The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Antigen Bias in T Cell Cross-Priming
Abstract
Activated CD8 + T cells detect virally infected cells and tumor cells by recognition of major histocompatibility complex class I–bound peptides derived from degraded, endogenously produced proteins. In contrast, CD8 + T cell activation often occurs through interaction with specialized antigen-presenting cells displaying peptides acquired from an exogenous cellular source, a process termed cross-priming. Here, we observed a marked inefficiency in exogenous presentation of epitopes derived from signal sequences in mouse models. These data indicate that certain virus- and tumor-associated antigens may not be detected by CD8 + T cells because of impaired cross-priming. Such differences in the ability to cross-present antigens should form important considerations in vaccine design.
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Cites
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544
Cited by
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
Gubin, M. M., Zhang, X., Schuster, H., Caron, E., Ward, J. P., Noguchi, T., Ivanova, Y., Hundal, J., Arthur, C. D., Krebber, W.-J., et al. (2014) · Nature · doi:10.1038/nature13988 · Cited by 1,974
“For these types of tumours, it is likely that TSMA vaccines targeting multiple antigens will be possible thereby providing better coverage of the tumour cell population in part due to dealing more effectively with tumour heterogeneity 27,28 .”
Self-citationCross‐presentation: underlying mechanisms and role in immune surveillance
Rock, K. L., & Shen, L. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00301.x · Cited by 451
Apoptotic Vesicles Crossprime CD8 T Cells and Protect against Tuberculosis
Winau, F., Weber, S., Sad, S., de Diego, J., Hoops, S. L., Breiden, B., Sandhoff, K., Brinkmann, V., Kaufmann, S. H. E., & Schaible, U. E. (2006) · Immunity · doi:10.1016/j.immuni.2005.12.001 · Cited by 395
Annulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis
Kaufmann, S. H. E., & McMichael, A. J. (2005) · Nature Medicine · doi:10.1038/nm1221 · Cited by 273
Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection
Rawson, P. M., Molette, C., Videtta, M., Altieri, L., Franceschini, D., Donato, T., Finocchi, L., Propato, A., Paroli, M., Meloni, F., et al. (2007) · Nature Medicine · doi:10.1038/nm1679 · Cited by 86
Metadata
- Authors
- Wolkers, M. C., Brouwenstijn, N., Bakker, A. H., Toebes, M., & Schumacher, T. N. M.
- Venue
- Science
- Published
- 2004-05-28
- Volume
- 304
- Issue
- 5675
- Pages
- 1314-1317
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2030577394
- Cited by
- 181
- References
- 1
- FWCI
- 10.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Antigen Bias in T Cell Cross-Priming. https://app.cochat.ai/papers/10.1126/science.1096268
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- Wolkers, M. C., Brouwenstijn, N., Bakker, A. H., Toebes, M., & Schumacher, T. N. M. (2004). Antigen Bias in T Cell Cross-Priming. Science. https://doi.org/10.1126/science.1096268
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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