Cited by 4,064Alzheimer's disease research and treatmentsPrion Diseases and Protein MisfoldingAmyloidosis: Diagnosis, Treatment, Outcomes

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Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

Kayed, Rakez, Head, Elizabeth, Thompson, Jennifer L., McIntire, Theresa M., Milton, Saskia C., Cotman, Carl W., Glabe, Charles G.·2003·Science

DOI 10.1126/science.1079469

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Abstract

Soluble oligomers are common to most amyloids and may represent the primary toxic species of amyloids, like the Abeta peptide in Alzheimer's disease (AD). Here we show that all of the soluble oligomers tested display a common conformation-dependent structure that is unique to soluble oligomers regardless of sequence. The in vitro toxicity of soluble oligomers is inhibited by oligomer-specific antibody. Soluble oligomers have a unique distribution in human AD brain that is distinct from fibrillar amyloid. These results indicate that different types of soluble amyloid oligomers have a common structure and suggest they share a common mechanism of toxicity.

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Authors: Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., & Glabe, C. G.
Affiliations: University of California, Irvine (US)
Corresponding author: Glabe, Charles G.
ORCID: Kayed, Rakez
Head, Elizabeth
Thompson, Jennifer L.
Cotman, Carl W.
Glabe, Charles G.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2003-04-18
Volume: 300
Issue: 5618
Pages: 486-489
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1079469
OpenAlex: W2121963977
Cited by: 4,064
References: 20
Citations by year: 2026: 74 · 2025: 87 · 2024: 100 · 2023: 106 · 2022: 114 · 2021: 135 · 2020: 155 · 2019: 177 · 2018: 184 · 2017: 190 · 2016: 172 · 2015: 217 · 2014: 215 · 2013: 209 · 2012: 244
FWCI: 99.85
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG 16573, AG 00538, P50AG016573)
National Institute of Neurological Disorders and Stroke (NS 31230, R01NS031230)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
Health Sciences › Medicine › Internal Medicine › Amyloidosis: Diagnosis, Treatment, Outcomes
Keywords: amyloid conformation, oligomeric structure, amyloid toxicity, Alzheimer's disease, amyloid-beta, amyloid fibrils, pathogenesis mechanisms
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Animals, Antibodies, Antibody Specificity, Biopolymers, Brain, Brain Chemistry, Cell Survival, Humans, Microscopy, Electron, Peptide Fragments, Protein Conformation, Rabbits, Solubility, Tumor Cells, Cultured, Amyloid beta-Peptides, Neurofibrillary Tangles, Microscopy, Confocal, Molecular Mimicry

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Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

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