has been shown to correlate with telomere erosion in the leucocytes of MDD patients, leading to the model of accelerated aging. However, the significance of telomere length as an exclusive biomarker of aging has been questioned on both methodological and biological grounds. Furthermore, telomeres significantly shorten only in patients with long lasting MDD. Sensitive and dynamic functional biomarkers of aging would be clinically useful to evaluate the somatic impact of MDD. METHODOLOGY: To address this issue we have measured in the blood leucocytes of MDD patients (N=17) and controls (N=16) the expression of two genes identified as robust biomarkers of human aging and telomere dysfunction: p16(INK4a) and STMN1. We have also quantified the transcripts of genes involved in the repair of oxidative DNA damage at telomeres (OGG1), telomere regulation and elongation (TERT), and in the response to biopsychological stress (FOS and DUSP1). RESULTS: The OGG1, p16(INK4a), and STMN1 gene were significantly up-regulated (25 to 100%) in the leucocytes of MDD patients. Expression of p16(INK4a) and STMN1 was directly correlated with anxiety scores in the depression group, and that of p16(INK4a), STMN and TERT with the depression and anxiety scores in the combined sample (MDD plus controls). Furthermore, we identified a unique correlative pattern of gene expression in the leucocytes of MDD subjects. CONCLUSIONS: Expression of p16(INK4) and STMN1 is a promising biomarker for future epidemiological assessment of the somatic impact of depressive and anxious symptoms, at both clinical and subclinical level in both depressive patients and general population.

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  • Teyssier et al. (2012) found no significant difference in LTL between subjects with MDD and controls, but did find increased expression of p16INK4a and STMN1 genes in the depressed sample.

    “Despite finding no difference in mean LTL, however, the latter study did find increased expression of p16INK4a and stathmin (STMN1) genes in the depressed sample, which are markers of cellular senescence, telomere dysfunction, microtubule dynamics and biological aging, and are regulators of cell cycle dynamics (Teyssier et al., 2012).”

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Authors
Teyssier, J.-R., Chauvet-Gelinier, J.-C., Ragot, S., & Bonin, B.
Affiliations
  • Université de Bourgogne (FR)
  • CHU Dijon Bourgogne (FR)
Corresponding author
Teyssier, Jean-Raymond
Venue
PLoS ONE
Published
2012-11-21
Volume
7
Issue
11
Pages
e49677
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2057065562
Cited by
73
References
67
Citations by year
2026: 4 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 10 · 2018: 5 · 2017: 2 · 2016: 8 · 2015: 10 · 2014: 8 · 2013: 4
FWCI
4.72
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
major depressive disorder, anxiety, telomere dysfunction, cellular senescence, accelerated aging, p16INK4a, STMN1, OGG1, telomerase reverse transcriptase, leukocyte gene expression, aging biomarkers, oxidative DNA damage, inflammation, allostatic load, FOS, MKP-1
MeSH terms
Adult, Aging, Anxiety, Depression, Major Depressive Disorder, DNA, DNA Damage, Female, Gene Expression Regulation, Humans, Leukocytes, Middle Aged, Oxygen, Biomarkers, Up-Regulation, Telomere, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Stathmin

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