Responses of vomeronasal neurons to natural stimuli
Abstract
The vomeronasal organ (VNO) of mammals plays an essential role in the detection of pheromones. We obtained simultaneous recordings of action potentials from large subsets of VNO neurons. These cells responded to components of urine by increasing their firing rate. This chemosensory activation required phospholipase C function. Unlike most other sensory neurons, VNO neurons did not adapt under prolonged stimulus exposure. The full time course of the VNO spiking response is captured by a simple quantitative model of ligand binding. Many individual VNO neurons were strongly selective for either male or female mouse urine, with the effective concentrations differing as much as a thousandfold. These results establish a framework for understanding sensory coding in the vomeronasal system.
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Vomeronasal receptors detect pheromonal cues emitted during social encounters, leading to activation of distinct neural ensembles in the vomeronasal organ.
“Vomeronasal receptors (VRs) detect pheromonal cues emitted during social encounters, leading to the activation of distinct neural ensembles in the vomeronasal organ (VNO) (Dulac and Torello, 2003; Holy et al., 2000; Isogai et al., 2011).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Holy et al., 2000
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Pheromone reception in mammals
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One nose, one brain: contribution of the main and accessory olfactory system to chemosensation
Mucignat‐Caretta, C., Redaelli, M., & Caretta, A. (2012) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2012.00046 · Cited by 64 · see citing works
Mutual influences between the main olfactory and vomeronasal systems in development and evolution
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Pheromones, Odors, and Vasanas
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Functional organization of glomerular maps in the mouse accessory olfactory bulb
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Self-citationRoles of sex and gonadal steroids in mammalian pheromonal communication
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Ensemble Encoding of Nociceptive Stimulus Intensity in the Rat Medial and Lateral Pain Systems
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Melanopsin Is Highly Resistant to Light and Chemical Bleaching in Vivo
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Paradoxical contribution of SK3 and GIRK channels to the activation of mouse vomeronasal organ
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Sex Selectivity of Mouse Ultrasonic Songs
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Self-citationFaecal bile acids are natural ligands of the mouse accessory olfactory system
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Mammalian pheromones: from genes to behaviour.
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- Authors
- Holy, T. E., Dulac, C., & Meister, M.
- Affiliations
- Harvard University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Holy, Timothy E.
- Venue
- Science
- Published
- 2000-09
- Volume
- 289
- Issue
- 5484
- Pages
- 1569-1572
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999244078
- Cited by
- 275
- References
- 24
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 9 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 9 · 2019: 1 · 2018: 10 · 2017: 6 · 2016: 8 · 2015: 11 · 2014: 11 · 2013: 16 · 2012: 12
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- vomeronasal organ, vomeronasal sensory neurons, pheromone detection, urine, phospholipase C, sensory coding, ligand binding, neuronal firing rate
- MeSH terms
- Action Potentials, Animals, Chemoreceptor Cells, Female, Kinetics, Ligands, Male, Mice, Inbred DBA, Models, Biological, Neurons, Afferent, Pheromones, Type C Phospholipases, Potassium, Urine, Signal Transduction, Vomeronasal Organ, Mice
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