The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or α-Synuclein
Abstract
Genome-wide screens were performed in yeast to identify genes that enhance the toxicity of a mutant huntingtin fragment or of α-synuclein. Of 4850 haploid mutants containing deletions of nonessential genes, 52 were identified that were sensitive to a mutant huntingtin fragment, 86 that were sensitive to α-synuclein, and only one mutant that was sensitive to both. Genes that enhanced toxicity of the mutant huntingtin fragment clustered in the functionally related cellular processes of response to stress, protein folding, and ubiquitin-dependent protein catabolism, whereas genes that modified α-synuclein toxicity clustered in the processes of lipid metabolism and vesicle-mediated transport. Genes with human orthologs were overrepresented in our screens, suggesting that we may have discovered conserved and nonoverlapping sets of cell-autonomous genes and pathways that are relevant to Huntington's disease and Parkinson's disease.
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“In addition, YPL067C was chosen for its biological interest, as previous studies suggested that YPL067C is involved in preventing amyloid toxicity10.”
From Determining crystal structures through crowdsourcing and coursework (2016) · cites this paper as [10]
In the citing paper
“As mentioned above, HTC1 null mutants increase the toxicity of amyloid overproduction10.”
From Determining crystal structures through crowdsourcing and coursework (2016) · cites this paper as [10]
Citations
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Common pesticides and the development of Parkinson's disease
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Huntingtin proteolysis and toxicity
El‐Daher, M. (2013) · theses.fr (ABES) · doi:10.70675/63f5beacz7227z4e99z96c9z41f509914430
Interrogating the role of splicing factors in Huntington’s Disease
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Metadata
- Authors
- Willingham, S., Outeiro, T. F., DeVit, M. J., Lindquist, S. L., & Muchowski, P. J.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Muchowski, Paul J.
- Venue
- Science
- Published
- 2003-12-05
- Volume
- 302
- Issue
- 5651
- Pages
- 1769-1772
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013754033
- Cited by
- 422
- References
- 31
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 6 · 2023: 10 · 2022: 5 · 2021: 12 · 2020: 19 · 2019: 14 · 2018: 20 · 2017: 15 · 2016: 9 · 2015: 12 · 2014: 18 · 2013: 18 · 2012: 26
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- huntingtin, alpha-synuclein, Huntington's disease, Parkinson's disease, yeast genetic screen, stress response, protein folding, ubiquitin-dependent protein degradation, lipid metabolism, vesicle trafficking, human orthologs, neurodegeneration
- MeSH terms
- Huntingtin Protein, Biological Transport, Genes, Fungal, Humans, Mutation, Nerve Tissue Proteins, Nuclear Proteins, Osmotic Pressure, Proteins, Saccharomyces cerevisiae, Transformation, Genetic, Nitrosation, Gene Deletion, Protein Folding, Oxidative Stress, Ubiquitin, Lipid Metabolism, Synucleins, alpha-Synuclein
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