Vertebrate MicroRNA Genes
Abstract
MicroRNAs (miRNAs) are an abundant class of �22-nucleotide (nt) noncoding RNAs, some of which are known to control the expression of other genes at the posttranscriptional level (1–4). We developed a computational procedure (MiRscan) to identify miRNA genes (5) and apply it here to identify most of the miRNA genes in vertebrates. MiRscan relies on the observation that the known miRNAs derive from phylogenetically conserved stem loop precursor RNAs with characteristic features. MiRscan evaluates conserved stem loops as miRNA precursors by passing a 21-nt window along each conserved stem loop, assigning a log-likelihood score
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This study validates the existence of computationally predicted miRNAs.
“and validates the existence of computationally predicted miRNAs [8]”
The estimated number of total miRNAs in vertebrates is ∼250 molecules.
“The estimated number of the total miRNAs in vertebrates is ∼250 molecules (Lim et al. 2003).”
From A microRNA array reveals extensive regulation of microRNAs during brain development (2003) · cites this paper as Lim et al. 2003
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Sempere, L. F., Freemantle, S., Pitha-Rowe, I., Moss, E., Dmitrovsky, E., & Ambros, V. (2004) · Genome Biology · doi:10.1186/gb-2004-5-3-r13 · Cited by 1,578 · see citing works
Molecular regulation of stem cell quiescence
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Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability
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“miRNAs have been identified in organisms as diverse as roundworms, flies, fish, frogs, mammals, flowering plants, mosses, and even viruses, using genetics, molecular cloning, and predictions from bioinformatics [7–16].”
BackgroundSelf-citationLondin, E., Loher, P., Telonis, A. G., Quann, K., Clark, P., Jing, Y., Hatzimichael, E., Kirino, Y., Honda, S., Lally, M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1420955112 · Cited by 404 · see citing works
miR-223: An Effective Regulator of Immune Cell Differentiation and Inflammation
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MicroRNA signature and regulatory functions in the endometrium during normal and disease states
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<i>miR‐124</i> Contributes to the functional maturity of microglia
Svahn, A. J., Giacomotto, J., Graeber, M. B., Rinkwitz, S., & Becker, T. S. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22328 · Cited by 42 · see citing works
- Authors
- Lim, L. P., Glasner, M. E., Yekta, S., Burge, C. B., & Bartel, D. P.
- Venue
- Science
- Published
- 2003-03-07
- Volume
- 299
- Issue
- 5612
- Pages
- 1540-1540
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 967
- References
- 0
- Language
- en
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