Cited by 295Protein Structure and DynamicsEnzyme Structure and FunctionComputational Drug Discovery Methods

Progress in Modeling of Protein Structures and Interactions.

Schueler-Furman, Ora, Wang, Chu, Bradley, Phil, Misura, Kira, Baker, David·2005·Science

Abstract

The prediction of the structures and interactions of biological macromolecules at the atomic level and the design of new structures and interactions are critical tests of our understanding of the interatomic interactions that underlie molecular biology. Equally important, the capability to accurately predict and design macromolecular structures and interactions would streamline the interpretation of genome sequence information and allow the creation of macromolecules with new and useful functions. This review summarizes recent progress in modeling that suggests that we are entering an era in which high-resolution prediction and design will make increasingly important contributions to biology and medicine.

Integrity signals

Registry

Crossref · 10.1126/science.1112160

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65 of 65 references verified0 citation errors · 0 not checkable

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Authors
Schueler-Furman, O., Wang, C., Bradley, P., Misura, K., & Baker, D.
Affiliations
  • Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Howard Hughes Medical Institute (US)
Corresponding author
Baker, David
Venue
Science
Published
2005-10-28
Volume
310
Issue
5748
Pages
638-642
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2147752484
Cited by
294
References
65
Citations by year
2025: 4 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 8 · 2018: 2 · 2017: 8 · 2016: 9 · 2015: 9 · 2014: 8 · 2013: 10 · 2012: 16
FWCI
3.31
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
  • Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
Keywords
protein structure prediction, protein-protein interaction, interatomic interactions, genome interpretation
MeSH terms
Computer Simulation, Computing Methodologies, Models, Molecular, Protein Conformation

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