Encoding pheromonal signals in the accessory olfactory bulb of behaving mice

Luo, Minmin; Fee, Michale S.; Katz, Lawrence C.

doi:10.1126/science.1082133

Cited by 365Olfactory and Sensory Function StudiesNeuroendocrine regulation and behaviorNeurobiology and Insect Physiology Research

Encoding pheromonal signals in the accessory olfactory bulb of behaving mice

Luo, Minmin, Fee, Michale S., Katz, Lawrence C.·2003·Science

DOI 10.1126/science.1082133

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Abstract

Many mammalian species rely on pheromones-semiochemicals produced by other members of the same species-to communicate social status and reproductive readiness. To assess how the central nervous system integrates the complex repertoire of pheromones, we recorded from single neurons in the accessory olfactory bulb, a nucleus that processes pheromonal signals, of male mice engaged in natural behaviors. Neuronal firing was robustly modulated by physical contact with male and female conspecifics, with individual neurons activated selectively by specific combinations of the sex and strain of conspecifics. We infer that mammals encode social and reproductive information by integrating vomeronasal sensory activity specific to sex and genetic makeup.

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Crossref · 10.1126/science.1082133

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An important transformation of sensory information occurs in the AOB, from a segregated sampling system in the VNO to more integrated codes in the AOB.
“This organization suggests that an important transformation of sensory information occurs in the AOB, from a segregated sampling system in the VNO to more integrated codes in the AOB (Luo et al., 2003; Meeks et al., 2010).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Luo et al., 2003
Selective inhibition also shapes social discrimination in the AOB.
“Intriguingly, selective inhibition also shapes social discrimination in the AOB (Luo et al., 2003; Meeks et al., 2010).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Luo et al., 2003

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Authors: Luo, M., Fee, M. S., & Katz, L. C.
Affiliations: Howard Hughes Medical Institute (US)
Alcatel-Lucent (France) (FR)
Corresponding author: Luo, Minmin
ORCID: Luo, Minmin
Fee, Michale S.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2003-02-21
Volume: 299
Issue: 5610
Pages: 1196-1201
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1082133
OpenAlex: W2040886375
Cited by: 365
References: 47
Citations by year: 2026: 4 · 2025: 8 · 2024: 15 · 2023: 9 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 6 · 2018: 16 · 2017: 23 · 2016: 15 · 2015: 18 · 2014: 15 · 2013: 15 · 2012: 12
FWCI: 11.36
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: pheromones, vomeronasal system, accessory olfactory bulb, single-unit recording, social communication, reproductive status, sex-specific responses, genetic strain differences, natural behavior
MeSH terms: Action Potentials, Animals, Anal Canal, Behavior, Animal, Cues, Electrodes, Implanted, Face, Female, Genitalia, Male, Mice, Inbred BALB C, Mice, Inbred CBA, Mice, Inbred C57BL, Microelectrodes, Mouth, Neural Inhibition, Neurons, Neurons, Afferent, Odorants, Olfactory Bulb, Olfactory Pathways, Pheromones, Sex Characteristics, Smell, Species Specificity, Vomeronasal Organ, Mice

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Encoding pheromonal signals in the accessory olfactory bulb of behaving mice

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