Cited by 1,401TGF-β signaling in diseasesLiver physiology and pathologyCancer Cells and Metastasis

The DOI matches its Crossref record; 24 of the 26 references it cites were found in a registry or an index.

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

Bhowmick, Neil A., Chytil, Anna, Plieth, David, Gorska, Agnieszka E., Dumont, Nancy, Shappell, Scott, Washington, M. Kay, Neilson, Eric G., Moses, Harold L.·2004·Science

DOI 10.1126/science.1090922

Open this paper in CoChat — free account

Abstract

Stromal cells can have a significant impact on the carcinogenic process in adjacent epithelia. The role of transforming growth factor–β (TGF-β) signaling in such epithelial-mesenchymal interactions was determined by conditional inactivation of the TGF-β type II receptor gene in mouse fibroblasts ( Tgfbr2 fspKO ). The loss of TGF-β responsiveness in fibroblasts resulted in intraepithelial neoplasia in prostate and invasive squamous cell carcinoma of the forestomach, both associated with an increased abundance of stromal cells. Activation of paracrine hepatocyte growth factor (HGF) signaling was identified as one possible mechanism for stimulation of epithelial proliferation. Thus, TGF-β signaling in fibroblasts modulates the growth and oncogenic potential of adjacent epithelia in selected tissues.

Integrity signals

Registry

Crossref · 10.1126/science.1090922

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Generalized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
Massagué, J., Blain, S. W., & Lo, R. S. (2000) · Cell · doi:10.1016/s0092-8674(00)00121-5 · Cited by 2,391
Evidence that fibroblasts derive from epithelium during tissue fibrosis
Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215518 · Cited by 1,589
Self-citation
Signal Transduction by the TGF-β Superfamily
Attisano, L., & Wrana, J. L. (2002) · Science · doi:10.1126/science.1071809 · Cited by 1,286
c-MYC: more than just a matter of life and death
Pelengaris, S., Khan, M., & Evan, G. I. (2002) · Nature reviews. Cancer · doi:10.1038/nrc904 · Cited by 1,192
Identification and characterization of a fibroblast marker: FSP1.
Strutz, F. M., Okada, H., Lo, C. W., Danoff, T. M., Carone, R. L., Tomaszewski, J. E., & Neilson, E. G. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.2.393 · Cited by 1,075
Self-citation
Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction
Kaartinen, V., Voncken, J. W., Shuler, C. F., Warburton, D., Bu, D., Heisterkamp, N., & Groffen, J. (1995) · Nature Genetics · doi:10.1038/ng1295-415 · Cited by 1,042
Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction
Rønnov‐Jessen, L., PETERSEN, O. W., & Bissell, M. J. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.1.69 · Cited by 797
TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.Preprint
Oft, M., Peli, J., Rudaz, C., Schwarz, H., Beug, H., & Ernst Reichmann, A. (1996) · Genes & Development · doi:10.1101/gad.10.19.2462 · Cited by 679
Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.
Barcellos‐Hoff, M. H., & Ravani, S. A. (2000) · PubMed · Cited by 536

Flagged first, then by citations

Show all 26 references

2 of the 26 references couldn’t be matched to a known paper.

Research works printed but not linked: 7

T. Nakamura, K. Matsumoto, A. Kiritoshi, Y. Tano, Cancer Res.57, 3305 (1997).
M. H. Barcellos-Hoff, S. A. Ravani, Cancer Res.60, 1254 (2000).
N. Hayashi, G. R. Cunha, Cancer Res.51, 4924 (1991).
M. Cooper, H. Pinkus, Cancer Res.37, 2544 (1977).
I. Thesleff, A. Vaahtokari, A. M. Partanen, Int. J. Dev. Biol.39, 35 (1995).
S. Watanabeet al., J. Gastroenterol.35 (suppl. 12), 65 (2000).
H. Sakurai, S. K. Nigam, Am. J. Physiol.272, F139 (1997).

Sorted by citations

Items 501–600 of 1,001

The Tumor Microenvironment: Key to Early Detection
Ariztia, E. V., Lee, C. J., Gogoi, R. P., & Fishman, D. A. (2006) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360600778836 · Cited by 71
Niche contributions to oncogenesis: emerging concepts and implications for the hematopoietic system
Raaijmakers, M. H. G. P. (2011) · Haematologica · doi:10.3324/haematol.2010.028035 · Cited by 71
Differential Influence of Normal and Cancer-Associated Fibroblasts on the Growth of Human Epithelial Cells in an In vitro Cocultivation Model of Prostate Cancer
Paland, N., Kamer, I., Kogan-Sakin, I., Madar, S., Goldfinger, N., & Rotter, V. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0073 · Cited by 72
Delivery of RNAi Therapeutics to the Airways—From Bench to Bedside
Qiu, Y., Lam, J. K. W., Leung, S. W. S., & Liang, W. (2016) · Molecules · doi:10.3390/molecules21091249 · Cited by 73
Effect of increasing ratio of estrogen: Androgen on proliferation of normal human prostate stromal and epithelial cells, and the malignant cell line LNCaP
King, K. J., Nicholson, H. D., & Assinder, S. J. (2005) · The Prostate · doi:10.1002/pros.20327 · Cited by 70
Pathophysiological role of microRNA-29 in pancreatic cancer stroma
Kwon, J. J., Nabinger, S. C., Vega, Z., Sahu, S. S., Alluri, R. K., Sater, Z. A., Yu, Z., Gore, J., Nalepa, G., Saxena, R., et al. (2015) · Scientific Reports · doi:10.1038/srep11450 · Cited by 69
Transforming growth factor‑β signaling in head and neck squamous cell carcinoma: Insights into cellular responses (Review)
Pang, X., Tang, Y., & Liang, X. (2018) · Oncology Letters · doi:10.3892/ol.2018.9319 · Cited by 72
Three-dimensional bio-printing: A new frontier in oncology research
Charbe, N. B., McCarron, P. A., & Tambuwala, M. M. (2017) · World Journal of Clinical Oncology · doi:10.5306/wjco.v8.i1.21 · Cited by 70
PI3K in Cancer: Its Structure, Activation Modes and Role in Shaping Tumor Microenvironment
Liu, X., Xu, Y., Zhou, Q., Chen, M., Zhang, Y., Liang, H., Zhao, J., Zhong, W., & Wang, M. (2017) · Future Oncology · doi:10.2217/fon-2017-0588 · Cited by 70
In vitro modeling of the prostate cancer microenvironment
Ellem, S. J., De-Juan-Pardo, E. M., & Risbridger, G. P. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.04.008 · Cited by 68
Proteomimetic Libraries: Design, Synthesis, and Evaluation of p53−MDM2 Interaction Inhibitors
Lu, F., Chi, S., Kim, D., Han, K., Kuntz, I. D., & Guy, R. K. (2006) · Journal of Combinatorial Chemistry · doi:10.1021/cc050142v · Cited by 68
Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis
Koliaraki, V., Roulis, M., & Kollias, G. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63917 · Cited by 68
The tumor suppressor kinase LKB1: lessons from mouse models
Ollila, S., & Mäkelä, T. P. (2011) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjr016 · Cited by 76
Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer
Chen, W., Tsai, Y.-C., Yeh, H.-L., Suau, F., Jiang, K.-C., Shao, A., Huang, J., & Liu, Y. (2017) · Science Signaling · doi:10.1126/scisignal.aam6826 · Cited by 68
Transforming Growth Factor Beta and Prostate Cancer
Zhu, B., & Kyprianou, N. (2005) · Cancer treatment and research · doi:10.1007/0-387-24361-5_7 · Cited by 68
Inhibition of Transforming Growth Factor-β Signaling in Human Cancer: Targeting a Tumor Suppressor Network as a Therapeutic Strategy
Biswas, S., Criswell, T. L., Wang, S. E., & Arteaga, C. L. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0952 · Cited by 68
RETRACTED: The role of cardiac fibroblasts in post-myocardial heart tissue repair
Chistiakov, D. A., Orekhov, A. N., & Bobryshev, Y. V. (2016) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2016.09.002 · Cited by 69
Retracted
Suppressed Prostate Epithelial Development with Impaired Branching Morphogenesis in Mice Lacking Stromal Fibromuscular Androgen Receptor
Lai, K.-P., Yamashita, S., Vitkus, S., Shyr, C., Yeh, S., & Chang, C. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-1189 · Cited by 67
Tumor-Specific Efficacy of Transforming Growth Factor-βRI Inhibition in Eker Rats
Laping, N. J., Everitt, J. I., Frazier, K. S., Burgert, M. E., Portis, M. J., Cadacio, C., Gold, L. I., & Walker, C. L. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1811 · Cited by 67
Emerging Therapeutic Targets in Breast Cancer Bone Metastasis
Rose, A. A. N., & Siegel, P. M. (2009) · Future Oncology · doi:10.2217/fon.09.138 · Cited by 68
Phosphatidylinositol 3-kinase signaling determines kidney size
Chen, J.-K., Nagai, K., Chen, J., Plieth, D., Hino, M., Xu, J., Sha, F., Ikizler, T. A., Quarles, C. C., Threadgill, D. W., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78945 · Cited by 67
Self-citation
Small intestinal neuroendocrine tumours and fibrosis: an entangled conundrum
Blažević, A., Hofland, J., Hofland, L. J., Feelders, R. A., & de Herder, W. W. (2017) · Endocrine Related Cancer · doi:10.1530/erc-17-0380 · Cited by 67
Effects of pirfenidone targeting the tumor microenvironment and tumor-stroma interaction as a novel treatment for non-small cell lung cancer
Fujiwara, A., Funaki, S., Fukui, E., Kimura, K., Kanou, T., Ose, N., Minami, M., & Shintani, Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-67904-8 · Cited by 67
Expression of transforming growth factor‐beta 1 and growth in soft agar differentiate prostate carcinoma‐associated fibroblasts from normal prostate fibroblasts
Francisco, I. F. S., DeWolf, W. C., Peehl, D. M., & Olumi, A. F. (2004) · International Journal of Cancer · doi:10.1002/ijc.20388 · Cited by 68
Harnessing preclinical mouse models to inform human clinical cancer trials
Gutmann, D. H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28271 · Cited by 69
Development of pharmacological immunoregulatory anti-cancer therapeutics: current mechanistic studies and clinical opportunities
Yin, N., Li, X., Zhang, X., Xue, S., Cao, Y., Niedermann, G., Lu, Y., & Xue, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01826-z · Cited by 74
Significance of podoplanin expression in cancer-associated fibroblasts: A comprehensive review
Puła, B., Witkiewicz, W., Dzięgiel, P., & Podhorska‐Okołów, M. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1887 · Cited by 66
Tumour necrosis factor α confers an invasive, transformed phenotype on mammary epithelial cells
Montesano, R., Soulié, P., Eble, J. A., & Carrozzino, F. (2005) · Journal of Cell Science · doi:10.1242/jcs.02467 · Cited by 66
Lack of transforming growth factor-β signaling promotes collective cancer cell invasion through tumor-stromal crosstalk
Matise, L. A., Palmer, T. D., Ashby, W. J., Nashabi, A., Chytil, A., Aakre, M. E., Pickup, M. W., Gorska, A. E., Zijlstra, A., & Moses, H. L. (2012) · Breast Cancer Research · doi:10.1186/bcr3217 · Cited by 67
Self-citation
A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours
Fu, R., Han, C., Ni, T., Di, L., Liu, L., Lv, W., Bi, Y.-R., Jiang, N., He, Y., Li, H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11278-7 · Cited by 66
TGFβ and cancer metastasis: an inflammation link
Yang, L. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9226-3 · Cited by 65
Loss of TGF-β Responsiveness in Prostate Stromal Cells Alters Chemokine Levels and Facilitates the Development of Mixed Osteoblastic/Osteolytic Bone Lesions
Li, X., Sterling, J. A. R., Fan, K.-H., Vessella, R. L., Shyr, Y., Hayward, S. W., Matrisian, L. M., & Bhowmick, N. A. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0506 · Cited by 65
Self-citation
Tissue-Specific Consequences of Cyclin D1 Overexpression in Prostate Cancer Progression
He, Y., Franco, O. E., Jiang, M., Williams, K., Love, H. D., Coleman, I. M., Nelson, P. S., & Hayward, S. W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0418 · Cited by 66
Modeling embryogenesis and cancer: an approach based on an equilibrium between the autostabilization of stochastic gene expression and the interdependence of cells for proliferation
Laforge, B., Guez, D., Martinez, M., & Kupiec, J.-J. (2004) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2004.11.004 · Cited by 65
NDRG3 is an androgen regulated and prostate enriched gene that promotes in vitro and in vivo prostate cancer cell growth
Wang, W., Li, Y., Li, Y., Hong, A.-Z., Wang, J., Lin, B., & Li, R. (2008) · International Journal of Cancer · doi:10.1002/ijc.23961 · Cited by 64
Enhanced Hepatocyte Growth Factor Signaling by Type II Transforming Growth Factor-β Receptor Knockout Fibroblasts Promotes Mammary Tumorigenesis
Cheng, N., Chytil, A., Shyr, Y., Joly, A. H., & Moses, H. L. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3381 · Cited by 67
Self-citation
Endocannabinoids in endocrine and related tumours
Bifulco, M., Malfitano, A. M., Pisanti, S., & Laezza, C. (2008) · Endocrine Related Cancer · doi:10.1677/erc-07-0258 · Cited by 64
The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis
Xu, K., Tian, X., Oh, S. Y., Movassaghi, M., Naber, S. P., Kuperwasser, C., & Buchsbaum, R. J. (2016) · Breast Cancer Research · doi:10.1186/s13058-016-0674-8 · Cited by 66
Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth
Hammer, A. M., Sizemore, G. M., Shukla, V. C., Avendano, A., Sizemore, S. T., Chang, J. J., Kladney, R. D., Cuitiño, M. C., Thies, K., Verfurth, Q., et al. (2017) · Neoplasia · doi:10.1016/j.neo.2017.04.004 · Cited by 64
Modeling triple-negative breast cancer heterogeneity: Effects of stromal macrophages, fibroblasts and tumor vasculature
Norton, K., Jin, K., & Popel, A. S. (2018) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2018.05.003 · Cited by 66
Intratumoral heterogeneity: Clonal cooperation in epithelial-to-mesenchymal transition and metastasis
Neelakantan, D., Drasin, D. J., & Ford, H. L. (2014) · Cell Adhesion & Migration · doi:10.4161/19336918.2014.972761 · Cited by 64
Tumor–stromal interactions reciprocally modulate gene expression patterns during carcinogenesis and metastasis
Montel, V., Mose, E. S., & Tarin, D. (2006) · International Journal of Cancer · doi:10.1002/ijc.21757 · Cited by 63
Endoglin Regulates Cancer–Stromal Cell Interactions in Prostate Tumors
Romero, D., O'Neill, C., Terzic, A., Contois, L. W., Young, K. A., Conley, B. A., Bergan, R. C., Brooks, P. C., & Vary, C. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2665 · Cited by 64
Mesenchymal stem cells as a gene therapy carrier for treatment of fibrosarcoma
Xiang, J., Tang, J., Song, C., Yang, Z., Hirst, D. G., Zheng, Q., & Li, G. (2009) · Cytotherapy · doi:10.1080/14653240902960429 · Cited by 64
Stromal fibroblasts present in breast carcinomas promote tumor growth and angiogenesis through adrenomedullin secretion
Benyahia, Z., Dussault, N., Cayol, M., Sigaud, R., Berenguer‐Daizé, C., Delfino, C., Tounsi, A., Garcia, S., Martin, P., Mabrouk, K., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.14999 · Cited by 68
Exosomal microRNA: a Novel Biomarker for Breast Cancer
He, Y., Deng, F., Yang, S., Wang, D., Chen, X., Zhong, S., Zhao, J., & Tang, J. (2017) · Biomarkers in Medicine · doi:10.2217/bmm-2017-0305 · Cited by 64
Epithelial to Mesenchymal Transition and Cell Biology of Molecular Regulation in Endometrial Carcinogenesis
Chiu, H.-C., Li, C., Yiang, G., Tsai, A. P., & Wu, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8040439 · Cited by 64
Cancer cell survival depends on collagen uptake into tumor-associated stroma
Hsu, K.-S., Dunleavey, J. M., Szot, C. S., Yang, L., Hilton, M. B., Morris, K., Seaman, S., Feng, Y., Lutz, E. M., Koogle, R., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34643-5 · Cited by 65
Targeting the Tumor Stroma as a Novel Treatment Strategy for Breast Cancer
Tchou, J. C., & Conejo-Garcia, J. R. (2012) · Advances in pharmacology · doi:10.1016/b978-0-12-397927-8.00003-8 · Cited by 63
Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4
Matsumoto, K., Nakamura, T., Sakai, K., & Nakamura, T. (2008) · PROTEOMICS · doi:10.1002/pmic.200800156 · Cited by 63
Scleroderma – New aspects in pathogenesis and treatment
Balbir‐Gurman, A., & Braun‐Moscovici, Y. (2012) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2012.01.011 · Cited by 64
The Stroma—A Key Regulator in Prostate Function and Malignancy
Hägglöf, C., & Bergh, A. R. J. (2012) · Cancers · doi:10.3390/cancers4020531 · Cited by 67
Bioactive glass-based fibrous wound dressings
Homaeigohar, S., Li, M., & Boccaccini, A. R. (2022) · Burns & Trauma · doi:10.1093/burnst/tkac038 · Cited by 61
SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling
Koledova, Z. S., Zhang, X. M., Streuli, C. H., Clarke, R. B., Klein, O. D., Werb, Z., & Lu, P. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611532113 · Cited by 62
A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype
Melling, G. E., Flannery, S. E., Abidin, S. A. I. Z., Clemmens, H., Prajapati, P., Hinsley, E. E., Hunt, S., Catto, J. W. F., Coletta, R. D., Mellone, M., et al. (2018) · Carcinogenesis · doi:10.1093/carcin/bgy032 · Cited by 63
TGF-β, Bone Morphogenetic Protein, and Activin Signaling and the Tumor MicroenvironmentPreprint
Pickup, M. W., Owens, P., & Moses, H. L. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022285 · Cited by 63
Self-citation
BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation
Pickup, M. W., Hover, L. D., Polikowsky, E. R., Chytil, A. M., Gorska, A. E., Novitskiy, S. V., Moses, H. L., & Owens, P. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.08.004 · Cited by 60
Self-citation
Overexpression of REIC/Dkk-3 in Normal Fibroblasts Suppresses Tumor Growth via Induction of Interleukin-7
Sakaguchi, M., Kataoka, K., Abarzúa, F., Tanimoto, R., Watanabe, M., Murata, H., Than, S. S., Kurose, K., Kashiwakura, Y., Ochiai, K., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808002200 · Cited by 61
Oral Submucous Fibrosis: Review on Etiopathogenesis
Dyavanagoudar, S. N. (2009) · Journal of Cancer Science & Therapy · doi:10.4172/1948-5956.1000011 · Cited by 59
Modeling prostate cancer in mice: something old, something new, something premalignant, something metastatic
Irshad, S., & Abate-Shen, C. T. (2012) · Cancer and Metastasis Reviews · doi:10.1007/s10555-012-9409-1 · Cited by 63
Computational pathology: Exploring the spatial dimension of tumor ecology
Nawaz, S., & Yuan, Y. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.11.018 · Cited by 62
Exosomes are the Driving Force in Preparing the Soil for the Metastatic Seeds: Lessons from the Prostate Cancer
Saber, S. H., Ali, H. E. A., Gaballa, R., Gaballah, M. S. A., Ali, H. I., Zerfaoui, M., & Elmageed, Z. Y. A. (2020) · Cells · doi:10.3390/cells9030564 · Cited by 63
Epithelial-to-Mesenchymal Transition in the Light of Plasticity and Hybrid E/M States
Bornes, L., Belthier, G., & van Rheenen, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112403 · Cited by 62
Heterogeneity of cancer-associated fibroblasts in head and neck squamous cell carcinoma: opportunities and challenges
Chen, H., Zhang, Y., Wu, C., & Huang, Q. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01428-8 · Cited by 63
Role of Stromal Fibroblasts in Cancer: Promoting or Impeding?
Angeli, F., Koumakis, G., Chen, M.-C., Kumar, S., & Delinassios, J. G. (2009) · Tumor Biology · doi:10.1159/000218708 · Cited by 58
Roles of tumor suppressors in regulating tumor-associated inflammation
Yang, L., & Karin, M. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.131 · Cited by 59
The metabolic interactions between tumor cells and tumor-associated stroma (TAS) in prostatic cancer
Giatromanolaki, A. N., Koukourakis, M. I., Koutsopoulos, A. V., Mendrinos, S. E., & Sivridis, E. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.21785 · Cited by 60
Genotype, phenotype and cancer: Role of low penetrance genes and environment in tumour susceptibility
Kotnis, A. L., Sarin, R., & Mulherkar, R. (2005) · Journal of Biosciences · doi:10.1007/bf02705154 · Cited by 58
TGFBR1 Signaling and Breast Cancer
Moore-Smith, L. D., & Pasche, B. (2011) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-011-9216-2 · Cited by 58
Loss of Fibroblast HIF-1α Accelerates Tumorigenesis
Kim, J., Evans, C. E., Weidemann, A., Takeda, N., Lee, Y. S., Stockmann, C., Branco‐Price, C., Brandberg, F., Leone, G. W., Ostrowski, M. C., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0534 · Cited by 58
Relationship of Mammographic Density and Gene Expression: Analysis of Normal Breast Tissue Surrounding Breast Cancer
Sun, X., Gierach, G. L., Sandhu, R., Williams, T., Midkiff, B. R., Lissowska, J., Wesołowska, E., Boyd, N. F., Johnson, N. B., Figueroa, J. D., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0029 · Cited by 58
Stromal Deletion of the APC Tumor Suppressor in Mice Triggers Development of Endometrial Cancer
Tanwar, P. S., Zhang, L., Roberts, D. J., & Teixeira, J. M. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3166 · Cited by 57
Integrin-Specific Control of Focal Adhesion Kinase and RhoA Regulates Membrane Protrusion and Invasion
Costa, P., Scales, T. M. E., Ivaska, J., & Parsons, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074659 · Cited by 57
SHP2 Regulates Chondrocyte Terminal Differentiation, Growth Plate Architecture and Skeletal Cell Fates
Bowen, M. E., Ayturk, U. M., Kurek, K. C., Yang, W., & Warman, M. L. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004364 · Cited by 57
Bone Marrow Derived Mesenchymal Stem Cells Incorporate into the Prostate during Regrowth
Placencio, V. R., Li, X., Sherrill, T. P., Fritz, G. A., & Bhowmick, N. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012920 · Cited by 57
Self-citation
Microenvironment in metastasis: roadblocks and supportive niches
Pein, M., & Óskarsson, T. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00145.2015 · Cited by 59
Understanding c-MET signalling in squamous cell carcinoma of the head & neck
Szturz, P., Raymond, É., Abitbol, C., Albert, S., Gramont, A. D. E., & Faivre, S. J. (2017) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.01.004 · Cited by 57
Transforming Growth Factor-β: An Agent of Change in the Tumor Microenvironment
Stuelten, C. H., & Zhang, Y. E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.764727 · Cited by 57
The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment
Pajic, M., Herrmann, D., Vennin, C., Conway, J. R. W., Chin, V. T., Johnsson, A., Welch, H. C. E., & Timpson, P. (2015) · Small GTPases · doi:10.4161/21541248.2014.973749 · Cited by 57
MicroRNA applications for prostate, ovarian and breast cancer in the era of precision medicine
Smith, B., Agarwal, P., & Bhowmick, N. A. (2017) · Endocrine Related Cancer · doi:10.1530/erc-16-0525 · Cited by 56
Self-citation
Mechanisms of Fibroblast Activation and Myocardial Fibrosis: Lessons Learned from FB-Specific Conditional Mouse Models
Umbarkar, P., Ejantkar, S., Tousif, S., & Lal, H. (2021) · Cells · doi:10.3390/cells10092412 · Cited by 58
The role of matrix stiffness in cancer stromal cell fate and targeting therapeutic strategies
Wei, J., Yao, J., Yan, M., Xie, Y., Liu, P., Mao, Y., & Li, X. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.08.005 · Cited by 57
The role of fibroblast Tiam1 in tumor cell invasion and metastasis
Xu, K., Rajagopal, S., Klebba, I., Dong, S., Ji, Y., Liu, J., Kuperwasser, C., Garlick, J. A., Naber, S. P., & Buchsbaum, R. J. (2010) · Oncogene · doi:10.1038/onc.2010.385 · Cited by 56
TGF β : A player on multiple fronts in the tumor microenvironment
Čaja, F., & Vannucci, L. E. (2014) · Journal of Immunotoxicology · doi:10.3109/1547691x.2014.945667 · Cited by 56
Prostatic preneoplasia and beyond
Joshua, A. M., Evans, A., van der Kwast, T., Zieleńska, M., Meeker, A. K., Chinnaiyan, A. M., & Squire, J. A. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2007.12.001 · Cited by 62
The prognostic significance of CXCL1 hypersecretion by human colorectal cancer epithelia and myofibroblasts
Rolle, A.-F. L., Chiu, T. K., Fara, M. G., Shia, J., Zeng, Z., Weiser, M. R., Paty, P. B., & Chiu, V. K. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0555-4 · Cited by 56
RADIATION CARCINOGENESIS IN CONTEXT: HOW DO IRRADIATED TISSUES BECOME TUMORS?
Barcellos‐Hoff, M. H., & Nguyen, D. H. A. (2009) · Health Physics · doi:10.1097/hp.0b013e3181b08a10 · Cited by 57
ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-β/Smad-induced growth arrest of prostate cells
Noda, D., Itoh, S., Watanabe, Y., Inamitsu, M., Dennler, S., Itoh, F., Koike, S., Danielpour, D., ten Dijke, P., & Kato, M. (2006) · Oncogene · doi:10.1038/sj.onc.1209571 · Cited by 56
Dynamic allostery drives autocrine and paracrine TGF-β signaling
Jin, M., Seed, R., Cai, G., Shing, T., Wang, L., Ito, S., Cormier, A., Wankowicz, S. A. M., Jespersen, J. M., Baron, J. L., et al. (2024) · Cell · doi:10.1016/j.cell.2024.08.036 · Cited by 58
Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche
Ghiabi, P., Jiang, J., Pasquier, J., Maleki, M., Abu-Kaoud, N., Halabi, N. M., Guerrouahen, B. S., Rafii, S., & Rafii, A. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0386-3 · Cited by 58
HGF upregulation contributes to angiogenesis in mice with keratinocyte-specific Smad2 deletion
Hoot, K. E., Oka, M., Han, G., Böttinger, E. P., Zhang, Q., & Wang, X. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43304 · Cited by 55
Posttranscriptional regulation by RNA-binding proteins during epithelial-to-mesenchymal transition
Aparicio, L. A., Abella, V., Valladares, M., & Figueroa, A. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1379-0 · Cited by 58
The Role of Versican in Modulating Breast Cancer Cell Self-renewal
Du, W. W., Fang, L., Yang, X., Wang, S., Yang, B., Seth, A. K., Zhang, Y., Yang, B. B., & Yee, A. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0461 · Cited by 55
Role of TGF-β in cancer and the potential for therapy and prevention
Kaklamani, V., & Pasche, B. (2004) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.4.4.649 · Cited by 57
Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation
Hefetz-Sela, S., Stein, I., Klieger, Y., Porat, R. M., Sade-Feldman, M., Zreik, F., Nagler, A., Pappo, O., Quagliata, L., Dazert, E., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409700111 · Cited by 54
Complex temporal regulation of capillary morphogenesis by fibroblasts
Hurley, J. R., Balaji, S., & Narmoneva, D. A. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00572.2009 · Cited by 54
Diastereochemical Diversity of Imidazoline Scaffolds via Substrate Controlled TMSCl Mediated Cycloaddition of Azlactones
Sharma, V., & Tepe, J. J. (2005) · Organic Letters · doi:10.1021/ol052118w · Cited by 54
Colorectal cancer characterization and therapeutic target prediction based on microRNA expression profile
Xu, P., Zhu, Y., Sun, B., & Xiao, Z. (2016) · Scientific Reports · doi:10.1038/srep20616 · Cited by 55
Pancreatic Fibroblasts Stimulate the Motility of Pancreatic Cancer Cells through IGF1/IGF1R Signaling under Hypoxia
Hirakawa, T., Yashiro, M., Doi, Y., Kinoshita, H., Morisaki, T., Fukuoka, T., Hasegawa, T., Kimura, K., Amano, R., & Hirakawa, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159912 · Cited by 54
Proliferating fibroblasts at the invading tumour edge of colorectal adenocarcinomas are associated with endogenous markers of hypoxia, acidity, and oxidative stress
Sivridis, E., Giatromanolaki, A. N., & Koukourakis, M. I. (2005) · Journal of Clinical Pathology · doi:10.1136/jcp.2005.026260 · Cited by 54

Authors: Bhowmick, N. A., Chytil, A., Plieth, D., Gorska, A. E., Dumont, N., Shappell, S., Washington, M. K., Neilson, E. G., & Moses, H. L.
Affiliations: Vanderbilt University (US)
Corresponding author: Moses, Harold L.
ORCID: Bhowmick, Neil A.
Gorska, Agnieszka E.
Dumont, Nancy
Washington, M. Kay
Neilson, Eric G.
Moses, Harold L.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2004-02-06
Volume: 303
Issue: 5659
Pages: 848-851
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1090922
OpenAlex: W2031300004
Cited by: 1,401
References: 26
Citations by year: 2026: 19 · 2025: 23 · 2024: 26 · 2023: 43 · 2022: 42 · 2021: 42 · 2020: 47 · 2019: 36 · 2018: 52 · 2017: 57 · 2016: 50 · 2015: 73 · 2014: 78 · 2013: 92 · 2012: 94
FWCI: 33.34
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (R01CA085492, CA85492, CA102162, CA68485, R01CA102162, P30CA068485)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK046282, DK46282)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR41943, P30AR041943)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: TGF-beta signaling, fibroblasts, epithelial-mesenchymal interactions, TGFBR2, conditional knockout, stromal cells, prostatic intraepithelial neoplasia, hepatocyte growth factor, paracrine signaling, epithelial cell proliferation, carcinogenesis
MeSH terms: Receptor, Transforming Growth Factor-beta Type II, Animals, Carcinoma, Squamous Cell, Cell Division, Cell Transformation, Neoplastic, Cells, Cultured, Epithelial Cells, Female, Fibroblasts, Gastric Mucosa, Male, Mice, Inbred C57BL, Mice, Transgenic, Neoplasms, Glandular and Epithelial, Prostate, Recombination, Genetic, Stomach, Stomach Neoplasms, Signal Transduction, Transforming Growth Factor beta, Stromal Cells, Hepatocyte Growth Factor, Protein Serine-Threonine Kinases, Receptors, Transforming Growth Factor beta, Mice, Knockout, Prostatic Intraepithelial Neoplasia, Proto-Oncogene Proteins c-met, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks