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Dynamics of Thymocyte-Stromal Cell Interactions Visualized by Two-Photon Microscopy
Abstract
Thymocytes are selected to mature according to their ability to interact with self major histocompatibility complex (MHC)–peptide complexes displayed on the thymic stroma. Using two-photon microscopy, we performed real-time analysis of the cellular contacts made by developing thymocytes undergoing positive selection in a three-dimensional thymic organ culture. A large fraction of thymocytes within these cultures were highly motile. MHC recognition was found to increase the duration of thymocyte–stromal cell interactions and occurred as both long-lived cellular associations displaying stable cell-cell contacts and as shorter, highly dynamic contacts. Our results identify the diversity and dynamics of thymocyte interactions during positive selection.
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Citations
Cited by
Positive and negative selection of T cells
Starr, T. K., Jameson, S. C., & Hogquist, K. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141107 · Cited by 1,601
Tuning immune responses: diversity and adaptation of the immunological synapse
Friedl, P., den Boer, A. T., & Gunzer, M. (2005) · Nature Reviews Immunology · doi:10.1038/nri1647 · Cited by 276
Mathis, D., & Benoist, C. (2004) · Immunity · doi:10.1016/s1074-7613(04)00111-6 · Cited by 198
A stochastic view of lymphocyte motility and trafficking within the lymph node
Wei, S. H., Parker, I., Miller, M. J., & Cahalan, M. D. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00076.x · Cited by 117
Metadata
- Authors
- Bousso, P., Bhakta, N. R., Lewis, R. S., & Robey, E.
- Venue
- Science
- Published
- 2002-06-07
- Volume
- 296
- Issue
- 5574
- Pages
- 1876-1880
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2041516651
- Cited by
- 286
- References
- 0
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- closed
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