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The Genome Sequence of the SARS-Associated Coronavirus

Marra, Marco A., Jones, Steven J. M., Astell, Caroline R., Holt, Robert A., Brooks-Wilson, Angela, Butterfield, Yaron S. N., Khattra, Jaswinder, Asano, Jennifer K., Barber, Sarah A., Chan, Susanna Y., Cloutier, Alison, Coughlin, Shaun M., Freeman, Doug, Girn, Noreen, Griffith, Obi L., Leach, Stephen R., Mayo, Michael, McDonald, Helen, Montgomery, Stephen B., Pandoh, Pawan K., Petrescu, Anca S., Robertson, A. Gordon, Schein, Jacqueline E., Siddiqui, Asim, Smailus, Duane E., Stott, Jeff M., Yang, George S., Plummer, Francis, Andonov, Anton, Artsob, Harvey, Bastien, Nathalie, Bernard, Kathy, Booth, Timothy F., Bowness, Donnie, Czub, Martin, Drebot, Michael, Fernando, Lisa, Flick, Ramon, Garbutt, Michael, Gray, Michael, Grolla, Allen, Jones, Steven, Feldmann, Heinz, Meyers, Adrienne, Kabani, Amin, Li, Yan, Normand, Susan, Stroher, Ute, Tipples, Graham A., Tyler, Shaun, Vogrig, Robert, Ward, Diane, Watson, Brynn, Brunham, Robert C., Krajden, Mel, Petric, Martin, Skowronski, Danuta M., Upton, Chris, Roper, Rachel L.·2003·Science

DOI 10.1126/science.1085953

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Abstract

We sequenced the 29,751-base genome of the severe acute respiratory syndrome (SARS)âassociated coronavirus known as the Tor2 isolate. The genome sequence reveals that this coronavirus is only moderately related to other known coronaviruses, including two human coronaviruses, HCoV-OC43 and HCoV-229E. Phylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronaviruses. The genome sequence will aid in the diagnosis of SARS virus infection in humans and potential animal hosts (using polymerase chain reaction and immunological tests), in the development of antivirals (including neutralizing antibodies), and in the identification of putative epitopes for vaccine development.

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Authors: Marra, M. A., Jones, S. J. M., Astell, C. R., Holt, R. A., Brooks-Wilson, A., Butterfield, Y. S. N., Khattra, J., Asano, J. K., Barber, S. A., Chan, S. Y., Cloutier, A., Coughlin, S. M., Freeman, D., Girn, N., Griffith, O. L., Leach, S. R., Mayo, M., McDonald, H., Montgomery, S. B., Pandoh, P. K., Petrescu, A. S., Robertson, A. G., Schein, J. E., Siddiqui, A., Smailus, D. E., Stott, J. M., Yang, G. S., Plummer, F., Andonov, A., Artsob, H., Bastien, N., Bernard, K., Booth, T. F., Bowness, D., Czub, M., Drebot, M., Fernando, L., Flick, R., Garbutt, M., Gray, M., Grolla, A., Jones, S., Feldmann, H., Meyers, A., Kabani, A., Li, Y., Normand, S., Stroher, U., Tipples, G. A., Tyler, S., Vogrig, R., Ward, D., Watson, B., Brunham, R. C., Krajden, M., Petric, M., Skowronski, D. M., Upton, C., & Roper, R. L.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2003-05-30
Volume: 300
Issue: 5624
Pages: 1399-1404
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1085953
OpenAlex: W2169198329
Cited by: 2,026
References: 1
FWCI: 175.73
Type: journal article
Language: en
Open access: closed

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The Genome Sequence of the SARS-Associated Coronavirus

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