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Cited by 517

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Regulation of Flowering Time by Histone Acetylation in Arabidopsis

He, Yuehui, Michaels, Scott D., Amasino, Richard M.·2003·Science

Abstract

The Arabidopsis autonomous floral-promotion pathway promotes flowering independently of the photoperiod and vernalization pathways by repressing FLOWERING LOCUS C ( FLC ), a MADS-boxtranscription factor that blocks the transition from vegetative to reproductive development. Here, we report that FLOWERING LOCUS D ( FLD ), one of sixgenes in the autonomous pathway, encodes a plant homolog of a protein found in histone deacetylase complexes in mammals. Lesions in FLD result in hyperacetylation of histones in FLC chromatin, up-regulation of FLC expression, and extremely delayed flowering. Thus, the autonomous pathway regulates flowering in part by histone deacetylation. However, not all autonomous-pathway mutants exhibit FLC hyperacetylation, indicating that multiple means exist by which this pathway represses FLC expression.

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Crossref · 10.1126/science.1091109

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Metadata

Authors
He, Y., Michaels, S. D., & Amasino, R. M.
Venue
Science
Published
2003-12-05
Volume
302
Issue
5651
Pages
1751-1754
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2035736338
Cited by
517
References
23
FWCI
34.41
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Regulation of Flowering Time by Histone Acetylation in Arabidopsis. https://app.cochat.ai/papers/10.1126/science.1091109
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He, Y., Michaels, S. D., & Amasino, R. M. (2003). Regulation of Flowering Time by Histone Acetylation in Arabidopsis. Science. https://doi.org/10.1126/science.1091109

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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