Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or α-Synuclein

Cited by (429)

Items 301–400 of 429

  1. Calcineurin stimulation by Cnb1p overproduction mitigates protein aggregation and α-synuclein toxicity in a yeast model of synucleinopathy
    Srishti Chawla, Doryaneh Ahmadpour, Kara L. Schneider, Navinder Kumar, Arthur Fischbach, Mikael Molin, Thomas Nyström · 2023 · Cell Communication and Signaling
  2. Experimental Models for Identifying Modifiers of Polyglutamine-Induced Aggregation and Neurodegeneration
    Barbara Calamini, Donald C. Lo, Linda S. Kaltenbach · 2013 · Neurotherapeutics
  3. Triclabendazole protects yeast and mammalian cells from oxidative stress: Identification of a potential neuroprotective compound
    Yong Joo Lee, Elodie Burlet, Shaoxiao Wang, Baoshan Xu, Shile Huang, Floyd J. Galiano, Stephan N. Witt · 2011 · Biochemical and Biophysical Research Communications
  4. Advances in our Understanding of Neurodegeneration
    K. A. Jellinger · 2007 · Elsevier eBooks
  5. Yeast prions, mammalian amyloidoses, and the problem of proteomic networks
    Alexey P. Galkin, Ludmila N Mironova, Galina A. Zhouravleva, Sergey Georgievich Inge-Vechtomov · 2006 · Russian Journal of Genetics
  6. Proteome-Scale Mapping of Perturbed Proteostasis in Living Cells
    Isabel Lam, Erinc Hallacli, Vikram Khurana · 2019 · Cold Spring Harbor Perspectives in Biology
  7. Preclinical assessment of a ganglioside-targeted therapy for Parkinson’s disease with the first-in-class adaptive peptide AmyP53
    Jacques Fantini, Fodil Azzaz, Anaïs Aulas, Henri Chahinian, Nouara Yahi · 2025 · Scientific Reports
  8. Unbiased Screens for Modifiers of Alpha-Synuclein Toxicity
    Matthias Höllerhage, Marc Bickle, Günter U. Höglinger · 2019 · Current Neurology and Neuroscience Reports
  9. Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation
    Theodore W. Peters, Christopher S. Nelson, Akos A. Gerencser, Kathleen J. Dumas, Brandon Tavshanjian, Kyu Chul Chang, Gordon J. Lithgow, Robert E. Hughes · 2018 · G3 Genes Genomes Genetics
  10. Jid1 is a J‐protein functioning in the mitochondrial matrix, unable to directly participate in endoplasmic reticulum associated protein degradation
    Dejan Bursać, Trevor J. Lithgow · 2009 · FEBS Letters
  11. Sfp1 links TORC1 and cell growth regulation to the yeast SAGA‐complex component Tra1 in response to polyQ proteotoxicity
    Yuwei Jiang, Matthew D. Berg, Julie L. Genereaux, Khadija Ahmed, Martin L. Duennwald, Christopher J. Brandl, Patrick Lajoie · 2019 · Traffic
  12. The effect of copy number on α-synuclein’s toxicity and its protective role in Bax-induced apoptosis, in yeast
    Damilare D. Akintade, Bhabatosh Chaudhuri · 2020 · Bioscience Reports · Retracted
  13. Screening of Drugs That Suppress Ste11 MAPKKK Activation in Yeast Identified a c-Abl Tyrosine Kinase Inhibitor
    Takao Kitagawa, Y. Hashizume, Tatsuhiko Murakane, Emi KOGA, Yuki NOMURA, Yoshito Kakihara, Ayako Fujieda, Motoyuki Uchida, Hidetoshi Takahashi, Hisashi Hoshida et al. · 2007 · Bioscience Biotechnology and Biochemistry
  14. Identification of novel protein phosphatases as modifiers of alpha-synuclein aggregation in yeast
    Inês Caldeira Brás, Sandra Tenreiro, Andreia Machado da Silva, Tiago F. Outeiro · 2018 · FEMS Yeast Research
  15. Neurodegeneration in Parkinson’s Disease: Genetics Enlightens Physiopathology
    Olga Corti, Margot Fournier, Alexis Brice · 2009 · Springer eBooks
  16. Misfolding and Aggregation in Huntington Disease and Other Expanded Polyglutamine Repeat Diseases
    Ronald B. Wetzel · 2010 · Wiley eBooks
  17. Yeast-Based Screens to Target Alpha-Synuclein Toxicity
    Inês Caldeira Brás, Bilyana Popova, Gerhard H. Braus, Tiago F. Outeiro · 2019 · Methods in molecular biology
  18. One cell, one love: a journal for microbial research
    Didac Carmona‐Gutiérrez, Guido Kroemer, Frank Madeo · 2014 · Microbial Cell
  19. Insights from synthetic yeasts
    Damien Y. M. Coudreuse · 2016 · Yeast
  20. α-synuclein and phosphoinositide-binding proteins: α-synuclein inhibits the association of PX- but not FYVE-containing proteins with vesicles in vivo
    Santhanasabapathy Rajasekaran, Dhaval Patel, Stephan N. Witt · 2022 · Biochemical and Biophysical Research Communications
  21. ROS Production and Apoptosis Induction by Formation of Gts1p-Mediated Protein Aggregates
    Mitsuaki Sanada, Kouichi Kuroda, Mitsuyoshi Ueda · 2011 · Bioscience Biotechnology and Biochemistry
  22. From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae
    José Ribamar Ferreira-Júnior, Vittoria de Lima Camandona, Mario Henrique de Barros · 2025 · Yeast
  23. Yeast as a Model for Human Disease
    Bartłomiej Zieniuk, Katarzyna Wierzchowska, Karina Jasińska, J. Kobus, Aleksandra Piotrowicz, Şuheda Uğur, Agata Urszula Fabiszewska · 2026 · International Journal of Molecular Sciences
  24. Effects of heterologous human tau protein expression in yeast models of proteotoxic stress response
    Klara Zubčić, Dina Franić, Mihaela Pravica, Patrick R. Hof, Goran Šimić, Mirta Boban · 2023 · CNS Neuroscience & Therapeutics
  25. The growth behavior of the model eukaryotic yeast Saccharomyces cerevisiae in microgravity
    Ronnie Willaert · 2013 · Current Biotechnology
  26. Metodología estructural y funcional en Lingüística
    Emilio Alarcos Llorach · 1977 · Revista Española de Lingüística
  27. Unraveling Protein Misfolding Diseases Using Model Systems
    Sara Peffer, Kimberly J Cope, Kevin A. Morano · 2015 · Future Science OA
  28. Genetic modifiers of synucleinopathies—lessons from experimental models
    Rachel Min Qi Lee, Tong‐Wey Koh · 2023 · Oxford Open Neuroscience
  29. Drosophila Models of Parkinson Disease
    Leo J. Pallanck, Alexander J. Whitworth · 2005 · Elsevier eBooks
  30. Comparative analysis of the intracellular responses to disease-related aggregation-prone proteins
    André Melnik, Valentina Cappelletti, Federico Vaggi, Ilaria Piazza, Marco Tognetti, Carmen Schwarz, Gea Cereghetti, Mennat Allah Ahmed, Martin Soste, Kent E. S. Matlack et al. · 2020 · Journal of Proteomics
  31. Rationally designed peptides inhibit the formation of α-synuclein fibrils and oligomers
    Tariq Tammam Ali, Madiha Mohieldin Merghani, Mohammed Al‐Azzani, Luisa Maria Gatzemeier, Michael Hoppert, Dora V. Kaloyanova, Tiago F. Outeiro, Piotr Neumann, Bilyana Popova, Gerhard H. Braus · 2025 · European Journal of Medicinal Chemistry
  32. Chapter 8 α-Synuclein and Synucleinopathies
    Michael G. Schlossmacher · 2007 · Blue books of neurology
  33. TorsinA folding and N-linked glycosylation are sensitive to redox homeostasis
    Jonas Honer, Katie Niemeyer, Christian Fercher, Ana L. Diez Tissera, Noushin Jaberolansar, Yohaann Jafrani, Chun Zhou, Julio J. Caramelo, Annette M. Shewan, Benjamin Luke Schulz et al. · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  34. Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption
    John Yong, Jacqueline E. Villalta, Ngoc Vu, Matthew A. Kukurugya, Niclas Olsson, Magdalena Preciado López, Julia R. Lazzari-Dean, Kayley Hake, Fiona Elizabeth McAllister, Bryson D. Bennett et al. · 2024 · eLife
  35. Phosphatidylinositol 3-phosphate metabolism impacts cellular α-synuclein localization in Saccharomyces cerevisiae
    Timo Löser, Fazilet Bekbulat, Christian Behl, Jana Schepers · 2025 · Journal of Biological Chemistry
  36. Protein Quality Control in Neurodegeneration and Neuroprotection
    Yasmeena Akhter, Jahangir Nabi, Hinna Hamid, Nahida Tabassum, Faheem Hyder Pottoo, Aashish Sharma · 2020 · Advances in medical diagnosis, treatment, and care (AMDTC) book series
  37. Combining data integration and molecular dynamics for target identification in α-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1)
    Kirsten Jenkins, Teodora Mateeva, István Szabó, André Melnik, Paola Picotti, Attila Csikász‐Nagy, Edina Rosta · 2020 · Computational and Structural Biotechnology Journal
  38. From Yeast to Humans: Leveraging New Approaches in Yeast to Accelerate Discovery of Therapeutic Targets for Synucleinopathies
    Jeff S. Piotrowski, Daniel F. Tardiff · 2019 · Methods in molecular biology
  39. Modeling Huntington Disease in Yeast and Invertebrates
    Robert P. Mason, Carlo Breda, Gurdeep S. Kooner, Giovanna R. Mallucci, Charalambos Panayiotis Kyriacou, Flaviano Giorgini · 2014 · Elsevier eBooks
  40. Peroxisome inter-organelle cooperation in Drosophila
    Andy Y. Cheng, Andrew James Simmonds · 2024 · Genome
  41. Chaperone Suppression of Aggregated Protein Toxicity
    Jennifer L. Wacker, Paul J. Muchowski · 2007 · Springer eBooks
  42. Synthetic Lethality Induced by a Strong Drosophila Enhancer of Expanded Polyglutamine Tract
    Ping Zhang, Qiming Wang, Hannah Q. Hughes, Gino Intrieri · 2014 · Open Journal of Genetics
  43. Machado-Joseph Disease/Spinocerebellar Ataxia Type 3
    Henry Lauris Paulson · 2006 · Elsevier eBooks
  44. Mating-based Overexpression Library Screening in Yeast
    Elliott Hayden, Shuzhen Chen, Abagail Chumley, Quan Zhong, Shulin Ju · 2018 · Journal of Visualized Experiments
  45. Mechanistic Insights into the Polyglutamine Ataxias
    Victor M. Miller, Henry Lauris Paulson · 2007 · Springer eBooks
  46. A genome wide dosage suppressor network reveals genetic robustness and a novel mechanism for Huntington’s disease
    Biranchi N. Patra, Yoshiko Kon, Gitanjali Yadav, Anthony Sevold, Jesse P. Frumkin, Ravishankar Rao Vallabhajosyula, Arend Hintze, Bjørn Østman, Jory Schossau, Ashish Bhan et al. · 2013 · bioRxiv (Cold Spring Harbor Laboratory)
  47. Evaluation of Stp2p-dependent alpha-Synuclein Toxicity in Yeast: Role of GAPDH?
    Arun George Paul, Ruja Shrestha · 2005 · DOAJ (DOAJ: Directory of Open Access Journals)
  48. Deep behavioural phenotyping reveals divergent trajectories of ageing and quantifies health state in C. elegans
    Céline N. Martineau, Bora Baskaner, Renée I. Seinstra, William R Schafer, André EX Brown, Ellen A. A. Nollen, Patrick Laurent · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Impairment of lipid homoeostasis causes accumulation of protein aggregates in the lysosome
    John Yong, Jacqueline E. Villalta, Ngoc Vu, Matthew A. Kukurugya, Bryson D. Bennett, Magdalena Preciado López, Julia R. Lazzari-Dean, Kayley Hake, Calvin H. Jan · 2023 · eLife
  50. Core gene set of the species Saccharomyces cerevisiae
    Fred S. Dietrich, Paul M. Magwene, John H. McCusker · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  51. Using yeast as a model system for the genetic dissection of α-synuclein toxicity
    Vicente Sancenón, Sue-Ann Lee, Paul J. Muchowski · 2008 · Elsevier eBooks
  52. Alpha-Synuclein Interactions with Membranes
    Katja Pirc, Natasa Poklar · 2011 · InTech eBooks
  53. Current awareness on yeast
    2004 · Yeast
  54. CFS Biomarkers in Parkinson’s Disease
    Lucilla Parnetti, Anna Castrioto, Claudia De, Davide Chiasserini, Nicola Tambasco, Aroldo Rossi, Chiara Balducci, Tommaso Beccari, Paolo Calabresi · 2011 · InTech eBooks
  55. Parkinson’s Disease: Insights from the Laboratory and Clinical Therapeutics
    Jing-ye Zhou, Yong Yu, Xian-Lun Zhu, Chi-Ping Ng, Gang Lü, Wai-Sang Poo · 2012 · InTech eBooks
  56. The involvement of alpha-synuclein in parkinson’s disease
    Thomas K. Karikari · 2014
  57. Molecular Chaperones as Potential Therapeutic Targets for Neurological Disorders
    Marion Delenclos, Pamela J. McLean · 2013 · Royal Society of Chemistry eBooks
  58. Aging in the Single-Celled Eukaryote, S. cerevisiae
    Chong Z. He, Brian Keith Kennedy · 2015 · Springer eBooks
  59. The N-Acetylglucosamine Kinase from Yarrowia lipolytica Is a Moonlighting Protein
    Carmen‐Lisset Flores, Joaquı́n Ariño, Carlos Gancedo · 2021 · International Journal of Molecular Sciences
  60. Unbiased genome-wide approaches to identify vulnerability factors in Huntington's disease
    Suphinya Sathitloetsakun, Myriam Heiman · 2024 · Elsevier eBooks
  61. Apoptosis in Neurodegenerative Diseases
    Qiuli Liang, Jianhua Zhang · 2009 · Humana Press eBooks
  62. Response and Cytoprotective Mechanisms Against Proteotoxic Stress in Yeast and Fungi
    Yukio Kimata, Thi Mai Phuong Nguyen, Kenji Kohno · 2018 · Springer eBooks
  63. Drosophila and C. elegans Models of Human Age-Associated Neurodegenerative Diseases
    Julide Bilen, Nancy M. Bonini · 2007 · Springer eBooks
  64. Modulation of Amyloid Propagation in Yeast by Hsp70 and its Regulators and Chaperone Partners
    Daniel C. Masison · 2011 · Wiley eBooks
  65. Huntingtin toxicity is ameliorated by BAG1 through modulation of its aggregation, degradation and subcellular distribution
    Kamila Sroka · 2009 · eDiss (Georg-August-Universität Göttingen)
  66. Creating a protein-protein interaction network for alpha-synuclein
    Matthias Könn · 2012 · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver
  67. The Role of Mitochondrial Dysfunction in Neurodegenerative Proteinopathies and Aging.
    Alejandro Ocampo · 2012
  68. The cytoskeletal linker protein, Ezrin, inhibits α-synuclein fibrillization and toxicity by a novel mechanism
    Maliha Shah · 2014 · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver
  69. Vps28 Implicated in a-Synuclein Pathobiology: Building Support for Lysosome-Mediated Degradation
    Price, Jessica, Ruja Shrestha · 2005 · Eukaryon
  70. Insight Into Parkinson's Disease: Does alpha-Synuclein Use the MVB/Endocytosis Pathway as a Route for Degradation in the Lysosome?
    Alexandra Ayala · 2010 · Eukaryon
  71. Insight Into Parkinson's Disease Using Yeast as a Model to Evaluate the Role of Autophagy Genes in alpha-Synuclein Toxicity
    Ray S. Choi · 2010 · Eukaryon
  72. Yeast as a Model for Studying Aβ Aggregation, Toxicity and Clearance
    Prashant Bharadwaj · 2011 · Australasian Journal of Paramedicine
  73. TMEM85 (Transmembrane Protein 85)
    Michael T. Greenwood · 2017 · Springer eBooks
  74. Fitness defects due to cytosolic protein misfolding in S. cerevisiae can be alleviated by decreasing mitochondrial protein import capacity
    Zainab Zaidi, Devi Prasanna Dash, Akanksha Sharma, Soumen Kundu, Sarika Bhatt, Shikha Rao, Kedar Padia, Manish Rai, Kausik Chakraborty · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  75. The Role of Molecular Chaperones in the ER Associated Degradation of the Cystic Fibrosis Transmembrane Conductance Regulator in the Budding Yeast S. cerevisiae
    Robert T. Youker · 2006 · D-Scholarship@Pitt (University of Pittsburgh)
  76. Genomics
    Jeremy S. Caldwell, Sumit K. Chanda, Jeffrey T. Irelan, R. Koenig · 2007 · Elsevier eBooks
  77. Regional lysosomal malfunction underlies the selectivity of alpha-synuclein neurodegeneration
    Kristen A. Malkus · 2011 · Scholarly Commons (University of Pennsylvania)
  78. Identification Of Deletion Mutants Of Inositol Kinases And Phosphatases Hypersensitive To Valproate
    W. M. M. S. Bandara · 2010 · Human Biology
  79. Caenorhabditis Elegansas a Model System to Study the Biology of Protein Aggregation and Toxicity
    Elise Alexandra Kikis, Anat Ben‐Zvi, Richard I. Morimoto · 2010 · Wiley eBooks
  80. Protein Aggregation in Unicellular Eukaryotes
    Marina Caldara, Joris Winderickx, Vanessa Franssens · 2014 · Wiley eBooks
  81. Chemical-genetic profiling of platelet-activating factor in yeast
    Nazir Kabbani · 2009 · uO Research (University of Ottawa)
  82. The Proteasome, Protein Aggregation, and Neurodegeneration
    S. Wilk · 2007 · Springer eBooks
  83. Study of animal viruses in yeast
    Yuko MORIKAWA · 2006 · Uirusu
  84. New genetic strategies for protein discovery based on whole-genome sequences
    Michael J. DeVit, Trey Powers · 2004 · Drug Discovery Today TARGETS
  85. Oxidative Stress, a-Synuclein, and Apoptosis in Parkinson’s Disease
    Katrina A. Brandis · 2006 · Eukaryon
  86. Yeast? Yes! A New Trend in Modeling Parkinson’s Disease
    Katrina A. Brandis · 2006 · Eukaryon
  87. A Genome-Wide RNAi Screen for Modifiers of Polyglutamine-Induced Neurotoxicity in Drosophila
    Hannes Voßfeldt · 2013 · eDiss (Georg-August-Universität Göttingen)
  88. Interactions of p24 proteins characterized by yeast two-hybrid, mutagenesis, and overexpression
    Tan, Elaine · 2009 · eScholarship@McGill (McGill)
  89. a-Synuclein Toxicity and Localization in Yeast That Lack Superoxide Dismutases
    Katrina A. Brandis, Ruja Shrestha · 2005 · Eukaryon
  90. a-Synuclein Causes Non-Specific Toxicity in vps34 Yeast
    Mithaq Vahedi · 2007 · Eukaryon
  91. Oxidants Induce α-Synuclein-Independent Toxicity in a Fission Yeast Model for Parkinson's Disease
    Lokesh Kukreja, Shubhik K. DebBurman · 2009 · Biochemistry and Molecular Biology Education
  92. Genetic Evidence in Yeast Model Implicates Autophagy in the Degradation of Parkinson's Disease Protein alpha-Synuclein
    Ahlstrand, Kayla, Peter M. Sullivan · 2010 · Eukaryon
  93. The role of alpha-synuclein phosphorylation in synucleinopathies
    Elisa Basso · 2014 · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
  94. Protein reporters to study in vivo protein interactions and aggregation
    Montse Morell · 2008 · TDX (Tesis Doctorals en Xarxa)
  95. The ubiquitin proteasome system in Huntington disease : impairment of the proteolytic machinery aggravates huntingtin aggregation and toxicity
    Remko de Pril · 2011
  96. Parkin Misfolding, Dysfunction, and Degradation in Parkinson's Disease
    Alexander S McCarton · 2016 · Scholarship@Western (Western University)
  97. Yeast Cells as a Discovery Platform for Parkinson's Disease and other Protein Misfolding Diseases
    Karen L. Allendoerfer, Linhui Julie Su, Susan Lee Lindquist · 2008 · Elsevier eBooks
  98. The remarkable effects of misfolded proteins: Infection, Evolution, & Disease
    Katrina J. Campbell · 2014
  99. Yeast Proteasome Structure and Biogenesis
    Cordula Enenkel · 2007 · Springer eBooks
  100. Genetic Screens in Neurodegeneration
    Abraham Acevedo‐Arozena, Silvia Corrochano · 2017 · Wiley eBooks