Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or α-Synuclein

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

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AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

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Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes

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Alpha-synuclein and neurodegenerative diseases

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Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo

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Toxic Proteins in Neurodegenerative Disease

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Chaperone Suppression of α-Synuclein Toxicity in a <i>Drosophila</i> Model for Parkinson's Disease

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Amyloid fibrillogenesis: themes and variations

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Characterization of a novel protein regulated during the critical period for song learning in the zebra finch

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Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70

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Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology

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Vesicle Permeabilization by Protofibrillar α-Synuclein: Implications for the Pathogenesis and Treatment of Parkinson's Disease

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Hsp70 and Hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

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Identification of genes that modify ataxin-1-induced neurodegeneration

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Genetic Suppression of Polyglutamine Toxicity in Drosophila

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Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

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Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

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Binding of α-Synuclein to Brain Vesicles Is Abolished by Familial Parkinson's Disease Mutation

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Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions

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Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

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Interaction of Human α-Synuclein and Parkinson's Disease Variants with Phospholipids

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Regulation of Phospholipase D2: Selective Inhibition of Mammalian Phospholipase D Isoenzymes by α- and β-Synucleins

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Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

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Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease

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Untitled work

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-Synuclein in Parkinson's Disease

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Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

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Modulation of neurodegeneration by molecular chaperones

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The function of α-synuclein

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Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology

Outeiro, T. F., & Lindquist, S. L. (2003) · Science · doi:10.1126/science.1090439 · Cited by 808 · see citing works

Parkinson’s disease: genetics and pathogenesis

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Intravesicular Localization and Exocytosis of α-Synuclein and its Aggregates

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THE BIOCHEMISTRY OF PARKINSON'S DISEASE

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Anti-apoptosis and cell survival: A review

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What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease

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Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein*♦

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Neuropathology, biochemistry, and biophysics of α‐synuclein aggregation

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Cellular Strategies of Protein Quality ControlPreprint

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Gene Overexpression: Uses, Mechanisms, and Interpretation

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The Yeast Deletion Collection: A Decade of Functional Genomics

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Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS

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C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

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Increased glutathione S -transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

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α-Synuclein and neuronal cell death

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Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation

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A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

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Huntington's disease: from pathology and genetics to potential therapies

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Heat Shock Proteins 70 and 90 Inhibit Early Stages of Amyloid β-(1–42) Aggregation in Vitro

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Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection

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A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

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Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins

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Genetics of Parkinson's disease and parkinsonism

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Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity

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Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

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Replicative Aging in Yeast: The Means to the End

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Chaperonin TRiC Promotes the Assembly of polyQ Expansion Proteins into Nontoxic Oligomers

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Ubiquitin ligase Nedd4 promotes α-synuclein degradation by the endosomal–lysosomal pathway

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TOR-Mediated Cell-Cycle Activation Causes Neurodegeneration in a Drosophila Tauopathy Model

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The ubiquitin–proteasome pathway in Parkinson's disease and other neurodegenerative diseases

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Huntington's DiseasePreprint

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Dysregulated Lipid Metabolism and Its Role in α-Synucleinopathy in Parkinson’s Disease

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Dietary fatty acids and the risk of Parkinson disease

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Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models

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Relationships between the Sequence of α-Synuclein and its Membrane Affinity, Fibrillization Propensity, and Yeast Toxicity

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α-Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis

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The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of -synuclein, and enhances its secretion and nuclear localization in cells

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Heat Shock Prevents Alpha-synuclein-induced Apoptosis in a Yeast Model of Parkinson's Disease

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Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

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CHIP Suppresses Polyglutamine Aggregation and ToxicityIn VitroandIn Vivo

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Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

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Yeast as a model for medical and medicinal research

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Yeast genome-wide screen reveals dissimilar sets of host genes affecting replication of RNA viruses

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Ubiquitin–proteasome system and Parkinson's disease

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Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells

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Optical Reporters for the Conformation of α-Synuclein Reveal a Specific Interaction with Mitochondria

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A Yeast Model of FUS/TLS-Dependent Cytotoxicity

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Protein interactions and disease: computational approaches to uncover the etiology of diseases

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Genome-Wide Screen for Modifiers of Ataxin-3 Neurodegeneration in Drosophila

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GTPase Activity Plays a Key Role in the Pathobiology of LRRK2

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The molecular genetics of Huntington disease — a history

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Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis

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Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles

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Protein Homeostasis in Models of Aging and Age-Related Conformational Disease

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α-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease

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Cell systems and the toxic mechanism(s) of α-synuclein

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Machado–Joseph disease/spinocerebellar ataxia type 3

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