Progress in Modeling of Protein Structures and Interactions.
Abstract
The prediction of the structures and interactions of biological macromolecules at the atomic level and the design of new structures and interactions are critical tests of our understanding of the interatomic interactions that underlie molecular biology. Equally important, the capability to accurately predict and design macromolecular structures and interactions would streamline the interpretation of genome sequence information and allow the creation of macromolecules with new and useful functions. This review summarizes recent progress in modeling that suggests that we are entering an era in which high-resolution prediction and design will make increasingly important contributions to biology and medicine.
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Proteins are not random heteropolymers but their sequences are formed following a tentative design.
“Only recently it has been realized that proteins are not random heteropolymers but their sequences are formed following a tentative design (for a review see [39], [40]).”
From Lethal mutants and truncated selection together solve a paradox of the origin of life (2011) · cites this paper as [40]
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- Authors
- Schueler-Furman, O., Wang, C., Bradley, P., Misura, K., & Baker, D.
- Affiliations
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
- Howard Hughes Medical Institute (US)
- Corresponding author
- Baker, David
- Venue
- Science
- Published
- 2005-10-28
- Volume
- 310
- Issue
- 5748
- Pages
- 638-642
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2147752484
- Cited by
- 294
- References
- 65
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 8 · 2018: 2 · 2017: 8 · 2016: 9 · 2015: 9 · 2014: 8 · 2013: 10 · 2012: 16
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
- Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
- Keywords
- protein structure prediction, protein-protein interaction, interatomic interactions, genome interpretation
- MeSH terms
- Computer Simulation, Computing Methodologies, Models, Molecular, Protein Conformation
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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