The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
MHC Class I Peptides as Chemosensory Signals in the Vomeronasal Organ
Abstract
The mammalian vomeronasal organ detects social information about gender, status, and individuality. The molecular cues carrying this information remain largely unknown. Here, we show that small peptides that serve as ligands for major histocompatibility complex (MHC) class I molecules function also as sensory stimuli for a subset of vomeronasal sensory neurons located in the basal Gao- and V2R receptor–expressing zone of the vomeronasal epithelium. In behaving mice, the same peptides function as individuality signals underlying mate recognition in the context of pregnancy block. MHC peptides constitute a previously unknown family of chemosensory stimuli by which MHC genotypic diversity can influence social behavior.
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Cites
Ultrasensitive pheromone detection by mammalian vomeronasal neurons
Leinders-Zufall, T., Lane, A. P., Puche, A. C., Ma, W., Novotny, M. V., Shipley, M. T., & Zufall, F. (2000) · Nature · doi:10.1038/35015572 · Cited by 576
Self-citationEncoding pheromonal signals in the accessory olfactory bulb of behaving mice
Luo, M., Fee, M. S., & Katz, L. C. (2003) · Science · doi:10.1126/science.1082133 · Cited by 365
Responses of vomeronasal neurons to natural stimuli
Holy, T. E., Dulac, C., & Meister, M. (2000) · Science · doi:10.1126/science.289.5484.1569 · Cited by 275
Something in the Air? New Insights into Mammalian Pheromones
Brennan, P. A., & Keverne, E. B. (2004) · Current Biology · doi:10.1016/j.cub.2003.12.052 · Cited by 236
Self-citationRole of the brain and accessory olfactory system in the block to pregnancy in mice
Lloyd-Thomas, A., & Keverne, E. B. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90051-3 · Cited by 138
Cited by
The importance of immune gene variability (MHC) in evolutionary ecology and conservation
Sommer, S. (2005) · Frontiers in Zoology · doi:10.1186/1742-9994-2-16 · Cited by 913
Immune proteins in brain development and synaptic plasticity
Boulanger, L. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.001 · Cited by 555
Mate choice decisions of stickleback females predictably modified by MHC peptide ligands
Milinski, M., Griffiths, S., Wegner, K. M., Reusch, T. B. H., Haas-Assenbaum, A., & Boehm, T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408264102 · Cited by 396
Self-citationLiberles, S. D. (2014) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170334 · Cited by 291
The Genetic Basis of Individual-Recognition Signals in the Mouse
Cheetham, S. A., Thom, M. D., Jury, F., Ollier, W. E. R., Beynon, R. J., & Hurst, J. L. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.007 · Cited by 212
Metadata
- Authors
- Leinders-Zufall, T., Brennan, P., Widmayer, P., S., P. C., Maul-Pavicic, A., Jäger, M., Li, X.-H., Breer, H., Zufall, F., & Boehm, T.
- Venue
- Science
- Published
- 2004-11-05
- Volume
- 306
- Issue
- 5698
- Pages
- 1033-1037
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2092290968
- Cited by
- 609
- References
- 5
- FWCI
- 19.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Leinders-Zufall, T., Brennan, P., Widmayer, P., S., P. C., Maul-Pavicic, A., Jäger, M., Li, X.-H., Breer, H., Zufall, F., & Boehm, T. (2004). MHC Class I Peptides as Chemosensory Signals in the Vomeronasal Organ. Science. https://doi.org/10.1126/science.1102818
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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