TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

Generalized lacZ expression with the ROSA26 Cre reporter strain

Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

Massagué, J., Blain, S. W., & Lo, R. S. (2000) · Cell · doi:10.1016/s0092-8674(00)00121-5 · Cited by 2,391

Evidence that fibroblasts derive from epithelium during tissue fibrosis

Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215518 · Cited by 1,589

Signal Transduction by the TGF-β Superfamily

Attisano, L., & Wrana, J. L. (2002) · Science · doi:10.1126/science.1071809 · Cited by 1,286

c-MYC: more than just a matter of life and death

Pelengaris, S., Khan, M., & Evan, G. I. (2002) · Nature reviews. Cancer · doi:10.1038/nrc904 · Cited by 1,192

Identification and characterization of a fibroblast marker: FSP1.

Strutz, F. M., Okada, H., Lo, C. W., Danoff, T. M., Carone, R. L., Tomaszewski, J. E., & Neilson, E. G. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.2.393 · Cited by 1,075

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

Kaartinen, V., Voncken, J. W., Shuler, C. F., Warburton, D., Bu, D., Heisterkamp, N., & Groffen, J. (1995) · Nature Genetics · doi:10.1038/ng1295-415 · Cited by 1,042

Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction

Rønnov‐Jessen, L., PETERSEN, O. W., & Bissell, M. J. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.1.69 · Cited by 797

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.Preprint

Oft, M., Peli, J., Rudaz, C., Schwarz, H., Beug, H., & Ernst Reichmann, A. (1996) · Genes & Development · doi:10.1101/gad.10.19.2462 · Cited by 679

Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.

Barcellos‐Hoff, M. H., & Ravani, S. A. (2000) · PubMed · Cited by 536

The functional multipotency of transforming growth factor β signaling at the intersection of senescence and cancer

Mikuła‐Pietrasik, J., Rutecki, S., & Książek, K. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04236-y · Cited by 27

Epicardial‐derived adrenomedullin drives cardiac hyperplasia during embryogenesis

Wetzel‐Strong, S. E., Li, M., Klein, K. R., Nishikimi, T., & Caron, K. M. (2013) · Developmental Dynamics · doi:10.1002/dvdy.24065 · Cited by 28

Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs

Pasche, B., Wisinski, K. B., Sadim, M. S., Kaklamani, V., Pennison, M. J., Zeng, Q., Bellam, N., Zimmerman, J. W., Yi, N., Zhang, K., et al. (2010) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-29-57 · Cited by 27

Multiple hereditary exostoses (MHE): elucidating the pathogenesis of a rare skeletal disorder through interdisciplinary research

Jones, K. B., Pacifici, M., & Hilton, M. J. (2014) · Connective Tissue Research · doi:10.3109/03008207.2013.867957 · Cited by 27

Targeting Stromal-cancer Cell Interactions with siRNAs

Aharinejad, S., Sioud, M., Lucas, T., & Abraham, D. (2008) · Methods in molecular biology · doi:10.1007/978-1-60327-547-7_12 · Cited by 28

Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation

Liu, H., Dowdle, J. A., Khurshid, S., Sullivan, N. J., Bertos, N., Rambani, K., Mair, M., Daniel, P., Wheeler, E., Tang, X., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.04.024 · Cited by 27

Stromal PTEN determines mammary epithelial response to radiotherapy

Sizemore, G. M., Balakrishnan, S., Thies, K., Hammer, A. M., Sizemore, S. T., Trimboli, A. J., Cuitiño, M. C., Steck, S. A., Tozbikian, G. H., Kladney, R. D., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05266-6 · Cited by 27

Tumour invasion and metastasis: challenges facing drug discovery

Elvin, P., & GARNER, A. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.02.008 · Cited by 27

Improvement of a Predictive Model of Castration-Resistant Prostate Cancer: Functional Genetic Variants in TGFβ1 Signaling Pathway Modulation

Teixeira, A. L., Gomes, M. P., Nogueira, A., Azevedo, A. S., Assis, J., Dias, F., Santos, J. I., Lobo, F., Morais, A., Maurício, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072419 · Cited by 26

Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis

Peters, D. E., Zhang, Y., Molinolo, A. A., Miller-Randolph, S., Szabo, R., Bugge, T. H., Leppla, S. H., & Liu, S. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.04.160 · Cited by 26

TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion

Bras, G. F. L., Taylor, C. J., Koumangoye, R. B., Revetta, F. L., Loomans-Kropp, H. A., & Andl, C. D. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.07.021 · Cited by 26

Loss of Cdh1 and Pten Accelerates Cellular Invasiveness and Angiogenesis in the Mouse Uterus1

Lindberg, M. E., Stodden, G. R., King, M. L., MacLean, J. A., Mann, J. L., DeMayo, F. J., Lydon, J. P., & Hayashi, K. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.109462 · Cited by 26

CXCL1 Derived from Mammary Fibroblasts Promotes Progression of Mammary Lesions to Invasive Carcinoma through CXCR2 Dependent Mechanisms

Bernard, S., Myers, M. J., Fang, W. B., Zinda, B., Smart, C., Lambert, D., Zou, A., Fan, F., & Cheng, N. (2018) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-018-9407-1 · Cited by 26

Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome

Yin, J. C., Platt, M. J., Tian, X., Wu, X., Backx, P. H., Simpson, J. A., Araki, T., & Neel, B. G. (2017) · Nature Communications · doi:10.1038/ncomms15518 · Cited by 26

Uterine smooth muscle cells increase invasive ability of endometrial carcinoma cells through tumor–stromal interaction

Tsukamoto, H., Shibata, K., Kajiyama, H., Terauchi, M., Nawa, A., & Kikkawa, F. (2007) · Clinical & Experimental Metastasis · doi:10.1007/s10585-007-9079-5 · Cited by 26

Prostate development and pathogenesis

Thomson, A. A., Cunha, G. R., & Marker, P. C. (2008) · Differentiation · doi:10.1111/j.1432-0436.2008.00303.x · Cited by 26

Fibroblasts in cancer dormancy: foe or friend?

Dai, L., Mao, L., Zhang, W., Tang, Y.-J., Tang, Y., & Liang, X. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01883-2 · Cited by 27

Molecular Signatures of the Primitive Prostate Stem Cell Niche Reveal Novel Mesenchymal-Epithelial Signaling Pathways

Blum, R., Gupta, R., Burger, P. E., Ontiveros, C. S., Salm, S. N., Xiong, X., Kamb, A., Wesche, H., Marshall, L., Cutler, G., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013024 · Cited by 25

Targeting the tumour stroma to increase efficacy of chemo- and radiotherapy

Chometon, G., & Jendrossek, V. (2009) · Clinical & Translational Oncology · doi:10.1007/s12094-009-0317-y · Cited by 25

Overexpression of Ephrin A2 receptors in cancer stromal cells is a prognostic factor for the relapse of gastric cancer

Kikuchi, S., Kaibe, N., Morimoto, K., Fukui, H., Niwa, H., Maeyama, Y., Takemura, M., Matsumoto, M., Nakamori, S., Miwa, H., et al. (2014) · Gastric Cancer · doi:10.1007/s10120-014-0390-y · Cited by 25

Systemic activation of K-ras rapidly induces gastric hyperplasia and metaplasia in mice.

Matkar, S. S., Durham, A. C., Brice, A. K., Wang, T. C., Rustgi, A. K., & Hua, X. (2011) · PubMed Central · Cited by 25

Cell Motility in Cancer Invasion and Metastasis

Qin, Z., Tan, S. X. D., & Cheng, C.-K. (2006) · Cancer metastasis · doi:10.1007/b103440 · Cited by 25

The Cain and Abl of Epithelial-Mesenchymal Transition and Transforming Growth Factor-β in Mammary Epithelial Cells

Allington, T. M., & Schiemann, W. P. (2010) · Cells Tissues Organs · doi:10.1159/000320163 · Cited by 25

Prostate epithelial stem and progenitor cells.

Kwon, O., & Xin, L. (2014) · PubMed Central · Cited by 24

A Signaling View into the Inflammatory Tumor Microenvironment

Pereira, J., Jordan, P., & Matos, P. (2021) · Immuno · doi:10.3390/immuno1020007 · Cited by 24

Wnt1 Expression Induces Short-Range and Long-Range Cell Recruitments That Modify Mammary Tumor Development and Are Not Induced by a Cell-Autonomous β-Catenin Effector

Kim, Y. C., Clark, R. J., Ranheim, E. A., & Alexander, C. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2992 · Cited by 24

Hic-5 controls BMP4 responses in prostate cancer cells through interacting with Smads 1, 5 and 8

Shola, D. T. N., Wang, H., Wahdan-Alaswad, R. S., & Danielpour, D. (2011) · Oncogene · doi:10.1038/onc.2011.422 · Cited by 24

Crossroads of integrins and cadherins in epithelia and stroma remodeling

Epifano, C., & Pérez‐Moreno, M. (2012) · Cell Adhesion & Migration · doi:10.4161/cam.20253 · Cited by 28

A functional in vitro model of heterotypic interactions reveals a role for interferon-positive carcinoma associated fibroblasts in breast cancer

Hosein, A. N., Livingstone, J. M., Buchanan, M., Reid, J. F., Hallett, M. T., & Basik, M. (2015) · BMC Cancer · doi:10.1186/s12885-015-1117-0 · Cited by 24

Proliferating fibroblasts and HeLa cells co-cultured in vitro reciprocally influence growth patterns, protein expression, chromatin features and cell survival.

Delinassios, J. G., Angeli, F., Koumakis, G., Kumar, S., Kang, W.-H., Sica, G., Iacopino, F., Lama, G., Lamprecht, S. A., Sigal-Batikoff, I., et al. (2015) · PubMed · Cited by 24

Genetic Mosaicism and Cancer: Cause and Effect

Lichtenstein, A. V. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2769 · Cited by 24

From Cancer Immunoediting to New Strategies in Cancer Immunotherapy: The Roles of Immune Cells and Mechanics in Oncology

Aragon‐Sanabria, V., Kim, G. B., & Dong, C. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-95294-9_7 · Cited by 24

Helicobacter pylori ‐activated gastric fibroblasts induce epithelial‐mesenchymal transition of gastric epithelial cells in vitro in a TGF‐β‐dependent manner

Krzysiek-Mączka, G., Wróbel, T., Targosz, A., Szczyrk, U., Strzałka, M., Ptak‐Belowska, A., Czyż, J., & Brzozowski, T. (2019) · Helicobacter · doi:10.1111/hel.12653 · Cited by 24

Oncogenes as Novel Targets for Cancer Therapy (Part I)

Zhang, Z., Li, M., Rayburn, E. R., Hill, D. L., Zhang, R., & Wang, H. (2005) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200505030-00004 · Cited by 25

Different matrix micro-environments in colon cancer and diverticular disease

Klinge, U., Rosch, R., Junge, K., Krones, C. J., Stumpf, M., Lynen-Jansen, P., Mertens, P. R., & Schumpelick, V. (2006) · International Journal of Colorectal Disease · doi:10.1007/s00384-006-0199-1 · Cited by 24

Targeted TGF-β chemotherapies: friend or foe in treating human malignancies?

Schiemann, W. P. (2007) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.7.5.609 · Cited by 24

Macro-environment of breast carcinoma: frequent genetic alterations in the normal appearing skins of patients with breast cancer

Moinfar, F., Beham, A., FRIEDRICH, G. E., Deutsch, A. J. A., Hrzenjak, A., Luschin, G., & Tavassoli, F. A. (2008) · Modern Pathology · doi:10.1038/modpathol.2008.28 · Cited by 24

Transforming Growth Factor-Beta Orchestrates Tumour and Bystander Cells in B-Cell Non-Hodgkin Lymphoma

Timmins, M. A., & Ringshausen, I. (2022) · Cancers · doi:10.3390/cancers14071772 · Cited by 24

The recent advances of cancer associated fibroblasts in cancer progression and therapy

Wu, C., Gu, J., Gu, H., Zhang, X.-X., Zhang, X., & Ji, R. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1008843 · Cited by 24

Nano-Drug Delivery Systems Targeting CAFs: A Promising Treatment for Pancreatic Cancer

Wang, M., Xue, W., Yuan, H., Wang, Z., & Yu, L. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s451151 · Cited by 24

Antidepressant fluoxetine and its potential against colon tumors

Stopper, H. (2014) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v6.i1.11 · Cited by 23

TGF-β signalling and immunity in prostate tumourigenesis

Diener, K. R., Need, E. F., Buchanan, G., & Hayball, J. D. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903544507 · Cited by 23

Pro-Metastatic Tumor–Stroma Interactions in Breast Cancer

Gangadhara, S., Barrett-Lee, P. J., Nicholson, R. I., & Hiscox, S. (2012) · Future Oncology · doi:10.2217/fon.12.134 · Cited by 23

Interaction of prostate carcinoma-associated fibroblasts with human epithelial cell lines in vivo

Sasaki, T., Franco, O. E., & Hayward, S. W. (2017) · Differentiation · doi:10.1016/j.diff.2017.07.002 · Cited by 24

Drug repurposing screening identifies bortezomib and panobinostat as drugs targeting cancer associated fibroblasts (CAFs) by synergistic induction of apoptosis

Lee, H., Lee, E., Yeo, S.-Y., Shin, S. H., Park, H., Nam, D., & Kim, S. (2018) · Investigational New Drugs · doi:10.1007/s10637-017-0547-8 · Cited by 24

Zearalenone Exposure Enhanced the Expression of Tumorigenesis Genes in Donkey Granulosa Cells via the PTEN/PI3K/AKT Signaling Pathway

Zhang, G.-L., Song, J., Ji, C., Feng, Y.-L., Yu, J., Nyachoti, C. M., & Yang, G.-S. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00293 · Cited by 23

The Tumor Suppressor TGFBR3 Blocks Lymph Node Metastasis in Head and Neck Cancer

Fang, W., Kuo, Y.-Z., Chang, J., Hsiao, J., Kao, H., Tsai, S., & Wu, L. (2020) · Cancers · doi:10.3390/cancers12061375 · Cited by 23

Animal and Human Models of Tissue Repair and Fibrosis: An Introduction

Lagares, D., & Hinz, B. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1382-5_20 · Cited by 23

Recognizing Paradigm Instability in Theories of Carcinogenesis

Baker, S. G. (2014) · Journal of Advances in Medicine and Medical Research · doi:10.9734/bjmmr/2014/6855 · Cited by 26

Role of stromal tenascin-C in mouse prostatic development and epithelial cell differentiation

Ishii, K., Imanaka‐Yoshida, K., Yoshida, T., & Sugimura, Y. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.09.029 · Cited by 26

Stem Cells and the Phenomena of Plasticity and Diversity: A Limiting Property of Carcinogenesis

Filip, S., Mokrý, J., Horáček, J., & English, D. K. (2008) · Stem Cells and Development · doi:10.1089/scd.2007.0234 · Cited by 23

Intercellular adhesion molecule 1: Recent findings and new concepts involved in mammalian spermatogenesis

Mruk, D. D., Xiao, X., Łydka, M., Li, M., Bilińska, B., & Cheng, C. Y. (2013) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2013.07.003 · Cited by 23

Systems-Level Modeling of Cancer-Fibroblast Interaction

Wadlow, R. C., Wittner, B. S., Finley, S. A., Bergquist, H., Upadhyay, R., Finn, S. P., Loda, M. F., Mahmood, U., & Ramaswamy, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006888 · Cited by 23

STROMAL HYPERPLASIA IN MALE BLADDERS UPON LOSS OF TRANSFORMING GROWTH FACTOR-β SIGNALING IN FIBROBLASTS

Sharif‐Afshar, A., Donohoe, J. M., POPE, J. C. I., Adams, M. C., Brock, J. W. I., & Bhowmick, N. A. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000164720.72732.9c · Cited by 23

Targeting the Wnt Pathway in Cancer

Goss, K. H., & Kahn, M. R. (2011) · Springer eBooks · doi:10.1007/978-1-4419-8023-6 · Cited by 23

Conditional Knockout Mouse Models of CancerPreprint

Deng, C. (2014) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top074393 · Cited by 23

Origin and maintenance of the intestinal cancer stem cell

Davies, E. J., Marsh, V. L., & Clarke, A. R. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20631 · Cited by 22

ELTD1 Function in Hepatocellular Carcinoma is Carcinoma-Associated Fibroblast-Dependent

Kan, A., Le, Y., Zhang, Y., Duan, F., Zhong, X.-P., Lu, L.-H., Ling, Y., & Guo, R. (2018) · Journal of Cancer · doi:10.7150/jca.24406 · Cited by 22

Antibacterial coaxial hydro-membranes accelerate diabetic wound healing by tuning surface immunomodulatory functions

Zhang, W., Xia, S.-Z., Weng, T.-T., Yang, M., Shao, J., Zhang, M., Wang, J.-L., Xu, P., Wei, J.-T., Jin, R.-H., et al. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100395 · Cited by 22

ASPORIN: A root of the matter in tumors and their host environment

Lall, S. P., Alsafwani, Z. W., Batra, S. K., & Seshacharyulu, P. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.189029 · Cited by 22

Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models

DeCant, B. T., Principe, D. R., Guerra, C. E., di Magliano, M. P., & Grippo, P. J. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00464 · Cited by 22

Gradient-on-a-Chip with Reactive Oxygen Species Reveals Thresholds in the Nucleus Response of Cancer Cells Depending on the Matrix Environment

Chittiboyina, S., Rahimi, R., Atrian, F., Ochoa, M., Ziaie, B., & Lelièvre, S. A. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00087 · Cited by 22

Laser‐capture microdissection in prostate cancer research: establishment and validation of a powerful tool for the assessment of tumour–stroma interactions

Shukla, C. J., Pennington, C. J., Riddick, A. C. P., Sethia, K. K., Ball, R. Y., & Edwards, D. R. (2008) · British Journal of Urology · doi:10.1111/j.1464-410x.2007.07372.x · Cited by 22

A Visual-Quantitative Analysis of Fibroblastic Stromagenesis in Breast Cancer Progression

Cukierman, E. (2004) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-004-1403-y · Cited by 22

Solid-Phase Synthesis of Chlorofusin Analogues

Woon, E. C. Y., Arcieri, M., Wilderspin, A. F., Malkinson, J. P., & Searcey, M. (2007) · The Journal of Organic Chemistry · doi:10.1021/jo070450a · Cited by 22

Benign mammary epithelial cells enhance the transformed phenotype of human breast cancer cells

Poczobutt, J. M., Tentler, J. J., Lu, X. J. D., Schedin, P. S., & Gutierrez‐Hartmann, A. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-373 · Cited by 23

Intestinal GUCY2C Prevents TGF-β Secretion Coordinating Desmoplasia and Hyperproliferation in Colorectal Cancer

Gibbons, A. V., Lin, J. E., Kim, G. W., Marszalowicz, G. P., Li, P., Stoecker, B. A., Blomain, E. S., Rattan, S. C., Snook, A. E., Schulz, S., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0887 · Cited by 22

Pediatric Solid Cancers: Dissecting the Tumor Microenvironment to Improve the Results of Clinical Immunotherapy

Belgiovine, C., Mebelli, K., Raffaele, A., Cicco, M. D., Rotella, J., Pedrazzoli, P., Zecca, M., Riccipetitoni, G., & Comoli, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063225 · Cited by 22

An innovative strategy harnessing self-activating CAR-NK cells to mitigate TGF-β1-driven immune suppression

Shin, S. H., Lee, Y. E., Yoon, H., Yuk, C. M., An, J. Y., Seo, M., Yoon, S. W., Oh, M.-S., Shin, S. C., Kim, J. H., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122888 · Cited by 21

Modeling Human Prostate Cancer in Genetically Engineered Mice

Wang, F. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-384878-9.00001-7 · Cited by 21

Breast cancer, stem cells and sex hormones

Eden, J. (2010) · Maturitas · doi:10.1016/j.maturitas.2010.05.005 · Cited by 21

Targeting the stromal fibroblasts: a novel approach to melanoma therapy

Smalley, K. S. M., Lioni, M., & Herlyn, M. (2005) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.5.6.1069 · Cited by 21

Nanotherapeutics for multiple myeloma

Zheleznyak, A., Shokeen, M., & Achilefu, S. (2018) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1526 · Cited by 21

Cancer epithelia-derived mitochondrial DNA is a targetable initiator of a paracrine signaling loop that confers taxane resistance

Haldar, S., Mishra, R., Billet, S., Thiruvalluvan, M., Placencio-Hickok, V., Madhav, A., Duong, F. L., Angara, B., Agarwal, P., Tighiouart, M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1910952117 · Cited by 22

The up-regulation of cysteine-rich protein 61 induced by transforming growth factor beta enhances osteosarcoma cell migration

Chen, J., Song, Y., Yang, J., Gong, L., Zhao, P., Zhang, Y., & Su, H. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1807-3 · Cited by 21

Proliferation and Polarity in Breast Cancer: Untying the Gordian Knot

Liu, H., Radisky, D. C., & Bissell, M. J. (2005) · Cell Cycle · doi:10.4161/cc.4.5.1674 · Cited by 21

Oncogenes as Novel Targets for Cancer Therapy (Part IV)

Zhang, Z., Li, M., Rayburn, E. R., Hill, D. L., Zhang, R., & Wang, H. (2005) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200505060-00006 · Cited by 21

In vitro three-dimensional models in cancer research: a review

Imparato, G., Urciuolo, F., & Netti, P. A. (2015) · International Materials Reviews · doi:10.1179/1743280415y.0000000003 · Cited by 20

Gene expressional changes in prostate fibroblasts from cancerous tissue

Reinertsen, T., Halgunset, J., Viset, T., Flatberg, A., Haugsmoen, L. L., & Skogseth, H. (2012) · Apmis · doi:10.1111/j.1600-0463.2011.02865.x · Cited by 20

Cancer‐associated fibroblasts promote malignancy of gastric cancer cells via Nodal signalling

Pang, T., Yin, X., Luo, T., Lu, Z., Nie, M., Yin, K., & Xue, X. (2019) · Cell Biochemistry and Function · doi:10.1002/cbf.3446 · Cited by 20

Is carcinoma a mesenchymal disease? The role of the stromal microenvironment in carcinogenesis

Hemmings, C. (2013) · Pathology · doi:10.1097/pat.0b013e328360b600 · Cited by 20

Cancer vaccines: Harnessing the potential of anti-tumor immunity

Suckow, M. A. (2013) · The Veterinary Journal · doi:10.1016/j.tvjl.2013.06.005 · Cited by 20

The mesenchyme in malignancy: A partner in the initiation, progression and dissemination of cancer

Glaire, M. A., El-Omar, E. M., Wang, T. C., & Worthley, D. L. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.08.007 · Cited by 20

Promiscuous recombination of LoxP alleles during gametogenesis in cornea Cre driver mice.

Weng, D. Y., Zhang, Y., Hayashi, Y., Kuan, C.-Y., Liu, C., Babcock, G. F., Weng, W.-L., Schwemberger, S. J., & Kao, W. W. ‐. (2008) · PubMed Central · Cited by 20

microRNAs and Prostate Cancer

Josson, S., Chung, L. W. K., & Gururajan, M. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-23730-5_7 · Cited by 20

Modulating Tumor Microenvironment: A Review on STK11 Immune Properties and Predictive vs Prognostic Role for Non-small-cell Lung Cancer Immunotherapy

Mazzaschi, G., Leonetti, A., Minari, R., Gnetti, L., Quaini, F., Tiseo, M., & Facchinetti, F. (2021) · Current Treatment Options in Oncology · doi:10.1007/s11864-021-00891-8 · Cited by 21

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(2004) · Science s STKE · doi:10.1126/stke.2192004tw48

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