Cited by 275Olfactory and Sensory Function StudiesIon Channels and ReceptorsBiochemical Analysis and Sensing Techniques

Responses of vomeronasal neurons to natural stimuli

Holy, Timothy E., Dulac, Catherine, Meister, Markus·2000·Science

Abstract

The vomeronasal organ (VNO) of mammals plays an essential role in the detection of pheromones. We obtained simultaneous recordings of action potentials from large subsets of VNO neurons. These cells responded to components of urine by increasing their firing rate. This chemosensory activation required phospholipase C function. Unlike most other sensory neurons, VNO neurons did not adapt under prolonged stimulus exposure. The full time course of the VNO spiking response is captured by a simple quantitative model of ligand binding. Many individual VNO neurons were strongly selective for either male or female mouse urine, with the effective concentrations differing as much as a thousandfold. These results establish a framework for understanding sensory coding in the vomeronasal system.

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Crossref · 10.1126/science.289.5484.1569

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24 of 24 references verified0 citation errors · 0 not checkable

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  • Vomeronasal receptors detect pheromonal cues emitted during social encounters, leading to activation of distinct neural ensembles in the vomeronasal organ.

    “Vomeronasal receptors (VRs) detect pheromonal cues emitted during social encounters, leading to the activation of distinct neural ensembles in the vomeronasal organ (VNO) (Dulac and Torello, 2003; Holy et al., 2000; Isogai et al., 2011).”

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Authors
Holy, T. E., Dulac, C., & Meister, M.
Affiliations
  • Harvard University (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Holy, Timothy E.
Venue
Science
Published
2000-09
Volume
289
Issue
5484
Pages
1569-1572
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1999244078
Cited by
275
References
24
Citations by year
2026: 4 · 2025: 5 · 2024: 9 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 9 · 2019: 1 · 2018: 10 · 2017: 6 · 2016: 8 · 2015: 11 · 2014: 11 · 2013: 16 · 2012: 12
FWCI
8.13
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords
vomeronasal organ, vomeronasal sensory neurons, pheromone detection, urine, phospholipase C, sensory coding, ligand binding, neuronal firing rate
MeSH terms
Action Potentials, Animals, Chemoreceptor Cells, Female, Kinetics, Ligands, Male, Mice, Inbred DBA, Models, Biological, Neurons, Afferent, Pheromones, Type C Phospholipases, Potassium, Urine, Signal Transduction, Vomeronasal Organ, Mice

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