The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
A MicroRNA as a Translational Repressor of APETALA2 in Arabidopsis Flower Development
Open accessAbstract
Plant microRNAs (miRNAs) show a high degree of sequence complementarity to, and are believed to guide the cleavage of, their target messenger RNAs. Here, Ishow that miRNA172, which can base-pair with the messenger RNA of a floral homeotic gene, APETALA2 , regulates APETALA2 expression primarily through translational inhibition. Elevated miRNA172 accumulation results in floral organ identity defects similar to those in loss-of-function apetala2 mutants. Elevated levels of mutant APETALA2 RNA with disrupted miRNA172 base pairing, but not wild-type APETALA2 RNA, result in elevated levels of APETALA2 protein and severe floral patterning defects. Therefore, miRNA172 likely acts in cell-fate specification as a translational repressor of APETALA2 in Arabidopsis flower development.
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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
Reinhart, B. J., Slack, F. J., Basson, M., Pasquinelli, A. E., Bettinger, J. C., Rougvie, A. E., Horvitz, H. R., & Ruvkun, G. (2000) · Nature · doi:10.1038/35002607 · Cited by 4,981
Aukerman, M. J., & Sakai, H. (2003) · The Plant Cell · doi:10.1105/tpc.016238 · Cited by 1,946
Cleavage of Scarecrow-like mRNA Targets Directed by a Class of Arabidopsis miRNA
Llave, C., Xie, Z., Kasschau, K. D., & Carrington, J. C. (2002) · Science · doi:10.1126/science.1076311 · Cited by 1,627
Park, W., Li, J., Song, R., Messing, J., & Chen, X. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01017-5 · Cited by 1,244
Self-citationOlsen, P. H., & Ambros, V. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9523 · Cited by 1,234
MicroRNA Pathways in Flies and Worms
Ambros, V. (2003) · Cell · doi:10.1016/s0092-8674(03)00428-8 · Cited by 1,217
Genetic interactions among floral homeotic genes of Arabidopsis
Bowman, J. L., Smyth, D. R., & Meyerowitz, E. M. (1991) · Development · doi:10.1242/dev.112.1.1 · Cited by 1,166
Control of Arabidopsis flower and seed development by the homeotic gene APETALA2.
Jofuku, K. D., den Boer, B. G., Van Montagu, M., & Okamuro, J. K. (1994) · The Plant Cell · doi:10.1105/tpc.6.9.1211 · Cited by 1,137
A biochemical framework for RNA silencing in plants
Tang, G., Reinhart, B. J., Bartel, D. P., & Zamore, P. D. (2003) · Genes & Development · doi:10.1101/gad.1048103 · Cited by 983
Kasschau, K. D., Xie, Z., Allen, E., Llave, C., Chapman, E. J., Krizan, K. A., & Carrington, J. C. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00025-x · Cited by 968
Cited by
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
MicroRNAs: small RNAs with a big role in gene regulation
He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 7,118
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
MicroRNA targets in Drosophila
Enright, A. J., John, B., Gaul, U., Tuschl, T., Sander, C., & Marks, D. S. (2003) · Genome Biology · doi:10.1186/gb-2003-5-1-r1 · Cited by 3,597
The Microprocessor complex mediates the genesis of microRNAs
Gregory, R. I., Yan, K.-P., Amuthan, G., Chendrimada, T., Doratotaj, B., Cooch, N., & Shiekhattar, R. (2004) · Nature · doi:10.1038/nature03120 · Cited by 2,742
Metadata
- Authors
- Chen, X.
- Venue
- Science
- Published
- 2004-03-26
- Volume
- 303
- Issue
- 5666
- Pages
- 2022-2025
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2057606871
- Cited by
- 1,770
- References
- 18
- FWCI
- 82.97
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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