The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Diminished Pupillary Light Reflex at High Irradiances in Melanopsin-Knockout Mice
Abstract
In the mammalian retina, a small subset of retinal ganglion cells (RGCs) are intrinsically photosensitive, express the opsin-like protein melanopsin, and project to brain nuclei involved in non–image-forming visual functions such as pupillary light reflex and circadian photoentrainment. We report that in mice with the melanopsin gene ablated, RGCs retrograde-labeled from the suprachiasmatic nuclei were no longer intrinsically photosensitive, although their number, morphology, and projections were unchanged. These animals showed a pupillary light reflex indistinguishable from that of the wild type at low irradiances, but at high irradiances the reflex was incomplete, a pattern that suggests that the melanopsin-associated system and the classical rod/cone system are complementary in function.
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Citations
Cites
Phototransduction by retinal ganglion cells that set the circadian clock
Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629
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Cited by
Dacey, D. M., Liao, H.-W., Peterson, B. B., Robinson, F. R., Smith, V. C., Pokorny, J., Yau, K.-W., & Gamlin, P. D. (2005) · Nature · doi:10.1038/nature03387 · Cited by 1,333
Self-citationMeasuring and using light in the melanopsin age
Lucas, R. J., Peirson, S. N., Berson, D. M., Brown, T. M., Cooper, H. M., Czeisler, C. A., Figueiro, M. G., Gamlin, P. D., Lockley, S. W., O’Hagan, J. B., et al. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2013.10.004 · Cited by 1,278
Self-citationHattar, S., Lucas, R. J., Mrosovsky, N., Thompson, S., Douglas, R. H., Hankins, M. W., Lem, J., Biel, M., Hofmann, F., Foster, R. G., et al. (2003) · Nature · doi:10.1038/nature01761 · Cited by 1,245
Self-citationLight as a central modulator of circadian rhythms, sleep and affect
LeGates, T. A., Fernandez, D. C., & Hattar, S. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3743 · Cited by 1,001
Self-citationCentral projections of melanopsin‐expressing retinal ganglion cells in the mouse
Hattar, S., Kumar, M., Park, A., Tong, P., Tung, J., Yau, K., & Berson, D. M. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.20970 · Cited by 996
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Metadata
- Authors
- Lucas, R. J., Hattar, S., Takao, M., Berson, D. M., Foster, R. G., & Yau, K.-W.
- Venue
- Science
- Published
- 2003-01-10
- Volume
- 299
- Issue
- 5604
- Pages
- 245-247
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2056888759
- Cited by
- 832
- References
- 1
- FWCI
- 13.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lucas, R. J., Hattar, S., Takao, M., Berson, D. M., Foster, R. G., & Yau, K.-W. (2003). Diminished Pupillary Light Reflex at High Irradiances in Melanopsin-Knockout Mice. Science. https://doi.org/10.1126/science.1077293
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