The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
EDEM As an Acceptor of Terminally Misfolded Glycoproteins Released from Calnexin
Abstract
Terminally misfolded proteins in the endoplasmic reticulum (ER) are retrotranslocated to the cytoplasm and degraded by proteasomes through a mechanism known as ER-associated degradation (ERAD). EDEM, a postulated Man8B-binding protein, accelerates the degradation of misfolded proteins in the ER. Here, EDEM was shown to interact with calnexin, but not with calreticulin, through its transmembrane region. Both binding of substrates to calnexin and their release from calnexin were required for ERAD to occur. Overexpression of EDEM accelerated ERAD by promoting the release of terminally misfolded proteins from calnexin. Thus, EDEM appeared to function in the ERAD pathway by accepting substrates from calnexin.
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Cites
Intracellular Functions of N-Linked Glycans
Helenius, A., & Aebi, A. M. (2001) · Science · doi:10.1126/science.291.5512.2364 · Cited by 2,405
Jakob, C. A., Burda, P., Roth, J., & Aebi, M. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.5.1223 · Cited by 338
Dissecting glycoprotein quality control in the secretory pathway
Cabral, C. M., Liu, Y., & Sifers, R. N. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01942-9 · Cited by 230
Cited by
One step at a time: endoplasmic reticulum-associated degradation
Vembar, S. S., & Brodsky, J. L. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2546 · Cited by 1,299
Yoshida, H. (2007) · The FEBS Journal · doi:10.1111/j.1742-4658.2007.05639.x · Cited by 1,086
Protein quality control in the early secretory pathway
Anelli, T., & Sitia, R. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601974 · Cited by 623
OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD
Christianson, J. C., Shaler, T. A., Tyler, R. E., & Kopito, R. R. (2008) · Nature Cell Biology · doi:10.1038/ncb1689 · Cited by 509
Protein translocation across biological membranes
Wickner, W., & Schekman, R. (2005) · Science · doi:10.1126/science.1113752 · Cited by 458
Metadata
- Authors
- Oda, Y., Hosokawa, N., Wada, I., & Nagata, K.
- Venue
- Science
- Published
- 2003-02-28
- Volume
- 299
- Issue
- 5611
- Pages
- 1394-1397
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1984672567
- Cited by
- 453
- References
- 3
- FWCI
- 15.86
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
