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Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins

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Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease

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Amyloid pores from pathogenic mutations

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Nucleated conformational conversion and the replication of conformational information by a prion determinant.

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Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons

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Fibrils Formed in Vitro from α-Synuclein and Two Mutant Forms Linked to Parkinson's Disease are Typical Amyloid

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Water-soluble Aβ(N-40, N-42) oligomers in normal and Alzheimer disease brains

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Assembly of Aβ Amyloid Protofibrils: An in Vitro Model for a Possible Early Event in Alzheimer's Disease

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The complement cascade: Yin-Yang in neuroinflammation—neuro-protection and -degeneration

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Membrane interaction of islet amyloid polypeptide

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Baicalein Inhibits Formation of α‐Synuclein Oligomers within Living Cells and Prevents Aβ Peptide Fibrillation and Oligomerisation

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GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals

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Single-channel Ca2+ imaging implicates Aβ1–42 amyloid pores in Alzheimer’s disease pathology

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Islet Amyloid Polypeptide Inserts into Phospholipid Monolayers as Monomer

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Microbial amyloids – functions and interactions within the host

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Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases

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Protein aggregation and neurodegenerative diseases: From theory to therapy

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Structural, morphological, and functional diversity of amyloid oligomers

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We find them here, we find them there: Functional bacterial amyloid

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Isolation and Characterization of Patient-derived, Toxic, High Mass Amyloid β-Protein (Aβ) Assembly from Alzheimer Disease Brains

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The Amyloid Phenomenon and Its Significance in Biology and MedicinePreprint

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Atg7 Induces Basal Autophagy and Rescues Autophagic Deficiency in CryAB R120G Cardiomyocytes

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Rapid Self-assembly of α-Synuclein Observed by In Situ Atomic Force Microscopy

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Chaperone-dependent amyloid assembly protects cells from prion toxicity

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α-Synuclein Reactive Antibodies as Diagnostic Biomarkers in Blood Sera of Parkinson's Disease Patients

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Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons

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Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease

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How Do Membranes Initiate Alzheimer’s Disease? Formation of Toxic Amyloid Fibrils by the Amyloid β-Protein on Ganglioside Clusters

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Machado–Joseph disease/spinocerebellar ataxia type 3

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Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity

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A High-Throughput Screen for Compounds That Inhibit Aggregation of the Alzheimer’s Peptide

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C1q-induced LRP1B and GPR6 Proteins Expressed Early in Alzheimer Disease Mouse Models, Are Essential for the C1q-mediated Protection against Amyloid-β Neurotoxicity

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Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's disease‐linked APPswe/PS1ΔE9 mice

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A spoonful of sugar: the application of glycopolymers in therapeutics

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MEK Guards Proteome Stability and Inhibits Tumor-Suppressive Amyloidogenesis via HSF1

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The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?

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Tau Oligomers: The Toxic Player at Synapses in Alzheimer’s Disease

Guerrero-Muñoz, M. J., Gerson, J., & Castillo-Carranza, D. L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00464 · Cited by 168

A polymer physics perspective on driving forces and mechanisms for protein aggregation

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Methionine oxidation, α-synuclein and Parkinson's disease

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Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity

Matlack, K. E. S., Tardiff, D. F., Narayan, P. S., Hamamichi, S., Caldwell, K. A., Caldwell, G. A., & Lindquist, S. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402228111 · Cited by 166

Residues 17–20 and 30–35 of beta‐amyloid play critical roles in aggregation

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Aβ42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in Drosophila

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Designing Peptide Inhibitors for Oligomerization and Toxicity of Alzheimer's β-Amyloid Peptide

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Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer’s disease

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Conformation‐Dependent Anti‐Amyloid Oligomer Antibodies

Kayed, R., & Glabe, C. G. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)13017-7 · Cited by 167

Inhibition of human IAPP fibril formation does not prevent β-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP

Meier, J. J., Kayed, R., Lin, C., Gurlo, T., Haataja, L., Jayasinghe, S. A., Langen, R., Glabe, C. G., & Butler, P. C. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00082.2006 · Cited by 166

Protein misfolding and aggregation in neurodegenerative diseases: a review of pathogeneses, novel detection strategies, and potential therapeutics

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ERK1/2 Activation Mediates Aβ Oligomer-induced Neurotoxicity via Caspase-3 Activation and Tau Cleavage in Rat Organotypic Hippocampal Slice Cultures

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Cytochrome c polymerization by successive domain swapping at the C-terminal helix

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The Two-stage Pathway of Ataxin-3 Fibrillogenesis Involves a Polyglutamine-independent Step

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Selective Neuronal Degeneration in Huntington's Disease

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Dynamics of α‐synuclein aggregation and inhibition of pore‐like oligomer development by β‐synuclein

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Mitochondrial membrane permeabilisation by amyloid aggregates and protection by polyphenols

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Development of a Proteolytically Stable Retro-Inverso Peptide Inhibitor of β-Amyloid Oligomerization as a Potential Novel Treatment for Alzheimer’s Disease

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Aluminum, copper, iron and zinc differentially alter amyloid-Aβ1–42 aggregation and toxicity

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Amyloid fibrils from the viewpoint of protein folding

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Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

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Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide

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Liver X Receptor Agonist Treatment Ameliorates Amyloid Pathology and Memory Deficits Caused by High-Fat Diet in APP23 Mice

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Metal Ion-dependent Effects of Clioquinol on the Fibril Growth of an Amyloid β Peptide

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A canine model of human aging and Alzheimer's disease

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Fibrillar Oligomers Nucleate the Oligomerization of Monomeric Amyloid β but Do Not Seed Fibril Formation

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Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function

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AggFluor: Fluorogenic Toolbox Enables Direct Visualization of the Multi-Step Protein Aggregation Process in Live Cells

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Immunotherapy for Alzheimer's disease

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Amyloid Fibril Formation Can Proceed from Different Conformations of a Partially Unfolded Protein

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Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes

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Aβ Oligomer-Induced Synapse Degeneration in Alzheimer’s Disease

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The elimination of accumulated and aggregated proteins: A role for aggrephagy in neurodegeneration

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Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross‐seeding behavior

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Experimental investigation of protein folding and misfolding

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Aqueous urea solution destabilizes Aβ 16–22 oligomers

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Atomic-Level Description of Amyloid β-Dimer Formation

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Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

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Estimation of Shape, Volume, and Dipole Moment of Individual Proteins Freely Transiting a Synthetic Nanopore

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Conformation-dependent antibodies target diseases of protein misfolding

Glabe, C. C. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.08.009 · Cited by 154

Kinetics of amyloid formation and membrane interaction with amyloidogenic proteins

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Tau Immunotherapy Modulates Both Pathological Tau and Upstream Amyloid Pathology in an Alzheimer's Disease Mouse Model

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Soluble and Mature Amyloid Fibrils in Drusen Deposits

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Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease

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Inflammatory Mediators Induced by Amyloid-Beta in the Retina and RPE In Vivo: Implications for Inflammasome Activation in Age-Related Macular Degeneration

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The role of molecular chaperones in human misfolding diseases

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Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases

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Cytosolic phospholipase A 2 mediates neuronal apoptosis induced by soluble oligomers of the amyloid‐β peptide

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Transformation of amyloid β(1–40) oligomers into fibrils is characterized by a major change in secondary structure

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Impact of nanoparticles on amyloid peptide and protein aggregation: a review with a focus on gold nanoparticles

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