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Tryptophan Hydroxylase-2 Controls Brain Serotonin Synthesis
Abstract
Dysregulation of brain serotonin contributes to many psychiatric disorders. Tryptophan hydroxylase-2 (Tph2), rather than Tph1, is preferentially expressed in the brain. We report a functional (C1473G) single-nucleotide polymorphism in mouse Tph2 that results in the substitution of Pro 447 with Arg 447 and leads to decreased serotonin levels in PC12 cells. Moreover, in BALB/cJ and DBA/2 mice that are homozygous for the 1473G allele, brain serotonin tissue content and synthesis are reduced in comparison to C57Bl/6 and 129X1/SvJ mice that are homozygous for the 1473C allele. Our data provide direct evidence for a fundamental role of Tph2 in brain serotonin synthesis.
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Cited by
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Metadata
- Authors
- Zhang, X., Beaulieu, J.-M., Sotnikova, T. D., Gainetdinov, R. R., & Caron, M. G.
- Venue
- Science
- Published
- 2004-07-09
- Volume
- 305
- Issue
- 5681
- Pages
- 217-217
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2092446347
- Cited by
- 683
- References
- 0
- FWCI
- 14.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, X., Beaulieu, J.-M., Sotnikova, T. D., Gainetdinov, R. R., & Caron, M. G. (2004). Tryptophan Hydroxylase-2 Controls Brain Serotonin Synthesis. Science. https://doi.org/10.1126/science.1097540
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