Cited by 1,182Gut microbiota and healthMicrobial Community Ecology and PhysiologyInfant Nutrition and Health

The first 1000 cultured species of the human gastrointestinal microbiota

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Rajilić-Stojanović, Mirjana, de Vos, Willem M.·2014·FEMS Microbiology Reviews

Abstract

The microorganisms that inhabit the human gastrointestinal tract comprise a complex ecosystem with functions that significantly contribute to our systemic metabolism and have an impact on health and disease. In line with its importance, the human gastrointestinal microbiota has been extensively studied. Despite the fact that a significant part of the intestinal microorganisms has not yet been cultured, presently over 1000 different microbial species that can reside in the human gastrointestinal tract have been identified. This review provides a systematic overview and detailed references of the total of 1057 intestinal species of Eukarya (92), Archaea (8) and Bacteria (957), based on the phylogenetic framework of their small subunit ribosomal RNA gene sequences. Moreover, it unifies knowledge about the prevalence, abundance, stability, physiology, genetics and the association with human health of these gastrointestinal microorganisms, which is currently scattered over a vast amount of literature published in the last 150 years. This detailed physiological and genetic information is expected to be instrumental in advancing our knowledge of the gastrointestinal microbiota. Moreover, it opens avenues for future comparative and functional metagenomic and other high-throughput approaches that need a systematic and physiological basis to have an impact.

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  • The increase in Bacteroidetes plays an essential role in the metabolic conversions of complex sugar polymers and degradation of proteins.

    “the increase in Bacteroidetes plays an essential role in the metabolic conversions of complex sugar polymers and degradation of proteins [110].”

    From The athletic gut microbiota (2020) · cites this paper as [110]

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  1. Hungate RE Methods in Microbiology 1969 London Academic Press

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Authors
Rajilić-Stojanović, M., & de Vos, W. M.
Affiliations
University of Belgrade (RS)
Venue
FEMS Microbiology Reviews
Published
2014-09
Volume
38
Issue
5
Pages
996-1047
ISSN
  • 0168-6445 (ISSN-L)
  • 1574-6976
OpenAlex
W2126295648
Cited by
1,182
References
375
Citations by year
2026: 44 · 2025: 86 · 2024: 107 · 2023: 109 · 2022: 135 · 2021: 132 · 2020: 136 · 2019: 128 · 2018: 110 · 2017: 92 · 2016: 66 · 2015: 32 · 2014: 4
FWCI
6.10
Type
journal article
Language
en
Open access
Locations
  • FEMS Microbiology Reviews (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • TechnoRep (University of Belgrade – Faculty of Technology and Metallurgy) (publishedVersion, other-oa)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • Työväentutkimus Vuosikirja (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
FP7 Ideas: European Research Council (250172)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords
intestinal microorganisms, small subunit rRNA phylogeny, archaea, microbial physiology, microbial genetics, host-microbe interactions, health and disease
MeSH terms
Archaea, Bacteria, Humans, Bacterial Physiological Phenomena, Gastrointestinal Tract, Biodiversity, Eukaryota

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