The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
NompC TRP Channel Required for Vertebrate Sensory Hair Cell Mechanotransduction
Abstract
The senses of hearing and balance in vertebrates rely on the sensory hair cells (HCs) of the inner ear. The central element of the HC's transduction apparatus is a mechanically gated ion channel of unknown identity. Here we report that the zebrafish ortholog of Drosophila no mechanoreceptor potential C ( nompC ), which encodes a transient receptor potential (TRP) channel, is critical for HC mechanotransduction. In zebrafish larvae, nompC is selectively expressed in sensory HCs. Morpholino-mediated removal of nompC function eliminated transduction-dependent endocytosis and electrical responses in HCs, resulting in larval deafness and imbalance. These observations indicate that nompC encodes a vertebrate HC mechanotransduction channel.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A capsaicin-receptor homologue with a high threshold for noxious heat
Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J., & Julius, D. (1999) · Nature · doi:10.1038/18906 · Cited by 1,603
Liedtke, W., Choe, Y., Martí-Renom, M. A., Bell, A. M., Denis, C. S., AndrejŠali, Hudspeth, A. J., Friedman, J. M., & Heller, S. (2000) · Cell · doi:10.1016/s0092-8674(00)00143-4 · Cited by 1,389
Clapham, D. E., Runnels, L. W., & Strübing, C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35077544 · Cited by 1,153
Loss of Sex Discrimination and Male-Male Aggression in Mice Deficient for TRP2
Stowers, L., Holy, T. E., Meister, M., Dulac, C., & Koentges, G. (2002) · Science · doi:10.1126/science.1069259 · Cited by 880
Hudspeth, A. J. (1989) · Nature · doi:10.1038/341397a0 · Cited by 875
Molecular basis of mechanosensory transduction
Gillespie, P. G., & Walker, R. G. (2001) · Nature · doi:10.1038/35093011 · Cited by 706
Pickles, J. O., Comis, S. D., & Osborne, M. P. (1984) · Hearing Research · doi:10.1016/0378-5955(84)90041-8 · Cited by 702
A Drosophila Mechanosensory Transduction Channel
Walker, R. G., Willingham, A. T., & Zuker, C. S. (2000) · Science · doi:10.1126/science.287.5461.2229 · Cited by 696
Colbert, H. A., Smith, T. L., & Bargmann, C. I. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08259.1997 · Cited by 630
Kinetics of the receptor current in bullfrog saccular hair cells
Corey, D., & Hudspeth, A. (1983) · The Journal of Neuroscience · doi:10.1523/jneurosci.03-05-00962.1983 · Cited by 545
Cited by
Venkatachalam, K., & Montell, C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142819 · Cited by 1,909
The TRP Superfamily of Cation Channels
Montell, C. (2005) · Science's STKE · doi:10.1126/stke.2722005re3 · Cited by 989
Ding, L., Stilwell, J., Zhang, T., Elboudwarej, O., Jiang, H., Selegue, J. P., Cooke, P. A., Gray, J. W., & Chen, F. F. (2005) · Nano Letters · doi:10.1021/nl051748o · Cited by 549
Zhang, M., Ma, Y., Ye, X., Zhang, N., Pan, L., & Wang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01464-x · Cited by 522
Gating of TRP channels: a voltage connection?
Nilius, B., Talavera, K., Owsianik, G., Prenen, J., Droogmans, G., & Voets, T. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.088377 · Cited by 299
Metadata
- Authors
- Sidi, S., Friedrich, R. W., & Nicolson, T.
- Venue
- Science
- Published
- 2003-07-04
- Volume
- 301
- Issue
- 5629
- Pages
- 96-99
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965950702
- Cited by
- 347
- References
- 18
- FWCI
- 14.38
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: NompC TRP Channel Required for Vertebrate Sensory Hair Cell Mechanotransduction. https://app.cochat.ai/papers/10.1126/science.1084370
- The paper
- Sidi, S., Friedrich, R. W., & Nicolson, T. (2003). NompC TRP Channel Required for Vertebrate Sensory Hair Cell Mechanotransduction. Science. https://doi.org/10.1126/science.1084370
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
