The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Critical Role for STAT4 Activation by Type 1 Interferons in the Interferon-γ Response to Viral Infection
Abstract
Interferons (IFNs) are essential for host defense. Although the antiviral effects of the type 1 IFNs IFN-α and IFN-β (IFN-α/β) have been established, their immunoregulatory functions, especially their ability to regulate IFN-γ production, are poorly understood. Here we show that IFN-α/β activate STAT4 directly (STAT, signal transducers and activators of transcription) and that this is required for IFN-γ production during viral infections of mice, in concert with T cell receptor–derived signals. In contrast, STAT1 appears to negatively regulate IFN-α/β induction of IFN-γ. Thus, type 1 IFNs, in addition to interleukin-12, provide pathways for innate regulation of adaptive immunity, and their immunoregulatory functions are controlled by modulating the activity of individual STATs.
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NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines
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Self-citationT-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells
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Self-citationMassive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection
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Self-citationSignaling and Transcription in T Helper Development
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Self-citationBiologic consequences of Stat1-independent IFN signaling
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Cited by
Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906
Type I interferons in infectious disease
McNab, F., Mayer-Barber, K., Sher, A., Wack, A., & O'Garra, A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3787 · Cited by 2,780
Interferons, interferon‐like cytokines, and their receptors
Pestka, S., Krause, C. D., & Walter, M. R. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00204.x · Cited by 1,766
Transcriptional control of effector and memory CD8+ T cell differentiation
Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology · doi:10.1038/nri3307 · Cited by 1,628
Mechanisms and consequences of Jak–STAT signaling in the immune system
Villarino, A. V., Kanno, Y., & O'Shea, J. J. (2017) · Nature Immunology · doi:10.1038/ni.3691 · Cited by 1,221
Self-citation
Metadata
- Authors
- Nguyen, K. B., Watford, W. T., Salomon, R., Hofmann, S. R., Pien, G. C., Morinobu, A., Gadina, M., O'Shea, J. J., & Biron, C. A.
- Venue
- Science
- Published
- 2002-09-20
- Volume
- 297
- Issue
- 5589
- Pages
- 2063-2066
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1997691172
- Cited by
- 494
- References
- 27
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nguyen, K. B., Watford, W. T., Salomon, R., Hofmann, S. R., Pien, G. C., Morinobu, A., Gadina, M., O'Shea, J. J., & Biron, C. A. (2002). Critical Role for STAT4 Activation by Type 1 Interferons in the Interferon-γ Response to Viral Infection. Science. https://doi.org/10.1126/science.1074900
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