The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Loss of Sex Discrimination and Male-Male Aggression in Mice Deficient for TRP2
Abstract
The mouse vomeronasal organ (VNO) is thought to mediate social behaviors and neuroendocrine changes elicited by pheromonal cues. The molecular mechanisms underlying the sensory response to pheromones and the behavioral repertoire induced through the VNO are not fully characterized. Using the tools of mouse genetics and multielectrode recording, we demonstrate that the sensory activation of VNO neurons requires TRP2, a putative ion channel of the transient receptor potential family that is expressed exclusively in these neurons. Moreover, we show that male mice deficient in TRP2 expression fail to display male-male aggression, and they initiate sexual and courtship behaviors toward both males and females. Our study suggests that, in the mouse, sensory activation of the VNO is essential for sex discrimination of conspecifics and thus ensures gender-specific behavior.
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Cites
A novel family of genes encoding putative pheromone receptors in mammals
Dulac, C., & Axel, R. (1995) · Cell · doi:10.1016/0092-8674(95)90161-2 · Cited by 1,001
Self-citationA Multigene Family Encoding a Diverse Array of Putative Pheromone Receptors in Mammals
Matsunami, H., & Buck, L. B. (1997) · Cell · doi:10.1016/s0092-8674(00)80537-1 · Cited by 706
Keverne, E. B. (1999) · Science · doi:10.1126/science.286.5440.716 · Cited by 457
A map of pheromone receptor activation in the mammalian brain
Belluscio, L., Koentges, G., Axel, R., & Dulac, C. (1999) · Cell · doi:10.1016/s0092-8674(00)80731-x · Cited by 293
Self-citationHuman Vomeronasal Organ Function: A Critical Review of Best and Worst Cases
Meredith, M. (2001) · Chemical Senses · doi:10.1093/chemse/26.4.433 · Cited by 280
Responses of vomeronasal neurons to natural stimuli
Holy, T. E., Dulac, C., & Meister, M. (2000) · Science · doi:10.1126/science.289.5484.1569 · Cited by 275
Self-citationVan Oortmerssen, G. A. (1971) · Behaviour · doi:10.1163/156853971x00014 · Cited by 201
Cited by
TRP channels as cellular sensors
Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779
Venkatachalam, K., & Montell, C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142819 · Cited by 1,909
Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region
Moffitt, J. R., Bambah-Mukku, D., Eichhorn, S. W., Vaughn, E., Shekhar, K., Perez, J. D., Rubinstein, N. D., Hao, J., Regev, A., Dulac, C., et al. (2018) · Science · doi:10.1126/science.aau5324 · Cited by 1,365
Self-citationThe TRP Superfamily of Cation Channels
Montell, C. (2005) · Science's STKE · doi:10.1126/stke.2722005re3 · Cited by 989
ThermoTRP channels and beyond: mechanisms of temperature sensation
Patapoutian, A., Peier, A. M., Story, G. M., & Viswanath, V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1141 · Cited by 873
Metadata
- Authors
- Stowers, L., Holy, T. E., Meister, M., Dulac, C., & Koentges, G.
- Venue
- Science
- Published
- 2002-02-22
- Volume
- 295
- Issue
- 5559
- Pages
- 1493-1500
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999633796
- Cited by
- 880
- References
- 7
- FWCI
- 22.48
- Type
- journal article
- Language
- en
- Open access
- closed
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