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Modulation of ATP-Dependent Chromatin-Remodeling Complexes by Inositol Polyphosphates
Abstract
Eukaryotes use adenosine triphosphate (ATP)–dependent chromatin-remodeling complexes to regulate gene expression. Here, we show that inositol polyphosphates can modulate the activities of several chromatin-remodeling complexes in vitro. Inositol hexakisphosphate (IP 6 ) inhibits nucleosome mobilization by NURF, ISW2, and INO80 complexes. In contrast, nucleosome mobilization by the yeast SWI/SNF complex is stimulated by inositol tetrakisphosphate (IP 4 ) and inositol pentakisphosphate (IP 5 ). We demonstrate that mutations in genes encoding inositol polyphosphate kinases that produce IP 4 , IP 5 , and IP 6 impair transcription in vivo. These results provide a link between inositol polyphosphates, chromatin remodeling, and gene expression.
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“Several further studies have supported the importance of Arg82 kinase activity in transcriptional regulation and chromatin remodelling 37-39, together suggesting that Ins(1,4,5,6)P4 has an important regulatory role in yeast.”
From Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate (2012) · cites this paper as [39]
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Self-citation
Metadata
- Authors
- Shen, X., Xiao, H., Ranallo, R., Wu, W.-H., & Wu, C.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Shen, Xuetong
- Wu, Carl
- Venue
- Science
- Published
- 2003-01-03
- Volume
- 299
- Issue
- 5603
- Pages
- 112-114
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994473838
- Cited by
- 338
- References
- 28
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 10 · 2019: 7 · 2018: 7 · 2017: 9 · 2016: 14 · 2015: 14 · 2014: 10 · 2013: 13 · 2012: 31
- FWCI
- 11.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- inositol polyphosphates, chromatin remodeling, phytic acid, inositol tetrakisphosphate, inositol pentakisphosphate, INO80 complex, SWI/SNF complex, inositol polyphosphate kinase, transcriptional regulation, gene expression regulation
- MeSH terms
- Adenosine Triphosphatases, Adenosine Triphosphate, Chromatin, DNA-Binding Proteins, Inositol Phosphates, Myo-Inositol-1-Phosphate Synthase, Nuclear Proteins, Nucleosomes, Phytic Acid, Recombinant Proteins, RNA, Messenger, Transcription Factors, Yeasts, Signal Transduction, Gene Expression Regulation, Fungal
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